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31 results on '"Voges J"'

1. S2k-Leitlinie: Tremor

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Schwingenschuh, P., Becktepe, J., Brancato, A., Buechele, F., Hopfner, F., Kaegi, G., Klingelhoefer, L., Pirker, W., Raethjen, J., Schnitzler, A., Voges, J., Volkmann, J., Zeuner, K., and Deuschl, G.

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2023
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13. Abstracts

Author

Derlon, J. M., Petit-taboué, M. C., Dauphin, F., Courtheoux, P., Chapon, F., Creissard, P., Darcel, F., Houtteville, J. P., Kaschten, B., Sadzot, B., Stevenaert, A., Tjuvajev, Juri G., Macapinlac, Homer A., Daghighian, Farhad, Ginos, James Z., Finn, Ronald D., Jiaju Zhang, M. S., Beattie, Bradley, Graham, Martin, Larson, Steven M., Blasberg, Ronald G., Levivier, M., Goldman, S., Pirotte, B., Brucher, J. M., Balériaux, D., Luxen, A., Hildebrand, J., Brotchi, J., Go, K. G., Kamman, R. L., Mooyaart, E. L., Heesters, M. A. A. M., Sijens, P. E., Oudksrk, M., van Dijk, P., Levendag, P. C., Vecht, Ch. J., Metz, R. J., Kennedy, D. N., Rosen, B. R., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Caviness, V. S., Gross, M. W., Weinzierl, F. X., Trappe, A. E., Goebel, W. E., Frank, A. M., Becker, Georg, Krone, Andreas, Schmidt, Karsten, Hofmann, Erich, Bogdahn, Ulrich, Bencsch, H., Fclber, S., Finkenstedt, G., Kremser, C., Sfockhammer, G., Aichner, F., Bogdahn, U., Fröhlich, T., Becker, G., Krone, A., Schlief, R., Schürmann, J., Jachimczak, P., Hofmann, E., Roggendorf, W., Roosen, K., Carapella, C. M., Carpinelli, G., Passalacqua, R., Raus, L., Giannini, M., Mastrostefano, R., Podo, F., Tofani, A., Maslrostefano, R., Mottoles, M., Ferraironi, A., Scelsa, M. G., Oppido, P., Riccio, A., Maini, C. L., Collombier, L., Taillandier, L., Dcbouverie, M., Laurens, M. H., Thouvenot, P., Weber, M., Bertrand, A., Cruickshank, G. S., Patterson, J., Hadley, D., De Witte, Olivier, Hildebrand, Jerzy, Luxen, André, Goldman, Serge, Ernestus, R. -I., Bockhorst, K., Eis, M., Els, T., Hoehn-Berlage, M., Gliese, M., Fründ, R., Geissler, A., Woertgen, C., Holzschuh, M., Goldman, Serge, Levivier, M., Pirotte, B., Brucher, J. M., Luxen, A., Brotchi, J., Hildebrand, J., Hausmann, O., Merlo, A., Jerrnann, E., Uirich, J., Chiquet-Ehrismann, R., Müller, J., Mäcke, H., Gratzl, O., Herholz, K., Ghaemi, M., Würker, M., Pietrzyk, U., Heiss, W. -D., Kotitschke, K., Brandl, M., Tonn, J. C., Haase, A., Bogdahn, U., Kotitschke, K., Muigg, S., Felber, S., Aichner, F., Haase, A., Bogdahn, U., Krone, A., Becker, G., Woydt, M., Roggendorf, W., Hofmann, E., Bogdahn, U., Roosen, K., Lanfermann, Heinrich, Heindel, Walter, Kugel, Harald, Erneslus, Ralf -Ingo, Röhn, Gabricle, Lackner, Klaus, Metz, R. J., Kennedy, D. N., Pardo, F. S., Kutke, S., Sorensen, A. G., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Rosen, B. R., Caviness, V. S., Mechtler, L. L., Withiam-Lench, S., Shin, K., Klnkel, W. R., Patel, M., Truax, B., Kinkel, P., Shin, K., Mechtler, L., Ricci, M., Pantano, P., Maleci, A., Pierallini, S., Di Stefano, D., Bozzao, L., Cantore, G. P., Röhn, Gabriele, Els, T., Schröder, R., Hoehn-Berlage, M., Ernestus, R. -I., Ruda, R., Mocellini, C., Soffietti, R., Campana, M., Ropolo, R., Riva, A., de Filippi, P. G., Schiffer, D., Salgado, D., Rodrigues, M., Salgado, L., Fonseca, A. T., Vieira, M. R., Bravo Marques, J. M., Satoh, H., Uozumi, T., Kiya, K., Kurisu, K., Arita, K., Sumida, M., Ikawa, F., Tzuk-Shina, Tz., Gomori, J. M., Rubinstein, R., Lossos, A., Siegal, T., Vaalburg, W., Paans, A. M. J., Willemsen, A. T. M., van Waarde, A., Pruim, J., Visser, G. M., Go, K. G., Valentini, S., Ting, Y. L. T., De Rose, R., Chidichimo, G., Corricro, G., van Lcycn-Pilgram, Karin, Erncslus, Ralf -Ingo, Klug, Norfried, van Leyen-Pilgram, K., Ernestus, R. -I., Schröder, R., Klug, N., Woydt, M., Krone, A., Tonn, J. C., Becker, G., Neumann, U., Roggendorf, W., Roosen, K., Plate, Karl H., Breier, Georg, Millaucr, Birgit, Weich, Herbert A., Ullrich, Axel, Risau, Werner, Roosen, N., Chopra, R. K., Mikkelsen, T., Rosenblum, S. D., Yan, P. S., Knight, R., Windham, J., Rosenblum, M. L., Schiffer, D., Attanasio, A., Cavalla, P., Chio, A., Giordana, M. T., Migheli, A., Amberger, V., Hensel, T., Schwab, M. E., Cervoni, Luigi, Celli, Paolo, Tarantino, Roberto, Huettner, C., Tonn, J. C., Berweiler, U., Roggendorf, W., Salmon, I., Rorive, S., Rombaut, K., Pirotte, B., Haot, J., Brotchi, J., Kiss, R., Maugard-Louboutin, C., Charrier, J., Fayet, G., Sagan, C., Cuillioere, P., Ricolleau, G., Martin, S., Menegalli-Bogeelli, D., Lajat, Y., Resche, F., Molnàr, Péter, Bárdos, Helga, Ádány, Róza, Rogers, J. P., Pilkington, G. J., Pollo, B., Giaccone, G., Allegranza, A., Bugiani, O., Prim, J., Badia, J., Ribas, E., Coello, F., Shezen, E., Lossos, A., Abramsky, O., Siegal, T., Scerrati, M., Roselli, R., Iacoangeli, M., Pompucci, A., Rossi, G. F., Deeb, Saleh