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Induction motor (IM) drive systems are pivotal in modern industrial and commercial applications, driving essential processes and systems across various sectors efficiently and reliably. The accurate estimation of IM and load parameters is challenging but vital to guarantee the optimal performance of the entire drive system. The IEEE Standard 112A and existing online methods take hours to estimate only IM parameters after shutting down, disconnecting, estimating, reconnecting, and realigning the motor and its load using specialized tools. Offline techniques assume a known IM manufacturer datasheet, which is often unavailable. Therefore, this article proposes a novel online self-commissioning algorithm that estimates the parameters of an IM and its load in a remarkably swift time frame of just 180 s without disconnecting the IM from the load or using the IM manufacturer datasheet. The proposed method only requires the IM nameplate information and employs a discrete normalized model reference adaptive system. In addition, its computational burden is minimal, making it suitable for practical real-time implementation using the commercial and cost-effective microcontroller for power electronics, i.e., c2000 TMS320F28388D control platform. Comprehensive experimental results for fan-type loads driven by 1.1- and 7.5-kW IMs are discussed to validate the proposal.

Graphene doped with different transition metals has been recently proposed to adsorb CO2and help reduce the greenhouse effect. Iron-doped graphene is one of the most promising candidates for this task, but there is still a lack of full understanding of the adsorption mechanism. In this work, we analyze the electronic structure, geometry, and charge redistribution during adsorption of CO2molecules by single vacancy iron-doped graphene by DFT calculations using the general gradient approximation of Perdew, Burke, and Ernzernhof functional (PBE) and the van der Waals density functional (vdW). To understand the impact of the pyridinic-N coordination of the iron atom, we gradually replaced the neighboring carbon atoms by nitrogen atoms. The analysis indicates that chemisorption and physisorption occur when the molecule is adsorbed in the side-on and end-on orientation, respectively. Adsorption is stronger when pyridinic-N coordination increases, and the vdW functional describes the chemical interactions and adsorption energy differently in relation to PBE without significant structural changes. The development of the chemical interactions with the change of coordination in the system is further investigated in this work with crystal overlap Hamilton population (COHP) analysis.

Background: To examine the associations between early onset of nonmedical prescription stimulant use (NPSU) and cocaine use.Methods: Nationally representative samples of high school seniors were surveyed annually. Data were collected via self-administered questionnaires in nationally representative public and private schools in the United States (1976-2020) as part of the Monitoring the Future Study. The sample consisted of 45 cohorts of 12th grade students (N = 121 909). The main outcome was lifetime, past-year, and past-month cocaine use.Results: An estimated one in every 10 (10.1%) individuals reported lifetime NPSU while 8.5% reported any cocaine use. The vast majority of youth (87.2%) initiated NPSU before cocaine among those who reported both substances. Cocaine use was most prevalent among youth who reported early onset of NPSU in 8th grade or earlier (51.7%) followed by those who reported later onset of NPSU in 12th grade (24.7%), and those who never initiated NPSU (3.7%). Binary logistic regression analysis indicated that early onset of NPSU had greater adjusted odds of cocaine use compared to those with later onset of NPSU or those who never reported NPSU. Moreover, the adjusted odds of cocaine use were higher for adolescents who initiated NPSU before or after medical use of prescription stimulants compared to those with no history of medical use or NPSU. Similar results were found for lifetime, past-year, and past-month cocaine use as a function of NPSU onset; this association was stronger among more recent cohorts.Conclusions: Early onset of NPSU appears to be a signal of increased risk of cocaine use among US adolescents. NPSU should be included in screening and early prevention strategies among secondary school students. Health professionals, school officials, and families are encouraged to monitor youth for NPSU based on the increased risk of later cocaine use and related consequences.

