1,195 results on '"Valera, A."'
Search Results
2. A cross-sectional analysis from a real-world cohort of patients with microsatellite instability colorectal cancer (MSI-CRC) with localized disease from the Spanish RETUD registry.
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Fernandez Montes, Ana Fernandez, Lopez, Carolina Muriel, López, Sandra, Ferriol Martinez, Candela, Paez, David, de Frutos González, Belén, Gomez Espana, Maria Auxiliadora, García-Benito, Carmé, Vidal-Tocino, Rosario, Melian Sosa, Marcos, Sastre Valera, Javier, Garcia-Alfonso, Pilar, Ghanem, Ismael, La Casta, Adelaida, Gallego, Javier, Martínez de Castro, Eva, Verdaguer, Helena, Santos, Cristina, Jimenez, Encarnacion, and Gravalos, Cristina
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- 2025
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3. Ex ante Evaluation of a Multi-Level Governance Cap Strategic Plan for Farmland Bird Conservation.
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Pozuelo, Pablo Pérez, Concepción, Elena D., Azcárate, Francisco M., Bota, Gerard, Brotons, Lluis, García, Daniel, Giralt, David, Vicente López-Bao, José, Mañosa, Santi, Morales, Manuel B., Navarro, Alberto, Olea, Pedro P., Peco, Begoña, Rey, Pedro J., Seoane, Javier, Suárez-Seoane, Susana, Schöb, Christian, Tarjuelo, Rocío, Traba, Juan, and Valera, Francisco
- Abstract
Copyright of Ardeola is the property of Sociedad Espanola de Ornitologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2025
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4. Biomarkers of oxidation, inflammation and intestinal permeability in persons with diabetes mellitus with parenteral nutrition: A multicenter randomized trial.
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Soria-Utrilla, Virginia, Sasso, Corina Verónica, Romero-Zerbo, Silvana Yanina, Adarve-Castro, Antonio, López-Urdiales, Rafael, Herranz-Antolín, Sandra, García-Almeida, José Manuel, García-Malpartida, Katherine, Ferrer-Gómez, Mercedes, Moreno-Borreguero, Alicia, Luengo-Pérez, Luis Miguel, Álvarez-Hernández, Julia, Aragón-Valera, Carmen, Ocón-Bretón, María Julia, García-Manzanares, Álvaro, Bretón-Lesmes, Irene, Serrano-Aguayo, Pilar, Pérez-Ferre, Natalia, López-Gómez, Juan José, and Olivares-Alcolea, Josefina
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Parenteral nutrition (PN) composition could play a role in the management of systemic inflammatory response and intestinal barrier disruption. We aimed to evaluate changes in biomarkers of inflammation, oxidative status and intestinal permeability in patients with type 2 diabetes mellitus (T2DM) who received different PN lipid formulas. This was a prospective study, including 94 patients with T2DM who received omega (n)-3 polyunsaturated fatty acids (PUFA)-enriched PN, a mixture of medium and long chain triglycerides (MCT/LCT) PN, or an olive oil-based PN. Serum levels of biomarkers of oxidative status, intestinal permeability and inflammation biomarkers were determined at day 1 and day 5 after PN initiation. Registered under ClinicalTrials.gov Identifier no. NCT02706119. At day 5 after the onset of PN, the MCT/LCT group had a significant reduction of 2 proinflammatory cytokines [interleukin (IL)-15, IL-17A], elevation of the anti-inflammatory cytokine IL-13 and increase of zonulin and indoxylsulfate. The olive oil group showed a statistically significant reduction of 5 proinflammatory cytokines [IL-1β, IL-17A, IL-6, cytokine-leukemia inhibitory factor (LIF) and tumor necrosis factor alpha (TNF-α)] and reduced concentrations of the anti-inflammatory cytokine IL-1RA, while the n-3 PUFA-enriched group presented a statistically significant reduction of 8 proinflammatory cytokines (interferon-gamma, IL-1β, IL-15, IL-17A, IL-6, LIF, monocyte chemoattractant protein 1, and TNF-α). In the between-group comparisons, indoxylsulfate significantly increased in the MCT/LCT group compared to the n-3 PUFA-enriched group, while 8-isoprostane and indoxylsulfate significantly increased in the MCT/LCT group compared to the other groups and superoxide dismutase significantly decreased in the MCT/LCT group compared to the other groups. In patients with T2DM, PN lipid composition exerts a profound impact on proinflammatory, prooxidative and intestinal permeability biomarkers. [ABSTRACT FROM AUTHOR]
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- 2025
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5. Muscle-Targeted Robotic Assistive Control Using Musculoskeletal Model of the Lower Limb
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Escarabajal, Rafael J., Zamora-Ortiz, Pau, Pulloquinga, Jose L., Valles, Marina, and Valera, Angel
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Conventional assistive and rehabilitative robotic systems often overlook human biomechanics, particularly muscular forces, as they predominantly operate in joint or task space and focus on position and exchanged forces. Similarly, traditional manual rehabilitation techniques employed by physiotherapists struggle to obtain quantitative measurements and make precise modifications to key human variables, resulting in predominantly qualitative methods and outcomes. In response to these limitations, this article introduces an innovative assistive robot controller that operates in the muscular space, targeting specific muscles in the lower limb, and distinguishing itself from existing solutions that focus primarily on joint or task space. A key innovation of our approach is the real-time measurement of muscular forces during dynamic tasks, obtained from a calibrated musculoskeletal model. These measurements enable the establishment of a multistep closed-loop controller, with the outer loop precisely tracking the desired muscular forces. Implemented within a configurable viscous environment, the controller provides a natural response for the user. Experimental evaluations conducted using a parallel robot designed for rehabilitation demonstrate the controller’s efficacy. Incorporating the outer loop reduced the median relative error of the tracked muscular force by nearly 80% and decreased the variability of this error by over 85% compared to a pure viscous environment defined as the baseline. These findings highlight the potential applications of this control framework in areas, such as assistive robotics and precision rehabilitation. By achieving objective measurement and control, the system may enhance rehabilitation outcomes, offering tailored exercises that match the individual needs, capabilities, and engagement of each patient.
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- 2025
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6. A Comprehensive Numerical Study on the Inhibition Effect of Ammonia on Various (Un)strained Premixed Stoichiometric Hydrogen/Air Flame Systems.
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Yu, Chunkan and Valera-Medina, Agustin
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- 2025
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7. A Comprehensive Numerical Study on the Inhibition Effect of Ammonia on Various (Un)strained Premixed Stoichiometric Hydrogen/Air Flame Systems
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Yu, Chunkan and Valera-Medina, Agustin
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This study numerically investigates the potential use of ammonia as a chemical inhibitor in hydrogen/air premixed combustion systems, aiming to reduce the risks associated with hydrogen use. Various flame configurations are explored using zero-dimensional and one-dimensional reacting models, including the homogeneous reactor, perfectly stirred reactor, unstrained premixed flame (freely propagating and quenching), and strained premixed flame in counterflow. The impact of ammonia addition on key flame behaviors, such as the ignition delay time, laminar burning velocity, flame thickness, and extinction strain rate, is evaluated. Results show that adding 20% ammonia achieves up to 50% inhibition efficiency across these metrics. Furthermore, heat release rate analysis is conducted for unstrained premixed flames during both free propagation and head-on quenching. It is found that the controlling elementary reactions contributing to the heat release rate differ significantly between these two phases. The study also examines the environmental implications of ammonia addition, particularly regarding NOx and N2O emissions. While pure stoichiometric hydrogen/air combustion produces minimal NOx and N2O, the addition of ammonia results in emissions on the order of O(103)ppm or higher, indicating significant environmental challenges. This dual focus on inhibition and emission informs future strategies to balance the efficiency and environmental impact of hydrogen combustion systems. This study emphasizes the importance of experimental validation and encourages future experiments to collect data for further research.