M. Al., Koreich, Osama, Yaqub, Basim, Moutaery, Khalaf R. Al., Giordana, M. T., Cavalla, P., Chio, A., Marino, S., Vigliani, M. C., Schiffer, D., Deburghgraeve, V., Darcel, F., Gedouin, D., Hassel, M. Ben, Guegan, Y., Jeremic, B., Grujicic, D., Antunovic, V., Matovic, M., Shibamoto, Y., Kallio, Merja, Huhmar, Helena, Kudoh, Ch., Detta, A., Sugiura, K., Hitchcock, E. R., Mastrostefano, R., Di Russo, R., Cipriani§, M., Occhipinti, E. M., Conti, E. M. S., Clowegeser, A., Ortler, M., Seiwald, M., Kostron, H., Rajan, B., Ross, G., Lim, C., Ashlcy, S., Goode, D., Traish, D., Brada, M., Sanden, G. A. C. vd, Schouten, L. J., Coebergh, J. W. W., Razenberg, P. P. A., Twijnstra, A., Snilders-Keilholz, A., Voormolen, J. H. C., Hermans, J., Leer, J. W. H., Taillandier, L., Baylac, F., Dcbouvcrie, M., Anxionnal, R., Bracard, S., Vignand, J. M., Duprcz, A., Weber, M., Winking, M., Böker, D. K., Simmet, T., Rothbart, David, Strugar, John, Balledux, Jeroen, Criscuolo, Gregory R., Jachimczak, Piotr, Blesch, Armin, Heβdörfer, Birgit, Bogdahn, Ulrich, Ernestus, Ralf -Ingo, Schröder, Roland, Klug, Norfrid, Krouwer, H. G. J., Duinen, S. G. v., Algra, A., Zentner, J., Wolf, H. K., Ostertun, B., Hufnagel, A., Campos, M. G., Solymosi, L., Schramm, J., Newlands, E. S., O'Reilly, S. M., Brampton, M., Soffietti, R., Chio, A., Mocellini, C., Ruda, R., Vigliani, M. C., Schiffer, D., Sciolla, R., Seliak, D., Henriksson, R., Bergenheim, A. T., Björk, P., Gunnarsson, P. -O., Hariz, Ml., Grant, R., Collie, D., Gregor, A., Ebmeier, K. P., Jarvis, G., Lander, F., Cull, A., Sellar, R., Brada, M., Thomas, C., Elyan, S., Hines, F., Ashley, S., Stenning, S., Bernstein, J. J., Goldberg, W. J., Roelcke, U., Von Ammon, K., Hausmann, O., Radu, E. W., Kaech, D., Leenders, K. L., Fitzek, M. M., Aronen, J. Efird, Hochberg, F., Gruber, M., Schmidt, E., Rosen, B., Flschman, A., Pardo, P., Afra, U. M. U., Sipos, L., Slouik, F., Boiardi, A., Salmaggi, A., Pozzi, A., Farinotti, L., Fariselli, L., Silvani, A., Brandes, A., Scelzi, E., Rigon, A., Zampieri, P., Pignataro, M., Amanzo, P. D'., Amista, P., Rotilio, A., Fiorentino, M. V., Thomas, R., Brazil, L., O'Connor, A. M., Ashley, S., Brada, M., Salvati, Maurizio, Cervoni, Luigi, Puzzilli, Fabrizio, Cervoni, Luigi, Salvati, Maurizio, Raguso, Michele, Cruickshank, G. S., Duckworth, R., Rumpling, R., Rottuci, M., Fariselli, L., Boiardi, A., Broggi, G., Plrint, N. G., Sabattini, E., Manetto, V., Gambacorta, H., Poggi, S., Pileri, S., Ferracini, R., Grant, R., Plev, D. V., Hopf, N. J., Knosp, E., Bohl, J., Perncczky, A., Kiss, R., Salmon, I., Catnby, I., Dewitte, O., Brotchi, J., Pasteels, J. L., Camby, I., Salmon, I., Darro, F., Danguy, A., Brotchi, J., Pasteels, J. L., Kiss, R., Kiu, M. C., Lai, G. M., Yang, T. S., Ng, K. T., Chen, J. S., Chang, C. N., Leung, W. M., Ho, Y. S., Rychter, M. Deblec, Klimek, A., Liberski, P. P., Karpinaka, A., Krauseneck, P., Schöffel, V., Müller, B., Kreth, F. W., Faist, M., Warnke, P. C., Ostertag, C. B., Nielen, K. M. B. v., Visscr, M. C., Lebrun, C., Lonjon, M., Desjardin, T., Michiels, J. F., Chanalet, Sa. Lagrange J. L., Roche, J. L., Chatel, M., Mastronardi, L., Puzzilli, F., Osman, Farah J., Lunardi, P., Matsutani, M., Ushio, Y., Takakura, K., Menten, Johan, Hamers, Han, Ribot, Jacques, Dom, René, Tcepen, Hans, Müller, B., Weidner, N., Krauseneck, P., Naujocks, G., van Roost, D., Wiestler, O. D., Kuncz, A., Nieder, C., Setzel-Sesterhein, M., Niewald, M., Schnabel, I., O'Neill, K. S., Kitchen, N. D., Wilkins, P. R., Marsh, H. T., Pierce, E., Doshi, R., Deane, R., Previtali, S., Quattrini, A., Nemni, R., Ducati, A., Wrabetz, L., Canal, N., Punt, C. J. A., Stamatakis, L., Giroux, B., Rutten, E., Quigley, Matthew R., Beth Sargent, P. A. -C., Flores, Nicholas, Simon, Sheryl, Maroon, Joseph C., Quigley, Matthew R., Beth Sargent, P. A. -C., Flores, Nicholas, Maroon, Joseph C., Rocca, A. A., Gervasoni, C., Castagna, A., Picozzi, P., Giugni, E., Rocca, A. A., Tonnarelli, G. P., Ducati, A., Mangili, F., Truci, G., Canal, N., Giovanelli, M., Roelcke, U., Von Ammon, K., Radu, E. W., Leenders, K. L., Sachsenheimer, W., Bimmler, T., Seiwald, M., Eiter, H. Rhomberg