Hyperthermophile microorganisms have been discovered worldwide, and several studies regarding biodiversity and the potential biotechnological applications have been reported. In this work, we describe for the first time the diversity of hyperthermophile communities in the Calientes Geothermal Field (CGF) located 4400 m above sea level in Tacna Region, Perú. Three hot springs were monitored and showed a temperature around 84 to 88 °C, for the microbiome analyzed was taken by sampling of sediment and water (pH 7.3–7.6). The hyperthermophile diversity was determined by PCR, DGGE, and DNA sequencing. The sediments analyzed showed a greater diversity than water samples. Sediments showed a more abundant population of bacteria than archaea, with the presence of at least 9 and 5 phylotypes, respectively. Most interestingly, in some taxa of bacteria (Bacillus) and archaea (Haloarcula and Halalkalicoccus), any of operational taxonomic units (OTUs) have not been observed before in hyperthermophile environments. Our results provide insight in the hyperthermophile diversity and reveal the possibility to develop new biotechnological applications based on the kind of environments.

•CART-38 cells are effective against preclinical models of human AML, T-ALL, and MM.•CART-38 cells are at least as effective as current immunotherapies for these diseases.

Eleven different laboratory experiments were designed and executed throughout a semester to provide a meaningful research experience for 23 undergraduate biochemistry majors at UTSA. The topic of the semester was based on the idea of exploring new aspects to enhance our understanding of how the human body uses cytochrome P450 enzymes to metabolize artemisinin, an endoperoxide-containing plant natural product used to treat malaria. Biochemical techniques introduced to the students included computational (dry lab) techniques: the use of bioinformatics tools to design plasmids for protein expression, software to analyze the 3-dimensional structure of proteins, metabolomics software to analyze enzyme-catalyzed reaction extracts by mass spectrometry, and docking software to dock ligands into the active site of proteins. In addition, students performed experimental (wet lab) techniques including: a transformation experiment to incorporate plasmid DNA into bacteria, an extraction of plasmid DNA from bacterial cells, performing enzymatic incubations and preparing samples for analysis by mass spectrometry, and running an SDS protein gel electrophoresis. The semester ended with the use of a web-based program to allow students to visualize the proteins they were studying throughout the semester with a virtual reality headset. This course was taught for the first time at the university, so this manuscript should inspire ideas for future biochemistry laboratory courses taught in the course based undergraduate research experiences (CUREs) format.

ABSTRACTWe know little about the level of the sport industry that impacts the most athletes in the United States, high school sport. This study seeks to understand the experiences of women coaching in high schools and how they balance their full-time jobs with their part-time coaching. Without girls seeing women in leadership positions in sport, they may not consider playing or coaching in higher levels of sport, much less the front office or other lead administrative roles. Ecological systems theory with a focus on organizational support and interpersonal relationships theoretically frame the study. Qualitative interviews with 20 high school coaches were conducted. We found that support within the family, community, and organization allowed these women to persist within these coaching positions. Women who had flexible and accommodating administrators were able to balance expectations of work and family better. Avenues for future research to build on this exploratory study are offered.

Background: Agricultural producers are frequently exposed to noise that is hazardous to their hearing and cardiovascular health, and have among the highest rates of noise-induced hearing loss of all occupations. However, despite information-sharing approaches, few producers wear sufficient hearing protection. There is a need to develop effective methods of protecting producers from their noise exposure.Methods: We provided a series of 2 to 3 short (30-minute) telephone-based motivational interviewing (MI) sessions to noise-exposed agricultural producers. We assessed intervention effectiveness through changes in measuring hearing protector use pre- and post-intervention using a one-group pre/posttest design.Results: The sample (N= 29) predominantly consisted of crop producers from Michigan. The mean percentage of time hearing protection was used increased from 44.9% to 51.8% after the intervention, approximately a 7% increase (p=.105). Regression analysis suggested the relationship between intervention dose and use of hearing protection was not correlative.Discussion/Conclusion: There was a marginal increase in the use of hearing protection after the intervention, although setting-specific increases in use were uneven. Intervention dose did not correlate with a change in hearing protection use. Further research is warranted to determine the effectiveness of MI, how it compares to information sharing, and to identify intervention dose parameters that promote efficiency.

Chile tradicionalmente tiene un proceso estable de migración de personas provenientes desde Perú, Bolivia y Colombia. En los últimos ocho años comienza un fuerte incremento de llegada de nuevos migrantes, fundamentalmente de Haití y Venezuela.

