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2 results on '"Tuan Anh, Hoang Le"'

1. Chemical constituents of Panax ginsengsprouts cultivated in Vietnam

Author

Tuan Anh, Hoang Le, Duc, Ngo Viet, Van Cong, Pham, Van Hieu, Ngo, Van Dan, Nguyen, Trang, Vu Thi, Hien, Do Thi Thu, Tuan, Do Thanh, Anh, Le Tuan, and Kim, Jeong Ah

Abstract

Eight compounds, including 20(R)‐ginsenoside Rg3(1), Ginsenoside Rd (2), ginsenosides Rg2(3), ginsenosides Re (4), β‐sitosterol (5), daucosterol (6), stigmasterol (7), and stigmasterol‐3‐O‐β‐glucoside (8) were isolated from the Panax ginsengsprouts cultivated in Vietnam. Their structures were elucidated by 1H, 13C NMR, and MS spectroscopic techniques and compared with the previous publication. In addition, their inhibitory activity on NO production and cytotoxic effects against human embryonic kidney cells (HEK‐293A) and human hepatocellular carcinoma (HepG2) were evaluated. This is the first study of the phytochemical investigation of P. ginsengsprouts cultivated in Vietnam and ginseng sprouts also contained the same main active ginsenosides as in the 4–6‐year old roots.

Published
2024
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2. Phytochemical constituents and cytotoxic activity of Physalis angulata L. growing in Vietnam.

Author

Tuan Anh, Hoang Le, Thao, Do Thi, Dung, Duong Thi, Kiem, Phan Van, Quang, Tran Hong, Hai Yen, Pham Thi, Tuan, Do Thanh, Cuong, Pham Viet, Viet Cuong, Le Canh, and Hung, Tran Manh

Abstract

Graphical abstract Highlights • Eight compounds including two new withanolides, physagulins P and Q were isolated from Physalis angulata. • Their chemical structures were identified by spectroscopic data interpretation comprising 1D, 2D NMR and MS data. • The cytotoxic activity of these metabolites was investigated against A549, HeLa, and PANC-1 cancer cell lines. Abstract A comprehensive phytochemical investigation of the dichloromethane-soluble fraction of Physalis angulata led to the isolation of eight compounds (1–8) including two new withanolides named physagulin P and Q (compounds 5 and 8). Their chemical structures were established using two-dimensional nuclear magnetic resonance (spectroscopy. The cytotoxic activity of these metabolites was investigated against A549, HeLa, and PANC-1 cancer cell lines. Among them, compound 1 showed significant cytotoxic activity against A549 cells with a half-maximal inhibitory concentration (IC 50) value of 8.27 μM, while compound 7 showed the most potent activity against PANC-1 cells with an IC 50 value of 3.18 μM. [ABSTRACT FROM AUTHOR]

Published
2018
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