W., Ortler, M., Obwegesser, A., Kostron, H., Steilen, H., Henn, W., Moringlane, J. R., Kolles, H., Feiden, W., Zang, K. D., Sleudel, W. I., Steinbrecher, Andreas, Schabet, Martin, Heb, Clemens, Bamberg, Michael, Dichgans, Johannes, Stragliotto, G., Delattre, J. Y., Poisson, M., Zampieri, P., Brandes, A., Rigon, A., Tosatto, L., D'Amanzo, P., Menicucci, N., Rotilio, A., Mingrino, S., Steudel, W. I., Feld, R., Henn, W., Zang, K. D., Maire, J. Ph., Caudry, M., Guerin, J., Celerier, D., Salem, N., Demeaux, H., Fahregat, J. F., Kusak, M. E., Bucno, A., Albisua, J., Jerez, P., Sarasa, J. L., Garefa, R., de Campos, J. M., Kusak, M. E., de Campos, J. M., Bueno, A., García-Delgado, R., Sarasa, J. L., García-Sola, R., Lantsov, A. A., Shustova, T. I., Lcnartz, D., Wellenreuther, R., von Deirnling, A., Köning, W., Menzel, J., Scarpa, S., Manna, A., Reale, M. G., Oppido, P. A., Carapella, C. M., Frati, L., Valery, C. A., Ichen, M., Foncin, J. P., Soubrane, C., Khayat, D., Philippon, J., Vaz, R., Cruz, C., Weis, S., Protopapa, D., März, R., Winkler, P. A., Reulen, H. J., Bise, K., Beuls, E., Berg, J., Deinsberger, W., Böker, D. K., Samii, M., Caudry, M., Darrouzet, V., Guérin, J., Trouette, R., Causse, N., Bébéar, J. P., Parker, F., Vallee, J. N., Carlier, R., Zerah, M., Lacroix-Jousselin, C., Piepmeier, Joseph M., Kveton, John, Czibulka, Agnes, Tigliev, G. S., Chernov, M. P., Maslova, L. N., Valdueza, José M., Jänisch, Werner, Bock, Alexander, Harms, Lutz, Bessell, E. M., Graus, F., Punt, J., Firth, J., Hope, T., Koriech, Osama, Al Deeb, Saleh, Al Moutaery, Khalaf, Yaqub, B., Silvani, A., Salmaggi, A., Pozzi, A., Franzini, A., Boiardi, A., Goldbrunner, R., Warmuth-Metz, M., Paulus, W., Tonn, J. -Ch., Roosen, K., Strik, I. I., Müller, B., Markert, C., Pflughaupt, K. -W., Krauseneck, P., O'Neill, B. P., Dinapoli, R. P., Voges, J., Sturm, V., Deuß, U., Traud, C., Treuer, H., Lehrke, R., Kim, D. G., Müller, R. P., Alexandrov, Yu. S., Moutaery, K., Aabed, M., Koreich, O., Ross, G. M., Rajan, B., Traish, D., Ashley, S., Ford, D., Brada, M., Schmeets, I. L. O., Jager, J. J., Pannebakker, M. A. G., de Jong, J. M. A., van Lindert, E., Knosp, E., Kitz, K., Blond, S., Dubois, F., Assaker, R., Baranzelli, M. C., Sleiman, M., Pruvo, J. P., Coche-Dequeant, B., Matsutani, M., Takakura, K., Sano, K., PetriČ-Grabnar, G., Jereb, B., Župančič, N., Koršič, M., Rainov, N. G., Burkert, W., Ushio, Yukitaka, Kochi, Masato, Itoyama, Youichi, de Campos, J. M., Kusak, M. E., Sarasa, J. L., García, R., Bueno, A., Ferrando, L., Hoang-Xuan, K., Sanson, M., Merel, P., Delattre, J. Y., Poisson, M., Delattre, O., Thomas, G., Hoang-Xuan, K., Delattre, J. Y., Poisson, M., Thomas, G., Haritz, D., Obersen, B., Grochulla, F., Gabel, D., Haselsberger, K., Radner, H., Pendl, G., Brada, M., Laing, R. W., Warrington, A. P., Nowak, P. J. C. M., Kolkman-Deurloo, I. K. K., Visser, A. G., Berge, Hv. d., Niël, C. G. J. H., Levendag, P. C., Bergström, P., Hariz, M., Löfroth, P. -O., Bergenheim, T., Henriksson, R., Blond, S., Assaker, R., Cortet-rudelli, C., Dewailly, D., Coche-dequeant, B., Castelain, B., Dinapoli, R., Shaw, E., Coffey, R., Earle, J., Foote, R., Schomberg, P., Gorman, D., Girard, N., Courel, M. N., Delpech, B., Haselsberger, K., Friehs, G. M., Schröttner, O., Pendl, G., Pötter, R., hawliczek, R., Sperveslage, P., Prott, F. J., Wachter, S., Dieckmann, K., Würker, M., Herholz, K., Pietrzyk, U., Voges, J., Treuer, H., Sturm, V., Bauer, B., Heiss, W. -D., Jund, R., Zimmermann, F., Feldmann, H. J., Gross, M. W., Kneschaurek, P., Molls, M., Lederman, G., Lowry, J., Wertheim, S., Voulsinas, L., Fine, M., Lederman, G., Lowry, J., Wertheim, S., Fine, M., Voutsinas, I., Qian, G., Rashid, H., Lederman, G., Lowry, J., Wertheim, S., Fine, M., Voulsinas, L., Qian, G., Rashid, H., Moutaery, K., Aabed, M., Koreich, O., Scerrati, M., Montemaggi, P., Iacoangeli, M., Pompucci, A., Roselli, R., Trignani, R., Rossi, G. F., Shin, K., Mechtler, L., West, C., Grand, W., Shin, K., Sibata, C., West, C., Mechtler, L., Grand, W., Thomas, R., Guerrero, D., James, N., Ashley, S., Gregor, A., Brada, M., Voges, J., Sturm, V., Bramer, R., Pahlke, H., Lehrke, R., Treuer, H., Banik, N., Kim, D. G., Hövels, M., Bernsen, H. J. J. A., Rijken, P. F. J. W., Van der Sanden, B. P. J., Hagemeier, N. E. M., Van der