10 results on '"Villadsen, Anton Boel"'
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2. Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial
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Hausenloy, Derek J, Kharbanda, Rajesh K, Møller, Ulla Kristine, Ramlall, Manish, Aarøe, Jens, Butler, Robert, Bulluck, Heerajnarain, Clayton, Tim, Dana, Ali, Dodd, Matthew, Engstrom, Thomas, Evans, Richard, Lassen, Jens Flensted, Christensen, Erika Frischknecht, Garcia-Ruiz, José Manuel, Gorog, Diana A, Hjort, Jakob, Houghton, Richard F, Ibanez, Borja, Knight, Rosemary, Lippert, Freddy K, Lønborg, Jacob T, Maeng, Michael, Milasinovic, Dejan, More, Ranjit, Nicholas, Jennifer M, Jensen, Lisette Okkels, Perkins, Alexander, Radovanovic, Nebojsa, Rakhit, Roby D, Ravkilde, Jan, Ryding, Alisdair D, Schmidt, Michael R, Riddervold, Ingunn Skogstad, Sørensen, Henrik Toft, Stankovic, Goran, Varma, Madhusudhan, Webb, Ian, Terkelsen, Christian Juhl, Greenwood, John P, Yellon, Derek M, Bøtker, Hans Erik, Junker, Anders, Kaltoft, Anne, Madsen, Morten, Christiansen, Evald Høj, Jakobsen, Lars, Carstensen, Steen, Kristensen, Steen Dalby, Thim, Troels, Pedersen, Karin Møller, Korsgaard, Mette Tidemand, Iversen, Allan, Jørgensen, Erik, Joshi, Francis, Pedersen, Frants, Tilsted, Hans Henrik, Alzuhairi, Karam, Saunamäki, Kari, Holmvang, Lene, Ahlehof, Ole, Sørensen, Rikke, Helqvist, Steffen, Mark, Bettina Løjmand, Villadsen, Anton Boel, Raungaard, Bent, Thuesen, Leif, Christiansen, Martin Kirk, Freeman, Philip, Jensen, Svend Eggert, Skov, Charlotte Schmidt, Aziz, Ahmed, Hansen, Henrik Steen, Ellert, Julia, Veien, Karsten, Pedersen, Knud Erik, Hansen, Knud Nørregård, Ahlehoff, Ole, Cappelen, Helle, Wittrock, Daniel, Hansen, Poul Anders, Ankersen, Jens Peter, Hedegaard, Kim Witting, Kempel, John, Kaus, Henning, Erntgaard, Dennis, Pedersen, Danny Mejsner, Giebner, Matthias, Hansen, Troels Martin Hansen, Radosavljevic-Radovanovic, Mina, Prodanovic, Maja, Savic, Lidija, Pejic, Marijana, Matic, Dragan, Uscumlic, Ana, Subotic, Ida, Lasica, Ratko, Vukcevic, Vladan, Suárez, Alfonso, Samaniego, Beatriz, Morís, César, Segovia, Eduardo, Hernández, Ernesto, Lozano, Iñigo, Pascual, Isaac, Vegas-Valle, Jose M., Rozado, José, Rondán, Juan, Avanzas, Pablo, del Valle, Raquel, Padrón, Remigio, García-Castro, Alfonso, Arango, Amalia, Medina-Cameán, Ana B., Fente, Ana I., Muriel-Velasco, Ana, Pomar-Amillo, Ángeles, Roza, César L., Martínez-Fernández, César M., Buelga-Díaz, Covadonga, Fernández-Gonzalo, David, Fernández, Elena, Díaz-González, Eloy, Martinez-González, Eugenio, Iglesias-Llaca, Fernando, Viribay, Fernando M., Fernández-Mallo, Francisco J., Hermosa, Francisco J., Martínez-Bastida, Ginés, Goitia-Martín, Javier, Vega-Fernández, José L., Tresguerres, Jose M., Rodil-Díaz, Juan A., Villar-Fernández, Lara, Alberdi, Lucía, Abella-Ovalle, Luis, de la Roz, Manuel, Fernández-Carral, Marcos Fernández-Carral, Naves, María C., Peláez, María C., Fuentes, María D., García-Alonso, María, Villanueva, María J., Vinagrero, María S., Vázquez-Suárez, María, Martínez-Valle, Marta, Nonide, Marta, Pozo-López, Mónica, Bernardo-Alba, Pablo, Galván-Núñez, Pablo, Martínez-Pérez, Polácido J., Castro, Rafael, Suárez-Coto, Raquel, Suárez-Noriega, Raquel, Guinea, Rocío, Quintana, Rosa