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Sorafenib was first approved as the standard treatment for advanced hepatocellular carcinoma (HCC). Despite providing an advantage in terms of patient survival, sorafenib has shown poor clinical efficacy and severe side effects after long-term treatment. Thus, combination treatment is a potential way to increase the effectiveness and reduce the dose-limiting toxicity of sorafenib. Extracts of the seeds of Annona montanahave shown synergistic antitumor activity with sorafenib, and seven annonaceous acetogenins, including three new acetogenins, muricin P (2), muricin Q (3), and muricin R (4), were isolated from the extracts by bioguided fractionation and showed synergy with sorafenib. The structures of these compounds were determined using spectroscopic and chemical methods. Annonacin (1) and muricin P (2), which reduced intracellular ATP levels and promoted apoptosis, exhibited synergistic cytotoxicity with sorafenib in vitro. In vivo, annonacin (1) displayed synergistic antitumor activity by promoting tumor cell apoptosis. Moreover, the potential mechanism of annonacin (1) was predicted by transcriptomic analysis, which suggested that SLC33A1 is a potential target in HCC. Annonacin (1) might be a novel candidate for combination therapy with sorafenib against advanced HCC.

Abstract: We present a new improvement to the Alekseev inverse scattering method. This improved inverse scattering method is extended to a double form, followed by the generation of some new solutions of the double-complex Kinnersley equations. As the double-complex function method contains the Kramer-Neugebauer substitution and analytic continuation, a pair of real gravitation soliton solutions of the Einstein's field equations can be obtained from a double N-soliton solution. In the case of the flat Minkowski space background solution, the general formulas of the new solutions are presented.

In this paper, the Fokas-Lenells equation describing soliton dynamics in optical fibers is studied. The topological properties of the corresponding Hamiltonian system are obtained by qualitative analysis of the equation, and the prior estimation of the solution of the equation is given. The exact traveling wave solutions of Fokas-Lenells equation are obtained by using trial equation method and the complete discrimination system for polynomial method. At the end of the article, the three-dimensional images of the solutions under specific values are provided, which can better help us understand the dynamic properties of the model.

The morphology of nickel and vanadium compounds in the asphaltenes were investigated via hydropyrolysis with the help of inductively coupled plasma mass spectrometer (ICP-MS), ultraviolet-visible (UV-Vis), high-temperature gas chromatography atomic emission detection (HT GC-AED), and positive-ion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (+ESI FT-ICR MS). The results showed that the toluene soluble yields of products decreased from 64% to 19% as the hydropyrolysis temperature increased from 330 to 410 °C, while the abundance of nickel and vanadium compounds detected by GC-AED increased significantly. The molecular composition distribution of nickel and vanadyl porphyrins showed rhythmic changes with different temperatures in the hydropyrolysis of asphaltenes.

Anxiety is a normal and transitory emotional state that allows the organisms to cope well with the real or perceived threats, while excessive or prolonged anxiety is a key characteristic of anxiety disorders. We have recently revealed that prolonged anxiety induced by chronic stress is associated with the circuit-varying dysfunction of basolateral amygdala projection neurons (BLA PNs). However, it is not yet known whether similar mechanisms also emerge for acute stress-induced, short-lasting increase of anxiety. Here, using a mouse model of acute restraint stress (ARS), we found that ARS mice showed increased anxiety-like behavior at 2 h but not 24 h after stress, and this effect was accompanied by a transient increase of the activity of BLA PNs. Specifically, ex vivo patch-clamp recordings revealed that the increased BLA neuronal activity did not differ among the distinct BLA neuronal populations, regardless of their projection targets being the dorsomedial prefrontal cortex (dmPFC) or elsewhere. We further demonstrated that such effects were mainly mediated by the enhanced presynaptic glutamate release in dmPFC-to-BLA synapses but not lateral amygdala-to-BLA ones. Furthermore, while optogenetically weakening the presynaptic glutamate release in dmPFC-to-BLA synapses ameliorated ARS-induced anxiety-like behavior, strengthening the release increased in unstressed mice. Together, these findings suggest that acute stress causes short-lasting increase in anxiety-like behavior by facilitating synaptic transmission from the prefrontal cortex to the amygdala in a circuit-independent fashion.

