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A series of aminophenylhydroxamates and aminobenzylhydroxamates were synthesized and screened for their antiparasitic activity against Leishmania , Trypanosoma , and Toxoplasma . Their anti-histone deacetylase (HDAC) potency was determined. Moderate to no antileishmanial or antitrypanosomal activity was found (IC 50  > 10 μM) that contrast with the highly efficient anti- Toxoplasma activity (IC 50  < 1.0 μM) of these compounds. The antiparasitic activity of the synthetized compounds correlates well with their HDAC inhibitory activity. The best-performing compound (named 363) express a high anti-HDAC6 inhibitory activity (IC 50 of 0.045 ± 0.015 μM) a moderate cytotoxicity and a high anti- Toxoplasma activity in the range of known anti- Toxoplasma compounds (IC 50 of 0.35–2.25 μM). The calculated selectivity index (10–300 using different human cell lines) of the compound 363 makes it a lead compound for the future development of anti- Toxoplasma molecules. [ABSTRACT FROM AUTHOR]