B., de Cima, Sara, Hedrera, Segundo A., Laca, Sonia I., Llorente-Álvarez, Susana, Pascual, Susana, Cimas, Teodorna, Mathur, Anthony, McFarlane-Henry, Eleanor, Leonard, Gerry, Veerapen, Jessry, Westwood, Mark, Colicchia, Martina, Prossora, Mary, Andiapen, Mervyn, Mohiddin, Saidi, Lenzi, Valentina, Chong, Jun, Francis, Rohin, Pine, Amy, Jamieson-Leadbitter, Caroline, Neal, Debbie, Din, J., McLeod, Jane, Roberts, Josh, Polokova, Karin, Longman, Kristel, Penney, Lucy, Lakeman, Nicki, Wells, Nicki, Hopper, Oliver, Coward, Paul, O'Kane, Peter, Harkins, Ruth, Guyatt, Samantha, Kennard, Sarah, Orr, Sarah, Horler, Stephanie, Morris, Steve, Walvin, Tom, Snow, Tom, Cunnington, Michael, Burd, Amanda, Gowing, Anne, Krishnamurthy, Arvindra, Harland, Charlotte, Norfolk, Derek, Johnstone, Donna, Newman, Hannah, Reed, Helen, O'Neill, James, Greenwood, John, Cuxton, Josephine, Corrigan, Julie, Somers, Kathryn, 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Alan, McSkeane, Anna, Smith, Bethany, Shaw, Caroline, Leathers, Chris, Armstrong, Elissa, Carruthers, Gayle, Simpson, Holly, Smith, Jan, Hodierne, Jeremy, Kelly, Julie, Barclay, Justin, Scott, Kerry, Gregson, Lisa, Buchanan, Louise, McCormick, Louise, Varma, Madhusudhan, Kelsall, Nicci, Mcarthy, Rachel, Taylor, Rebecca, Thompson, Rebecca, Shelton, Rhidian, Moore, Roger, Tomlinson, Sharon, Thambi, Sunil, Cooper, Theresa, Oakes, Trevor, Deen, Zakhira, Relph, Chris, prentice, Scott, Hall, Lorna, Dillon, Angela, Meadows, Deborah, Frank, Emma, Markham-Jones, Helene, Thomas, Isobel, Gale, Joanne, Denman, Joanne, Gale, Joanne, O'Connor, John, Hindle, Julia, Jackson-Lawrence, Karen, Warner, Karen, Lee, Kelvin, Upton, Robert, Elston, Ruth, Lee, Sandra, Venugopal, Vinod, Finch, Amanda, Fleming, Catherine, Whiteside, Charlene, Pemberton, Chris, Wilkinson, Conor, Sebastian, Deepa, Riedel, Ella, Giuffrida, Gaia, Burnett, Gillian, Spickett, Helen, Glen, James, Brown, Janette, Thornborough, Lauren, Pedley, Lauren, Morgan, Maureen, Waddington, Natalia, Brennan, Oliver, More, Ranjit, Brady, Rebecca, Preston, Stephen, Loder, Chris, Vlad, Ionela, Laurence, Julia, Smit, Angelique, Dimond, Kirsty, Hayes, Michelle, Paddy, Loveth, Crause, Jacolene, Amed, Nadifa, Kaur-Babooa, Priya, Rakhit, Roby, Kotecha, Tushar, Fayed, Hossam, Francis, Rohin, Pavlidis, Antonis, Prendergast, Bernard, Clapp, Brian, Perara, Divaka, Atkinson, Emma, Ellis, Howard, Wilson, Karen, Gibson, Kirsty, Smith, Megan, Khawaja, Muhammed Zeeshan, Sanchez-Vidal, Ruth, Redwood, Simon, Jones, Sophie, Tipping, Aoife, Oommen, Anu, Hendry, Cara, Fath-Orboubadi, DR Fazin, Phillips, Hannah, Kolakaluri, Laurel, Sherwood, Martin, Mackie, Sarah, Aleti, Shilpa, Charles, Thabitha, Roy, Liby, Henderson, Rob, Stables, Rod, Redwood, Simon, Marber, Michael, Berry, Alan, Redington, Andrew, Thygesen, Kristian, Andersen, Henning Rud, Berry, Colin, Copas, Andrew, Meade, Tom, Kelbæk, Henning, Bueno, Hector, von Weitzel-Mudersbach, Paul, Andersen, Grethe, Ludman, Andrew, Cruden, Nick, Topic, Dragan, Mehmedbegovic, Zlatko, de la Hera Galarza, Jesus Maria, Robertson, Steven, Van Dyck, Laura, Chu, Rebecca, Astarci, Josenir, Jamal, Zahra, Hetherington, Daniel, and Collier, Lucy
- Abstract
Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months.