The low side friction of piles in coral sand results in the low bearing capacity of foundations. In this paper, expansive concrete pile is utilized to improve the bearing capacity of pile foundations in coral sand. Both model tests and numerical simulation are performed to reveal the bearing mechanism of expansive concrete pile in coral sand. Results showed that the lateral earth pressure near pile increases obviously and the side friction of piles is improved, after adding expansion agent to the concrete. The horizontal linear expansion is 1.11% and the bearing capacity increased 41% for the pile, when 25% expansion agent is added. Results in finite element numerical simulation also show that ultimate bearing capacity increases with the increase of the linear expansion ratio. Besides, the area for obvious increase in side friction is below the surface of soil about three times the pile diameter, and the expansion leads to a high side friction sharing of the pile. Therefore, the cast-in-place expansive concrete pile is effective in improving the bearing capacity of piles in coral sand.

IMPORTANCE: Lymphopenia is common and correlates with poor clinical outcomes in patients with coronavirus disease 2019 (COVID-19). OBJECTIVE: To determine whether a therapy that increases peripheral blood leukocyte and lymphocyte cell counts leads to clinical improvement in patients with COVID-19. DESIGN, SETTING AND PARTICIPANTS: Between February 18 and April 10, 2020, we conducted an open-label, multicenter, randomized clinical trial at 3 participating centers in China. The main eligibility criteria were pneumonia, a blood lymphocyte cell count of 800 per μL (to convert to ×109/L, multiply by 0.001) or lower, and no comorbidities. Severe acute respiratory syndrome coronavirus 2 infection was confirmed with reverse-transcription polymerase chain reaction testing. EXPOSURES: Usual care alone, or usual care plus 3 doses of recombinant human granulocyte colony-stimulating factor (rhG-CSF, 5 μg/kg, subcutaneously at days 0-2). MAIN OUTCOMES AND MEASURES: The primary end point was the time from randomization to improvement of at least 1 point on a 7-category disease severity score. RESULTS: Of 200 participants, 112 (56%) were men and the median (interquartile range [IQR]) age was 45 (40-55) years. There was random assignment of 100 patients (50%) to the rhG-CSF group and 100 (50%) to the usual care group. Time to clinical improvement was similar between groups (rhG-CSF group median of 12 days (IQR, 10-16 days) vs usual care group median of 13 days (IQR, 11-17 days); hazard ratio, 1.28; 95% CI, 0.95-1.71; P = .06). For secondary end points, the proportion of patients progressing to acute respiratory distress syndrome, sepsis, or septic shock was lower in the rhG-CSF group (rhG-CSF group, 2% vs usual care group, 15%; difference, −13%; 95%CI, −21.4% to −5.4%). At 21 days, 2 patients (2%) had died in the rhG-CSF group compared with 10 patients (10%) in the usual care group (hazard ratio, 0.19; 95%CI, 0.04-0.88). At day 5, the lymphocyte cell count was higher in the rhG-CSF group (rhG-CSF group median of 1050/μL vs usual care group median of 620/μL; Hodges-Lehmann estimate of the difference in medians, 440; 95% CI, 380-490). Serious adverse events, such as sepsis or septic shock, respiratory failure, and acute respiratory distress syndrome, occurred in 29 patients (14.5%) in the rhG-CSF group and 42 patients (21%) in the usual care group. CONCLUSION AND RELEVANCE: In preliminary findings from a randomized clinical trial, rhG-CSF treatment for patients with COVID-19 with lymphopenia but no comorbidities did not accelerate clinical improvement, but the number of patients developing critical illness or dying may have been reduced. Larger studies that include a broader range of patients with COVID-19 should be conducted. TRIAL REGISTRATION: Chinese Clinical Trial Registry: ChiCTR2000030007

Since December 2019, increasing attention has been paid to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Wuhan, China. SARS-CoV-2 primarily invades the respiratory tract and lungs, leading to pneumonia and other systemic disorders. The effect of SARS-CoV-2 in transplant recipients has raised significant concerns, especially because there is a large population of transplant recipients in China. Based on the current epidemic situation, this study reviewed publications on this virus and coronavirus disease 2019 (COVID-19), analyzed common features of respiratory viral pneumonias, and presented the currently reported clinical characteristics of COVID-19 in transplant recipients to improve strategies regarding the diagnosis and treatment of COVID-19 in this special population.

