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The HIV Prevention Trials Network (HPTN) 083 trial showed that long-acting injectable cabotegravir was more effective than tenofovir disoproxil fumarate plus emtricitabine in preventing HIV in cisgender men and transgender women who have sex with men. We aimed to characterise the cohort of transgender women included in HPTN 083.

Lunar intrusive igneous domes have not been the center of much research in the past due to their rare occurrence on the lunar surface, and the difficulty in locating them. Most of the known structures were discovered using images with low illumination angles, including data from the Lunar Orbiter, telescopic images, and photos taken during the Apollo Missions. These intrusive domes are characterized by an oval shape and low slopes. We analyzed one of these systems, the Valentine domes, located near the rim of the western Serenitatis basin, with modern techniques and data sets from the Lunar Reconnaissance Orbiter (LRO) and Chandrayaan‐1 missions. We created a geostratigraphic map of the area, combining geomorphological and spectral classifications. The aspect map (direction of the slope) proved to be the most suitable product to locate and delimit these structures; using it, we identified a new dome southeast of the principal body, suggesting that the intrusive system is larger than previously thought. It was found that the three domes can be classified as laccoliths, and that several derived structures such as rilles, dykes, and secondary domes represent different stages of intrusive activity in the area. Based on crater counting analysis, we determined that the intrusive activity began after 2.98 ± 0.15 Ga and lasted at least until 1.88 ± 0.5 Ga ago. Igneous intrusive domes have not been extensively studied, in part due to their rare occurrence on the lunar surface. In this work, we used data derived from the Lunar Reconnaissance Orbiter (LRO) and Chandrayaan‐1 to analyze and construct a comprehensive map of the Valentine Domes system near the rim of the Serenitatis basin, a group of small hills formed from the cooling and emplacement of magma below the surface. This type of dome is difficult to identify from satellite imagery due to its subtle effect on the topography; however, using modern data sets, we discovered a new dome, while also studying those that are already known. The detailed mapping allowed us to identify several smaller structures around the main domes, which proved that the system is more complex and bigger than previously thought. Our analyses suggest that the igneous system was active at least until 1.8 Ga ago. A new intrusive dome was discovered using high‐resolution data from the Narrow Angle Camera (NAC) on board the Lunar Reconnaissance Orbiter (LRO)Smaller intrusive structures on top of the main domes are aligned with each other and share spectral propertiesFrom the crater count analysis of the system, it was found that the intrusion was active at least from 2.8 to 1.8 Ga A new intrusive dome was discovered using high‐resolution data from the Narrow Angle Camera (NAC) on board the Lunar Reconnaissance Orbiter (LRO) Smaller intrusive structures on top of the main domes are aligned with each other and share spectral properties From the crater count analysis of the system, it was found that the intrusion was active at least from 2.8 to 1.8 Ga

The purpose of this article was to determine the change in the volume of pacemaker implantations with the COVID‐2019 pandemic and to assess the change in the number of pacemaker implants according to etiology during the pandemic. The establishment of a mandatory social isolation have generated a decrease in activities in cardiology units. Descriptive, cross‐sectional study that used a database of a Peruvian Hospital. Time was divided into three categories: Before COVID period and COVID period including Previous to Social isolation (SI) and Social Isolation. The number of pacemaker implantations were compared per the same amount of time. A reduction in the pacemaker implant of 73% (95% CI: 33‐113; P< .001) was observed during the COVID‐19 pandemic period, and a reduction of 78% of patients with the diagnosis of complete or high‐grade atrioventricular block and a reduction in the de‐novo pacemaker implant was observed, regardless of the etiology. Our results indicate a very significant reduction (73%) in de‐novo pacemaker implantation during the months of the COVID‐19 pandemic. The reduction in the number of de‐novo pacemaker occurred independent of the etiology. This article reports the reduction of de‐novo pacemaker implants in a Peruvian hospital due to the COVID‐19 pandemic. The reduction in the number of de‐novo pacemaker occurred independently of the etiology.

Antiretroviral therapy (ART) management is challenging for individuals in resource-limited settings presenting for third-line treatment because of complex resistance patterns, partly due to reduced access to viral load monitoring. We aimed to evaluate use of newer antiretroviral drugs and contemporary management approaches, including population-based sequencing, to select appropriate antiretrovirals, plasma viral load monitoring, and interventions to improve adherence in individuals presenting with second-line viral failure.