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- 2025
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8. Initial approach for knowing the impact of informal trade on freight trips attraction estimates
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Ortiz-Valera, Adrián Esteban and Lozano, Angélica
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The knowledge of the characteristics of a commercial area allows a better understanding of its urban freight trips, then a better freight attraction estimation and better selection and implementation of urban freight transport initiatives.
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- 2025
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9. Characterisation of white facial markings in Pura Raza Española horses (a worldwide population genetic study)
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Encina, A., Valera, M., Ligero, M., Rodriguez Sainz de los Terreros, A., and Sánchez-Guerrero, M.J.
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AbstractWhite markings are characteristic of many equine breeds, being quite common in the Pura Raza Español horses (PRE). These white markings are the result of a lack of melanocytes in the skin and hair. In certain horse breeds, such as the PRE, the presence and extension of white facial markings is penalised in the breed’s patron and morphological competitions, so it would be interesting to include it in their selection genetics programs to select against the presence of this special feature. The aim of this study was to calculate the prevalence of white facial markings in a representative population sample of PRE and determine its prevalence depending on the coat colour, its genetic parameters and the influence of systematic effects. The white facial markings have been classified into 5 score. A total of 42,080 PRE horses were analysed. Genetic parameters were estimated using a Bayesian procedure with the BLUPF90 software. Systematic effects included in the model were: birth period, sex, birth stud geographical area and inbreeding coefficient. The pedigree information included 93,322 horses. The prevalence was 34.2%. Systematics factors were significant in the presentation of facial white markings. Heritability in real scale ranged from 0.53 for black to 0.32 for the chestnut coat colour population, both in the linear heterogeneity model. White facial markings were more prevalent in inbred chestnut males of Spain. The additive genetic base shows that the prevalence could be managed by genetic selection.
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- 2024
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10. Early genetic selection of Spanish Trotter Horses by new precocity criteria
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Ripollés-Lobo, María, Perdomo-González, Davinia Isabel, Gómez, María Dolores, Molina, Antonio, and Valera, Mercedes
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AbstractNational trotting races held in Spain between 1990–2022 were used to estimate genetic para-meters for 5 precocity criteria: age at first ranked race (AFR), age when the animal reached 50% of ranked races (A50%), age when the animal reached the first 10 ranked races (A10), total number of races in which the animal has competed before the first ranked race (NRC) and percentage of first placings/year of participation (PFP), in order to evaluate their usefulness for genetic evaluation and their possible inclusion in the Spanish Trotter Horse official genetic program. A total of 176,137 records belonging to 4947 animals were used. A Bayesian multivariate BLUP animal model showed heritability values between 0.08 (NRC) and 0.44 (A10). Medium-high genetic co-rrelations were obtained between precocity traits, ranging between −0.78 (A10-PFP) and 0.96 (A50%-A10). NRC and PFP exhibited negative correlations, with the lowest range for NRC. Additionally, a Random Regression Model (RRM) was applied to PFP to evaluate changes in performance during the animals’ sporting life. Heritability values decreased slightly up to 4 years of age (0.26–0.17), with a slight increase after the age of 5 (0.22). Genetic and permanent environmental correlations between age groups were in the high range between the nearest age groups. Variations of the expected breeding values (EBV) over the trajectory of all the age groups allowed us to differentiate robust and plastic animals (animals capable of maintaining sporting potential throughout their lives or not). Correlations between the EBV estimated with both methodologies evidenced the benefits of PFP for the early selection of performance traits in STH. Therefore, the application of an RRM for the PFP trait is recommended as it has shown acceptable heritability and adequate correlations with the rest of the precocity criteria studied. The incorporation of this trait in the breed improvement program will allow breeders to have early genetic information on animal precocity potential and ensure the inclusion of more robust individuals in their mating design.
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- 2024
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11. Ecosystem services potential and soil conservation policies with emphasis on degraded pastures in Brazil
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da Costa, Adriana Monteiro, de Moura, Maise Soares, Navarro, Isadora Fonseca, da Silva, Victor Cordeiro, Pissarra, Teresa Cristina Tarlé, Valera, Carlos Alberto, Fernandes, Luís Filipe Sanches, and Pacheco, Fernando Antonio Leal
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•The correct use of soils are essential for providing different ecosystem services (ES).•Soil use must comply with its natural potential to ensure long-term preservation of ES.•Soil quality indicators should guide public policies of soil conservation, before other factors.•Implementation and monitoring of public policies are key to guarantee soil conservation.
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- 2024
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12. Research on the Cognitive Orientation to daily Occupational Performance Approach: A Bibliometric Review.
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Valera-Gran, Desirée, Delgado-Lobete, Laura, Montes-Montes, Rebeca, and Navarrete-Muñoz, Eva María
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ALLIED health education ,CLINICAL medicine ,PERIODICAL articles ,INTERPROFESSIONAL relations ,LABOR productivity ,BIBLIOGRAPHIC databases ,CITATION analysis ,INFORMATION storage & retrieval systems ,DESCRIPTIVE statistics ,AUTHORSHIP ,POPULATION geography ,EVALUATION of medical care ,OCCUPATIONAL therapy ,RESEARCH ,MEDICAL literature ,PUBLISHING ,BIBLIOMETRICS ,IMPACT factor (Citation analysis) ,DATA analysis software ,COGNITION ,ACTIVITIES of daily living - Abstract
Importance: The Cognitive Orientation to daily Occupational Performance (CO-OP) is an evidence-based intervention approach that has significantly increased in popularity over the past two decades. However, how the research literature on this topic is patterned is still unknown, so it is difficult to identify potential areas for research and clinical interest. Aims: To analyze the literature published on the CO-OP approach to provide a detailed and structured analysis of the publication patterns. Data Sources: All literature related to CO-OP included in the Web of Science database through June 15, 2024. Study Selection and Data Collection: All published studies related to CO-OP were included in the bibliometric analysis, which was conducted on the raw data retrieved from the Web of Science database using the Bibliometrix R package. Findings: The annual growth rate in CO-OP research has been 0.8%, significantly increasing from 2015 onward. Most of the research has been published in occupational therapy and rehabilitation journals by English-speaking research teams, and its scope has expanded from developmental coordination disorder to a wide range of health conditions. In addition, two main lines of research have emerged: one focusing on understanding the underlying cognitive processes involved in CO-OP and the other focusing on its clinical effectiveness. Conclusions and Relevance: Research on CO-OP has significantly increased over the past decade, and it currently encompasses a wide range of areas. This analysis may facilitate the advancement of research on and the clinical practical application of CO-OP. Plain-Language Summary: The Cognitive Orientation to daily Occupational Performance (CO-OP) is an evidence-based intervention approach that has significantly increased in popularity over the past two decades. Occupational therapists use it to improve the occupational performance of both children and adults with movement difficulties. However, it is unknown how the research literature on this topic is patterned, so it is difficult to identify potential areas for research and clinical interest. This study found that scientific literature on CO-OP has significantly increased in the past decade and that its scope has expanded from developmental coordination disorder to a wider range of health conditions, such as cerebral palsy. Moreover, research is now focused on two main questions: What are the underlying cognitive processes involved during intervention, and how effective is the CO-OP approach? These findings can be used to further improve occupational performance and participation among occupational therapy clients who struggle with motor performance and planning. This review found that scientific literature on the Cognitive Orientation to daily Occupational Performance (CO-OP) has significantly increased to include a wider range of clients, including people with developmental coordination disorder (DCD), ADHD, and cerebral palsy. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Assessing the Disruption of Health Services During the COVID-19 Pandemic Among Adults Living With HIV by Age in Essex County, NJ: A Cross-Sectional Study.