Elevated circulating levels of ceramides (Cers) are associated with increased risk of cardiometabolic diseases, and Cers may play a causative role in metabolic dysfunction that precedes cardiac events, such as mortality as a result of coronary artery disease. Although the mechanisms involved are likely complex, these associations suggest that lowering circulating Cer levels could be protective against cardiovascular diseases. Conversely, dietary fibers, such as inulin, have been reported to promote cardiovascular and metabolic health. However, the mechanisms involved in these protective processes also are not well understood. We studied the effects of inulin on lipid metabolism with a model of atherosclerosis in LDL receptor-deficient mice using lipidomics and transcriptomics. Plasma and tissues were collected at 10 days and/or 12 weeks after feeding mice an atherogenic diet supplemented with inulin or cellulose (control). Compared with controls, inulin-fed mice displayed a decreased C16:0/C24:0 plasma Cer ratio and lower levels of circulating Cers associated with VLDL and LDL. Liver transcriptomic analysis revealed that Smpd3, a gene that encodes neutral SMase (NSMase), was downregulated by 2-fold in inulin-fed mice. Hepatic NSMase activity was 3-fold lower in inulin-fed mice than in controls. Furthermore, liver redox status and compositions of phosphatidylserine and FFA species, the major factors that determine NSMase activity, were also modified by inulin. Taken together, these results showed that, in mice, inulin can decrease plasma Cer levels through reductions in NSMase expression and activity, suggesting a mechanism by which fiber could reduce cardiometabolic disease risk.

Currently, research on biopsy-proven acute drug-induced liver injury (DILI) remains limited. This study aimed to identify clinical characteristics and risk factors for significant hepatic inflammation in patients with acute DILI.

Nonalcoholic steatohepatitis (NASH), an inflammatory form of non-alcoholic fatty liver disease, can progress to advanced liver fibrosis, cirrhosis, and liver cancer. Metabolic syndrome (MetS) parallels the prevalence of non-alcoholic fatty liver disease/NASH and increases patients’ risk of advanced liver disease. This study aimed to determine whether MetS was associated with the histological progression of NASH.

There has been a growing concern in recent years about the increasing occurrence of oil spills into the environment and the proven toxic potential of these pollutants on human health and wildlife. Precisely and rapidly determining the sources of spilled oils can provide scientific evidence for the investigation and handling of spilled oil accidents. As traditional fluorescence spectroscopy detects in the linear concentration range, a concentration-resolved fluorescence spectroscopy (CRFS) is proposed in this paper, which introduces concentration as a new dimension. A data processing strategy combining multiple algorithms was applied to the CRFS for oil spill identification. Dual-tree complex wavelet transform (DTCWT) is used to extract multi-scale and multi-directional features of CRFS to ensure the accuracy of identification, while principal component analysis (PCA) is used to reduce the dimensions of the feature spectrum for the purpose of improving the identification speed. Three kinds of artificial neural networks (back propagation neural network (BP), probabilistic neural network (PNN), and generalized regression neural network (GRNN)), which are used as powerful classifiers for oil identification, were compared based on the spectral data processed by DTCWT and PCA. With 100% accuracy, GRNN was proved to be more suitable for oil classification and identification, especially for small sample sizes. The combination of the CRFS technique and this data processing strategy was revealed as a powerful methodology to differentiate a challenging sample set involving diesel (diesel 2002), fuel (heavy fuel 4#) and crude oils (Xia, Shang, Zhengqi), offering potential applications for use in real-time and economic oil fingerprint identification.

C36H52Ag2N10O8S2, orthorhombic, Pna21(no. 33), a= 11.7911(16) Å, b= 31.310(5) Å, c= 10.6883(11) Å, V= 3945.9(9) Å3, Z= 4, Rgt(F) = 0.0353, wRref(F2) = 0.0784, T= 293(2) K.

