722 results on '"Wagner G"'
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2. Associations of socioeconomic disparities with buccal DNA-methylation measures of biological aging.
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Raffington, L., Schwaba, T., Aikins, M., Richter, D., Wagner, G. G., Harden, K. P., Belsky, D. W., and Tucker-Drob, E. M.
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- 2023
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3. First case of canine visceral leishmaniasis in the midwestern of Santa Catarina State, Brazil.
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Pinto, A. O., Carvalho, D., Frizzo, C., Lopes, K., Tessari, G. B., Catecati, T., Dhom-Lemos, L. C., Pasquali, A. K. S., Quaresma, P. F., Stoco, P. H., Grisard, E. C., Steindel, M., and Wagner, G.
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VISCERAL leishmaniasis ,ZOONOSES ,DNA polymerases ,POLYMERASE chain reaction - Abstract
Copyright of Brazilian Journal of Biology is the property of Instituto Internacional de Ecologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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4. Deep Brain Stimulation in Epilepsy: A Role for Modulation of the Mammillothalamic Tract in Seizure Control?
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Schaper, Frédéric L W V J, Plantinga, Birgit R, Colon, Albert J, Wagner, G Louis, Boon, Paul, Blom, Nadia, Gommer, Erik D, Hoogland, Govert, Ackermans, Linda, Rouhl, Rob P W, and Temel, Yasin
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- 2020
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5. Deep Brain Stimulation in Epilepsy: A Role for Modulation of the Mammillothalamic Tract in Seizure Control?
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Schaper, Frédéric L W V J, Plantinga, Birgit R, Colon, Albert J, Wagner, G Louis, Boon, Paul, Blom, Nadia, Gommer, Erik D, Hoogland, Govert, Ackermans, Linda, Rouhl, Rob P W, and Temel, Yasin
- Abstract
Graphical Abstract
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- 2020
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6. Aqueous extracts of jet-black ant Lasius fuliginosusnests for controlling nosemosis, a disease of honeybees caused by fungi of the genus Nosema
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Kunat, M., Wagner, G. K., Staniec, B., Jaszek, M., Matuszewska, A., Stefaniuk, D., and Ptaszyńska, A. A.
- Abstract
AbstractRecent years have witnessed a fall in the numbers of bee colonies worldwide. To a large extent, this is due to diseases affecting honeybees. One such disease is nosemosis, which is caused by fungi from the genus Nosema. The antibiotic fumagallin used to be administered to treat nosemosis, but as it was found capable of being transferred to bee products, this practice has ceased. We therefore focused on natural substances for treating this disease, among them, aqueous extracts of the nest carton produced by the jet-black ant (Lasius fuliginosus). We tested the influence of 0.1% and 1% concentrations of such extracts on the incidence of nosemosis in honeybees. The “birch carton 2” extract turned out to be the most effective inhibitor of this disease. The incidence of nosemosis following the administration of this extract, as manifested by the number of spores, fell ca 18-fold in comparison with the control. Moreover, the “birch carton 2” extract was not found to be toxic towards bees.
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- 2020
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7. The microbiota of the Lasius fuliginosus– Pella laticollismyrmecophilous interaction
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Kaczmarczyk-Ziemba, A., Zagaja, M., Wagner, G. K., Pietrykowska-Tudruj, E., and Staniec, B.
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AbstractMyrmecophilous insects depend on their ant hosts during at least part of their life cycle. Lasiusants appear to be primarily involved as host in myrmecophilous interactions, especially with aphids and beetles, e.g. staphylinid. Pella laticollisis a rove beetle having a close ecological association with Lasius fuliginosus, which is correlated to its behavior adapted to avoid attack. Microorganisms can also play an important role in the maintenance of such relationships. We used 16S rRNA sequencing on the Illumina MiSeq platform to identify the bacterial communities associated with larvae and adults of both L. fuliginosusand P. laticollis. In addition, we determined the microbiota profiles of the nest-carton, an organic material lining the nest chambers. We obtained more than two million good quality reads. Taxonomic annotation showed that the profiles consisted of a total of 20 phyla, among which Proteobacteria was the most abundant. The samples were grouped according to the host’s developmental stage or the nest material, and the differences between those groups were significant. Only the microbiota of L. fuliginosuslarvae and adults did not differ significantly. Analyses at the genus level indicated a heightened abundance of Pseudomonasin the insects’ profiles. The bacterial communities associated with the nest-carton included bacterial genera recorded from soil and dead wood. The profiles showed the presence of two well-known endosymbiotic bacteria, namely, Rickettsiaand Wolbachia. According to our findings, the bacterial communities associated with larvae and adults of both L. fuliginosusand P. laticollisformed clusters according to the host’s identity and its developmental stage. The profiles determined for the nest-carton formed a separate group. Our study is in line with a new research trend that is focusing on microbiota associated not only with ants, but also with myrmecophiles and ant nests inhabited by those species.
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- 2020
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8. The phthalimide analogues N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide exhibit activity in experimental models of inflammatory and neuropathic pain
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Batista, Carla R.A., Godin, Adriana M., Melo, Ivo S.F., Coura, Giovanna M.E., Matsui, Tamires C., Dutra, Marcela M.G.B., Brito, Ana Mercy S., Canhestro, Wagner G., Alves, Ricardo J., Araújo, Débora P., de Fátima, Ângelo, Machado, Renes R., and Coelho, Márcio M.
- Abstract
Phthalimide analogues devoid of the glutarimide moiety exhibit multiple biological activities, thus making them candidates for the treatment of patients with different diseases, including those with inflammatory and painful disorders. In the present study, the activities of five phthalimide analogues devoid of the glutarimide moiety (N-hydroxyphthalimide, N-hydroxymethylphthalimide, N-3-hydroxypropylphthalimide, N-carboxy-3-methylphthalimide, N-carboxymethyl-3-nitrophthalimide) were evaluated in experimental models of acute and chronic inflammatory and neuropathic pain.
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- 2019
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9. Demonstration of a Multi‐Layer, Lithographically Manufactured Plasma Spectrometer
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Scime, E. E., Dugas, M., Gilbert, T. J., John, R., Keesee, A. M., and Wagner, G.