AbstractBackground:The objectives of this study were to: (1) estimate the prevalence of family history of alcohol and other drug (AOD) misuse (positive family history [FH+]) in first- and second-degree relatives across sexual identity subgroups (i.e., lesbian, gay, bisexual, heterosexual); (2) compare AOD misuse among offspring of sexual minority and heterosexual parents; and (3) examine the relationships between FH+ and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition(DSM-5) alcohol use disorder (AUD) and other drug use disorder (ODUD) across sexual identity subgroups. Methods:Data were from the National Epidemiologic Survey on Alcohol and Related Conditions-III (n = 36,309 non-institutionalized U.S. adults aged ≥ 18 years). Data collection occurred in households using structured diagnostic face-to-face interviews during 2012–2013. Results:The presence of FH+ in first- and second-degree relatives was most prevalent among bisexual women relative to all other sexual orientation subgroups. Multivariable regression analyses indicated that the odds of AUD and ODUD were higher among FH+ adults relative to negative family history (FH-) adults. Lesbian and bisexual women had higher odds of AUD compared to heterosexual women, controlling for any FH+; this sexual identity difference was not found for men. There were no significant differences in ODUD between heterosexual FH- men and gay FH- men. We found differences in AOD misuse among offspring of bisexual parents, but not gay or lesbian parents compared to heterosexual parents. Conclusions:Health professionals should consider the higher likelihood of a family history of AOD misuse among sexual minorities, especially bisexual women, when treating these individuals. The lack of differences in AOD misuse among offspring of gay or lesbian parents relative to heterosexual parents warrants attention for legal, policy, and clinical decisions.

AbstractBackground:Adolescent e-cigarette use has increased, as has e-cigarette use during pregnancy, yet little is known about how these types of tobacco/nicotine (cigarettes/e-cigarettes) use during adolescence are associated with tobacco/nicotine use during the third trimester of pregnancy among young adults. Methods:National longitudinal data (2013–2018) from the Population Assessment of Tobacco and Health (PATH) study were used. Young adults ages 18–20 who indicated past-year pregnancy made up the analytic sample (N = 246). Logistic regression was used to evaluate the association between history of past 30-day use of cigarettes/e-cigarettes during adolescence (i.e., 14–17) and later use during the third trimester of pregnancy among young women (i.e., 18–20). Results:Within the sample of young women who indicated a pregnancy during the past year, 18.9% indicated smoking cigarettes and 4.2% indicated using e-cigarettes during their last trimester. Cigarette smoking in adolescence (wave 1 or 2) was associated with cigarette use during the last trimester (aOR = 4.76, 95% CI = 1.36, 16.6); however, e-cigarette use during adolescence was not associated with either cigarette or e-cigarette use during the third trimester of pregnancy. Conclusions:Tobacco/nicotine prevention in early adolescence has implications for preventing tobacco/nicotine-related harms during pregnancy among young adults. Intervention programs and clinicians informed about various types of tobacco/nicotine are needed to address tobacco/nicotine cessation among adolescents to prevent consequences of tobacco/nicotine use during pregnancy.

Background: Adolescent e-cigarette use has increased, as has e-cigarette use during pregnancy, yet little is known about how these types of tobacco/nicotine (cigarettes/e-cigarettes) use during adolescence are associated with tobacco/nicotine use during the third trimester of pregnancy among young adults. Methods:National longitudinal data (2013–2018) from the Population Assessment of Tobacco and Health (PATH) study were used. Young adults ages 18–20 who indicated past-year pregnancy made up the analytic sample (N= 246). Logistic regression was used to evaluate the association between history of past 30-day use of cigarettes/e-cigarettes during adolescence (i.e., 14–17) and later use during the third trimester of pregnancy among young women (i.e., 18–20). Results:Within the sample of young women who indicated a pregnancy during the past year, 18.9% indicated smoking cigarettes and 4.2% indicated using e-cigarettes during their last trimester. Cigarette smoking in adolescence (wave 1 or 2) was associated with cigarette use during the last trimester (aOR = 4.76, 95% CI = 1.36, 16.6); however, e-cigarette use during adolescence was not associated with either cigarette or e-cigarette use during the third trimester of pregnancy. Conclusions:Tobacco/nicotine prevention in early adolescence has implications for preventing tobacco/nicotine-related harms during pregnancy among young adults. Intervention programs and clinicians informed about various types of tobacco/nicotine are needed to address tobacco/nicotine cessation among adolescents to prevent consequences of tobacco/nicotine use during pregnancy.