Kogel, A. J., Koehler, P. J., Verbiest, H., Jager, J., Vecht, Ch. J., Ross, G. M., McIlwrath, A., Brown, R., Mottolesb, C., Pierre'Kahn, A., Croux, M., Roche, J. L., Marchai, J., Delhemes, P., Tremoulet, M., Stilhart, B., Chazai, J., Caillaud, P., Ravon, R., Passacha, J., Bouffet, E., Dirven, C. M. F., Mooy, J. J. A., Molenaar, W. M., Lewandowicz, G. M., Grant, N., Harkness, W., Hayward, R., Thomas, D. G. T., Darling, J. L., Delepine, N., Subovici, I. I., Cornille, B., Markowska, S., Alkallaf, JC. Desbois, KühI, J., Niethammer, D., Spaar, H. J., Gnekow, A., Havers, W., Berthold, F., Graf, N., Lampert, F., Maass, E., Mertens, R., Schöck, V., Aguzzi, A., Boukhny, A., Smirtukov, S., Prityko, A., Hoiodov, B., Geludkova, O., Nikanorov, A., Levin, P., Rothbart, David, Balledux, Jeroen, Criscuolo, Gregory R., D'haen, B., Van Calenbergh, F., Casaer, P., Dom, R., Menten, J., Goffin, J., Plets, C., Hertel, A., Hernaiz, P., Seipp, C., Siegler, K., Baum, R. P., Maul, F. D., Schwabe, D., Jacobi, G., Kornhuber, B., Hör, G., Menten, J., Casaer, P., Pilkington, G. J., Merzak, A., Rooprai, H. K., Bullock, P., van Domburg, P. H. M. F., Wesseling, P., Thijssen, H. O. M., Wolff, J. E. A., Boos, J., Krähling, K. H., Gressner-Brocks, V., Jürgens, H., Schlegel, J., Scherthan, H., Arens, N., Stumm, Gabi, Kiessling, Marika, Merzak, A., Koochekpour, S., Pilkington, G. J., Reifenberger, G., Reifenberger, J., Liu, L., James, C. D., Wechsler, W., Collins, V. P., Fabel-Schulte, Klaus, Jachimczak, Plotr, Heßdörfer, Birgitt, Baur, Inge, Schlingensiepen, Karl -Hermann, Brysch, Wolgang, Bogdahn, Ulrich, Blesch, A., Bosserhoff, A. K., Apfel, R., Lottspeich, F., Jachimczak, P., Büttner, R., Bogdahn, U., Cece, R., Barajon, I., Tazzari, S., Cavaletti, G., Torri-Tarelli, L., Tredici, G., Hecht, B., Turc-Carel, C., Atllas, R., Chatel, M., Gaudray, P., Gioanni, J., Hecht, F., Balledux, Jeroen, Rothbart, David, Criscuolo, Gregory R., de Campos, J. M., Kusak, M. E., Rey, J. A., Bello, M. J., Sarasa, J. L., Dubois, F., Blond, S., Parent, M., Assaker, R., Gosselin, P., Christiaens, J. L., Feld, R., Moringlane, J. R., Steudel, W. I., Schaudies, J. R., Janka, M., Tonn, J. C., Fischer, U., Meese, E., Roosen, K., Remmelink, M., Salmon, I., Cras, P., Pasteels, J. L., Brotchi, J., Kiss, R., Bensadoun, R. J., Frenay, M., Formento, J. L., Milano, G., Lagrange, J. L., Grellier, P., Lee, J. -Y., Ernestus, R. -I., Riese, H. -H., Cervós-Navarro, J., Reutter, W., Lippitz, B., Scheitinger, C., Scholz, M., Weis, J., Gilsbach, J. M., Füzesi, L., Koochekpour, S., Merzak, A., Pilkington, G. J., Sanson, M., Li, Y. J., Hoang-Xuan, K., Delattre, J. Y., Poisson, M., Hamelin, R., Van de Kelft, Erik, Dams, Erna, Martin, Jean -Jacques, Willems, Patrick, Lehrke, R., Voges, J., Treuer, H., Erdmann, J., Müller, R. P., Sturm, V., Wurm, R. E., Warrington, A. P., Laing, R. W., Sardell, S., Hines, F., Graham, J. D., Brada, M., Ushio, Yukitaka, Kuratsu, Jun -ichi, Kochi, Masato, Kitz, K., Aichholzer, M., Rössler, K., Alesch, F., Ertl, A., Sorensen, P. S., Helweg-Larsen, S., Mourldsen, H., Hansen, H. H., El Sharoum, S. Y., Berfelo, M. W., Theunissen, P. H. M. H., Jager, J. J., de Jong, J. M. A., Fedorcsák, I., Nyáry, I., Osztie, É., Horvath, Á., Kontra, G., Frenay, M., Burgoni-chuzel, J., Paquis, P., Lagrange, J. L., Helweg-Larsen, S., Hansen, SW., Sørensen, PS., Salmon, I., Kiss, R., Krauseneck, P., Müller, B., Morche, M., Tonn, J. C., Lagerwaard, F. J., Levendag, P. C., Eijkenboom, W. M. H., Schmilz, P. I. M., Lentzsch, S., Weber, F., Franke, J., Dörken, B., Lunardi, P., Schettini, G., Osman, Farah J., Qasho, R., Mocellini, C., Ruda, R., Soffietti, R., Garabello, D., Sales, S., De Lucchi, R., Vasario, E., Schiffer, D., Muracciole, X., Régis, J., Manera, L., Peragut, J. C., Juin, P., Sedan, R., Nieder, C., Niewald, M., Walter, K., Schnabel, K., Nieder, C., Niewald, N., Nestle, U., Schnabel, K., Berberich, W., Oschmann, P., Theißen, R. D., Reuner, K. H., Kaps, M., Dorndorf, W., Martin, K. K., Akinwunmi, J., Rooprai, H. K., Kennedy, A., Linke, A., Ognjenovic, N., Pilkington, G. J., Svadovsky, A. I., Peresedov, V. V., Bulakov, A. A., Butyalko, M. Y., Zhirnova, I. G., Labunsky, D. A., Gnazdizky, V. V., Gannushkina, I. V., Taphoorn, M. J. B., Potman, R., Barkhof, F., Weerts, J. G., Karim, A. B. M. F., Heimans, J. J., van de Pol, M., van Aalst, V. C., Wilmink, J. T., Twijnstra, A., van der Sande, J. J., Boogerd, W., Kröger, R., Jäger, A., Wismeth, C., Dekant, A., Brysch, W., Schlingensiepen, K. H., Jachimczak, P., Bogdahn, U., Pirolte, B., Cool, V., Gérard, C., Levivier, M., Dargent, J. L., Goldman, S., Brotchi, J., Hildebrand, J., Velu, T., Herrlinger, U., Schabet, M., Ohneseit, P., Buchholz, R., Zhu, Jianhong, Reszka, Regina, Weber, Friedrich, Walther, Wolfgang, Zhang, L. I., Brock, Mario, Roosen, N., Rock, J. P., Zeng, H., Feng, J., Fenstermacher, J. D., Rosenblum, M. L., Siegal, T., Gabizon, A., Beljanski, M., Crochet, S., Bergenheim, A. T., Zackrisson, B., Elfverson, J., Bergström, P., Henriksson, R., Butti, G., Baetta, R., Magrassi, L., De