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The waterlogging phenomenon of spur dike as a common type of waterway regulation building is very common. In this article, turbulence and mechanics research around the spur dike was carried out through physical model experiment; which illuminates the turbulence and Karman Vortex of spur dike erosion, the influence of pulsation kinetic energy is established and the corresponding relationship between pulse pressure and local scour, analyzed the Karman Vortex and the relationship between the dike after flushing, the influence of different influencing factors (discharge, water depth, bottom slope, length of spur dike) on the force of spur dike is systematically analyzed. The research results are of great significance for understanding the mechanism of scour and failure of spur dikes, and can provide reference for the design of spur dikes.

Objective:To identify the potential biological mechanisms by which Rhodiola crenulata(RC) treats cytokine storm (CS) using network pharmacology, molecular docking, and experimental verification. Methods:The ingredients and targets of RC were collected from the Organchem database. CS-related genes were collected using the GeneCards and OMIM databases. Cytoscape 3.7.2 software was used to construct the RC-CS network diagram. These data were inputted into the STRING database to construct a protein–protein interaction network. we performed gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes enrichment analysis using DAVID and R software. Molecular docking of the active ingredient and pathway-related targets was carried out using AutoDock Vina and PyMOL, and then a CS model was established in rats induced by lipopolysaccharide for in vivo experimental verification. Results:The network pharmacology results showed that kaempferol was the most important active component of RC in the treatment of CS, and IL6 and STAT3 were identified as key targets. Molecular docking results showed that RC active components kaempferol had a good binding ability to IL6/STAT3. At the same time, compared with the model group, different doses of kaempferol could down-regulate the expression of inflammatory factors (P< .05), and protect against systemic inflammatory response multiple organ damage. Conclusion:This study preliminarily revealed that RC can prevent and treat CS by regulating the expression of inflammatory factors, inhibiting the systemic inflammatory response induced by lipopolysaccharide, and providing a theoretical basis for the study of its pharmacodynamic material basis and mechanism of action.