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Krause, Kristen D., Karr, Anita G., Aggarwal, Juhi, Subramhanya, Sanjana, DallaPiazza, Michelle, Swaminathan, Shobha, Valera, Pamela, Halkitis, Perry N., and Shiau, Stephanie
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At the onset of the COVID-19 pandemic, clinicians and researchers were concerned about its impact on the health of people living with HIV (PLWH). Although mitigation measures during the early part of the pandemic used telehealth, it was uncertain whether PLWH would be amenable to this type of care and whether health outcomes would be affected. PLWH actively seeking treatment at a large urban outpatient practice in Essex County, New Jersey, were interviewed from October 2020 to June 2021 about their healthrelated experiences during COVID-19. The sample was dichotomized by age (< 55 and ≥ 55). In all, participants (69.2%, n = 92) used telehealth during this period, 85.0% (n = 113) actively tested for COVID-19, with only 7% (n = 8) testing positive at the time of interview. Our findings demonstrate that PLWH who engaged with health care before the COVID-19 pandemic continued doing that and had relatively favorable health outcomes with few differences by age. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Selective Area Growth of GaN μ‑Platelets on Graphene.
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Henriques, Jonathan, Tamsaout, Dyhia, Largeau, Ludovic, Cambril, Edmond, Valera, Lucie, Jacopin, Gwénolé, Tchernycheva, Maria, Harmand, Jean-Christophe, Eymery, Joël, and Durand, Christophe
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- 2024
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15. Patient engagement in a community-partnered hybrid health-related social needs navigation intervention for adolescents and young adults with cancer (AYA-NAV).
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Khurana, Rhea, Crespo, Stephen, Alvarado, Sabrina, Raghunathan, Rohit R., Valera, Kathryn, Gallagher, Kathleen, Bradshaw, Erin, Patton, Janet, Angove, Rebekah SM, Hershman, Dawn L., and Beauchemin, Melissa P.
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- 2024
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16. AI implementation in big data: Shaping data analysis for business decisions.
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Ojeda, Angel, Valera, Juan, Medina, Enrique, Samadian, Hiva, and Padilla, Rafael
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ARTIFICIAL intelligence ,DATABASES ,DATA mining ,BIG data ,DATA science - Abstract
This research measures the association of Big data and AI, focusing on how these technologies enhance various types of data analysis critical for business decision-making. By analyzing a substantial dataset of data scientists and analysts from countries of the world, the study identifies patterns and relationships between different types of Big data, AI techniques, and the resultant data analyses. It aimed to establish the relationship between big data and artificial intelligence and the relationship between artificial intelligence and the types of data analysis for the strategies or decision-making that companies require. This research attempts to understand better how companies make decisions about how or what types of analysis are most appropriate, incorporating artificial intelligence to analyze the various data structures generated in companies. A sample of 3,574 data science and analytics specialists from countries was analyzed from a database https://www.kaggle.com. The results indicated a relationship between Big data and intelligence, as well as between artificial intelligence and different types of data analysis. 66% of data mining artificial intelligence algorithms mainly were implemented for structured data. Data mining artificial intelligence algorithms mostly analyzed 37% of diagnostic data types. 3% of prescriptive data types were analyzed mainly by text-mining artificial intelligence algorithms. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Multiplex Determination of Glycan Profiles on Urinary Prostate-Specific Antigen by Quartz-Crystal Microbalance Combined with Surface-Enhanced Raman Scattering.
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Armero, Laura, Plou, Javier, Valera, Pablo S., Serna, Sonia, García, Isabel, and Liz-Marzán, Luis M.
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- 2024
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18. UV‑A Flexible LEDs Based on Core–Shell GaN/AlGaN Quantum Well Microwires.
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Amador-Mendez, Nuno, Kochetkov, Fedor M., Hernandez, Roberto, Neplokh, Vladimir, Grenier, Vincent, Finot, Sylvain, Valera, Lucie, Duraz, Jules, Fominykh, Nikita, Parshina, Elizaveta K., Deriabin, Konstantin V., Islamova, Regina M., Herth, Etienne, Bouchoule, Sophie, Julien, François, Abraham, Malini, Das, Subrata, Jacopin, Gwénolé, Krasnikov, Dmitry V., and Nasibulin, Albert
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- 2024
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19. Structural modification and encapsulation process of palygorskite for development of flame retardant additives: study of their thermal and mechanical properties in PLA/EVA blends.
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Sánchez-Valdes, Saul, Pozos-Sanchez, Gerardo, Rodríguez-Gonzalez, Jose Alberto, Rivera-Salinas, Jorge Enrique, Uribe-Calderon, Jorge Alonso, Valera-Zaragoza, Mario, Romero-Zúñiga, Gabriela Yolatzin., Hernandez-Hernandez, Ernesto, Cabrera-ALvarez, Eedgar, and Da Silva, L.
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- 2024
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20. Study protocol for the iMarkHD study in individuals with Huntington's disease
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van Wamelen, Daniel J, Martin, Naomi H, Makos, Orsolya, Badenoch, James, Valera-Bermejo, Jose Manuel, Hartmann, Monika, Cristales, Alay Rangel, Wood, Tobias C, Veronese, Mattia, Moretto, Manuela, Zelaya, Fernando, dell’Acqua, Flavio, O’Daly, Owen, Lythgoe, David J, Ginestet, Cedric, Turkheimer, Federico, Palasits, Nikki, Mrzljak, Ladislav, Warner, John H, Rabiner, Eugenii A, Gunn, Roger, Tabrizi, Sarah J, Sampaio, Cristina, Wood, Andrew, and Williams, Steven CR
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Background:Huntington's disease (HD) is still often defined by the onset of motor symptoms, inversely associated with the size of the CAG repeat expansion in the huntingtingene. Although the cause of HD is known, much remains unknown about mechanisms underlying clinical symptom development, disease progression, and specific clinical subtypes/endophenotypes. Objective:In the iMarkHD study, we aim to investigate four discrete molecular positron emission tomography (PET) tracers and magnetic resonance imaging (MRI) markers as biomarkers for disease and symptom progression. Methods:Following MRI optimization in five healthy volunteers (cohort 1), we aim to recruit 108 participants of whom 72 are people with HD (PwHD) and 36 healthy volunteers (cohort 2). Pending interim analysis, these numbers could increase to 96 PwHD and 48 healthy controls. Participants will complete a total of 10 study visits, consisting of a screening visit followed by a clinical and MRI visit and PET visits at baseline, year 1, and year 2. PET targets include the cannabinoid 1, histamine 3, and serotonin 2A receptors, and phosphodiesterase 10A, whereas MRI will be multimodal, including, but not limited to, the assessment of cerebral blood flow, functional connectivity, and brain iron. Results:Recruitment is currently active and started in September 2022. Conclusions:By combining PET and multi-modal MRI assessments we expect to provide a comprehensive examination of the molecular, functional, and structural framework of HD progression. As such, the iMarkHD study will provide a solid base for the identification of treatment targets and novel outcome measures for future clinical trials.
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- 2024
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21. Perspectives on NOX Emissions and Impacts from Ammonia Combustion Processes.