Renzis, M. R., Soma, M. R., Davegna, C., Pezzotta, S., Paoletti, R., Fumagalli, R., Infuso, L., Sankar, A. A., Darling, J. L., Thomas, D. G. T., Defer, G. -L., Brugières, P., Gray, F., Chomienne, C., Poirier, J., Degos, L., Degos, J. D., Colombo, Bruno M., DiDonato, Stefano, Finocchiaro, Gaetano, Hebeda, K. M., Sterenborg, H. J. C. M., Saarnak, A. E., Wolbers, J. G., van Gemert, M. J. C., Kaaijk, P., Troost, D., Leenstra, S., Das, P. K., Bosch, D. A., Kostron, H., Hochleitner, B. W., Obwegeser, A., Ortler, M., Seiwald, M., Vooys, W., Krouwer, H. G. J., de Gast, G. C., Marx, J. J. M., Osman, Farah J., Lunardi, P., Puzzilli, F., Menovsky, T., Beek, J. F., Wolbers, J. G., van Gemert, M. J. C., Naujocks, G., Wiestler, O. D., Schirrmacher, V., Schramm, J., Schmitz, A., Eis-Hübinger, A. M., Piepmeier, p. h., Pedersen, Patricia, Greer, Charles, Quigley, Matthew R., Shih, Tommy, Elrifal, Amr, Rothfus, William, Maroon, Joseph C., Rohertson, L., Rampling, R., Whoteley, T. L., Piumb, J. A., Kerr, D. J., Falina, P. A., Crossan, I. M., Roosen, N., Rock, J. P., Feng, J., Zeng, H., Ho, K. L., Fenstermacher, J. D., Rosenblum, M. L., Ruchoux, M. M., Vincent, S., Jonca, F., Plouet, J., Lecomte, M., Samid, D., Thibault, A., Ram, Z., Oldfield, E. H., Myers, C. E., Reed, E., Schabet, M., Herrlinger, U., Buchholz, R., Shoshan, Y., Siegal, T., Siegal, T., Shezen, E., Siegal, Tz., Stockhammer, G., Rosenblum, M., Samid, D., Lieberman, F., Terzis, A. J. A., Bjerkvig, R., Laerum, O. D., Arnold, H., Thibault, A., Samid, D., Figg, W. D., Myers, C. E., Reed, E., Thomas, R., Flux, G., Chittenden, S., Doshi, P., Brazil, L., Thomas, D. G. T., Bignor, D., Zalutsky, M., Brada, M., Tjuvajev, Juri, Kaplitt, Michael, Desai, Revathi, Bradley, M. S., Bettie, B. S., Gansbacher, Bernd, Blasberg, Ronald, Haugland, H. K., Saraste, J., Rooseni, K., Laerum, O. D., Vincent, A. J. P. E., Avezaat, C. J. J., Bout, A., Noteboom, J. L., Vecht, C. h., Valerio, D., Hoogerbrugge, P. M., Weber, F., Reszka, R., Zhu, J., Walther, W., List, J., Schulz, W., Wolbers, J. G., Sterenborg, I. I. J. C. M., Kamphorst, W., van Gemert, M. J. C., van Alplien, H. A. M., Salander, P., Bergenheim, T., Henriksson, R., Grant, R., Brazil, L., Thomas, R., Guerrero, D., Laing, R., Ashley, S., Brada, M., Schmidt, B., Bauer, B., Grau, G., Bohnstedt, T., Frydrych, A., Franz, K., Lorenz, R., Brandes, A., Amanzo, P. D'., Zampieri, P., Rigon, A., Scelzi, E., Rotilio, A., Berti, F., Paccagnella, A., Fiorentino, M. V., Müller, B., Krauseneck, P., van Deventer, P. L., Dellemijn, P. L. I., van den Bent, M. J., Vecht, Ch. J., Kansen, P. J., Tredici, G., Petruccioli, N. G., Cavaletti, G., Cavalletti, E., Kiburg, B., Müller, L. J., Moorer-van Delft, C. M., Heimans, J. J., Boer, H. H., Pace, A., Bove, L., Pietrangeli, A., Innocenti, P., Aloe, A., Nardi, M., Jandolo, B., Kellie, S. J., De Graaf, S. S. N., Bloemhof, H., Roebuck, D., Dalla, Pozza L., Uges, D. D. R., Johnston, I., Besser, M., Chaseling, R. A., Koeppen, S., Gründemann, S., Lossos, A., Siegal, T., Nitschke, M., Vieregge, P., Reusche, E., Rob, P., Kömpf, D., Postma, T. J., Vermorken, J. B., Heimans, J. J., Rampling, R. P., Dunlop, D. J., Steward, M. S., Campbell, S. M., Roy, S., Hilkens, P. H. E., Verweij, J., van Putten, W. L. J., Vecht, Ch. J., van den Bent, M. J., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., Vecht, Ch. J., van den Bent, M. J., Wondrusch, E., Zifko, U., Drlicek, M., Liszka, U., Grisold, W., Zifko, U., Fazeny, B., Dittrich, Ch., Wondrusch, E., Grisold, W., Verschuuren, Jan J., Meneses, Patricio I., Rosenfeld, Myrna R., Kaplitt, Michael G., Posner, Jerome B., Dalmau, Josep, Sillevis Smitt, P. A. E., Manley, G., Posner, J. B., Cavaletti, G., Bogliun, G., Margorati, L., Bianchi, G., Drlicek, M., Liska, U., Casati, B., Kolig, C., Grisold, H., Graus, F., Reñe, R., Uchuya, M., Valldeoriola, F., Delattre, J. Y., Benedetti de Cosentiro, C., Ortale, D., Martinez, R., Lambre, J., Cagnolati, S., Vinai, C., Salmaggi, A., Nemni, R., Silvani, A., Forno, M. G., Luksch, R., Confalonieri, P., Boiardi, A., Nitschke, M., Scholz, J., Vieregge, P., Kömpf, D., Hochberg, F. H., Pfeiffer, G., Netzer, J., Hansen, Ch., Eggers, Ch., Hagel, Ch., Kunze, K., Verschuuren, Jan J., Rosenblum, Marc K., Lieberman, Frank S., Posner, Jerome B., and Dalmau, Josep

