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Your search keyword '"Vezir, Özden"' showing total 6 results
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6 results on '"Vezir, Özden"'

1. mTOR inhibition modulates apoptosis and oxidative stress in hindlimb ischemia/reperfusion injury.

Author

Pire, Zarife, Güden, Demet Sinem, Reşitoğlu, Meryem Temiz, Şenol, Şefika Pınar, Vezir, Özden, Sucu, Nehir, Tunçtan, Bahar, Malik, Kafait U., and Fırat, Seyhan Şahan

Subjects
APOPTOSIS inhibition, RAPAMYCIN, REPERFUSION injury, OXIDATIVE stress, OXIDANT status, BAX protein
Abstract

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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2. Identification of variations in genes encoding ATP-dependent potassium channel proteins in patients with primary Raynaud's phenomenon.

Author

Akkapulu, Merih, Yıldırım, Metin, Vezir, Özden, Sucu, Nehir, and Yalın, Ali Erdinç

Subjects
RAYNAUD'S disease, POTASSIUM channels, CEREBRAL vasospasm, CHANNEL coding, TURKS, GENETIC variation
Abstract

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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3. Inhibition of mTOR protects against skeletal muscle and kidney injury following hindlimb ischemia-reperfusion in rats by regulating MEK1/ERK1/2 activity.

Author

Akıncı-Uysal, Çağla, Temiz-Reşitoğlu, Meryem, Güden, Demet Sinem, Senol, Şefika Pınar, Vezir, Özden, Sucu, Nehir, Tunçtan, Bahar, Malik, Kafait U., and Sahan-Fırat, Seyhan

Subjects
RAPAMYCIN, SKELETAL muscle injuries, NICOTINAMIDE adenine dinucleotide phosphate, MYOCARDIAL reperfusion, NITRIC-oxide synthases, HINDLIMB
Abstract

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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4. Role of cytokine gene polymorphisms on ramipril-altered inflammatory response and myocardial injury in patients undergoing coronary artery bypass surgery.

Author

Küçük, Meral Urhan, Karaca, Kerem, Firat, Seyhan Şahan, Vezir, Özden, Canacankatan, Necmiye, Aytaçoğlu, Barlas Naim, Erden, Sema, Tunçtan, Bahar, and Sucu, Nehir

Subjects
RAMIPRIL, CYTOKINES, GENETIC polymorphisms
Abstract

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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5. N-Acetylcysteine-induced vasodilatation is modulated by KATPchannels, Na+/K+-ATPase activity and intracellular calcium concentration: An in vitrostudy

Author

Vezir, Özden, Çömelekoğlu, Ülkü, Sucu, Nehir, Yalın, Ali Erdinç, Yılmaz, Şakir Necat, Yalın, Serap, Söğüt, Fatma, Yaman, Selma, Kibar, Kezban, Akkapulu, Merih, Koç, Meryem İlkay, and Seçer, Didem

Abstract

In this study, we aimed to investigate the role of ATP-sensitive potassium (KATP) channel, Na+/K+-ATPase activity, and intracellular calcium levels on the vasodilatory effect of N-acetylcysteine (NAC) in thoracic aorta by using electrophysiological and molecular techniques.

Published
2017
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6. N-Acetylcysteine-induced vasodilatation is modulated by KATPchannels, Na+/K+-ATPase activity and intracellular calcium concentration: An in vitrostudy

Author

Vezir, Özden, Çömelekoglu, Ülkü, Sucu, Nehir, Yalin, Ali Erdinç, Yilmaz, Sakir Necat, Yalin, Serap, Sögüt, Fatma, Yaman, Selma, Kibar, Kezban, Akkapulu, Merih, Koç, Meryem Ilkay, and Seçer, Didem

Abstract

Background: In this study, we aimed to investigate the role of ATP-sensitive potassium (KATP) channel, Na+/K+-ATPase activity, and intracellular calcium levels on the vasodilatory effect of N-acetylcysteine (NAC) in thoracic aorta by using electrophysiological and molecular techniques. Methods: Rat thoracic aorta ring preparations and cultured thoracic aorta cells were divided into four groups as control, 2 mM NAC, 5 mM NAC, and 10 mM NAC. Thoracic aorta rings were isolated from rats for measurements of relaxation responses and Na+/K+-ATPase activity. In the cultured thoracic aorta cells, we measured the currents of KATPchannel, the concentration of intracellular calcium and mRNA expression level of KATPchannel subunits (KCNJ8, KCNJ11, ABCC8 and ABCC9). Results: The relaxation rate significantly increased in all NAC groups compared to control. Similarly, Na+/K+-ATPase activity also significantly decreased in NAC groups. Outward KATPchannel current significantly increased in all NAC groups compared to the control group. Intracellular calcium concentration decreased significantly in all groups with compared control. mRNA expression level of ABCC8 subunit significantly increased in all NAC groups compared to the control group. Pearson correlation analysis showed that relaxation rate was significantly associated with KATPcurrent, intracellular calcium concentration, Na+/K+-ATPase activity and mRNA expression level of ABCC8 subunit. Conclusion: Our findings suggest that NAC relaxes vascular smooth muscle cells through a direct effect on KATPchannels, by increasing outward K+flux, partly by increasing mRNA expression of KATPsubunit ABCC8, by decreasing in intracellular calcium and by decreasing in Na+/K+-ATPase activity.

Published
2017
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