The bumper system always directly causes the injury of the pedestrian leg in the car–pedestrian accidents. Therefore, it is of practical significance to optimize the bumper structure to enhance the protective effect of the pedestrian leg. Based on the original bumper system, this work proposes a novel negative Poisson’s ratio energy-absorbing forepart with inner hexagonal cellular structure, which is designed at the lower leg impact zone between the bumper beam and the cover. The parametric model of the negative Poisson’s ratio forepart, the lower legform impactor model, and the car–pedestrian collision model are firstly established. Then, through integrating the response surface method, second-order reliability method, and archive-based micro genetic algorithm, a reliability optimization design is further conducted for the negative Poisson’s ratio forepart based on the deterministic optimization results. Simulation results show that the optimized negative Poisson’s ratio forepart not only can significantly enhance the reliability and robustness, but also improve the protective effect of the pedestrian leg.

探索老年患者尿液中肝型脂肪酸结合蛋白 (L-FABP)、中性粒细胞明胶酶相关脂质运载 蛋白(NGAL)及肾损伤分子1(KIM-1)三种新 型肾损伤标志物对经皮冠状动脉介入(PCI)术 后急性肾损伤(AKI)的早期预测作用。 本研究主要评估PCI 术后肾损伤标志物的上升倍 数对AKI 早期诊断的价值,对基线标志物水平不 同的患者而言,具有一定意义。 采用巢式病例对照研究的方法来比较PCI 术后 AKI 患者和对照组患者围手术期肾损伤标志物的 变化。 老年患者PCI 术后6 小时尿L-FABP 和NGAL 的 上升倍数对AKI 具有一定的预测价值。二者联合 检验预测价值更高。而尿KIM-1 的早期预测价值 较低。

The effect of MTH1 inhibition on cancer cell survival has been elusive. Here we report that although silencing of MTH1 does not affect survival of melanoma cells, TH588, one of the first-in-class MTH1 inhibitors, kills melanoma cells through apoptosis independently of its inhibitory effect on MTH1. Induction of apoptosis by TH588 was not alleviated by MTH1 overexpression or introduction of the bacterial homolog of MTH1 that has 8-oxodGTPase activity but cannot be inhibited by TH588, indicating that MTH1 inhibition is not the cause of TH588-induced killing of melanoma cells. Although knockdown of MTH1 did not impinge on the viability of melanoma cells, it rendered melanoma cells sensitive to apoptosis induced by the oxidative stress inducer elesclomol. Of note, treatment with elesclomol also enhanced TH588-induced apoptosis, whereas a reactive oxygen species scavenger or an antioxidant attenuated the apoptosis triggered by TH588. Indeed, the sensitivity of melanoma cells to TH588 was correlated with endogenous levels of reactive oxygen species. Collectively, these results indicate that the cytotoxicity of TH588 toward melanoma cells is not associated with its inhibitory effect on MTH1, although it is mediated by cellular production of ROS.

The purpose of the current study was to investigate the effect of the dosing time on the pharmacokinetics of erlotinib and the circadian rhythms of the metabolism enzymes in tumor-bearing mice. Female C57BL mice were randomly assigned to six groups. Erlotinib was orally administrated to the mice in each group at six different times of day. The plasma concentration of erlotinib was determined through a high-performance liquid-chromatographic assay, and the total mRNA was extracted from liver tissues to determine the expression of the mRNA of the related drug metabolism enzymes by qRT-PCR. The results indicated that AUC0–24 hand MRT0–24 hwere the lowest in the 20:00 group (P< 0.01). Tmaxof the 13 HALO (hour after light onset), 17 HALO and 21 HALO groups was higher than that of the 1 HALO and 5 HALO groups (P< 0.01). CL of the light-phase groups was lower than that of the dark-phase groups (P< 0.01). The peak value of Cmaxappeared in the 5 HALO group (P< 0.01). The mRNA levels of Cyp3a11, Cyp3a13 and Cyp1a2 were generally higher during the afternoon and the dark phase. Circadian rhythm plays a critical role in the pharmacokinetics of erlotinib in mice, and the mechanisms may be attributed to gene expression rhythms of drug-metabolizing enzymes in liver tissues.