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Mashruk, Syed, Shi, Hao, Mazzotta, Luca, Ustun, Cihat Emre, Aravind, B., Meloni, Roberto, Alnasif, Ali, Boulet, Elena, Jankowski, Radoslaw, Yu, Chunkan, Alnajideen, Mohammad, Paykani, Amin, Maas, Ulrich, Slefarski, Rafal, Borello, Domenico, and Valera-Medina, Agustin
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- 2024
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22. Perspectives on NOXEmissions and Impacts from Ammonia Combustion Processes
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Mashruk, Syed, Shi, Hao, Mazzotta, Luca, Ustun, Cihat Emre, Aravind, B., Meloni, Roberto, Alnasif, Ali, Boulet, Elena, Jankowski, Radoslaw, Yu, Chunkan, Alnajideen, Mohammad, Paykani, Amin, Maas, Ulrich, Slefarski, Rafal, Borello, Domenico, and Valera-Medina, Agustin
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Climate change and global warming necessitate the shift toward low-emission, carbon-free fuels. Although hydrogen boasts zero carbon content and high performance, its utilization is impeded by the complexities and costs involved in liquefaction, preservation, and transportation. Ammonia has emerged as a viable alternative that offers potential as a renewable energy storage medium and supports the global economy’s decarbonization. With its broader applicability in large power output applications, decentralized energy sources, and industrial locations off the grid, ammonia is increasingly regarded as an essential fuel for the future. Although ammonia provides a sustainable solution for future low-carbon energy fields, its wide-scale adoption is limited by NOXemissions and poor combustion performance under certain conditions. As research on ammonia combustion expands, recent findings reveal factors impacting the chemical reaction pathways of ammonia-based fuels, including the equivalence ratio, fuel mixture, pressure, and temperature. Investigations into ammonia combustion and NOXemissions, at both laboratory and industrial scales, have identified NOXproduction peaks at equivalence ratios of 0.8–0.9 for ammonia/hydrogen blends. The latest studies about the NOXemissions of the ammonia flame at different conditions and their generating pathways are reviewed in this work. Effective reduction in NO production from ammonia-based flames can be achieved with richer blends, which generate more NHiradicals. Other advanced NOXmitigation techniques such as plasma-assisted combustion have been also explored. Further research is required to address these challenges, reduce emissions, and improve efficiencies of ammonia-based fuel blends. Finally, the extinction limit of ammonia turbulent flame, its influential factors, and different strategies to promote the ammonia flame stability were discussed. The present review contributes to disseminating the latest advancements in the field of ammonia combustion and highlights the importance of refining reaction mechanisms, computational models, and understanding fundamental phenomena for practical implications.
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- 2024
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23. Psychometric properties of the Spanish version of the Frontal Assessment Battery (FAB-E) and normative values in a representative adult population sample
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Hurtado-Pomares, M., Juárez-Leal, I., Company-Devesa, V., Sánchez-Pérez, A., Peral-Gómez, P., Espinosa-Sempere, C., Valera-Gran, D., and Navarrete-Muñoz, E.-M.
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The Frontal Assessment Battery is a short bedside test used to assess executive functions (EF). The aims of the present study were, first, to evaluate the psychometric proprieties of the Spanish version of the FAB (FAB-E) in a representative sample, and second, to establish cut-off points for impairment in executive function according to age and education level.
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- 2024
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24. Tiempos y condiciones de almacenamiento de las muestras en anatomía patológica. Recomendaciones de la Sociedad Española de Anatomía Patológica parte 1: muestras destinadas al diagnóstico
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Tresserra Casas, Francesc, Rosello Sastre, Esther, Fernández Aceñero, María Jesús, Zaragoza Macián, Lara, Azúa Romeo, Javier, Alfaro-Cervelló, Clara, Navarro Fos, Samuel, García Fernández, Eugenia, Temprana-Salvador, Jordi, Iglesias Coma, Mar, Olivares Vegas, Francesc, Fernández Figueras, Maite, Aso Manso, Sonsoles, Aguirre Anda, José Javier, Salas Valién, José Santos, Álvarez Alegret, Ramiro, Hernández Losa, Javier, Jou Muñoz, Cristina, Dinarès Fernández, Carme, Urbano Carrillo, Marina, Béjar Valera, Javier, Chappuis de Oliveira, César, Centeno Haro, Macarena, Leiva-Cepas, Fernando, and Martínez Lorente, Antonio
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El almacenamiento correcto de muestras en el Servicio de anatomía patológica es de vital importancia para la seguridad del paciente. A pesar de ello, no existen unas recomendaciones claras sobre cuánto tiempo deben de conservarse como mínimo.
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- 2024
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25. Recomendaciones de la SEAP-IAP para la recolección, el almacenamiento y el uso de materiales biológicos de origen humano y los datos relacionados, destinados a la investigación. Consideración genérica de biobanco y revisión ético-legal (Parte II)
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Martínez Lorente, Antonio, Rosello Sastre, Esther, Jesús Fernández Aceñero, María, Zaragoza Macián, Lara, Azúa Romeo, Javier, Alfaro-Cervelló, Clara, Navarro, Samuel, García Fernández, Eugenia, Temprana-Salvador, Jordi, Iglesias Coma, Mar, Olivares Vegas, Francesc, Fernández Figueras, Maite, Aso Manso, Sonsoles, Aguirre Anda, José Javier, Salas Valién, José Santos, Álvarez Alegret, Ramiro, Hernández Losa, Javier, Jou Muñoz, Cristina, Dinarès Fernández, Carme, Urbano Carrillo, Marina, Béjar Valera, Javier, Chappuis de Oliveira, César, Centeno Haro, Macarena, Leiva Cepas, Fernando, and Tresserra Casas, Francesc
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El grupo de trabajo constituido por la SEAP-IAP aborda en esta Parte IIunas consideraciones generales y cinco consideraciones particulares a tener en cuenta cuando una muestra biológica de origen humano, proveniente de nuestros archivos, adquiere un destino distinto al habitual, en este caso para la investigación. A partir de este momento debemos conducirnos por normas, de obligado cumplimiento, tanto legales como éticas y los distintos considerandos nos dan pautas para garantizar una buena práctica, tanto del material biológico como de sus datos asociados. La labor tradicional de custodia otorgada a la anatomía patológica se aborda, como siempre, desde la responsabilidad y, además en este artículo, ajustada a su tiempo.
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- 2024
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26. UV-A Flexible LEDs Based on Core–Shell GaN/AlGaN Quantum Well Microwires
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Amador-Mendez, Nuno, Kochetkov, Fedor M., Hernandez, Roberto, Neplokh, Vladimir, Grenier, Vincent, Finot, Sylvain, Valera, Lucie, Duraz, Jules, Fominykh, Nikita, Parshina, Elizaveta K., Deriabin, Konstantin V., Islamova, Regina M., Herth, Etienne, Bouchoule, Sophie, Julien, François, Abraham, Malini, Das, Subrata, Jacopin, Gwénolé, Krasnikov, Dmitry V., Nasibulin, Albert, Eymery, Joël, Durand, Christophe, Mukhin, Ivan S., and Tchernycheva, Maria
- Abstract
Nanostructured ultraviolet (UV) light sources represent a growing research field in view of their potential applications in wearable optoelectronics or medical treatment devices. In this work, we report the demonstration of the first flexible UV-A light emitting diode (LED) based on AlGaN/GaN core–shell microwires. The device is based on a composite microwire/poly(dimethylsiloxane) (PDMS) membrane with flexible transparent electrodes. The electrode transparency in the UV range is optimized: namely, we demonstrate that single-walled carbon nanotube electrodes provide a stable electrical contact to the membrane with high transparency (70% at 350 nm). The flexible UV-A membrane demonstrating electroluminescence around 345 nm is further applied to excite Zn–Ir–BipyPDMS luminophores: the UV-A LED is combined with the elastic luminophore-containing membrane to produce a visible amber emission from 520 to 650 nm. The obtained results pave the way for flexible inorganic light-emitting diodes to be employed in sensing, detection of fluorescent labels, or light therapy.