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Development of new plasma instruments is needed to enable constellation‐ and small satellite‐based missions. Key steps in the development pathway of ultra‐compact plasma instruments employing lithographically patterned wafers are the implementation of layer‐to‐layer electrical interconnects and demonstration of massively parallel measurements, that is, simultaneous measurements through multiple identical plasma analyzer structures. Here we present energy resolved measurements of electron beams using a 5‐layer stack of wafer‐based, energy‐per‐charge, electrostatic analyzers. Each layer has eight distinct analyzer groups that are comprised of multiple micron scale energy‐per‐charge analyzers. The process of fabricating the electrical interconnects between the layers is described and the measured energy resolution and the angular resolution compared to theoretical predictions. The measurements demonstrate successful operation of 400 micron scale analyzers operating in parallel. Spacecraft are expensive and difficult to build. CubeSats, a class of small, inexpensive spacecraft are being used for scientific missions. However, standard instruments to measure the local plasma environment cannot fit on such small spacecraft. Here we describe a new type of space plasma instrument that is manufactured with processes similar to how computer chips are made. These plasma instruments are made by stacking layers of micro‐scale plasma analyzers to create a larger instrument with a significant geometric factor. Each layer includes nearly one hundred small energy‐per‐charge plasma analyzers working in parallel. Initial measurements from a 5‐layer instrument along with the processes used to build the instrument are described in this work. Microscale plasma energy analyzer demonstrated in laboratory testsLithographic fabrication process enables low voltage analysis of charged particles up to tens of keV/chargeMulti‐layer instrument required development of a novel fabrication process Microscale plasma energy analyzer demonstrated in laboratory tests Lithographic fabrication process enables low voltage analysis of charged particles up to tens of keV/charge Multi‐layer instrument required development of a novel fabrication process
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- 2024
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10. Disturbed glutathione antioxidative defense is associated with structural brain changes in neuroleptic-naïve first-episode psychosis patients.
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Langbein, K., Hesse, J., Gussew, A., Milleit, B., Lavoie, S., Amminger, G.P., Gaser, C., Wagner, G., Reichenbach, J.R., Hipler, U.-C., Winter, D., and Smesny, S.
- Abstract
Abstract Background Oxidative stress and impaired antioxidant defense are reported in schizophrenia and are thought to be associated with disturbed neurodevelopment, brain structural alterations, glutamatergic imbalance, negative symptomatology, and cognitive impairment. To test some of these assumptions we investigated the glutathione (GSH) antioxidant defense system (AODS) and brain structural abnormalities in drug-naïve individuals with first acute episode of psychosis (FEP). Method The study involved 27 drug-naïve FEP patients and 31 healthy controls (HC). GSH AODS markers and TBARS (thiobarbituric acid reactive substances) were measured in blood plasma and erythrocytes. High-resolution T 1 -weighted 3T MRI were acquired from all subjects. To investigate brain structural abnormalities and effects of illness on interactions between GSH metabolites or enzyme activities and local grey matter density, voxel-based morphometry (VBM) with the computational anatomy toolbox (CAT12) was used. Symptomatology was assessed using the Positive and Negative Syndrome Scale (PANSS) and the Symptom Checklist 1990 revised (SCL-90-R). Results (i) In FEP patients, glutathione reductase activity (GSR) was lower than in the HC group. GSR activity in plasma was inversely correlated with SCL-90-R scores of depression and PANSS scores of the negative symptom subscale. (ii) A reduction of GM was observed in left inferior frontal, bilateral temporal, as well as parietal cortices of FEP patients. (iii) Interaction analyses revealed an influence of illness on GSR/GM associations in the left orbitofrontal cortex (BA 47). Conclusion Our findings support the notion of altered GSH antioxidative defense in untreated acute psychosis as a potential pathomechanism for localized brain structural abnormalities. This pathology relates to a key brain region of social cognition, affective motivation control and decision making, and is clinically accompanied by depressive and negative symptoms. Highlights • Alterations of the glutathione AODS are associated with brain structural abnormalities in drug-naïve FEP patients. • The effect of illness on associations between GSR activity and grey matter density relates to the left orbitofrontal cortex. • Glutathione reductase activity in FEP patients was associated with negative symptoms. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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11. The phthalimide analogues N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide exhibit activity in experimental models of inflammatory and neuropathic pain
- Author
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Batista, Carla R. A., Godin, Adriana M., Melo, Ivo S. F., Coura, Giovanna M. E., Matsui, Tamires C., Dutra, Marcela M. G. B., Brito, Ana Mercy S., Canhestro, Wagner G., Alves, Ricardo J., Araújo, Débora P., de Fátima, Ângelo, Machado, Renes R., and Coelho, Márcio M.
- Abstract
Background: Phthalimide analogues devoid of the glutarimide moiety exhibit multiple biological activities, thus making them candidates for the treatment of patients with different diseases, including those with inflammatory and painful disorders. In the present study, the activities of five phthalimide analogues devoid of the glutarimide moiety (N-hydroxyphthalimide, N-hydroxymethylphthalimide, N-3-hydroxypropylphthalimide, N-carboxy-3-methylphthalimide, N-carboxymethyl-3-nitrophthalimide) were evaluated in experimental models of acute and chronic inflammatory and neuropathic pain. Methods: The phthalimide analogues were administered per os (po)in Swiss mice or Wistar rats. Nociceptive response induced by formaldehyde and mechanical allodynia induced by chronic constriction injury (CCI) of the sciatic nerve or intraplantar (ipl) injection of complete Freund’s adjuvant (CFA) were used as experimental models of pain. Results: N-carboxymethyl-3-nitrophthalimide (700 mg/kg, -1 h) inhibited the second phase of the nociceptive response induced by the intraplantar injection of formaldehyde in mice. N-3-hidroxypro-pylphthalimide (546 mg/kg, -1 h) inhibited both phases of the nociceptive response induced by formaldehyde. Treatment of rats with N-carboxymethyl-3-nitrophthalimide (700 mg/kg) or JV-3-hydroxypropylphthalimide (546 mg/kg) inhibited the mechanical allodynia induced by CCI of the sciatic nerve or iplinjection of CFA in rats. Intraperitoneal administration of the opioid antagonist naltrexone (10 mg/kg, -1.5h) attenuated the antinociceptive activity of N-carboxymethyl-3-nitrophthalimide (700 mg/kg) in the model of nociceptive response induced by formaldehyde. Conclusions: N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide, two phthalimide analogues devoid of the glutarimide moiety, exhibited activities in different experimental models of pain, including models of chronic inflammatory and neuropathic pain.
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- 2019
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12. Effects of Turbulent Hyporheic Mixing on Reach‐Scale Transport
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Roche, K. R., Li, A., Bolster, D., Wagner, G. J., and Packman, A. I.
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Turbulence causes rapid mixing of solutes and fine particles between open channel flow and coarse‐grained streambeds. Turbulent mixing is known to control hyporheic exchange fluxes and the distribution of vertical mixing rates in the streambed, but it is unclear how turbulent mixing ultimately influences mass transport at the reach scale. We used a particle‐tracking model to simulate local‐ and reach‐scale solute transport for a stream with coarse‐grained sediments. Simulations were first used to determine profiles of vertical mixing rates that best described solute concentration profiles measured within a coarse granular bed in flume experiments. These vertical mixing profiles were then used to simulate a pulse solute injection to show the effects of turbulent hyporheic exchange on reach‐scale solute transport. Experimentally measured concentrations were best described by simulations with a nonmonotonic mixing profile, with highest mixing at the sediment–water interface and exponential decay into the bed. Reach‐scale simulations show that this enhanced interfacial mixing couples in‐stream and hyporheic solute transport. Coupling produces an interval of exponential decay in breakthrough curves and delays the onset of power law tailing. High streamwise velocities in the hyporheic zone reduce mass recovery in the water column and cause breakthrough curves to exhibit steeper power law slopes than predictions from mobile‐immobile modeling theory. These results demonstrate that transport models must consider the spatial variability of streamwise velocity and vertical mixing for both the stream and the hyporheic zone, and new analytical theory is needed to describe reach‐scale transport when high streamwise velocities are present in the hyporheic zone. We simulated local and reach‐scale solute transport for streams with a coarse‐sediment hyporheic zoneEnhanced mixing below the sediment–water interface results in exponential tailing of breakthrough curves at intermediate timesHigh hyporheic velocities cause BTCs to deviate from current transport modeling theory
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- 2019
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13. Wetting behavior of AlAgCu brazing filler on aluminum matrix composites and stainless steel.