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- 2019
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3. Everolimus-Eluting Versus Biolimus-Eluting Stents With Biodegradable Polymers in Unselected Patients Undergoing Percutaneous Coronary Intervention: A Randomized Noninferiority Trial With 1-Year Follow-Up (SORT OUT VIII Trial).
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Maeng, Michael, Christiansen, Evald Høj, Raungaard, Bent, Kahlert, Johnny, Terkelsen, Christian Juhl, Kristensen, Steen Dalby, Carstensen, Steen, Aarøe, Jens, Jensen, Svend Eggert, Villadsen, Anton Boel, Lassen, Jens Flensted, Thim, Troels, Eftekhari, Ashkan, Veien, Karsten Tange, Hansen, Knud Nørregaard, Junker, Anders, Bøtker, Hans Erik, and Jensen, Lisette Okkels
- Abstract
Abstract Objectives The aim of this study was to compare the thin-strut biodegradable-polymer everolimus-eluting platinum-chromium stent (EES) with the biodegradable-polymer biolimus-eluting stainless-steel stent (BES). Background Currently available drug-eluting coronary stents have been refined to reduce the risk for coronary events following implantation. Methods This randomized, multicenter, all-comers, noninferiority trial was undertaken at 3 sites in western Denmark. Patients with clinical indications for percutaneous coronary intervention were eligible for inclusion. Patients were randomly assigned (1:1) to either EES or BES. The primary endpoint, target lesion failure, was a composite of safety (cardiac death and myocardial infarction not clearly attributable to a nontarget lesion) and efficacy (target lesion revascularization) at 12 months, analyzed using intention-to-treat principles. The trial was powered to assess target lesion failure noninferiority of the EES compared with the BES with a predetermined noninferiority margin of 3%. Results A total of 1,385 patients were assigned to treatment with EES and 1,369 patients to treatment with BES. The analysis showed that 55 patients (4.0%) assigned to the EES and 60 (4.4%) assigned to the BES met the primary endpoint (absolute risk difference 0.4%; upper limit of 1-sided 95% confidence interval: 1.7%; p < 0.001). Conclusions At 1-year follow-up, the EES was found to be noninferior to the BES with respect to target lesion failure. (Everolimus-eluting SYNERGY Stent Versus Biolimus-Eluting Biomatrix NeoFlex Stent—SORT-OUT VIII; NCT02093845) Central Illustration [ABSTRACT FROM AUTHOR]
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- 2019
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4. Fractional Flow Reserve-Guided Complete Revascularization Improves the Prognosis in Patients With ST-Segment-Elevation Myocardial Infarction and Severe Nonculprit Disease.
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Lønborg, Jacob, Engstrøm, Thomas, Kelbæk, Henning, Helqvist, Steffen, Kløvgaard, Lene, Holmvang, Lene, Pedersen, Frants, Jørgensen, Erik, Saunamäki, Kari, Clemmensen, Peter, De Backer, Ole, Ravkilde, Jan, Tilsted, Hans-Henrik, Villadsen, Anton Boel, Aarøe, Jens, Jensen, Svend Eggert, Raungaard, Bent, Køber, Lars, and Høfsten, Dan Eik
- Abstract
Background--The impact of disease severity on the outcome after complete revascularization in patients with ST-segment-elevation myocardial infarction and multivessel disease is uncertain. The objective of this post hoc study was to evaluate the impact of number of diseased vessel, lesion location, and severity of the noninfarct-related stenosis on the effect of fractional flow reserve-guided complete revascularization. Methods and Results--In the DANAMI-3-PRIMULTI study (Primary PCI in Patients With ST-Elevation Myocardial Infarction and Multivessel Disease: Treatment of Culprit Lesion Only or Complete Revascularization), we randomized 627 ST-segment-elevation myocardial infarction patients to fractional flow reserve-guided complete revascularization or infarct-related percutaneous coronary intervention only. In patients with 3-vessel disease, fractional flow reserve-guided complete revascularization reduced the primary end point (all-cause mortality, reinfarction, and ischemia-driven revascularization; hazard ratio [HR], 0.33; 95% confidence interval [CI], 0.17-0.64; P=0.001), with no significant effect in patients with 2-vessel disease (HR, 0.77; 95% CI, 0.47-1.26; P=0.29; P for interaction =0.046). A similar effect was observed in patients with diameter stenosis ≥90% of noninfarct-related arteries (HR, 0.32; 95% CI, 0.18-0.62; P=0.001), but not in patients with less severe lesions (HR, 0.72; 95% CI, 0.44-1.19; P=0.21; P for interaction =0.06). The effect was most pronounced in patients with 3-vessel disease and noninfarct-related stenoses ≥90%, and in this subgroup, there was a nonsignificant reduction in the end point of mortality and reinfarction (HR, 0.32; 95% CI, 0.08-1.32; P=0.09). Proximal versus distal location did not influence the benefit from complete revascularization. [ABSTRACT FROM AUTHOR]
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- 2017
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5. Randomized Comparison of a Biodegradable Polymer Ultrathin Strut Sirolimus-Eluting Stent With a Biodegradable Polymer Biolimus-Eluting Stent in Patients Treated With Percutaneous Coronary Intervention The SORT OUT VII Trial.