Published
1994
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14. Frontal FDG-PET activity correlates with cognitive outcome after STN-DBS in Parkinson disease

Author

Kalbe, E, Voges, J, Weber, T, Haarer, M, Baudrexel, S, Klein, J C., Kessler, J, Sturm, V, Heiss, W D., and Hilker, R

Abstract

Inconsistent changes of cognitive functioning have been reported in patients with Parkinson disease (PD) with deep brain stimulation (DBS) of the subthalamic nucleus (STN). To investigate the underlying pathomechanisms, we correlated alterations of cognitive test performance and changes of neuronal energy metabolism in frontal basal ganglia projection areas under bilateral STN stimulation.

Published
2009
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16. Bilateral subthalamic stimulation in Parkinand PINK1parkinsonism

Author

Moro, E, Volkmann, J, König, I R., Winkler, S, Hiller, A, Hassin-Baer, S, Herzog, J, Schnitzler, A, Lohmann, K, Pinsker, M O., Voges, J, Djarmatic, A, Seibler, P, Lozano, A M., Rogaeva, E, Lang, A E., Deuschl, G, and Klein, C

Abstract

To study the frequency of different gene mutations in patients with early-onset parkinsonism and bilateral subthalamic nucleus deep brain stimulation (STN-DBS) and the short- and long-term surgical outcome in mutation-positive (MUT) and -negative (MUT−) patients.

Published
2008
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17. The influence of head frame distortions on stereotactic localization and targeting

Author

Treuer, H, Hunsche, S, Hoevels, M, Luyken, K, Maarouf, M, Voges, J, and Sturm, V

Abstract

A strong attachment of a stereotactic head frame to the patient's skull may cause distortions of the head frame. The aim of this work was to identify possible distortions of the head frame, to measure the degree of distortion occurring in clinical practice and to investigate its influence on stereotactic localization and targeting. A model to describe and quantify the distortion of the Riechert–Mundinger (RM) head frame was developed. Distortions were classified as (a) bending and (b) changes from the circular ring shape. Ring shape changes were derived from stereotactic CT scans and frame bending was determined from intraoperative stereotactic x-ray images of patients with implanted 125I-seeds acting as landmarks.From the examined patient data frame bending was determined to be 0.74 mm ± 0.32 mm and 1.30 mm in maximum. If a CT-localizer with a top ring is used, frame bending has no influence on stereotactic CT-localization. In stereotactic x-ray localization, frame bending leads to an overestimation of the z-coordinate by 0.37 mm ± 0.16 mm on average and by 0.65 mm in maximum. The accuracy of patient positioning in radiosurgery is not affected by frame bending. But in stereotactic surgery with an RM aiming bow trajectory displacements are expected. These displacements were estimated to be 0.36 mm ± 0.16 mm (max. 0.74 mm) at the target point and 0.65 mm ± 0.30 mm (max. 1.31 mm) at the entry point level. Changes from the circular ring shape are small and do not compromise the accuracy of stereotactic targeting and localization. The accuracy of CT-localization was found to be close to the resolution limit due to voxel size.Our findings for frame bending of the RM frame could be validated by statistical analysis and by comparison with an independent patient examination. The results depend on the stereotactic system and details of the localizers and instruments and also reflect our clinical practice. Therefore, a generalization is not possible. Preliminary experience with a new MR-compatible RM head frame made of ceramics shows no frame distortions as with the conventional frame made of an Al–Cu–Mg alloy.

Published
2004

18. Imaging in Gene Therapy of Patients with Glioma

Author

Jacobs, A.H., Voges, J., Kracht, L.W., Dittmar, C., Winkeler, A., Thomas, A., Wienhard, K., Herholz, K., and Heiss, W.D.

Abstract

Over 10 years ago, the first successful gene therapy paradigms for experimental brain tumors models have been conducted, and they were thought to revolutionize the treatment of patients with gliomas. Application of gene therapy has been quickly forced into clinical trials, the first patients being enrolled in 1994, with overall results being disappointing. However, single patients seemed to benefit from gene therapy showing long-term treatment response, and most of these patients bearing small glioblastomas. Whereas the gene therapy itself has been performed with high sophistication, limited attention has been paid on technologies, which (i) allow an identification of viable target tissue in heterogenous glioma tissue and which (ii) enable an assessment of successful vector administration and vector-mediated gene expression in vivo. However, these measures are a prerequisite for the development of successful gene therapy in the clinical application. As biological treatment strategies such as gene and cell-based therapies hold promise to selectively correct disease pathogenesis, successful clinical implementation of these treatment strategies rely on the establishment of molecular imaging technology allowing the non-invasive assessment of endogenous and exogenous gene expression in vivo. Imaging endogenous gene expression will allow the characterization and identification of target tissue for gene therapy. Imaging exogenously introduced cells and genes will allow the determination of the `tissue dose' of transduced cell function and vector-mediated gene expression, which in turn can be correlated to the induced therapeutic effect. Only these combined strategies of non-invasive imaging of gene expression in vivowill enable the establishment of safe and efficient vector administration and gene therapy protocols for clinical application. Here, we review some aspects of imaging in gene therapy trials for glioblastoma, and we present a `proof-of-principle' 2nd-generation gene therapy protocol integrating molecular imaging technology for the establishment of efficient gene therapy in clinical application.

Published
2003
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19. Neural Precursor Cells as Carriers for a Gene Therapeutical Approach in Tumor Therapy

Author

Arnhold, S., Hilgers, M., Lenartz, D., Semkova, I., Kochanek, S., Voges, J., Andressen, C., and Addicks, K.