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Weis, S., Elßner, M., Wielage, B., and Wagner, G.
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- 2017
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14. Joining of material compounds of aluminium matrix composites (AMC) by arc brazing using Al-Ag-Cu system filler alloy.
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Elßner, M., Weis, S., Wagner, G., and Grund, T.
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- 2017
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15. Mosquitoes (Diptera: Culicidae) from crepuscular period in an Atlantic Forest area in Southern Brazil.
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Orlandin, E., Santos, E. B., Piovesan, M., Favretto, M. A., Schneeberger, A. H., Souza, V. O., Muller, G. A., and Wagner, G.
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MOSQUITOES ,PHOTOPERIODISM ,BLOODSUCKING insects ,ANIMAL feeding behavior ,EFFECT of light on insects ,ANIMAL behavior ,INSECTS - Abstract
Copyright of Brazilian Journal of Biology is the property of Instituto Internacional de Ecologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
16. Properties of newly developed Co-based brazing fillers.
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Uhlig, T, Weis, S., Wielage, B., Wagner, G., and Schuberth, S.
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- 2017
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17. A Novel Method for Uniaxial HCF Testing of Austenitic Stainless Steels.
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Cruchley, S., Twite, M., Tweddle, A., Wagner, G., Wisbey, A., and Lee, R.
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HIGH cycle fatigue ,AUSTENITIC stainless steel ,FATIGUE life ,ATMOSPHERIC temperature ,STRAIN energy - Abstract
Fatigue endurance testing of nuclear plant materials is typically carried out using uniaxial specimens tested under strain control using a triangular waveform and a defined strain rate. This leads to long test durations and high testing costs when testing in the High Cycle Fatigue (HCF) regime, meaning few results for fatigue lives above 10 6 cycles are available. A novel test method is proposed here, in which the traditional strain-controlled test method is used until 10 5 cycles have elapsed, before testing is switched to load control at a higher frequency. Testing of a Type 304LN austenitic stainless steel in room temperature air was performed at an R ratio of -1, strain rate of 0.4%/s and strain amplitude of 0.18%. The results show no statistically significant difference between the HCF lives gained from the traditional and new test methods. The proposed new fatigue endurance test method is considered to be validated for use in the testing of nuclear grades of unstabilised austenitic stainless steel in air at room temperature. [ABSTRACT FROM AUTHOR]
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- 2016
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18. From Continental Hyperextension to Seafloor Spreading: New Insights on the Porcupine Basin From Wide‐Angle Seismic Data
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Chen, C., Watremez, L., Prada, M., Minshull, T. A., Edwards, R. A., O'Reilly, B. M., Reston, T. J., Wagner, G., Gaw, V., Klaeschen, D., and Shannon, P. M.
- Abstract
The deep structure and sedimentary record of rift basins provide an important insight into understanding the geological processes involved in lithospheric extension. We investigate the crustal structure and large‐scale sedimentary architecture of the southern Porcupine Basin, offshore Ireland along three wide‐angle seismic profiles, supplemented by 13 selected seismic reflection profiles. The seismic velocity and crustal geometry models obtained by joint refraction and reflection traveltime inversion clearly image the deep structure of the basin. Our results suggest the presence of three distinct crustal domains along the rifting axis: (a) continental crust becoming progressively hyperextended from north to south through the basin, (b) a transitional zone of uncertain nature, and (c) a 7‐ to 8‐km‐thick zone of oceanic crust. The latter is overlain by an ~8‐km compacted Upper Paleozoic‐Mesozoic succession and ~ 2 km of Cenozoic strata. Due to the lack of clear magnetic anomalies and in the absence of well control, the precise age of interpreted oceanic crust is unknown. However, we can determine an age range of Late Jurassic to Late Cretaceous from the regional context. We propose a northward propagating rifting process in the Porcupine Basin, resulting in variations in strain along the rift axis. New analysis of wide‐angle seismic data from the southern Porcupine BasinEvidence for presence of oceanic crust in the southern Porcupine Basin.Jurassic rifting propagated from south to north, resulting in nonuniform strain when rifting stopped.
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- 2018
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19. Integration of Humidity Sensors into Fibre-reinforced Thermoplastic Composites.
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Ebert, F., Seider, T., Illing-Günther, H., Nendel, K., Martin, J., Otto, T., Gessner, T., Nestler, D., and Wagner, G.
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Due to the functional integration and weight reduction lightweight structures are more and more important, e.g. for automotive, boat or aircraft engineering. Integration of sensors in composites gives information about different mechanical stresses and conditions (failure, impact etc). Furthermore, environmental conditions have a significant influence on operation and durability, e.g. temperature and humidity. Due to the importance of these parameters, this contribution deals with the detection of moisture in composites. The developed foil-based humidity sensors were placed on foil tapes by means of stitching and integrated into fibre-reinforced thermoplastic composites. [ABSTRACT FROM AUTHOR]
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- 2016
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20. Low temperature joining of copper by Ag nanopaste: correlation of mechanical properties and process parameters.
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Hausner, S., Weis, S., Wielage, B., and Wagner, G.
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- 2016
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21. The relationship between terminal QRS distortion on initial ECG and final infarct size at 4months in conventional ST- segment elevation myocardial infarct patients.
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Hassell, M.E.C.J., Delewi, R., Lexis, C.P.H., Smulders, M.W., Hirsch, A., Wagner, G., Bekkers, S.C.A.M., van der Horst, I.C.C., Zijlstra, F., van Rossum, A.C., Piek, J.J., van der Harst, P., and Nijveldt, R.