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Jensen, Lisette Okkels, Thayssen, Per, Maeng, Michael, Ravkilde, Jan, Krusell, Lars Romer, Raungaard, Bent, Junker, Anders, Terkelsen, Christian Juhl, Veien, Karsten Tange, Villadsen, Anton Boel, Kaltoft, Anne, Tilsted, Hans-Henrik, Hansen, Knud Nørregaard, Aaroe, Jens, Kristensen, Steen Dalby, Hansen, Henrik Steen, Jensen, Svend Eggert, Madsen, Morten, Bøtker, Hans Erik, and Berencsi, Klára
- Abstract
Background--Coronary drug-eluting stents with biodegradable polymers have been designed to improve safety and efficacy. Methods and Results--The Scandinavian Organization for Randomized Trials With Clinical Outcome (SORT OUT) VII trial--a large-scale registry-based randomized, multicenter, single-blind, 2-arm, noninferiority trial--compared 2 biodegradable polymer drug-eluting stents: the thin-strut cobalt-chromium sirolimus-eluting Orsiro stent and the stainless steel biolimus-eluting Nobori stent in an all-comer patient population. The primary end point target lesion failure was a composite of cardiac death, myocardial infarction (not related to other than index lesion), or target lesion revascularization within 1 year, analyzed by intention to treat (noninferiority margin of 3.0%). Clinically driven event detection based on Danish registries was used. A total of 1261 patients were assigned to receive the sirolimus-eluting stent (1590 lesions) and 1264 patients to the biolimus-eluting stent (1588 lesions). At 1 year, the composite end point target lesion failure occurred in 48 patients (3.8%) in the sirolimus-eluting group and in 58 patients (4.6%) in the biolimus-eluting group (absolute risk difference, -0.78% [upper limit of 1-sided 95% confidence interval, 0.61%]; P<0.0001). Rates of definite stent thrombosis occurred in 5 (0.4%) of the sirolimus-eluting group compared with 15 (1.2%) biolimus-eluting stent-treated patients (rate ratio, 0.33; 95% confidence interval, 0.12-0.92; P=0.034), which largely was attributable to a lower risk of subacute definite stent thrombosis: 0.1% versus 0.6% (rate ratio, 0.12; 95% confidence interval, 0.02-1.00; P=0.05). Conclusions--The thin-strut sirolimus-eluting Orsiro stent was noninferior to the biolimus-eluting Nobori stent in unselected patients for target lesion failure at 1 year. [ABSTRACT FROM AUTHOR]
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- 2016
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6. Complete revascularisation versus treatment of the culprit lesion only in patients with ST-segment elevation myocardial infarction and multivessel disease (DANAMI-3—PRIMULTI): an open-label, randomised controlled trial
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Engstrøm, Thomas, Kelbæk, Henning, Helqvist, Steffen, Høfsten, Dan Eik, Kløvgaard, Lene, Holmvang, Lene, Jørgensen, Erik, Pedersen, Frants, Saunamäki, Kari, Clemmensen, Peter, De Backer, Ole, Ravkilde, Jan, Tilsted, Hans-Henrik, Villadsen, Anton Boel, Aarøe, Jens, Jensen, Svend Eggert, Raungaard, Bent, and Køber, Lars
- Abstract
Patients with acute ST-segment elevation myocardial infarction (STEMI) and multivessel coronary disease have a worse prognosis compared with individuals with single-vessel disease. We aimed to study the clinical outcome of patients with STEMI treated with fractional flow reserve (FFR)-guided complete revascularisation versus treatment of the infarct-related artery only.