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- 2024
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27. Surface-Enhanced Raman Scattering Monitoring of Tryptophan Dynamics in 3D Pancreatic Tumor Models.
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Valera, Pablo S., Henriques-Pereira, Margarida, Wagner, Marita, Gaspar, Vítor M., Mano, João F., and Liz-Marzán, Luis M.
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- 2024
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28. Point-of-Care Multiplex Detection of Respiratory Viruses.
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Lim, Jongwon, Koprowski, Katherine, Stavins, Robert, Xuan, Nhat, Hoang, Trung-Hieu, Baek, Janice, Kindratenko, Victoria, Khaertdinova, Liliana, Kim, Alicia Yeun, Do, Minh, King, William P., Valera, Enrique, and Bashir, Rashid
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- 2024
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29. Structural model that determines the successful implementation of e-government.
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Ojeda, Angel, Valera, Juan, and Ravelo, Irak
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CONTROL (Psychology) ,CIVIL service ,STRUCTURAL models ,INTERNET in public administration ,ATTITUDE (Psychology) - Abstract
This research aimed to identify and measure the factors that influence the implementation of e-government. The study includes the variables of perceived ease of use, perceived behavioral control, subjective norm, perceived usefulness of use, attitude towards use, interoperability, maturity, accountability, and e-government implementation. A sample of 501 participants was collected, and a multivariate structural equation analysis was performed on each effect. The research results indicated that perceived ease of use, perceived behavioral control, subjective norm, and perceived usefulness explained 69% of the attitude towards use. Maturity, accountability, interoperability, and attitude toward use measured 75.9% of e-government implementation. Increased attitude toward use, maturity, responsibility, and interoperability increases e-government implementation. The increase in maturity implies having optimized services; the increase in responsibility implies having transparency, security, and integrity; the increase in interoperability implies agility and standardization of processes; the increase in attitude towards use implies adopting technology by citizens and civil servants. [ABSTRACT FROM AUTHOR]
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- 2024
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30. Maternal non-compliance with recommended folic acid supplement use alters global DNA methylation in cord blood of newborns: A cohort study.
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Morales, Eva, Prieto-Sánchez, María Teresa, Mendiola, Jaime, Cutillas-Tolín, Ana, Adoamnei, Evdochia, Valera-Gran, Desirée, Martínez-Graciá, Carmen, Santaella-Pascual, Marina, Suárez-Martinez, Clara, Vioque, Jesús, Castaños, María Jesús, del Castillo, Eva, and García-Marcos, Luis
- Abstract
Prenatal folate exposure may alter epigenetic marks in the offspring. We aimed to evaluate associations between prenatal exposure to folic acid (FA) in preconception and in utero with cord blood DNA methylation in long interspersed nuclear element 1 (LINE-1) and Alu short interspersed nuclear elements (SINEs) as markers of global DNA methylation levels. Data come from 325 mother–child pairs participating in the Nutrition in Early Life and Asthma (NELA) birth cohort (2015–2018). Pregnant women were asked about supplement use, including brand name and dose, one month before pregnancy (preconception) and through the trimesters of pregnancy. Maternal dietary folate intake was assessed using a validated food frequency questionnaire with additional questions for FA supplement use. Folate serum levels were measured in mothers at 24 weeks of gestation and in cord blood of newborns. DNA methylation was quantitatively assessed by bisulfite pyrosequencing on 5 LINE-1 and 3 Alu different elements. Associations were estimated using multivariable linear regression models. A reduction in methylation levels of LINE-1 in newborns was associated with the use of FA supplements below the recommended doses (<400 ug/day) during preconception (−0.50; 95% CI: −0.91, −0.09; P = 0.016), and from preconception up to 12 weeks of gestation (−0.48; 95% CI: −0.88, −0.08; P = 0.018). Maternal use of FA supplements above the tolerable upper intake level of 1000 ug/day from preconception until 12 weeks of gestation was also related to lower methylation in LINE-1 at birth (−0.77; 95% CI: −1.52, −0.02; P = 0.044). Neither FA supplement use after 12 weeks of gestation nor maternal total folate intake (diet plus supplements) were associated with global DNA methylation levels at birth. Maternal non-compliance with the use of FA supplement recommendations from preconception up to 12 weeks of gestation reduces offspring global DNA methylation levels at birth. [ABSTRACT FROM AUTHOR]
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- 2024
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31. TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging
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Sebastián, David, Beltrà, Marc, Irazoki, Andrea, Sala, David, Aparicio, Pilar, Aris, Cecilia, Alibakhshi, Esmaeil, Rubio-Valera, Maria, Palacín, Manuel, Castellanos, Juan, Lores, Luis, and Zorzano, Antonio
- Abstract
ABSTRACTSarcopenia is a major contributor to disability in older adults, and thus, it is key to elucidate the mechanisms underlying its development. Increasing evidence suggests that impaired macroautophagy/autophagy contributes to the development of sarcopenia. However, the mechanisms leading to reduced autophagy during aging remain largely unexplored, and whether autophagy activation protects from sarcopenia has not been fully addressed. Here we show that the autophagy regulator TP53INP2/TRP53INP2 is decreased during aging in mouse and human skeletal muscle. Importantly, chronic activation of autophagy by muscle-specific overexpression of TRP53INP2 prevents sarcopenia and the decline of muscle function in mice. Acute re-expression of TRP53INP2 in aged mice also improves muscle atrophy, enhances mitophagy, and reduces ROS production. In humans, high levels of TP53INP2 in muscle are associated with increased muscle strength and healthy aging. Our findings highlight the relevance of an active muscle autophagy in the maintenance of muscle mass and prevention of sarcopenia.Abbreviation: ATG7: autophagy related 7; BMI: body mass index; EIF4EBP1: eukaryotic translation initiation factor 4E binding protein 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; ROS: reactive oxygen species; TP53INP2: tumor protein p53 inducible nuclear protein 2; WT: wild type
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- 2024
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32. Social Determinant of Health Framework to Examine the Impact of COVID-19 on Latino Health
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Acevedo, Sebastian, Malarkey, Sarah, Baquerizo, Humberto, Lefebre, Asia, Sackey, Joachim, and Valera, Pamela
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Objectives: Evaluated how COVID-19 impacted Latino health across social, economic, and emotional dimensions and differentiated whether adverse COVID-19-related effects persisted across respondents. Methods: In both English and Spanish, a cross-sectional survey was conducted in the USA from June 2021 to April 2022. Chi-square tests, Z-tests, and T-tests were used to test for significant differences between Spanish- and English-speaking respondents. Multiple linear regressions were carried out to understand whether previously established determinants of health for Latinos accounted for greater COVID-19-related adversity across social, economic, and mental health dimensions. English as a primary language was significantly related to greater adverse emotional/mental health COVID-19 experiences after controlling for other social determinants of health factors (β= − 0.355, p< 0.001). Individuals who reported worrying about housing loss were significantly more likely to experience more adverse economic adversity due to COVID-19 (β= − 0.234, p< 0.001). Household income < $35,000 (β= 0.083, p< 0.05), having more than 5 people living in the same home (β= −0.102, p< 0.05), and work-related transportation barriers (β= − 0.114, p< 0.05) all increased the likelihood of household-related stressors occurring because of the pandemic. Conclusions: The study highlights the heterogeneity in the Latino community and the key social, economic, and community-level factors most strongly correlated with adverse COVID-19-related outcomes.