- Abstract
Background: In the Sclarovsky-Birnbaum Ischemia Severity Grading System for patients with ST-segment elevation myocardial infarction (STEMI), "Terminal QRS distortion" is considered as "Grade III". This evidence for most severe ischemia is associated with cardiovascular magnetic resonance imaging (CMR) markers of myocardial damage in the subacute phase. Our aim was to assess whether terminal QRS distortions on the initial electrocardiogram (ECG) is predictive for infarct size (IS) and left ventricular ejection fraction (LVEF) at 4months in anterior versus infarct locations.Methods: Patient data of the HEBE, GIPS III and MAST, were pooled. ECGs of 411 STEMI patients were classified as absence (Grade II) or presence (Grade III) of terminal QRS distortion according to Sclarovsky-Birnbaum grading. CMR was performed at approximately 4months and included IS and LVEF.Results: Grade III ischemia was present in 142 of 411 (35%) patients and was more frequently observed with inferior STEMI (P=0.01). In the total cohort and in anterior STEMI, no difference in LVEF or IS was observed between the two Grades. Whereas, in inferior STEMI Grade III was associated with a larger IS (P<0.01) and also, a trend towards a lower LVEF was observed (P=0.09).Conclusion: In inferior STEMI, terminal QRS distortion on the initial ECG is associated with a larger IS at approximately 4months, and can be used to identify a high-risk population in the acute phase. Also, a Grade III was associated with a trend towards a lower LVEF. [ABSTRACT FROM AUTHOR]- Published
- 2016
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22. Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis
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Wise, T, Radua, J, Via, E, Cardoner, N, Abe, O, Adams, T M, Amico, F, Cheng, Y, Cole, J H, de Azevedo Marques Périco, C, Dickstein, D P, Farrow, T F D, Frodl, T, Wagner, G, Gotlib, I H, Gruber, O, Ham, B J, Job, D E, Kempton, M J, Kim, M J, Koolschijn, P C M P, Malhi, G S, Mataix-Cols, D, McIntosh, A M, Nugent, A C, O'Brien, J T, Pezzoli, S, Phillips, M L, Sachdev, P S, Salvadore, G, Selvaraj, S, Stanfield, A C, Thomas, A J, van Tol, M J, van der Wee, N J A, Veltman, D J, Young, A H, Fu, C H, Cleare, A J, and Arnone, D
- Abstract
Finding robust brain substrates of mood disorders is an important target for research. The degree to which major depression (MDD) and bipolar disorder (BD) are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore, the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry (VBM) studies in MDD and BD. We identified studies published up to January 2015 that compared grey matter in MDD (50 data sets including 4101 individuals) and BD (36 data sets including 2407 individuals) using whole-brain VBM. We used statistical maps from the studies included where available and reported peak coordinates otherwise. Group comparisons and conjunction analyses identified regions in which the disorders showed common and distinct patterns of volumetric alteration. Both disorders were associated with lower grey-matter volume relative to healthy individuals in a number of areas. Conjunction analysis showed smaller volumes in both disorders in clusters in the dorsomedial and ventromedial prefrontal cortex, including the anterior cingulate cortex and bilateral insula. Group comparisons indicated that findings of smaller grey-matter volumes relative to controls in the right dorsolateral prefrontal cortex and left hippocampus, along with cerebellar, temporal and parietal regions were more substantial in major depression. These results suggest that MDD and BD are characterised by both common and distinct patterns of grey-matter volume changes. This combination of differences and similarities has the potential to inform the development of diagnostic biomarkers for these conditions.
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- 2017
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23. Tätowiermittel und ihre Unverträglichkeitsreaktionen
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Wagner, G., Meyer, V., and Sachse, M.
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Tätowierungen werden als Körperschmuck verstanden und haben in allen Schichten der Bevölkerung eine weite Verbreitung gefunden. Trotz der 2009 in Deutschland in Kraft getretenen Tätowiermittel-Verordnung ist der Schutz der Verbraucher lückenhaft. Betrachtet werden die Prävalenz von Tätowierungen und ihre rechtlichen Grundlagen, Inhaltsstoffe von Tätowiermitteln, klinische Befunde von Unverträglichkeitsreaktionen, Pathogenese und Therapie. Zugrunde gelegt wurden eine selektive Literaturrecherche in der Datenbank PubMed und klinische Erfahrungen der Autoren. Unverträglichkeitsreaktionen durch Tätowiermittel stellen ein besonderes Problem dar, da die auslösenden Substanzen biologisch nicht abbaubar im Gewebe verbleiben können. Neben einem quälenden Pruritus ist das klinische Bild durch erythematöse Plaques gekennzeichnet. Histopathologisch finden sich unterschiedliche Entzündungsmuster einschließlich pseudolymphomatöser Reaktionen. Die Behandlung ist problematisch. In vielen Fällen sind umfangreiche Exzisionen notwendig mit allen damit verbundenen kosmetischen Konsequenzen. Eine Zulassungsverordnung, die den Nachweis der Unbedenklichkeit von Tätowiermitteln regelt, existiert bis heute nicht. Tattoos are regarded as body jewelry and have become widespread in all parts of society. Despite introduction of the tattooing agents’ regulation (Tätowiermittelverordnung) in Germany in 2009, consumer protection is incomplete. Prevalence of tattoos and their legal basis, ingredients of tattooing agents, clinical findings of adverse reactions, pathogenesis and therapy. The work is based on a selective literature search in PubMed and on the clinical experience of the authors. Adverse reactions by tattooing are a particular problem, because the causing substances are not biodegradable within the tissue. In addition to an agonizing pruritus, the clinical picture is characterized by erythematous plaques. Histopathology reveals different patterns of inflammation, including pseudolymphomatous reactions. Treatment is problematic. In many cases, extensive surgical excision is necessary, which is associated with cosmetic consequences. A regulation to assess the safety of tattooing does not exist.
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- 2017
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24. Joining of material compounds of aluminium matrix composites (AMC) by arc brazing using Al-Ag-Cu system filler alloy
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Elßner, M., Weis, S., Wagner, G., and Grund, T.
- Abstract
Aluminium matrix composites (AMC) are in the focus of recent research. In the field of lightweight design, dissimilar joints with AMC are of current interest. To ensure the positive properties of AMC—like high specific strength, increased wear resistance, and low coefficient of thermal expansion (CTE)—a suitable joining technique is necessary. This work shows the state of the art of arc brazing using a filler material of the alloying system Al-Ag-Cu. Joints of AMC/stainless steel and AMC/aluminium alloy are investigated. The formation of brittle Al-Fe intermetallic phases in AMC/stainless steel joints must be reduced to obtain a sufficient joint strength. Therefore, an adapted alloying concept is used for the filler material. The filler (40 wt% Al, 40 wt% Ag, and 20 wt% Cu) is alloyed with various contents of Si (1.2, 1.3, and 1.4 wt%). Primarily solidified Si can be seen above 1.3 wt% Si in the microstructure. The melting temperature could be reduced about 10 K by additional Si. The microstructure analyzed by SEM, EDXS, and XRD, as well as the hardness profile of the joining zone, are characterized and discussed. In case of the interface braze metal/aluminium material, the formation of a thin (approx. 5 μm) phase layer, consisting of solid solution of Al, can be seen. Compared with that insights, the phase layer at the interface braze metal/stainless steel consists of intermetallics of the system Fe-Al. The results of the hardness measurements at the interface and XRD patterns prove the presence of Fe3Al, FeAl, and FeAl3. Cracks can occur between the brittle phases FeAl and FeAl3, due to their high hardness of approx. 600 HV0.005 (rep. FeAl) and 1020 HV0.005 (rep. FeAl3) and in combination of internal stress formation during cooling.
- Published
- 2017
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25. Wetting behavior of AlAgCu brazing filler on aluminum matrix composites and stainless steel
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Weis, S., Elßner, M., Wielage, B., and Wagner, G.
