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To compare oncological outcomes of women with stage II -IIIc endometrial cancer (EC) who underwent minimally invasive surgery (MIS) versus laparotomy. A retrospective cohort study. Academic multi-center. Consecutive women with EC treated at 11 Israeli institutions between 2002 and 2017 were recorded in an assimilated database with a median follow-up of 52 months (range 12-120 months). Women with stage II -IIIc were stratified into groups by intentional route of surgery; MIS vs. laparotomy. Clinical, pathological and outcome data were compared. MIS and laparotomy. Three hundred and four women met criteria: 200 underwent laparotomy and 104 MIS. Women in the MIS group were younger, had lower rate of diabetes and lower CA-125 level. Women who underwent laparotomy had higher grade EC and more advanced stage disease; Odds Ratio (OR) and 95% Confidence Interval (CI) 0.34 (0.21-0.56) and 0.56 (0.34-0.92), respectively. Brachytherapy rate was comparable between groups (p=0.715). In a multivariable analysis, including age, comorbidities, disease stage, tumor grade and lymph-vascular space invasion, MIS was not associated with an increased risk for recurrence, progression or decreased overall survival. However, patients operated by MIS had higher risk to recur locally (vaginal cuff or pelvic) (26.9% vs. 16.5%, p=0.032, OR, 1.86, 95% CI 1.05-3.30). MIS was the only independent factor associated with local recurrence, adjusted OR, 2.09, 95% CI 1.12-3.90. In women with stage II-IIIc EC, MIS was associated with an increased risk for local recurrence compared to laparotomy. [ABSTRACT FROM AUTHOR]

To describe the feasibility of hysteroscopy assisted suction curettage for early pregnancy loss and to investigate whether it reduces the rates of retained products of conception (RPOC) and intrauterine adhesions (IUA). Prospective single-arm cohort study. University-affiliated department of Obstetrics and Gynecology. Women admitted for surgical evacuation in cases of early pregnancy loss. Vaginal misoprostol was administered for cervical ripening preoperatively. Under general anesthesia, hysteroscopy was performed to identify the pregnancy's implantation wall, followed by ultrasound-guided suction and curettage directed to the implantation wall, and hysteroscopy to verify uterine cavity emptying. Postoperative IUA were evaluated by follow-up hysteroscopy. Identification of the pregnancy's implantation wall on hysteroscopy, and intra- and postoperative complications associated with the procedure. The evaluation of postoperative IUA was limited due to the COVID-19 pandemic restrictions. Main Results: 40 patients, with early pregnancy loss were studied. In 33 out of 40 cases (82.5%), the implantation wall was clearly visualized on hysteroscopy. In 4 cases, suspected RPOC were diagnosed intraoperatively by hysteroscopy and removed. The histology examination confirmed the presence of RPOC in 3 out of 4 cases. Follow-up office hysteroscopy was performed in 9 women, diagnosing mild IUA in one out of 9 cases. In 15 cases, a new pregnancy was reported at time of follow-up. Hysteroscopy assisted suction curettage for early pregnancy loss is safe procedure, which allows the identification of the pregnancy's implantation wall in most cases and may reduce the rates of RPOC and IUA. By identification of uterine anomalies, the procedure may offer a potential benefit in terms of reproductive outcomes for hypo-fertile patients. [ABSTRACT FROM AUTHOR]

To compare oncological outcomes of women with high-grade endometrial carcinoma (HGEC) who underwent surgery by minimally invasive surgery (MIS) versus laparotomy. A retrospective cohort study. Academic multi-center. Consecutive women with HGEC cancer treated at 11 Israeli institutions between 2002 and 2017 were accrued in an assimilated database with a median follow-up of 52 months (range 12-120 months). Women with HGEC were stratified into two groups by route of surgery; MIS vs. laparotomy by an intention to treat. Clinical, pathological and outcome data were compared. MIS and laparotomy. Six hundred and seventy-eight women met the inclusion criteria: 160 underwent MIS and 518 laparotomy. The two groups were comparable in demographic and clinical characteristics. Local recurrence was more common in the MIS group, Odds Ratio (OR) 95% Confidence Interval (CI) 2.80 (1.80-4.36). Disease progression rates were comparable (p=0.537). In a multivariable analysis, including age, comorbidities, disease stage, CA-125 and lymph-vascular space invasion, MIS was not associated with an increased risk for either overall recurrence rate, disease progression, or overall survival. Independent risk factors for local recurrence were diabetes, stage III-IV, LVSI and MIS, adjusted OR 95% CI 3.30 (1.69-6.48). In women with HGEC, MIS is associated with higher rates of local recurrence as compared to laparotomy. [ABSTRACT FROM AUTHOR]