AbstractBackground:Researchers have found applications for auricular therapy (AT) for treating depression. There is, however, a lack of comprehensive evaluation of AT's effects and safety.Objective:The objective of this review was to evaluate the safety and efficacy of AT for treating depression.Methods:Ten databases were used to search for randomized controlled and quasi-randomized controlled trials relating to AT and depression. Related available articles up to January 2016 were used for the research. Rev Man 5.2 software was used for data analysis with the effect estimate presented as relative risk and mean difference with a 95% confidence interval.Results:Interventions of trials included in this study were either ear buried seeds (EBS) or transcutaneous vagus nerve stimulation (tVNS). Compared to sham, tVNS produced significant differences on the Hamilton Depression (HAM-D) rating scale, Beck's Depression Inventory (BDI), Self-Rate Depression Scale (SDS), and Self-Rate Anxiety Scale (SAS), but no significant difference were seen on the Hamilton Anxiety (HAM-A) scale. Compared to other treatment, tVNS produced significant differences on the HAM-D, Clinical Global Impression Scale (CGI-S) and Clinical Global Impression—Improvement (CGI-I). tVNS also had an advantage with respect to reducing side-effects. When EBS combined with other treatments was compared to other treatments, there were also significant differences on the HAM-D, SDS, SAS, remission, and Patient Assessment of Constipation Quality of Life (PAC-QOL) questionnaire, but there was no significant difference seen on the Nerve Function Defect Score Scale Barthel Index (BI).Conclusions:tVNS and EBS forms of AT could alleviate depression symptoms measured by the HAM-D. It is suggested that the designs of AT trials should follow the recommendations of the Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) guidelines. AT clinicians should use the HAM-D to gauge depression, and somatic symptom reduction should be observed separately.

Fe3O4/MWCNTs nanocomposites were prepared by chemical oxidation coprecipitation method and developed as highly efficient heterogeneous Fenton-like catalyst. XRD results revealed that Fe3O4nanoparticles deposited onto MWCNTs surface remained the inverse spinel crystal structure of cubic Fe3O4phase. The FTIR characteristic peaks of MWCNTs weakened or disappeared due to the anchor of Fe3O4nanoparticles and Fe–O peak at 570 cm–1was indicative of the formation of Fe3O4. TEM observation revealed that Fe3O4nanoparticles were tightly anchored by MWCNTs. The Fenton-like catalytic activity of Fe3O4/MWCNTs nanocomposites for the discoloration of methyl orange (MO) was much higher than that of Fe3O4nanoparticles. The process optimization of this heterogeneous Fenton-like system was implemented by response surface methodology (RSM). The optimum conditions for MO discoloration were determined to be of 12.3 mmol/L H2O2concentration, 2.9 g/L catalyst dosage, solution pH 2.7 and 39.3 min reaction time, with the maximum predicted value for MO discoloration ratio of 101.85%. The corresponding experimental value under the identical conditions was obtained as 99.86%, which was very close to the predicted one with the absolute deviation of 1.99%.

To improve the stability of the electric vehicle with motorised wheels, the seven degrees of freedom (DOF) dynamic model of the vehicle is established. Based on sliding mode control theory, the dynamic quality of the system operation, dynamic and static characteristic of the sliding mode operation, and relationship between the front wheel angle and stability parameters of the vehicle are taken into account in the stability control. To enhance the stability of the vehicle, the course angle is introduced as one of the control variables. Considering the coupling relationship of the sideslip angle, yaw rate and course angle, three stability control strategies of yaw rate control, sideslip angle control and combination control of the yaw rate and course angle are designed, and the stability of the vehicle under three control strategies is simulated with the MATLAB/Simulink software. The simulation results show that the combination control of the yaw rate and course angle can control the sideslip angle and course angle within a reasonable range, and track the desired yaw rate effectively.

Porous Ti with an average pore size of 200-400 μm and porosity in the range of 25-50% has been manufactured using polymethyl methacrylate (PMMA) powders as spacer particles. The stress distribution of porous Ti was analyzed by Ansys software. The stress is prone to focusing on the surrounding of connected pore and weak cell. As the porosity and pore size increase, the concentration factor of stress increases due to the lager degree of pore connection and aggregation. Comparing with the ellipsoid pore model, the concentration factor of stress of the porous Ti with spherical pore is lower.