- Abstract
Suitable joining technologies are necessary for the application of aluminum matrix composites (AMC). Especially dissimilar joints between AMC and stainless steel are of enhanced interest. In this work, the approach of arc brazing source of this material combination is investigated. Therefore, basic examinations like the wetting behavior of a developed filler on the base metals is realized. The used filler of the system Al-Ag-Cu show a ternary eutectic of the phases Ag2Al, Al2Cu, and solid solution of Al. Sessile drop technique is applied for the wetting tests. To generate the arc, a TIG welding unit is used. The results of these wetting tests, like the wetting angles and the microstructure of the interfaces, are described and discussed. The wetting angle measured on cross sections show that the wetting on AMC is good (< 30°) while the wetting on stainless steel (~ 90 °) has to be improved. That demonstrates the excellent wettability of the AMC and the suitability of that approach. The wettability of stainless steel can be improved by pretreating, like preheating and polishing, which results in a wetting angle of approx. 35°. The influence of these pretreatments on the microstructure due to a various diffusion behavior of, for example, Al at the interface of the combined materials are described. Different phases in comparison to the filler can be seen at the interfaces of braze metal and the base metals by using SEM, due to a strong diffusion of Al. Analyze by energy-dispersive x-ray spectroscopy (EDXS) and x-ray diffraction (XRD) at the interface of braze metal to stainless steel indicate intermetallic layers of the system Fe-Al, like AlFe3, Al2Fe and Al13Fe4. In the case of the AMC, a solid solution of Al in shape of a not compact layer occurs and no formation of Al4C3can be detected.
- Published
- 2017
- Full Text
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26. Properties of newly developed Co-based brazing fillers
- Author
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Uhlig, T, Weis, S., Wielage, B., Wagner, G., and Schuberth, S.
- Abstract
Co-based materials are widely used in high temperature applications like aircraft industry, industrial furnaces, or gas turbine manufacturing. The main requirements on the Co superalloys are high temperature and corrosion resistance. To produce complex structures, it is necessary to join these alloys. In this work, Co-based brazing fillers for high temperature service conditions are developed. The influence of different alloying elements on the melting behavior as well as on the microstructure is investigated. A melting temperature below 1200 °C is achieved via addition of Ti to the near eutectic alloy CoZrTaC9, developed in previous studies. Brazing tests are carried out on the Co-based superalloy Mar M 509 using induction heating. The mechanical properties are determined by tensile tests at room temperature and at an elevated temperature of 850 °C. The fracture morphology of the tensile samples is investigated by light microscopy as well as SEM.
- Published
- 2017
- Full Text
- View/download PDF
27. A mid-scale plasma-electrode Pockels cell for the FLUX laser
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Awwal, Abdul A. S., Haefner, Constantin L., Kruschwitz, B. E., Agnello, S., Gibney, K., Nelson, D., Walker, T. W., Bittle, W. A., Carrier, N., Hettrick, J., Mitchell, G., Szczepanski, J., and Wagner, G. L.
- Published
- 2023
- Full Text
- View/download PDF
28. Acquired resistance of pancreatic cancer cells to cisplatin is multifactorial with cell context-dependent involvement of resistance genes
- Author
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Mezencev, R, Matyunina, L V, Wagner, G T, and McDonald, J F
- Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal of malignancies, in large measure, due to the propensity of PDAC cells to acquire resistance to chemotherapeutic agents. A better understanding of the molecular basis of acquired resistance is a major focus of contemporary PDAC research. We report here the results of a study to independently develop cisplatin resistance in two distinct parental PDAC cell lines, AsPC1 and BxPC3, and to subsequently examine the molecular mechanisms associated with the acquired resistance. Cisplatin resistance in both resistant cell lines was found to be multifactorial and to be associated with mechanisms related to drug transport, drug inactivation, DNA damage response, DNA repair and the modulation of apoptosis. Our results demonstrate that the two resistant cell lines employed alternative molecular strategies in acquiring resistance dictated, in part, by pre-existing molecular differences between the parental cell lines. Collectively, our findings indicate that strategies to inhibit or reverse acquired resistance of PDAC cells to cisplatin, and perhaps other chemotherapeutic agents, may not be generalized but will require individual molecular profiling and analysis to be effective.
- Published
- 2016
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29. Genetic association study of the HLA class II alleles DRB1, DQA1, and DQB1 in patients with pharmacoresistant temporal lobe epilepsy associated with mesial hippocampal sclerosis.
- Author
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Horta, Wagner G., Paradela, Eduardo, Figueiredo, André, Meira, Isabella D’Andrea, Pereira, Valéria C. Santa Rita, Rego, Cláudia C., Oliveira, Raquel, Andraus, Maria Emilia C., Lacerda, Glenda C. Borges de, Moura, Polyana, Souza, Jorge P. Marcondes de, Paiva, Carmen Lucia A., Alves-Leon, Soniza V., Meira, Isabella D'Andrea, de Lacerda, Glenda C Borges, and de Souza, Jorge P Marcondes
- Abstract
Purpose: Temporal lobe epilepsy (TLE) is the most common variety of focal epilepsy among adults. The neuroinflammatory mechanisms of epilepsies may be involved in the genesis of seizures and refractory epilepsies, particularly in the case of progressive syndromes such as TLE associated with mesial hippocampal sclerosis (TLE-HS). The goal of the present study is investigate the genetic profile of susceptibility of individuals with TLE-HS by analyzing the possible association of TLE-HS with human leukocyte antigen (HLA) DRB1, DQA1 and DQB1 alleles.Methods: Peripheral blood samples were collected from 42 individuals with pharmacoresistant TLE-HS and 89 healthy controls. The typing of the HLA class II alleles from DRB1, DQB1, and DQA1 loci were analyzed using sequence-specific primer-polymerase chain reaction (SSP-PCR) and identified through sequencing. Statistical analysis of relative allele frequencies was performed using an Excel spreadsheet; p-value, relative risk (RR), and odds ratio (OR) were calculated using the software Epi Info 6.0. p-values <0.05 following Bonferroni's method correction were considered statistically significant.Results: HLA-DRB1*13:02 was the only allele with a statistically significant difference (p=0.01) in frequency between patients and controls. However, the significance was lost following Bonferroni's method correction (p=0.44). The remainder of the alleles in the HLA-DRB1, HLA-DQB1 and HLA-DQA1 regions did not exhibit any significant association.Conclusion: The allele HLA DRB1*13:02 has exhibited a tendency to behave as a susceptibility factor for TLE-HS. [ABSTRACT FROM AUTHOR]- Published
- 2015
- Full Text
- View/download PDF
30. Behavioural Therapy and Counselling.
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Schill, Wolf-Bernhard, Comhaire, Frank, Hargreave, Timothy B., Jannini, E. A., Lenzi, A., and Wagner, G.
- Abstract
Some clinical aspects important for the diagnosis and therapy of andrological diseases have a deep behavioural impact, which are of particular practical interest to the clinical andrologist. It should be remembered that the diagnosis and therapy of andrological diseases interact with two biological functions — fertility and sexuality — that are more sensitive to psychological, educational, cultural, religious and social factors than any other body function. The clinical andrologist must take these aspects into account as an integral part of the pathophysiological mechanism and the entire process of diagnosis and therapy. Fertility, sexual, genetic and neoplastic andrological disorders require the clinician to give scientific information in the fundamental phase of counselling. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
31. Low temperature joining of copper by Ag nanopaste: correlation of mechanical properties and process parameters
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Hausner, S., Weis, S., Wielage, B., and Wagner, G.