Background: The objectives of this study were to: (1) estimate the prevalence of family history of alcohol and other drug (AOD) misuse (positive family history [FH+]) in first- and second-degree relatives across sexual identity subgroups (i.e., lesbian, gay, bisexual, heterosexual); (2) compare AOD misuse among offspring of sexual minority and heterosexual parents; and (3) examine the relationships between FH+ and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition(DSM-5) alcohol use disorder (AUD) and other drug use disorder (ODUD) across sexual identity subgroups. Methods:Data were from the National Epidemiologic Survey on Alcohol and Related Conditions-III (n?=?36,309 non-institutionalized U.S. adults aged = 18?years). Data collection occurred in households using structured diagnostic face-to-face interviews during 2012–2013. Results:The presence of FH+ in first- and second-degree relatives was most prevalent among bisexual women relative to all other sexual orientation subgroups. Multivariable regression analyses indicated that the odds of AUD and ODUD were higher among FH+ adults relative to negative family history (FH-) adults. Lesbian and bisexual women had higher odds of AUD compared to heterosexual women, controlling for any FH+; this sexual identity difference was not found for men. There were no significant differences in ODUD between heterosexual FH- men and gay FH- men. We found differences in AOD misuse among offspring of bisexual parents, but not gay or lesbian parents compared to heterosexual parents. Conclusions:Health professionals should consider the higher likelihood of a family history of AOD misuse among sexual minorities, especially bisexual women, when treating these individuals. The lack of differences in AOD misuse among offspring of gay or lesbian parents relative to heterosexual parents warrants attention for legal, policy, and clinical decisions.

The prediction of product translational, vibrational, and rotational energy distributions for arbitrary initial conditions for reactive atom + diatom collisions is of considerable practical interest in atmospheric re-entry. Because of the large number of accessible states, determination of the necessary information from explicit (quasi-classical or quantum) dynamics studies is impractical. Here, a machine-learned (ML) model based on translational energy and product vibrational states assigned from a spectroscopic, ro-vibrational coupled energy expression based on the Dunham expansion is developed and tested quantitatively. All models considered in this work reproduce final state distributions determined from quasi-classical trajectory (QCT) simulations with R2∼ 0.98. As a further validation, thermal rates determined from the machine-learned models agree with those from explicit QCT simulations and demonstrate that the atomistic details are retained by the machine learning which makes them suitable for applications in more coarse-grained simulations. More generally, it is found that ML is suitable for designing robust and accurate models from mixed computational/experimental data which may also be of interest in other areas of the physical sciences.

Capturing precipitation-based episodes is a longstanding issue for estimating tributary loads; however, wind-driven resuspension in Lake Huron creates similar uncertainties in its estimated load to Lake Erie. Recent suggestions that the phosphorus load from Lake Huron is underestimated because sampling frequencies miss contributions from resuspension events are speculative because they did not include direct load measurements, address all resuspension regions, or assess the potential bioavailability of the load. We address these shortcomings by evaluating Lake Huron’s nearshore regions, characterizing the biological availability of the load, and providing direct comparisons of load estimates with and without the resuspended load. We show that total phosphorus concentrations in Lake Huron and the St. Clair River are higher during resuspension events and that bioavailability of that material is comparable to that reported elsewhere. New load estimates, based on continuous turbidity measurements converted to phosphorus through P-turbidity relationships, were almost 90% higher than traditional load estimates, providing empirical evidence for the significantly underestimated previous load. This confirmation is important because if the Lake Huron load is not decreased, reductions from other sources would be needed to meet the overall reduction targets set by the binational Great Lakes Water Quality Agreement.

