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Plasma gonadotropin response to luteinizing hormone-releasing hormone (LH-RH) (200 μg intravenously) has been evaluated in a group of amenorrheic women. Eleven of them had primary amenorrhea due to isolated gonadotropin deficiency. Fifteen had secondary functional amenorrhea; this group included patients with anorexia nervosa, polycystic ovary, amenorrhea-galactorrhea, idiopathic amenorrhea. Most patients showed a significant elevation of gonadotropin plasma levels after LH-RH injection. However, a marked variability in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) rise was observed. The two groups included both patients with normal LH response and patients with blunted LH response. An evident FSH elevation has been found in the great majority of subjects. A frequent pattern of anomalous response observed in amenorrheic women was the occurrence of a blunted LH response associated with a markedly elevated FSH response.