- Abstract
Nanoparticles exhibit a decrease in sintering and melting temperature with decreasing particle size in comparison to the corresponding bulk material. After melting or sintering of the nanoparticles, the material behaves like the bulk material. Therefore, high-strength and temperature-resistant joints can be produced at low temperatures, which is of big interest for various joining tasks. Joints (substrate: Cu) were prepared with an Ag nanoparticle-containing paste. The influence of the adjustable process parameters joining pressure, joining temperature, holding time, heating rate, thickness of paste application, surface treatment, pre-drying process, and subsequent heat treatment on the strength behavior of the joints was investigated. It is shown that in particular, the joining pressure exerts an essential influence on the achievable strengths. In addition, temperature, holding time, and thickness of paste application have a significant effect on strength behavior. In contrast, the pre-drying process, heating rate, surface pre-treatment, and subsequent heat treatment possess hardly any influence on joint strength.
- Published
- 2016
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- View/download PDF
32. Prevalence of acute cardiac disorders in patients with suspected ST-segment elevation myocardial infarction and non-significant coronary artery disease.
- Author
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Andersson, H., Christensen, T. E., Ahtarovski, K. A., Bang, L. E., Hasbak, P., Vejlstrup, N., Pedersen, F., Holmvang, L., Grande, P., Clemmensen, P., and Wagner, G. S.
- Abstract
Background and purpose We aimed to study the prevalence of acute cardiac disorders in patients with suspected ST-segment elevation myocardial infarction (STEMI) and non-significant coronary artery disease (CAD). Methods From January to October 2012 we consecutively included patients admitted with suspected STEMI and non-significant CAD (coronary artery stenosis diameter < 50%). Patients were diagnosed with acute cardiac disorder in the presence of elevated cardiac biomarkers (troponin T > 50 ng/l or creatine kinase MB > 4 μg/l) or dynamic ECG changes (ST-segment changes or T-wave inversion). Results Of the 871 patients admitted with suspected STEMI, 11% (n = 95) had non-significant CAD. Of these, 67% (n = 64) had elevated cardiac biomarkers or dynamic ECG changes and were accordingly diagnosed with acute cardiac disorders. In the remaining 33% (n = 31) of patients, cardiac biomarkers were normal and ECG changes remained stationary. Conclusions Acute cardiac disorders were diagnosed in two thirds of patients with suspected STEMI and non-significant CAD. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
33. Consideration of QRS complex in addition to ST-segment abnormalities in the estimation of the "risk region" during acute anterior or inferior myocardial infarction.
- Author
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Vervaat, F. E., Bouwmeester, S., van Hellemond, I. E. G., Wagner, G. S., and Gorgels, A. P. M.
- Abstract
The myocardial area at risk (MaR) is an important aspect in acute ST-elevation myocardial infarction (STEMI). It represents the myocardium at the onset of the STEMI that is ischemic and could become infarcted if no reperfusion occurs. The MaR, therefore, has clinical value because it gives an indication of the amount of myocardium that could potentially be salvaged by rapid reperfusion therapy. The most validated method for measuring the MaR is
99m Tc-sestamibi SPECT, but this technique is not easily applied in the clinical setting. Another method that can be used for measuring the MaR is the standard ECG-based scoring system, Aldrich ST score, which is more easily applied. This ECG-based scoring system can be used to estimate the extent of acute ischemia for anterior or inferior left ventricular locations, by considering quantitative changes in the ST-segment. Deviations in the ST-segment baseline that occur following an acute coronary occlusion represent the ischemic changes in the transmurally ischemic myocardium. In most instances however, the ECG is not available at the very first moments of STEMI and as times passes the ischemic myocardium becomes necrotic with regression of the ST-segment deviation along with progressive changes of the QRS complex. Thus over the time course of the acute event, the Aldrich ST score would be expected to progressively underestimate the MaR, as was seen in studies with SPECT as gold standard; anterior STEMI (r = 0.21, p = 0.32) and inferior STEMI (r = 0.17, p = 0.36). Another standard ECG-based scoring system is the Selvester QRS score, which can be used to estimate the final infarct size by considering the quantitative changes in the QRS complex. Therefore, additional consideration of the Selvester QRS score in the acute phase could potentially provide the "component" of infarcted myocardium that is missing when the Aldrich ST score alone is used to determine the MaR in the acute phase, as was seen in studies with SPECT as gold standard: anterior STEMI (r = 0.47, p = 0.02) and inferior STEMI (r = 0.58, p < 0.001). The aim of this review will be to discuss the findings regarding the combining of the Aldrich ST score and initial Selvester QRS score in determining the MaR at the onset of the event in acute anterior or inferior ST-elevation myocardial infarction. [ABSTRACT FROM AUTHOR]- Published
- 2014
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34. Incorporation of Fe into NiSi2 precipitates.
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Langkau, S., Wagner, G., Bertoni, M.I., Buonassisi, T., and Kloess, G.
- Subjects
PRECIPITATION (Chemistry) ,NICKEL compounds ,SOLID state chemistry ,KIRKENDALL effect ,TRANSMISSION electron microscopy ,SILICIDES ,IRON - Abstract
Abstract: The present paper provides evidence that Fe can be incorporated into NiSi
2 precipitates by solid-state diffusion. Furthermore, analysis of Si crystals contaminated with Ni and Fe at 1100 °C and post annealed at 600 °C and 800 °C for 20–240 min revealed a strong indication that this incorporation is limited by bulk diffusion rather than incorporation kinetics. [Copyright &y& Elsevier]- Published
- 2011
- Full Text
- View/download PDF
35. Cyclic deformation behavior of a medium carbon steel in the VHCF regime.
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Koster, M., Wagner, G., and Eifler, D.
- Abstract
Abstract: At the Institute of Materials Science and Engineering an ultrasonic testing facility (UTF) for the fatigue assessment in the very high cycle fatigue (VHCF) regime was developed. The UTF allows to control the test and to measure process parameters like generator power and specimen temperature. In load increase tests (LIT), the critical stress amplitude leading to a first rise of the measured physical values is determined and can be used to identify suitable amplitudes for single step tests in the VHCF regime. The individual design of the UTF allows a defined interruption of the fatigue experiment for detailed microscopic investigations. [Copyright &y& Elsevier]
- Published
- 2010
- Full Text
- View/download PDF
36. Effect of WT1 gene silencing on the tumorigenicity of human glioblastoma multiforme cells.
- Author
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CLARK, AARON J., WARE, JOY L., CHEN, MIKE Y., GRAF, MARTIN R., VAN METER, TIMOTHY E., SANTOS, WAGNER G. DOS, FILLMORE, HELEN L., and BROADDUS, WILLIAM C.