Background: Disseminated neoplasia (DN) is a proliferative cell disorder of the circulatory system of bivalve mollusks. The disease is transmitted between individuals and can also be induced by external chemical agents such as bromodeoxyuridine. In Mya arenaria, we have cloned and characterized an LTR-retrotransposon named Steamer. Steamer mRNA levels and gene copy number correlates with DN and can be used as a marker of the disease. So far, the only mollusk where a retrotransposon expression relates to DN is Mya arenaria. On the other hand, it has been reported that the Chilean blue mussel Mytilus chilensiscan also suffers DN. Our aim was to identify retrotransposons in Mytilus chilensisand to study their expression levels in the context of disseminated neoplasia. Results: Here we show that 7.1% of individuals collected in August 2018, from two farming areas, presents morphological characteristics described in DN. Using Steamer sequence to interrogate the transcriptome of M. chilensiswe found two putative retrotransposons, named Steamer-like elements (MchSLEs). MchSLEs are present in the genome of M. chilensisand MchSLE1 is indeed an LTR-retrotransposon. Neither expression, nor copy number of the reported MchSLEs correlate with DN status but both are expressed at different levels among individual animals. We also report that in cultured M. chilensishaemocytes MchSLEs1 expression can be induced by bromodeoxyuridine. Conclusions: We conclude that SLEs present in Mytilus chilensisare differentially expressed among individuals and do not correlate with disseminated neoplasia. Treatment of haemocytes with a stressor like bromodeoxyuridine induces expression of MchSLE1 suggesting that in Mytilus chilensisenvironmental stressors can induce activation of LTR-retrotransposon.

Sets of marine terraces, sediments, and paleoshorelines are commonly found in forearc regions worldwide. A common assumption holds that crustal uplift prevents these features from littoral erosion. Here, we study the vertical deformation of Karpathos, a forearc island in the eastern Mediterranean, whose long axis extends at a high angle to the strike of the Hellenic Subduction System (HSS). We target three key coastal localities along the island to discuss spatial and temporal variability of vertical motion. We mapped sets of up to 19 marine terraces per locality, with elevations ranging from 1.5 to ∼350 masl. Ages for terraces and sediments are constrained by radiocarbon (<31 masl) and Sr‐isotope (2–310 masl) dating, and range from 2.4 ka to ∼4.3 Ma. Data analysis shows that average uplift rates are up to two orders of magnitude faster over shorter (⪅100 ka) than longer (⪆100 ka) timescales, in agreement with other local and global data sets. Further, we find evidence for multiple marine reoccupations of late Pleistocene terraces, indicating that carbonate beachrock is often resistant to multiple interactions with sea‐level. Neogene marine sequences that witness longer periods (∼4 Ma) show signs of alternating vertical motion. Using this novel data set, we explore the effects of various mechanisms (i.e., upper‐plate normal faulting, splay‐thrust faulting, basal underplating) on the spatial and temporal patterns of vertical deformation. Although the contribution of each mechanism to the net vertical deformation cannot be isolated with certainty, our results show that none alone could account for the observations. In this study, we focus on understanding how the landmass of Karpathos Island, in the Hellenic Subduction System in the Mediterranean Sea, moved vertically over time. We focus mainly on marine terraces, which are wave‐cut platforms near the sea forming staircase‐like topography. The age of these platforms has been constrained by dating fossil shells, shell fragments, and soils that mantle the terraces: for young (closer to the sea‐level) markers we used the isotope Carbon‐14, while for older terraces (further inland) Strontium‐87. We found that the island of Karpathos subsided prior to ∼4.3 Ma, but since then it experiences uplift. From our analysis, we find that the vertical motion of the island is the result of, at least, three interrelated processes: (a) sediment underplating, that scrapes sediments from the down‐going plate during subduction and attaches them to the base of the upper plate, pushing it upwards; (b) large earthquakes that occur either at the interface of two converging plates or on large faults that splay from this interface; and (c) smaller earthquakes produced by the horizontal stretching of the Aegean crust. Karpathos provides a natural transect across the Hellenic forearc for exploring vertical deformationNo single mechanism of vertical movement alone can explain the full range of observations and dataUnderplating, splay faulting, and normal faulting interact in space and time to produce overall uplift on Karpathos since ∼4.3 Ma Karpathos provides a natural transect across the Hellenic forearc for exploring vertical deformation No single mechanism of vertical movement alone can explain the full range of observations and data Underplating, splay faulting, and normal faulting interact in space and time to produce overall uplift on Karpathos since ∼4.3 Ma