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- 2024
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33. Alternatives to the Gold Standard: A Systematic Review of Profunda Artery Perforator and Lumbar Artery Perforator Flaps for Breast Reconstruction
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Minkhorst, Kathryn, Castanov, Valera, Li, Erica Ai, Farrokhi, Kaveh, Jaszkul, Katrina M., AlGhanim, Khalifa, DeLyzer, Tanya, and Simpson, Andrew M.
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- 2024
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34. Fossil or non‐fossil? A best‐practice guide for archaeobotanical taxa.
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Rivera, Diego, Ferrer‐Gallego, P. Pablo, Obón, Concepción, Alcaraz, Francisco, Valera, Javier, Goncharov, Nikolay P., Laguna, Emilio, and Kislev, Mordechai
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FOSSILS ,PLANT remains (Archaeology) ,HERBARIA - Abstract
Can archaeobotanical material be treated as a nomenclatural type of a fossil taxon? Here we show that archaeobotanical taxa should be named according to the rules for non‐fossil taxa. Examples of archaeobotanical taxa are summarized and discussed. A best‐practice guide for the correct treatment of archaeological plant remains as the type of a new name is presented. [ABSTRACT FROM AUTHOR]
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- 2024
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35. Research for city practice
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Grant, Marcus and Valera Sosa, Alvaro
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- 2024
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36. Neural networks implementation for the environmental optimisation of the recycled concrete aggregate inclusion in warm mix asphalt
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Polo-Mendoza, Rodrigo, Martinez-Arguelles, Gilberto, Peñabaena-Niebles, Rita, and Covilla-Valera, Elvis
- Abstract
Regarding the traditional Hot Mix Asphalt (HMA), Warm Mix Asphalt (WMA) with Recycled Concrete Aggregate (RCA) contents (WMA-RCA) requires lower production temperatures and diminishes the consumption of natural aggregates (NAs). Nonetheless, these environmental benefits may be counteracted by the higher optimal asphalt binder demanded by the WMA-RCAs. In this regard, this research develops a computational model to optimize the WMA-RCA design. In order to build a sufficiently accurate and adaptable model, it was decided to employ Artificial Neural Networks (ANNs). The ANN implementation was based on the postulates of the statistical learning theory, i.e., preferring to generate learning through low-complexity models. Also, a representative case study of the northern region of Colombia was assessed. In this scenario, the optimal coarse RCA content was 10%, and the sustainability savings were maintained up to an RCA's hauling distance of 200 km.
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- 2024
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37. Fossil or non‐fossil? A best‐practice guide for archaeobotanical taxa
- Author
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Rivera, Diego, Ferrer‐Gallego, P. Pablo, Obón, Concepción, Alcaraz, Francisco, Valera, Javier, Goncharov, Nikolay P., Laguna, Emilio, and Kislev, Mordechai
- Abstract
Can archaeobotanical material be treated as a nomenclatural type of a fossil taxon? Here we show that archaeobotanical taxa should be named according to the rules for non‐fossil taxa. Examples of archaeobotanical taxa are summarized and discussed. A best‐practice guide for the correct treatment of archaeological plant remains as the type of a new name is presented.
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- 2024
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- View/download PDF
38. Persistence of post-COVID symptoms in the general population two years after SARS-CoV-2 infection: A systematic review and meta-analysis.
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Fernandez-de-las-Peñas, Cesar, Notarte, Kin Israel, Macasaet, Raymart, Velasco, Jacqueline Veronica, Catahay, Jesus Alfonso, Ver, Abbygail Therese, Chung, William, Valera-Calero, Juan A., and Navarro-Santana, Marcos
- Abstract
This meta-analysis investigated the prevalence of post-COVID symptoms two-years after SARS-CoV-2 infection. Electronic literature searches on PubMed, MEDLINE, CINAHL, EMBASE, Web of Science databases, and on medRxiv/bioRxiv preprint servers were conducted up to October 1, 2023. Studies reporting data on post-COVID symptoms at two-years after infection were included. Methodological quality was assessed using the Newcastle-Ottawa Scale. Random-effects models were used for meta-analytical pooled prevalence of each symptom. From 742 studies identified, twelve met inclusion criteria. The sample included 7912 COVID-19 survivors (50.7% female; age: 59.5, SD: 16.3). Post-COVID symptoms were assessed at a follow-up of 722.9 (SD: 51.5) days after. The overall methodological quality of studies was moderate (mean: 6/10, SD: 1.2 points). The most prevalent post-COVID symptoms two-years after SARS-CoV-2 infection were fatigue (28.0%, 95%CI 12.0–47.0), cognitive impairments (27.6%, 95%CI 12.6–45.8), and pain (8.4%, 95%CI 4.9–12.8). Psychological disturbances such as anxiety (13.4%, 95%CI 6.3–22.5) and depressive (18.0%, 95%CI 4.8–36.7) levels as well as sleep problems (20.9%, 95%CI 5.25–43.25) were also prevalent. Pooled data showed high heterogeneity (I
2 ≥ 75%). This meta-analysis shows the presence of post-COVID symptoms in 30% of patients two-years after COVID-19. Fatigue, cognitive disorders, and pain were the most prevalent post-COVID symptoms. Psychological disturbances as well as sleep problems were still present two-years after COVID-19. • The prevalence of post-COVID symptoms is 30% two-years after COVID-19. • Fatigue, cognitive disorders, and pain are the most prevalent post-COVID symptoms two-years after. • The prevalence of anxiety, depression and sleep problems reaches 20% two-years after COVID-19. [ABSTRACT FROM AUTHOR]- Published
- 2024
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39. Minimal Clinically Important Differences in Hand Pain Intensity (Numerical Pain Rate Scale) and Related-Function (Boston Carpal Tunnel Questionnaire) in Women With Carpal Tunnel Syndrome.
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López-de-Uralde-Villanueva, Ibai, Fernández-de-las-Peñas, César, Cleland, Joshua A., Cook, Chad, de-la-Llave-Rincón, Ana I., Valera-Calero, Juan Antonio, and Plaza-Manzano, Gustavo
- Abstract
To calculate the minimal clinically important differences (MCIDs) for hand pain intensity and the Boston Carpal Tunnel Questionnaire (BCTQ) in a sample of women with carpal tunnel syndrome (CTS). Secondary analysis of a randomized controlled trial. A Hospital Rehabilitation Unit. One hundred twenty women with clinical and electromyographic diagnosis of CTS who were randomly assigned into 2 groups (N=120). One group received 3 sessions of manual physical therapy (n=60) and the other group received surgery (n=60). Mean and the worst pain intensity (numerical pain rate scale, 0-10 points) and functional status and symptoms' severity subscales of the BCTQ questionnaire were assessed before and 1 month after treatment. The Global Rating of Change (GROC) was used as the anchor variable for determining the MCID. A change of 1.5 and 2.5 points in mean and the worst pain intensity represents the MCID for Numerical Pain Rating Scale, whereas a change of 0.23 and 0.64 points in functional status and symptoms' severity represents the MCID for each subscale of the BCTQ. All variables showed acceptable discrimination between patients classified as "improved" and those classified as "stable/not improved" (area under the curve≥0.72). Mean pain intensity (Youden index, 0.53; sensitivity: 73.3%; specificity: 80%) and symptoms' severity (Youden index, 0.69; sensitivity: 90%; specificity: 77.8%) showed the best discriminative ability expressed as a percentage of prediction. Participants classified as "improved" had significantly greater improvements in pain intensity, functional status, and symptoms' severity compared with those classified as "stable/not improved". A change of 1.5 and 2.5 points in mean and the worst pain and a change of 0.23 and 0.64 points in functional status and symptoms' severity represents the MCID for pain intensity and BCTQ in women with CTS 1 month after treatment. [ABSTRACT FROM AUTHOR]
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- 2024
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40. UN PASEO POR LA FILOSOFÍA AMBIENTAL: LA BELLEZA DE LA NATURALEZA COMO VALOR ÉTICO.