- Published
- 2010
- Full Text
- View/download PDF
37. Deep Brain Stimulation in Epilepsy: A Role for Modulation of the Mammillothalamic Tract in Seizure Control?
- Author
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Schaper, Frédéric L W V J, Plantinga, Birgit R, Colon, Albert J, Wagner, G Louis, Boon, Paul, Blom, Nadia, Gommer, Erik D, Hoogland, Govert, Ackermans, Linda, Rouhl, Rob P W, and Temel, Yasin
- Published
- 2021
- Full Text
- View/download PDF
38. Resilience and distress among amyotrophic lateral sclerosis patients and caregivers.
- Author
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Rabkin, Judith G., Wagner, Glenn J., Del Bene, Maura, Rabkin, J G, Wagner, G J, and Del Bene, M
- Abstract
Objectives: The objectives of this study were to assess the prevalence of depressive disorders and symptoms and their correlates in patients with amyotrophic lateral sclerosis (ALS) and caregiver spouses and to identify dimensions of resilience as well as distress.Methods: Fifty-six patients with ALS and 31 caregivers were interviewed on one occasion, and 20 patients were subsequently reinterviewed during a scheduled medical visit at an ALS center. Major measures included the Structured Clinical Interview for DSM-IV, the Beck Depression Inventory, the Schedule of Attitudes Toward Hastened Death, quality of life, spirituality, and degree of hopelessness. The ALS Functional Rating Scale, spirometry measures of forced vital capacity, and the Karnofsky Performance Index were used to assess physical status.Results: Neither patients nor caregivers displayed significant psychopathology with respect to either current depressive disorders or scores on symptom scales. Depressive symptoms and psychological distress were not related to time since diagnosis, degree of disability, or illness progression during the period of observation. More interest in hastened death was associated with greater distress, but willingness to consider assisted suicide was not. Among caregivers, perceived caregiver burden was significantly associated with finding positive meaning in caregiving. Concordance between patient and caregiver distress was high, suggesting that attention to the mental health needs of caregivers may alleviate the patient's distress as well.Conclusions: Clinical depression or significant depressive symptomatology is not an inevitable or common outcome of life-threatening illness, even in the presence of major disability. [ABSTRACT FROM AUTHOR]- Published
- 2000
- Full Text
- View/download PDF
39. Neumonía por herpes virus simple tipo 1. Entidad infrecuente de difícil diagnóstico y mal pronóstico en trasplantados pulmonares
- Author
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Mazzucco, M.R., Paladini, H., Marinucci, F., Martínez, A.R., Mela, M., and Wagner, G.
- Abstract
La neumonía herpética es una rara enfermedad que afecta casi con exclusividad a personas con un déficit de inmunidad. Con frecuencia tiene un desenlace fatal.
- Published
- 2014
- Full Text
- View/download PDF
40. KIKS UP
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Mörler, J., Olshausen, I., Peil, J.M., Wagner, G., and Wüsten, B.
- Published
- 2013
- Full Text
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41. Phylloplanins Reduce the Severity of Gray Leaf Spot and Brown Patch Diseases on Turfgrasses
- Author
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King, Brian, Williams, D. W., and Wagner, G. J.
- Abstract
Plant‐produced, natural‐product fungicides should be evaluated for their potential to complement or replace synthetic fungicides that are major components in the management of high maintenance turf. Tobacco (Nicotiana tabacumL.) cultivar T.I. 1068 and sunflower (Helianthus annuusL.) phylloplanins (T‐ and S‐phylloplanins), collected in leaf‐water washes (LWWs) of plants, and recombinant T‐phylloplanin inhibit Peronospora tabacinaD.B. Adam (oomycete) spore germination and reduce blue mold disease on tobacco. Here, in vitro (hyphal extension) and in vivo studies were conducted to test the ability of T‐ and S‐phylloplanins to inhibit growth of the turf pathogens Pyricularia oryzaeCavara (ascomycete) and Rhizoctonia solaniJ.G. Kühn (basidiomycete) and to test protection of turfgrass plants from gray leaf spot and brown patch diseases. Hyphal extension assays showed that LWWs containing T‐ and S‐phylloplanins inhibited both pathogens. Spraying potted grass plants with LWWs containing T‐ and S‐phylloplanins followed by inoculation with pathogens resulted in 97 and 88% inhibition of P. oryzaedisease and 94 and 82% inhibition of R. solanion annual (Lolium multiflorumLam. cv. Linn) and perennial (Lolium perenneL. cv. Double Eagle Blend) ryegrasses, respectively, under the conditions tested. In addition, T‐ and S‐phylloplanins led to 94 and 100% symptom reduction, respectively, on creeping bentgrass (Agrostis stoloniferaL. cv. L‐93), for R. solanionly. Results indicate that T‐ and S‐phylloplanins have broad selectivity, inhibiting at least one member of the ascomycete and basidiomycete phyla, and may be useful as exogenously applied or endogenously expressed natural‐product antifungal agents to protect turf, crops, and other plants.
- Published
- 2011
- Full Text
- View/download PDF
42. Effects of post‐growth annealing on physical properties of SrRuO3thin film grown by MOCVD
- Author
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Anooz, S. Bin, Schwarzkopf, J., Dirsyte, R., Wagner, G., and Fornari, R.
- Abstract
We report on the annealing effects on strontium ruthenate thin films deposited on SrTiO3using liquid‐delivery metalorganic chemical vapor deposition (MOCVD). The results of high resolution X‐ray diffraction (HR‐XRD), Raman spectroscopy, atomic force microscopy (AFM), and electrical resistivity, before and after a post‐growth annealing process were analyzed and compared. XRD and Raman spectroscopy for the as‐deposited film revealed that the film had c‐axis orientation and contained RuO2as secondary phase. Single phase SrRuO3could be obtained by annealing the film at 700 °C. Annealing at higher temperatures up to 850 °C leads to ruthenium deficiency, which is revealed by an increase in the out‐of‐plane lattice parameter, while at even higher annealing temperatures a decrease in the out‐of‐plane lattice parameter was detected might be due to diffusion of Ti from the substrate. The electrical resistivity increased with increasing annealing temperature up to 950 °C and showed typical metallic temperature dependence, while for the film annealed at 1000 °C a semiconductor‐like behavior was observed.
- Published
- 2010
- Full Text
- View/download PDF
43. Großserientaugliche Formgebung durch Duroplast-Spritzgießen zur Herstellung von faserverstärkter Keramik
- Author
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Nier, N., Nestler, D., Roder, K., Todt, A., Päßler, E., Weißhuhn, J., Würfel, H., Spange, S., Kroll, L., and Wagner, G.
- Abstract
In gemeinsamer Kooperation der Professuren Verbundwerkstoffe (Prof. G. Wagner), Strukturleichtbau und Kunststoffverarbeitung (Prof. L. Kroll) sowie Polymerchemie (Prof. S. Spange) der Technischen Universität Chemnitz wurde ein großserientaugliches Formgebungsverfahren zur Herstellung faserverstärkter C/C-SiC-Verbunde entwickelt. Das Verfahren wird die Produktionskosten erheblich senken. In joint cooperation of the departments of composite materials (Prof. G. Wagner), lightweight structures and polymer technology (Prof. L. Kroll), and polymer chemistry (Prof. S. Spange) of Technische Universität Chemnitz a process suitable for large-scale production of fibre-reinforced C/C-SiC composites has been developed. This process will significantly reduce the production costs.