Leadless pacing has recently emerged as a promising therapy. The impact of frailty on the prognosis of these patients is currently unknown.

Aims and background To compare the results on disease control and toxicity of two different schedules of adjuvant combined treatment in advanced rectal cancer.Methods From January 1995 to September 1998, 127 patients with stage B2-C rectal cancer were treated with postoperative chemotherapy and radiotherapy with two different schemes: three cycles of 5-fluorouracil and leucovorin followed by pelvic radiotherapy and three weeks after radiation therapy was completed, another three cycles of chemotherapy were administered (alternating arm), or two cycles of 5-fluorouracil and leucovorin followed by concurrent radiochemotherapy and three weeks after ending another two cycles of 5-fluorouracil and leucovorin were administered (concomitant arm).Results Grade 3 acute toxicity was more frequent in the concomitant schedule group (33% vs 13%, P = 0.014). In the alternating schedule group, the acute adverse effects were observed after an average radiation dose of 28.4 Gy and in the concomitant schedule group after an average dose of 22.7 Gy (P = 0.012). In the arm of concomitant treatment, 37.8% of patients had to interrupt the irradiation for severe toxicity compared to 10.4% in the arm of alternating treatment (P = 0.001). There was no difference in the rate of late toxicity. The actuarial overall survival rates at 3 and 5 years were, respectively, 68.8% and 56.6% in the alternating arm and 75.5% and 61.8% in the concomitant arm (P = 0.4599). There were no differences between the two arms in the 5-year actuarial rates of overall recurrence (47% vs 51.3%, P= 0.722), local recurrence (34.6% vs 35.7%, P = 0.935) or distant recurrence (32.7% vs 31.8%, P = 0.983).Conclusions For patients with B2-C rectal cancer, postoperative treatment with an alternating scheme of chemoradiotherapy is as effective as a concomitant scheme in control of the disease. The concomitant scheme had a higher incidence, earlier appearance and higher severity of intestinal acute toxicity than the alternating scheme, with a lower completion rate of chemoradiotherapy but without any influence on late toxicity incidence.

Aims and background To assess the efficacy of orgotein in the treatment of acute secondary effects of radiotherapy on head and neck tumors.Material and methods Data were collected on 41 patients who received radiotherapy for tumors of the head and neck. Radiotherapy was the exclusive treatment in 19.5% of cases, with surgery in 24.4%, chemotherapy in 48.8%, and with both in 7.3%. The toxicity requiring use of orgotein was: oropharynx mucositis (26.8%), dysphagia (34.2%), or both (39%), in grade 2 or more according to the RTOG scale. Orgotein (8 mg im) was administered every 48 hrs until radiotherapy was finished.Results The overall response rate was 92.5%; a complete response was obtained in 12 patients (30%) and partial in 25 (62.5%). The reduction in toxicity at the end of radiotherapy was one grade in 18 patients (45%), 2 grades in 16 (40%), 3 in 2 patients (5%), and 4 grades in the only patient with grade 4 acute toxicity. A statistically significant influence was shown in obtaining complete response: laryngeal tumor location (P = 0.037), duration of radiotherapy of more than 53 days (P = 0.002), discontinuation for non-toxic reasons (P = 0.008).Conclusions We consider that orgotein is highly effective in dealing with acute secondary effects of radiotherapy on the head and neck area.

Two intrabony pockets on teeththat were to be extracted for prosthetic reasons, in two patients, were treated by means of papilla preservation flaps and implantation with porous hydroxylapatite. The teeth, with a portion of their periodontium, were extracted 5 and 6 months after treatment and processed histologically. Both cases showed the implants invaded by connective tissue, which was actively forming bone. There was no inflammatory reaction triggered by the implant material, although there was some recurrence of inflammation in the vicinity of the pocket wall. The junctional epithelium in both cases extended slightly beyond the coronal level of the implant. One of the cases had an abundant new cementum formation with fibrous tissue next to the implant, that appeared to be a rebuilt attachment of collagen fibers. Although some multinucleated giant cells were found in the pores and next to the newly formed bone, the implanted material did not appear to be resorbed in the period of time studied.

Antigenic competition in CD4+T cell responses occurs in HIV vaccine recipients.