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Valera, Luca and Giorgianni, Emanuela
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AESTHETICS ,HUMAN beings ,REFERENCE values ,MORIN ,ENVIRONMENTAL ethics - Abstract
Copyright of Estudios Filosóficos is the property of Estudios Filosoficos and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
41. The influence of inhibitors of apoptosis proteins (IAPs) on chronic rhinosinusitis with nasal polyps.
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Passos, Ivna M., Tamashiro, Edwin, Fantucci, Marina Z., Murashima, Adriana A. B., Silva, Lílian E. C. M., Garcia, Denny M., Faria, Francesca M., Martins, Ronaldo B., Arruda, Eurico, Anselmo-Lima, Wilma T., and Valera, Fabiana C. P.
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- 2024
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42. Smell loss associated with SARS-CoV-2 is not clinically different from other viruses: a multicenter cohort study.
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Menon Miyake, Marcel, Pereira Valera, Fabiana Cardoso, Bragança Martins, Ronaldo, Mattoso Compagnoni, Inaê, Zilio Fantucci, Marina, Batista Murashima, Adriana de Andrade, Costa Mendes da Silva, Lilian Eslaine, Melquiades de Lima, Thais, Oliveira de Souza, Maria Vitória, Rezende Melo, Stella, Lutaif Dolci, Ricardo Landini, Gomes Floriano, Caio, Correia de Campos, Carlos Augusto, Nakanishi, Marcio, Magalhães Freire, Gustavo Subtil, Lima Valente, André, Aurélio Fornazieri, Marco, Barbosa da Silva, José Lucas, Kanieski Anzolin, Lucas, and Abrão Issa, Maria Júlia
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- 2024
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43. Predictors and outcomes of acute kidney injury after bariatric surgery: analysis of the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program data registry.
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Valera, Roberto J., Sarmiento-Cobos, Mauricio, Montorfano, Lisandro, Khan, Mustafa, Lo Menzo, Emanuele, Szomstein, Samuel, and Rosenthal, Raul J.
- Abstract
Acute kidney injury (AKI) after surgery increases long-term risk of kidney dysfunction. The major risk factor for AKI after bariatric surgery is having preoperative renal insufficiency. Little is known about the outcomes and risk factors for developing AKI in patients undergoing bariatric surgery with normal renal function. We aimed to describe factors that may increase risk of AKI after primary bariatric surgery in patients without history of kidney disease. Academic hospital, United States. We performed a retrospective analysis of the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program data registry for patients aged ≥18 years undergoing laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass (LRYGB) from 2015 to 2019. Patients with diagnosis of chronic kidney disease were excluded. The primary outcome was incidence of AKI. Secondary outcomes included 30-day complications, readmissions, reoperations, and mortality. Univariate and multivariate analyses were performed to identify differences between patients with and without AKI. A total of 747,926 patients were included in our analysis (laparoscopic sleeve gastrectomy = 73.1%, LRYGB = 26.8%). Mean age was 44.40 ± 11.94 years, with female predominance (79.7%). AKI occurred in 446 patients (.05%). Patients with postoperative AKI had higher rates of complications, readmissions, reoperations, and mortality. Significant predictors of AKI were male sex, history of venous thromboembolism, hypertension, limitation for ambulation, and LRYGB. High albumin levels and White race were protective factors. New-onset AKI was associated with adverse 30-day outcomes in patients undergoing bariatric surgery. Male sex, venous thromboembolism, hypertension, limited ambulation, and LRYGB were independent predictors of AKI. Prospective studies are needed to better describe these results. • New onset of AKI was associated with adverse 30-day outcomes in patients undergoing bariatric surgery. • Cardiovascular comorbidities and gastric bypass are independent predictors of AKI. • Postoperative AKI after bariatric surgery has been associated with increased morbidity, mortality, and long-term kidney dysfunction. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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44. The Igarapé Weir decelerated transport of contaminated sediment in the Paraopeba River after the failure of the B1 tailings dam (Brumadinho).
- Author
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Salgado Terêncio, Daniela Patrícia, Leal Pacheco, Fernando António, Farias do Valle Junior, Renato, Abreu Pires de Melo Silva, Maytê Maria, Tarlé Pissarra, Teresa Cristina, Carvalho de Melo, Marília, Valera, Carlos Alberto, and Sanches Fernandes, Luís Filipe
- Abstract
The B1 dam of Córrego do Feijão Mine, owned by Vale, S.A. mining company and located on the Ferro-Carvão stream, collapsed and injected 2.8 Mm
3 of clayey, silty, and sandy iron- and manganese-rich tailings into the Paraopeba River (Minas Gerais state, Brazil). The accident occurred on 25 January 2019 and the tailings have been co-transported with coarser natural sediment since then, being partly trapped in the Igarapé Weir reservoir located on the Paraopeba River nearly 45 km downstream the injection point. The general purpose of the current study was to model suspended sediment transport in the vicinity of the Igarapé Weir aiming to assess the concomitant barrier effect imposed by this structure. Specifically, the spatial distributions of suspended clay, silt, and very fine-grained sand fractions (CSS) of sediment were mapped around the Igarapé Weir under low-flow (16 m3 /s) and high-flow (5 to 10,000 years return period stream discharge; 699–2,699 m3 /s) regimes, using RiverFlow2D as the modelling tool. The concentrations of the various grain materials in the upstream and downstream sectors were quantified linking the barrier effect to concentration reductions in the direction of stream flow. It was also a study goal to calculate differences of iron and manganese concentrations in the sediment + tailings mixtures along the Paraopeba River. The study results showed reductions in the CSS between 6.6% and 18%, from upstream to downstream of the Igarapé Weir, related with backwater effects, free and submerged hydraulic jumps, bank sedimentation in periods of high flow, and streambed sedimentation controlled by channel sinuosity and tailings density. These reductions were accompanied by drops in the concentrations of iron and manganese present in the clay and silt fractions, which varied between 6% and 42% under low flows and between 16% and 44% under high flows. Bank sedimentation was viewed as a potential threat to the riparian vegetation in the long-term. Dredging is the potentially most effective mitigation measure to help lead the Paraopeba River to a pre-rupture condition. The retention of sediment + tailings transported in suspension is less effective than the trapping of bedload sediment + tailings behind the Igarapé weir. The efficacy of sediment trapping is expected to be larger for natural sediment because it is much coarser than the tailings. In that context, the simulations revealed for the low-flow period that 33.6% of the sediment deposition comprised suspended transport of natural sediment (thus, was comprised 66.4% of bedload transport), this proportion rose to 86.9% for mixtures of natural sediment + tailings, a result that did not differ much for the high-flow periods. [Display omitted] • The Igarapé weir effectively retained B1 dam tailings composed of clay and silt; • The capacity to retain suspended clay+silt+very fine-grained sand was 6 – 18%; • The concomitant retention of Fe and Mn can reach nearly 50%; • The barrier effect relates with backwater effects, hydraulic jumps and bank sediment sedimentation; • Bank sedimentation is a threat to riparian vegetation and dredging a potentially effective mitigation measure; [ABSTRACT FROM AUTHOR]- Published
- 2023
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45. The impact of bariatric surgery on hospitalization due to peripheral artery disease and critical limb ischemia: a nationwide analysis.