- Published
- 2016
- Full Text
- View/download PDF
44. Deep Brain Stimulation in Epilepsy: A Role for Modulation of the Mammillothalamic Tract in Seizure Control?
- Author
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Schaper, Frédéric L W V J, Plantinga, Birgit R, Colon, Albert J, Wagner, G Louis, Boon, Paul, Blom, Nadia, Gommer, Erik D, Hoogland, Govert, Ackermans, Linda, Rouhl, Rob P W, and Temel, Yasin
- Abstract
Graphical Abstract
- Published
- 2021
- Full Text
- View/download PDF
45. The Fatigue Behaviour of Friction Stir Welded Aluminium Joints
- Author
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Gutensohn, M., Wagner, G., Walther, F., and Eifler, D.
- Abstract
The friction stir welding (FSW) technology enables the production of high-strength joints of light weight metal sheets. In this paper, the fatigue properties of AA5454-FSW-joints will be discussed. High-resolution plastic strain amplitude, temperature and electrical resistance measurements were performed to describe and evaluate the fatigue behaviour in detail. The plastic strain amplitude determined in mechanical stress-strain hysteresis measurements is qualified to describe the proceeding fatigue damage. Additionally, the change in temperature caused by plastic deformation work and measured with thermocouples fixed on the specimen surface allows a precise fatigue assessment. The electrical resistance measurements are directly related to the fatigue-induced defect structure and density in the welding zone. The fatigue behaviour of the welding zone, which corresponds to the specimen gauge length, is characterized by pronounced cyclic hardening leading to a plastic strain amplitude nearby zero. Additionally, results of microscopic investigations of the welding zone are presented for a microstructure-related interpretation of the fatigue properties.
- Published
- 2008
- Full Text
- View/download PDF
46. Monitoring of the Friction Stir Welding Process to Describe Parameter Effects on Joint Quality
- Author
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Jene, T., Dobmann, G., Wagner, G., and Eifler, D.
- Abstract
With the industrial use of FSW growing steadily, non-destructive testing methods that can detect the impending formation of flaws during welding must be developed. The present work accomplished two goals. First, the distribution of oxide fragments within aluminium welds could be correlated with certain welding process variables. Consequently, an approach was suggested to prevent the conglomeration of oxide fragments in the weld by reducing the surface roughness of the abutted edges. Second, welding forces can be used to predict the formation of elongated cavities inside the weld. This project showed that by monitoring the welding forces, the ability to change the welding variables in real time could prevent the formation of flaws in friction stir welds.
- Published
- 2008
- Full Text
- View/download PDF
47. Developing a Mechanistic Understanding of Fish Migrations by Linking Telemetry with Physiology, Behavior, Genomics and Experimental Biology: An Interdisciplinary Case Study on Adult Fraser River Sockeye Salmon
- Author
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Cooke, Steven J., Hinch, S. G., Farrell, A. P., Patterson, D. A., Miller-Saunders, K., Welch, D. W., Donaldson, M. R., Hanson, K. C., Crossin, G. T., Mathes, M. T., Lotto, A. G., Hruska, K. A., Olsson, I. C., Wagner, G. N., Thomson, R., Hourston, R., English, K. K., Larsson, S., Shrimpton, J. M., and Van der Kraak, G.
- Abstract
Fish migration represents one of the most complex and intriguing biological phenomena in the animal kingdom. How do fish migrate such vast distances? What are the costs and benefits of migration? Some of these fundamental questions have been addressed through the use of telemetry. However, telemetry alone has not and will not yield a complete understanding of the migration biology of fish a or provide solutions to problems such as identifying physical barriers to migration or understanding potential impacts of climate change. Telemetry can be coupled with other tools and techniques to yield new insights into animal biology. Using Fraser River sockeye salmon (Oncorhynchus nerka) as a model, we summarize the advances that we have made in understanding salmonid migration biology through the integration of disciplines (i.e., interdisciplinary research) including physiology, behavior, functional genomics, and experimental biology. We also discuss opportunities for using large-scale telemetry arrays and taking a more experimental approach to studies of fish migration that use telemetry (i.e., intervention studies involving endocrine implants, simulated migration studies) rather than simply focusing on descriptive or correlational techniques. Only through integrative and interdisciplinary research will it be possible to understand the mechanistic basis of fish migrations and to predict and possibly mitigate the consequences of anthropogenic impacts. Telemetry is a tool that has the potential to integrate research across disciplines and between the lab and the field to advance the science of fish migration biology. The techniques that we have applied to the study of Pacific salmon are equally relevant to other fish taxa in both marine and freshwater systems as well as migratory animals beyond ichthyofauna. The interdisciplinary approach used here was essential to address a pressing and complex conservation problem association with sockeye salmon migration.
- Published
- 2008
- Full Text
- View/download PDF
48. Ultrasonic spot welding of aluminum sheet/carbon fiber reinforced polymer – joints
- Author
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Balle, F., Wagner, G., and Eifler, D.
- Abstract
Current demands on light weight constructions lead to an increasing use of light weight metals such as aluminum or magnesium alloys as well as fiber reinforced polymers (FRP). Suitable welding methods are necessary to join these dissimilar material groups and to integrate them in engineering structures. At the Institute of Materials Science and Engineering the ultrasonic metal welding technique was successfully applied to realize aluminum sheet/carbon-fiber-reinforced polymer (CFRP) - joints. The welding during this process occurs in two steps: First the ultrasonic shear waves lead to a softening and displacement of the polymer matrix out of the welding zone. In the second step a direct weld between the load bearing carbon fibers of the CFRP and the aluminum alloy sheet is generated. A welding time of less than 5 s and no damage of the carbon fibers are important advantages of the process. Actually tensile shear strengths of about 30 MPa were achieved for the joints. By means of light microscopic and SEM investigations the bonding mechanisms can be described in detail. Possible application fields of such welds can be seen in the automotive or in the aircraft industry.
- Published
- 2007
- Full Text
- View/download PDF
49. Visualization of Vortices in Emulsification Processes
- Author
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Urban, K., Wagner, G., Schaffner, D., and Ulrich, J.
- Published
- 2006
- Full Text
- View/download PDF
50. Ultrasonically Welded Aluminium Foams/Sheet Metal – Joints
- Author
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Born, C., Wagner, G., and Eifler, D.
- Abstract
The ultrasonic welding technology enables to produce high‐strength joints between sheet metal and aluminium foam sandwich (AFS) without melting of the metal or any damage of the foam structure. In the investigations the used welding processes and different factors influencing the weldability were varied. The achievable mechanical properties for ultrasonically welded metal joints, especially under monotonic and cyclic load, will be discussed. Additionally, results of microscopic investigations of the bonding zone and possible applications are presented.
- Published
- 2006
- Full Text
- View/download PDF
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