Potassium is an important nutrient element requiring high concentration for photosynthetic metabolism. The potassium deficiency in soil could inhibit soybean (Glycine max(L.) Merr.) photosynthesis and result in yield reduction. Research on the photosynthetic variations of the different tolerant soyben varieties should provide important information for high yield tolerant soybean breeding program. Two representative soybean varieties Tiefeng 40 (tolerance to K+ deficiency) and GD8521 (sensitive to K+ deficiency) were hydroponically grown to measure the photosynthesis, chlorophyll fluorescence parameters and Rubisco activity under different potassium conditions. With the K-deficiency stress time extending, the net photosynthetic rate (Pn), transpiration rate (Tr) and stomatal conductance (Gs) of GD8521 were significantly decreased under K-deficiency condition, whereas the intercellular CO2concentration (Ci) was significantly increased. As a contrast, the variations of Tiefeng 40 were almost little under K-deficiency condition, which indicated tolerance to K+ deficiency variety could maintain higher efficient photosynthesis. On the 25th d after treatment, the minimal fluorescence (F0) of GD8521 was significantly increased and the maximal fluorescence (Fm), the maximum quantum efficiency of PSII photochemistry (Fv/Fm), actual photochemical efficiency of PSII (ϕPSII), photochemical quenching (qP), and electron transport rate of PSII (ETR) were significantly decreased under K+ deficiency condition. In addition, the Rubisco content of GD8521 was significantly decreased in leaves. It is particularly noteworthy that the chlorophyll fluorescence parameters and Rubisco content of Tiefeng 40 were unaffected under K+ deficiency condition. On the other hand, the non-photochemical quenching (qN) of Tiefeng 40 was significantly increased. The dry matter weight of Tiefeng 40 was little affected under K+ deficiency condition. Results indicated that Tiefeng 40 could avoid or relieve the destruction of PSII caused by exceeded absorbed solar energy under K-deficiency condition and maintain natural photosynthesis and plant growth. It was an essential physiological mechanism for low-K-tolerant soybean under K-deficiency stress.

The design scheme and engineering construction technology are proposed for an accommodation highway subgrade on the basis of forming reasons and hazard analysis of saline soil in Xinjiang region. In the design, major measures adopted include basement replacement, setting aeolian sand layer and composite geotextile layer, strengthening the subgrade waterproofing and drainage, antiseptic treatment of structures, etc. This paper introduces the subgrade design and construction technology, of which the implementation and application on the test section have achieved a favorable effect and can be taken as the basis for design and construction of similar saline soil subgrade.

A simple electrochemical method has been developed for the simultaneous determination of dihydroxybenzene isomers in wastewater samples with poly (glutamic acid) modified electrode (PGA/GCE). PGA/GCE was fabricated by electropolymerization of glutamic acid on a glassy carbon electrode (GCE) through cyclic voltammetry (CV). PGA/GCE showed an excellent electrocatalytic ability towards the oxidation of hydroquinone (HQ) and catechol (CC). With CV and differential pulse votammetric (DPV) measurements, HQ and CC in wastewater samples could be simultaneously analyzed at PGA/GCE. The linear range for HQ and CC were 5 - 100 μM and 2 - 160 μM, with a detection limit of 2.0 μM and 1.0 μM, respectively. Moreover, PGA/GCE exhibited good selectivity and repeatability. The method has a promising application in the monitoring of HQ and CC of wastewater.

Many studies have confirmed that brief remifentanil exposure can enhance pain sensitivity. We previously reported that activation of glycogen synthase kinase-3 (GSK-3) contributes to remifentanil-induced hyperalgesia via regulating N-methyl-D-aspartate receptor plasticity in the spinal dorsal horn. In this study, we demonstrated that GSK-3 inhibition prevented remifentanil-induced postoperative hyperalgesia via regulating -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) expression and function in the spinal dorsal horn.

How to implement the life-cycle management of water conservancy and hydro power project cost effectively, and how to distinguish the influence degree of different factors on project cost stage management. This is a key problem in project cost control. In this paper, based on the influence of each factor on the overall evaluation goal influence, FAHP is applied to set up Fuzzy Comprehensive Evaluation Model. Aiming at the variability characteristics of factors in each stage, the information entropy is used to determine the objective weight in the model, in combination with AHP the subjective weights to determine the weight.

