A study conducted at the Federal University Rio Grande do Norte in Natal, Brazil, has investigated the solid-state properties of two antidiabetic drugs, acetohexamide and tolazamide. The researchers used Density Functional Theory (DFT) to study the electronic, optical, and vibrational properties of the crystals, and performed Hirshfeld surface analysis to better understand their crystalline packing. The study found that acetohexamide had an indirect band gap of 2.49 eV, while tolazamide had a direct band gap of 3.25 eV. Both drugs exhibited strong optical absorption in the ultraviolet region. The research also interpreted the IR and Raman spectra of the drugs. This study was supported by Brazilian research agencies CAPES (PNPD), CNPQ, and FAPEAL. [Extracted from the article]