Abstract

Conventional therapeutical approaches such as surgery, radiotherapy, or chemotherapy have been shown to be rather unsuccessful in the treatment of infiltrative growing tumors such as the malignant glioblastoma multiforme. Thus, new therapeutical strategies have to be developed that are suitable for inducing cell death also in migrating tumor cells. These new therapeutical stategies include cell and/or gene therapeutical approaches. We demonstrate that glial-restricted progenitor cells as well as embryonic stem cell-derived neural stem cells belong to cell populations applicable to such therapeutical concepts. Both cell types can be efficiently transduced using a third-generation high-capacity “gutless” adenoviral vector, and show a tropism for the F98 glioma cells by migrating towards a spheroid of F98 glioma cells with a tendency to form a barrier around the tumor spheroid in an in vitro tumor confrontation model. Moreover, in a migration assay, secretion products of glial-restricted precursor cells have shown a potency to inhibit the migratory activity of glioma cells in vitro. In vivo, F98 glioma cell-derived tumor formation in the right striatum resulted in migration of glial as well as neural precursor cells towards the tumor area when cotransplanted in the corpus callosum of the contralateral hemisphere. After arrival, both cell types surround the tumor mass and even invade the experimentally induced tumor. These data indicate that glial-restricted as well as embryonic stem cell-derived neural precursor cells are good candidates as carriers for an ex vivo gene therapeutical approach in tumor therapy.

Published
2003
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20. Molecular and Functional Imaging Technology for the Development of Efficient Treatment Strategies for Gliomas

Author

Jacobs, A. H., Winkeler, A., Dittmar, C., Gossmann, A., Deckert, M., Kracht, L., Thiel, A., Garlip, G., Hilker, R., Sobesky, J., Vollmar, S., Kummer, C., Graf, R., Voges, J., Wienhard, K., Herholz, K., and Heiss, W. D.

Abstract

Gliomas are the most common types of brain tumors, which invariably lead to death over months or years. Before new and potentially more effective treatment strategies, such as gene therapy, can be effectively introduced into clinical application the following goals must be reached: (1) the determination of localization, extent and metabolic activity of the glioma; (2) the assessment of functional changes within the surrounding brain tissue; (3) the identification of genetic changes on the molecular level leading to disease; and in addition (4) a detailed non-invasive analysis of both endogenous and exogenous gene expression in animal models and in the clinical setting. Non-invasive imaging of endogenous gene expression by means of positron emission tomography (PET) may reveal insight into the molecular basis of pathogenesis and metabolic activity of the glioma and the extent of treatment response. When exogenous genes are introduced to serve for a therapeutic function, PET imaging techniques may reveal the assessment of the location, magnitudeand durationof therapeutic gene expression and its relation to the therapeutic effect. Here, we review the main principles of PET imaging and its key roles in neurooncology research.

Published
2002
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21. Tissue reactions after long-term intracerebral implantation of three different types of biodegradable polylactide rods in the rat

Author

Voges, J., Lehrke, R., Kim, D.G., Lucas, C., Schröder, R., Sturm, V., and Stricker, H.

Abstract

Purpose:
To investigate acute and late tissue reactions following intracerebral implantation of three different biodegradable dl-polylactids: Resomer® R104+R203 (1+1) (SU48), Resomer® R203 (SU49), and dl-polylactid-co-trimethylencarbonat (SU50).Methods:
Polylactide (PL) rods and small pieces of silicon (control) were stereotactically implanted in the forebrain of 60 Wistar rats. Twenty-eight, 70, and 112 days after implantation, five animals of each group (SU48, SU49, SU50, control) were sacrificed. Tissue slices of the paraffin-embedded brains were stained with hematoxylin and eosin (HE) for histological evaluation.Results:
Independent from the investigated sample, the site of implantation was visible on the brain sections as a clearly demarcated tissue defect surrounded by minimal inflammatory cellular reactions. Although not significant, implantation of SU50 caused the most distinct invasion of foamy macrophages. Despite SU48, which 112 days after implantation was surrounded by a thin layer of predominantly gliotic fibers, demarcation of surrounding brain tissue was of minor degree.Discussion:
The PL rods investigated in this study caused no significant early and late tissue alterations. Both the good biocompatibility of these samples and a high flexibility with regard to degradation time and release kinetics allow either long protracted drug release or short-term application of substances.

Published
2002
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22. Safety and efficacy of pallidal or subthalamic nucleus stimulation in advanced PD

Author

Volkmann, J., Allert, N., Voges, J., Weiss, P. H., Freund, H.-J., and Sturm, V.

Abstract

The authors retrospectively compared 1-year results of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN; n 16) and internal pallidum (GPi) (n 11) in advanced PD and found about equal improvements in “off” period motor symptoms, dyskinesias, and fluctuations. STN stimulation reduced medication requirements by 65 and required significantly less electrical power. These advantages contrasted with a need for more intensive postoperative monitoring and a higher incidence of adverse events related to levodopa withdrawal.

Published
2001

23. Brachytherapy

Author

Koot, R. W., Maarouf, M., Hulshof, M. C. C. M., Voges, J., Treuer, H., Koedooder, C., Sturm, V., and Bosch, D. A.

Abstract

In the current study, the authors describe and compare two different strategies of brachytherapy for the treatment of patients with primary glioblastoma multiforme (GBM). The study was comprised of 84 patients. Forty-five patients were implanted with permanent or temporary low activity iodine-125 (125I) seeds in Cologne and 21 patients were implanted with temporary iridium-192 (192Ir) wires in Amsterdam. Both groups received external beam radiation therapy (EBRT); the 125I group received 10–30 grays (Gy) with the implant in situ and the 192Ir group received 60 Gy before implantation. In Cologne, implantation was performed after a diagnostic stereotactic biopsy whereas in Amsterdam implantation took place after cytoreductive diagnostic surgery. In addition, 18 patients in Amsterdam served as a control group. This group received only EBRT after cytoreductive surgery. In both groups the mean age of the patients was between 50–55 years, with 80% of the patients age > 45 years. The mean implantation volume encompassed by the referenced isodose was 23 cm3 for 125I and 48 cm3 for 192Ir. Initial dose rates were 2.5–2.9 centigrays (cGy)/hour for permanent 125I, 4.6 cGy/hour for temporary 125I, and 44–100 cGy/hour (mean, 61 cGy) for 192Ir. A total dose of 50–60 Gy, 60–80 Gy, and 40 Gy, respectively, was administered at the outer margins of the tumor. The median survival was approximately 16 months for both the 125I group and the 192Ir group. This was 6 months longer than the median survival in the control group. Reoperations were performed in 4 patients in the 125I group (9%) versus 7 patients in the 192Ir group (33%). No complications or late reactions were reported in the 125I group, whereas one case of hemorrhage and three cases of delayed stroke were observed in the 192Ir group. The equal median survival times in these two brachytherapy groups with such different dose rate radiation schedules support the hypothesis that dose rate does not play a major role in the survival of patients with primary GBM. Cancer 2000;88:2796–802. © 2000 American Cancer Society.