Bolts as the key connection parts are directly related to the safety of high-speed train. Contact nonlinear static strength of CRH (China Railway High-Speed) coupler bolt was analyzed on traction and compression load with ANSYS software. According to maximum stress of bolts was appeared on tension load, CRH bolt strength was evaluated and compared based on three methods: finite element analysis (FEA), "Verein Deutscher Ingenieure 2230 standard (VDI 2230)" and “Mechanical Design Handbook”. The results show that the axial tensile stress is much greater than the shear stress and gradually increase with three methods.

Some Steel Plant in our country using the old formula annulus crane, this article introduce a new electrical control system. Using PLC + Inverter + Linkage console, use this control system, we can solve the question that the old crane always out of orbit, this system solve the crane out of the orbit, broken the orbit and slip perfectly. On the other hand, we subjoin vector control, which can prevent the weights fling off.

Ti-Al-Nb ternary phase diagrams were calculated by Thermo-Calc software. The analysis of the calculated vertical sections of Ti-Al-Nb phase diagram indicated that when Nb content is fixed at 5at.% and Al content is lower than 52.3at.%, the primary phase would be β phase during solidification. With 10 at.%Nb and Al content lower than 55.8at.%, or with 15 at.%Nb and Al content lower than 56.9at.%, the primary phase would be β phase. The vertical sections of Ti-Al-Nb ternary phase diagram were further simplified into pseudo-Ti-Al binary phase diagram. According to the pseudo-Ti-Al diagram, the expression of the aluminum equivalent was obtained in Ti-Al-5Nb ternary alloys.

The high temperature compressive tests of squeeze casting ZK60 magnesium alloy in the testing temperature range of 523-723K and strain rate range of 0.001-10s-1 were performed on Gleeble-1500D thermal simulator testing machine. Optical microscopy was performed to elaborate on the dynamic recrystallization (DRX) grain growth. TEM observation indicated that the mechanical twinning, dislocation slip, and dynamic recrystallization are the materials typical deformation features. Variations of flow behavior with deformation temperature as well as strain rate were analyzed. Analysis of the flowing deformation behavior and microstructure observations indicated that the flow localization was observed at lower testing temperature and higher strain rates. Dynamic recrystallization occurred at higher testing temperature and moderate strain rates, which improved the ductility of the material. The results indicated that at the testing temperatures lower than 573K and strain rates higher than 1s-1, the material exhibited flow instability manifesting as bands of flow localizations. These temperatures and strain rates should be avoided in processing the material. Dynamic recrystallization occurs in the temperature range 573-723K and the strain rate range 0.001-0.1s-1. The number of dynamic recrystallization grains is less at lower temperature and higher strain rate than higher temperature and lower strain rate. The dynamic recrystallization is inadequate at 573-623K while the dynamic recrystallization grain growth has been observed in the temperature range of 673-723K. Therefore it may be considered that the optimum processing parameters for hot working of squeeze casting ZK60 magnesium alloy are 648K and 0.001-0.01s-1, at which fine dynamic recrystallization microstructure can be obtained.

Non-motor symptoms (NMS) occur commonly in PD patients. The NMS is associated with the deterioration of life quality in Parkinsons disease (PD), even exceeding the effects of the motor disorder. To determine the effects of cognitive behavior therapy (CBT) on NMS in PD, fifty-five PD individuals with CBT intervention were matched for forty-eight control PD participants. NMS of all PD patients including depressive symptoms, sleep quality, cognitive function and physical and mental health-related quality of life were respectively assessed. Results indicate that CBT ameliorates NMS of PD patients, and that is significantly related with the decreases of serum inflammatory cytokines levels.

Through calculation of the seepage finite element, the result shows that the anti-seepage effect of clay core and grouting curtain is obvious. The phreatic line of dam conforms to the general law, and seepage stability of the dam meets the requirements. The sensitivity analysis of the different curtain depth indicate that there is a inflexion on the relation curve of seepage discharge and curtain depth, and to deepen continually the curtain have less effect on the dam seepage discharge when the curtain more than 50m.

The Lishui sag located at Southwest of the East China Sea Shelf Basin. It had undergone the four stages of syn-rift processes in Late Cretaceous to Paleocene: initial rift stage, main rift stage, stable rift stage and decline stage. The tectonic evolution has control effect on the development of sequence stratigraphy and the sediments distribution. Three second-order sequences, five third-order sequences and twelve system tracts are distinguished. Different sedimentary facies recognized in the Lishui sag.

