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Obesity is a global health issue, predisposing individuals to developing insulin resistance, diabetes, and cardiovascular diseases. Mushrooms are rich in bioactive compounds and have been found to modulate lipid metabolism. As a result, research in this field has been exploring alternative therapeutic options, emphasizing the potential of mushrooms and their bioactive compounds as promising candidates for future interventions. In this comprehensive review, we analyzed studies published in the last five years that linked mushrooms and their compounds to changes in lipid metabolism. During this period, researchers identified thirty-seven species, each regulating one or more of the following factors: fatty acid metabolism, inflammation, oxidative stress, cholesterol metabolism, and microbiota. Different species and their associated molecules or extracts effectively improved lipid profiles, obesity, and steatosis in various animal and cell models, highlighting the therapeutic potential of medicinal mushrooms. [ABSTRACT FROM AUTHOR]

This study investigated if the exposure to tributyltin (TBT), a chemical used worldwide in boat antifouling paints, could result in metabolic disturbances in the blue crab Callinectes sapidus. After the exposure to TBT 100 or 1000 ng.L−1 for 48 and 96 h, hemolymph and tissues were collected to determine the concentration of metabolites and lipid peroxidation. The levels of glucose, lactate, cholesterol, and triglycerides in the hemolymph were not affected by TBT exposure. Hemolymph protein and heart glycogen increased in the crabs exposed to TBT 1000 for 96 h. Anterior gills protein and lipoperoxidation decreased after 96 h in all groups. These results suggest that C. sapidus can maintain energy homeostasis when challenged by the TBT exposure for 48 h and that metabolic alterations initiate after 96 h. [Display omitted] • Despite its banishment, TBT is still an estuarine contaminant of concern. • Hemolymph protein increased after 96 h of 1000 ng.L−1 TBT exposure. • Heart glycogen increased after 96 h of 1000 ng.L−1 TBT exposure. • Lipid peroxidation and protein reduced in anterior gills after 96 h, independently of treatment. [ABSTRACT FROM AUTHOR]