Published
2000
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26. Bilateral high‐frequency stimulation of the internal globus pallidus in advanced Parkinson's disease

Author

Volkmann, J., Sturm, V., Weiss, P., Kappler, J., Voges, J., Koulousakis, A., Lehrke, R., Hefter, H., and Freund, H.‐J.

Abstract

We report here the results of an open prospective study in 9 patients suffering from severe Parkinson's disease with on/off fluctuations and restricted off‐period mobility, who underwent bilateral implantation of stimulating electrodes in the internal pallidum. At 3‐month follow‐up, the total Unified Parkinson's Disease Rating Scale (UPDRS) motor score in the medication‐off state was reduced from 54.1 ± 14.8 to 23.9 ± 11.7 (44.2%) when stimulation was turned on. Comparison of UPDRS subscores revealed significant improvements for tremor, rigidity, bradykinesia, gait and posture, and dyskinesias. The results of the clinical scoring could be confirmed by significant changes in the quantitative assessment of hand function and walking. Bilateral pallidal stimulation reduced the amount and severity of on/off fluctuations. Additional follow‐up at 6 months (n = 6), 9 months (n = 6), and 12 months (n = 4) did not show a decline in effectiveness of stimulation. There was no permanent morbidity associated with the procedure. A subtle reduction of verbal fluency, which was not evident to the patients, was the only cognitive side effect of the procedure in neuropsychological testing. Chronic bilateral high‐frequency stimulation of the internal pallidum seems to be a neurologically safe and highly effective treatment for “off” symptoms, dyskinesias, and motor fluctuations in advanced stages of Parkinson's disease.

Published
1998
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27. 11C-methionine PET for differential diagnosis of low-grade gliomas

Author

Herholz, K., Hölzer, T., Bauer, B., Schröder, R., Voges, J., Ernestus, R. I., Mendoza, G., Weber-Luxenburger, G., Löttgen, J., Thiel, A., Wienhard, K., and Heiss, W. D.

Abstract

Management of low-grade gliomas continues to be a challenging task, because CT and MRI do not always differentiate from nontumoral lesions. Furthermore, tumor extent and aggressiveness often remain unclear because of a lack of contrast enhancement. Previous studies indicated that large neutral amino acid tracers accumulate in most brain tumors, including low-grade gliomas, probably because of changes of endothelial and blood-brain barrier function. We describe 11C-methionine uptake measured with PET in a series of 196 consecutive patients, most of whom were studied because of suspected low-grade gliomas. Uptake in the most active lesion area, relative to contralateral side, was significantly different among high-grade gliomas, low-grade gliomas, and chronic or subacute nontumoral lesions, and this difference was independent from contrast enhancement in CT or MRI. Corticosteroids had no significant effect on methionine uptake in low-grade gliomas but reduced uptake moderately in high-grade gliomas. Differentiation between gliomas and nontumoral lesions by a simple threshold was correct in 79%. Recurrent or residual tumors had a higher uptake than primary gliomas. In conclusion, the high sensitivity of 11C-methionine uptake for functional endothelial or blood-brain barrier changes suggests that this tracer is particularly useful for evaluation and follow-up of low-grade gliomas.

Published
1998

28. CT-guided and computer assisted stereotactic biopsy

Author

Voges, J., Schröder, R., Treuer, H., Pastyr, O., Schlegel, W., Lorenz, W. -J., and Sturm, V.

Abstract

Summary On the base of a stereotactic device originally described by Riechert and Mundinger a three-dimensional localization and treatment planning system for CT-guided computer assisted stereotactic procedures has been developed. The experience with 338 patients, in which image guided stereotaxy has been used for the assessment of various intracerebral lesions, is presented. In 54 of these patients the cannula was introduced with a 20 MHz Doppler-probe positioned at the tip of the needle. A comparison of tissue specimens taken stereotactically with tissue material after tumour resection and/or autopsy was performed in 35 patients. The accuracy of the histological diagnosis was 88%. Bleeding as a complication due to the stereotactic intervention occurred in 8 patients (2.4%). Two of these patients had a fatal outcome (mortality: 0.6%). The morbidity (transient and permanent deterioration of the clinical status) was 1.2%.

Published
1993
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29. Glucose consumption and methionine uptake in low-grade gliomas after iodine-125 brachytherapy

Author

Würker, M., Herholz, K., Voges, J., Pietrzyk, U., Treuer, H., Bauer, B., Sturm, V., and Heiss, W. -D.

Abstract

We investigated whether 2-[18F]-fluoro-2-de-oxy-d-glucose (FDG) and carbon-11 methionine are suitable tracers to monitor the effects of therapy for low-grade gliomas. Ten patients with low-grade glioma without previous treatment were studied with FDG positron emission tomography. Additionally,l-[methyl-11C]-methionine uptake was measured in five subjects before and 1 year after computerized tomography (CT)-guided stereotactic and computer-assisted implantation of iodine-125 seeds. All scans were 3D-matched to CT, isodose volumes were determined, and changes in glucose metabolism and methionine uptake were evaluated in tumour and brain tissue as a function of radiation dose. After 1 year glucose metabolism was not significantly altered up to a radiation dose of 300 Gy, whereas methionine uptake showed a significant dose-dependent decrease. Higher rates of decline were found in tumours with high basal methionine incorporation activity before therapy. These data suggest that measurement of methionine uptake is more suitable than measurement of FDG uptake for monitoring therapeutic effects in low-grade gliomas.

Published
1996
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31. Interstitial irradiation of a large, low grade ependymoma with stereotactically implanted Iodine-125 seeds

Author

Voges, J., Gaus, C., Schlegel, W., Pastyr, O., Wowra, B., and Sturm, V.

Abstract

Summary In this case report a patient with a large intraventricular benign ependymoma is presented. The tumour was treated with stereotactically implanted Iodine-125 seeds and interstitial irradiation. Extension (diameter: 6.5 cm) and volume (112.5 ml) of the lesion caused the application of an unusually low dose (tumour surface dose: 40 Gy). The tumour shrank significantly within a few weeks. Follow-up at nearly 5 years shows the patient to be tumour free.

Published
1993
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