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Valera, Roberto J., Sarmiento-Cobos, Mauricio, Montorfano, Lisandro, Patnaik, Ronit, Hong, Liang, Lo Menzo, Emanuele, Szomstein, Samuel, and Rosenthal, Raul J.
- Abstract
Severe obesity could be an independent risk factor for peripheral artery disease (PAD) and critical limb ischemia (CLI). Bariatric surgery reduces cardiac risk factors, decreasing cardiovascular morbidity and mortality in subjects with severe obesity. We aimed to describe the impact of bariatric surgery on risk of hospitalization due to PAD and CLI. Academic hospital. The National Inpatient Sample data collected from 2010 to 2015 were examined. Patients were classified as treatment and control groups. Treatment was defined as patients with a previous history of bariatric surgery, and control was defined as patients with a body mass index ≥35 without a history of bariatric surgery. The primary outcome was hospitalization due to PAD; secondary outcomes were CLI, revascularization, major amputation, length of hospital stay (LOS), and total cost of hospitalization. Univariate and multivariate analyses were performed to assess the differences between groups. There were a total of 2,300,845 subjects: 2,004,804 controls and 296,041 treatment patients. Hospitalization rate for PAD was significantly lower compared to the control group (.10% versus.21%, P <.0001), which was confirmed after adjusting for covariables (control versus treatment: odds ratio= 1.20, confidence interval: 1.15-1.47). Subgroup analysis showed patients without a history of bariatric surgery had a higher prevalence of CLI (59.3% versus 52.4%, P <.0219) and a higher mean LOS (6.7 versus 5.7 days, P =.0023) and cost of hospitalization (78.756 versus 72.621$, P =.0089), with no significant differences in other outcomes. After multivariate analysis, only LOS and total costs were significantly different. Bariatric surgery may decrease the risk of hospitalization due to PAD, similarly to the LOS and total cost of hospitalization. Prospective studies should be performed to describe this relationship. • Bariatric Surgery may decrease the risk of hospitalization due to Peripheral Artery Disease. • Length of hospital stay and cost of hospitalization, is significantly decreased in patients with history of Bariatric Surgery. • The prevalence of Critical limb ischemia is significantly lower in patients who had undergone bariatric surgery interventions. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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46. Microstructure and Tribological Behavior of Plasma Sprayed (Ti,Cr)C-Ni Composite Coatings
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Storozhenko, Maryna, Umanskyi, Oleksandr, Melnyk, Oleksiy, Terentyev, Oleksandr, Chevychelova, Tatiana, Varchenko, Viktor, Koval, Oleksandr, Brazhevsky, Valera, and Chernyshov, Oleksandr
- Abstract
Thermally sprayed cermet coatings are widely used in many engineering applications to protect against wear and corrosion. In this study, three kinds of (Ti,Cr)C-based powders with 18, 25, 33 wt.% content of Ni binder were deposited onto stainless steel substrates by plasma spraying technique. The microstructure and dry sliding wear resistance of the (Ti,Cr)C-Ni coatings were investigated. The (Ti,Cr)C-Ni coatings have a heterogeneous structure composed of (Ti,Cr)C particles and Ni binder. Fracture and partial dissolution of the (Ti,Cr)C particles were found to occur during the plasma spray process. Among all the tested coatings, (Ti,Cr)C-33wt.%Ni coating exhibits lower wear rates and friction coefficients under all conditions. Worn surfaces of the coatings were analyzed using SEM to investigate the wear mechanism. With the increase in Ni content from 18 up to 33wt.%Ni wear mechanism of the (Ti,Cr)C-Ni coatings changes from abrasive to tribo-oxidation.
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- 2024
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47. Influence of Ni Content on Microstructure and Hardness of Nickel-Graphite Abradable Seal Coatings Produced by Plasma Spraying
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Umanskyi, Oleksandr, Kushchev, Oleksiy, Storozhenko, Maryna, Martsenyuk, Iryna, Terentyev, Oleksandr, Brazhevsky, Valera, Kostiunik, Ruslan, Chernyshov, Oleksandr, and Mosina, Tetyana
- Abstract
The influence of the initial shape of graphite powder and Ni content on the structure and properties of the nickel-graphite powders and plasma-sprayed coatings is investigated. The irregularly and spherically shaped graphite powders were produced by mechanical crushing and mechanical crushing with rolling, respectively. It is shown, that spherically shaped graphite powder has advantages in flowability and better deposition of Ni layer. The nickel-graphite core-shell powders with 50 and 75 wt.% Ni content were used to deposit coatings by plasma spraying. The composition, structure, and hardness of the nickel-graphite coatings were studied.
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- 2024
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48. Modified Frailty Index Predicts Postoperative Complications Following Parastomal Hernia Repair
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Khan, Mustafa, Patnaik, Ronit, Lue, Melinda, Dao Campi, Haisar, Montorfano, Lisandro, Sarmiento Cobos, Mauricio, Valera, Roberto J., Rosenthal, Raul J., and Wexner, Steven D.
- Abstract
Background The 5-factor frailty index (5-mFI), validated frailty index with Spearmen rho correlation of .95 and C statistic >.7 for predicting postoperative complications, can be preoperatively used to stratify patients prior to parastomal hernia repairs.Methods Retrospective review of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database identified patients from 2015 to 2020. 5-mFI scores were calculated by adding one point for each comorbidity present: diabetes mellitus, congestive heart failure (CHF), hypertension requiring medication, severe chronic obstructive pulmonary disease (COPD), non-independent functional status. Primary endpoint was 30-day overall complications; secondary endpoints were 30-day readmission, reoperation, and discharge to care facility.Results 2924 (52.2% female) patients underwent elective parastomal hernia repair. Univariate analysis showed 5-mFI >2 had higher rates of overall (P= .008), pulmonary (P= .002), cardiovascular (P= .003)), hematologic (P= .003), and renal (P= .002) complications and higher rates of readmission (P= .009), reoperation (P= .001), discharge to care facility (P< .001), and death (P< .001). Multivariate analysis identified a 5-mFI of 2 or more as an independent risk factor for overall complications [OR: 1.40, 1.03-1.78; P= .032], pulmonary complications [2.97, 1.63-5.39; P< .001], hematological complications [1.60, 1.03-2.47; P= .035], renal complications [2.04, 1.19-3.46; P= .009], readmission [1.54, 1.19-1.99; P <.001], and discharge to facility [2.50, 1.66-3.77; P< .001]. Reoperation was not signification on multivariate analysis.Conclusions Parastomal hernia repair patients with 5-mFI score of >2 had higher risk of renal, cardiovascular, pulmonary, and hematologic complications, readmissions, longer hospitalization, discharge to care facility, and mortality, and can be useful during preoperative risk stratification.
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- 2024
- Full Text
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49. Sleep and mental health among youth experiencing homelessness: A retrospective pilot diary study
- Author
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Budescu, Mia, Reid, Anne, Sisselman-Borgia, Amanda, Holbrook, Nicole, Valera, Dania, and Torino, Gina C.
- Abstract
The goal of this study was to describe the nightly sleep conditions of youth experiencing homelessness, and examine the association between sleep and mental health, both cross-sectionally and using diary data.
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- 2024
- Full Text
- View/download PDF
50. Deciphering gypsum reuse through green composites development and the effect of three different bioplasticizers on their properties
- Author
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Colina, Grecia G., Souza, Alana G., Rosa, Derval S., da Silveira, Éder B., Valera, Ticiane S., and Wiebeck, Hélio
- Abstract
Graphical Abstract:
- Published
- 2024
- Full Text
- View/download PDF
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