Volcanic lithology and lithofacies are important factors to control the formation of volcanic reservoir. It is a challenge for geologists and petrophysicist to identify lithofacies in the borehole by using well logs. According to the reservoir characters of Daqing volcanic reservoir in Songliao basin, five lithofacies and fifteen su-facies have been recognized through the drilled core analysis of lithology, texture and structure. The relationship between conventional well logs and volcanic lithology can be established by calibrating with core analysis which can be used to identify the rock composition by the established cross-plots. From the FMI measurement, the differences of resistivity values caused by volcanic rock texture and structure can be showed in the image clearly. It shows that four kinds of textures and five kinds of structure can be identified with FMI image. As the volcanic lithofacies marks, specific volcanics lithology, texture and structure corresponds to the specific lithofacies and sub-facies. So lithofacies distribution can be evaluated effectively with the model of volcanics texture and structure combined with rock composition. The results of study indicate that the composition, texture and structure characteristics of the volcanics can be identified by conventional log with FMI measurement, which is important to the further volcanic reservoir exploration and production.

Used the dynamic triaxial apparatus to test 4 group remodeling silt samples of different fines content. Studies the variation relationship on liquefaction resistance of silt with different fines content.And pore water pressure increase of silt with different fines content is analyzed through Exponential function model,the model parameters can be get. The numerical results show that the model has good applicability.

This tester is mainly used to test the firepower of armored vehicles weapon equipment, the artillery loosening amount and rigidity of fire control system, the largest mobilization artillery speed and other related static parameters. In this paper, the design of the tester include: static parameters optical probe, the vehicle central control device, the image processing device, the test target and so on. In the static parameter tests of weapon systems, the static probe is installed in the muzzle, the prescriptive force is imposed on the artillery tube to produce movement, CCD camera can photography the relative motion image of the target, then the computer processes images according to the corresponding program, and figures out the trajectory of the artillery tube, thus the corresponding static parameters is calculated. Experimental results show that: The system has reached a very good image quality, and the reliability is very high, Diagonal field of view>4°, the specification requirements are reached.

Cutting steel is required to have high wear resistance with certain hardness and deformation resistance. The commonly used machinery material for meat processing in china is 4Cr13, which is far inferior to the imported German steel X80CrVMo13-2. After studying the influence of different heat treatment process on its wear resistance, we have come to the following conclusion: X80CrVMo13-2 steel, after quenched at 1050℃ and tempered at 500℃, has an excellent wear resistance and 4Cr13 steel, after normalized at 1010℃ and tempered at 500℃ has a fairly good wear resistance.

Derived calculation formula of plastic strength, and used mortar consistency instrument to determine plastic strength. Through experiment, the fly ash and silicon powder that desulfurized or denitrated as grouting materials, its change rules of plastic strength were studid under different water cement ratio and different dosage conditions. Results shows that, between the two factors of water cement ratio and dosage, the water cement ratio affect significantly the plastic strength. The smaller the water cement ratio, the more obvious the increase of the plastic strength as time growth. Early plastic strength of silicon powder grouts is growing rapidly.

Used static finite element method to analyse the clay core rockfill dam of laojunshan reservoir whith Duncan-Chang E-B model. The results shows that the maximum of stress level is 0.78 under completion mode, and the maximum of stress level is 0.9 under normal operating condition. The stress and displacement value of the dam as well as its distribution rule is normal, and the maximum of stress level is less than 1. The possibility of occurring hydraulic split for core-wall is very small, and the dam is in a safe state.

Green tides outbreak frequently around Lianyungang surrounding waters in recent years. In order to understand the nutrient response relationship with the typical Enteromorpha species, the experiment investigated uptake kinetics of NO3-N, NH4-N and PO4-P with Michaelis-Menten equation. It was found that the Ks values of Enteromorpha linza are lower than that of Enteromorpha prolifera, which indicated E. linza have a better ability to adapt low nutrient environment. Vmax for various nitrogen species followed the order of NO3-N > NH4-N, indicating ammonia absorption can inhibit the uptake of nitrate. The study provided a theoretical basis for exploring the Enteromorpha outbreak mechanism and marine ecological effects assessment.