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- 2015
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7. Zotarolimus-eluting durable-polymer-coated stent versus a biolimus-eluting biodegradable-polymer-coated stent in unselected patients undergoing percutaneous coronary intervention (SORT OUT VI): a randomised non-inferiority trial
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Raungaard, Bent, Jensen, Lisette Okkels, Tilsted, Hans-Henrik, Christiansen, Evald Høj, Maeng, Michael, Terkelsen, Christian Juhl, Krusell, Lars Romer, Kaltoft, Anne, Kristensen, Steen Dalby, Bøtker, Hans Erik, Thuesen, Leif, Aarøe, Jens, Jensen, Svend Eggert, Villadsen, Anton Boel, Thayssen, Per, Veien, Karsten Tange, Hansen, Knud Nørregaard, Junker, Anders, Madsen, Morten, Ravkilde, Jan, and Lassen, Jens Flensted
- Abstract
New-generation drug-eluting coronary stents have reduced the risk of coronary events, especially in patients with complex disease or lesions. To what extent different stent platforms, polymers, and antiproliferative drugs affect outcomes, however, is unclear. We investigated the safety and efficacy of a third-generation stent by comparing a highly biocompatible durable-polymer-coated zotarolimus-eluting stent with a biodegradable-polymer-coated biolimus-eluting stent.
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- 2015
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8. Biolimus-eluting biodegradable polymer-coated stent versus durable polymer-coated sirolimus-eluting stent in unselected patients receiving percutaneous coronary intervention (SORT OUT V): a randomised non-inferiority trial
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Christiansen, Evald Høj, Jensen, Lisette Okkels, Thayssen, Per, Tilsted, Hans-Henrik, Krusell, Lars Romer, Hansen, Knud Nørregaard, Kaltoft, Anne, Maeng, Michael, Kristensen, Steen Dalby, Bøtker, Hans Erik, Terkelsen, Christian Juhl, Villadsen, Anton Boel, Ravkilde, Jan, Aarøe, Jens, Madsen, Morten, Thuesen, Leif, and Lassen, Jens Flensted
- Abstract
Third-generation biodegradable polymer drug-eluting stents might reduce the risk of stent thrombosis compared with first-generation permanent polymer drug-eluting stents. We aimed to further investigate the effects of a biodegradable polymer biolimus-eluting stent compared with a durable polymer-coated sirolimus-eluting stent in a population-based setting.
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- 2013
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9. Fractional Flow Reserve–Guided Complete Revascularization Improves the Prognosis in Patients With ST-Segment–Elevation Myocardial Infarction and Severe Nonculprit Disease
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Lønborg, Jacob, Engstrøm, Thomas, Kelbæk, Henning, Helqvist, Steffen, Kløvgaard, Lene, Holmvang, Lene, Pedersen, Frants, Jørgensen, Erik, Saunamäki, Kari, Clemmensen, Peter, De Backer, Ole, Ravkilde, Jan, Tilsted, Hans-Henrik, Villadsen, Anton Boel, Aarøe, Jens, Jensen, Svend Eggert, Raungaard, Bent, Køber, Lars, and Høfsten, Dan Eik
- Abstract
Supplemental Digital Content is available in the text.
- Published
- 2017
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10. Randomized Comparison of a Biodegradable Polymer Ultrathin Strut Sirolimus-Eluting Stent With a Biodegradable Polymer Biolimus-Eluting Stent in Patients Treated With Percutaneous Coronary Intervention
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Jensen, Lisette Okkels, Thayssen, Per, Maeng, Michael, Ravkilde, Jan, Krusell, Lars Romer, Raungaard, Bent, Junker, Anders, Terkelsen, Christian Juhl, Veien, Karsten Tange, Villadsen, Anton Boel, Kaltoft, Anne, Tilsted, Hans-Henrik, Hansen, Knud Nørregaard, Aaroe, Jens, Kristensen, Steen Dalby, Hansen, Henrik Steen, Jensen, Svend Eggert, Madsen, Morten, Bøtker, Hans Erik, Berencsi, Klára, Lassen, Jens Flensted, and Christiansen, Evald Høj
- Abstract
Supplemental Digital Content is available in the text.
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- 2016
- Full Text
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