13 results on '"Tan, Libin"'
Search Results
2. Rationally Constructed De Novo Fluorescent Nanosensor for Nitric Oxide Detection and Imaging in Living Cells and Inflammatory Mice Models.
- Author
-
Yang, Qiaomei, Zhou, Yizhuang, Tan, Libin, Xie, Can, Luo, Kun, Li, Xiaowen, Zeng, Miao, and Zhou, Liyi
- Published
- 2023
- Full Text
- View/download PDF
3. Numerical simulation on fluid flow and temperature prediction of motorcycles based on CFD.
- Author
-
Tan, Libin, Yuan, Yuejin, Tang, Lin, and Huang, Can
- Subjects
FLUID flow ,FLOW simulations ,TEMPERATURE distribution ,MOTORCYCLES ,THERMAL comfort - Abstract
The temperature distributions of solid parts in motorcycle is of significance to give an quantitative cooling performance evaluation for assuring the feasible running of motorcycles. Therefore, the present work mainly tend to systematically investigate the flow velocity distributions and temperature distributions of motorcycle by constructing a fluid-solid coupling analysis model via CFD using commercial software STAR-CCM+. Based on computational fluid dynamics method (CFD), fluid-solid coupling analysis model of motorcycle is realized by integration of porous media model, heat exchanger model and fluid-solid co-simulation module and numerical investigations on fluid flow and temperature distribution characteristics at maximum running speed 120 km/h is conducted. The thermal management experiment test considering three pressure measuring points, fifty-eight temperature measuring points and two flowrate measuring points is investigated to know its cooling performance of motorcycle experimentally and provide experimental data for validation of simulation model. Results show that CFD results are in good agreement with experimental results and the maximum relative error is less than 10%. Thermal management test results show that left and right cylinder temperature, oil temperature are 183 °C, 190 °C, 120 °C, respectively. Air temperature of radiator at inlet side are from 29 °C to 35 °C, Air temperature of radiator at outlet side are from 60 °C to 90 °C, water temperature of radiator inlet and radiator outlet are 96 °C and 89 °C, respectively. The air temperature around left thigh and right thigh are 31 °C and 34 °C, respectively. CFD results show that there is no flow dead-zone and high temperature area in engine main components and muffler front cover. The temperature around motorcycle covering and both two thigh is not high due to the radiation of high-temperature components and the outlet temperature of exhaust muffler is also not high, which will not cause enough heat feelings to the riders for being uncomfortable. From the temperature field analysis results, there is no obvious poor temperature distributions for thermal comfort of this motorcycle. The results of this work can provide simulation data support and theoretical reference for the design and development of motorcycle and its crucial components. Through engineering applications of fluid-solid coupling model in a two-cylinder engine and electric generator, it verifies the universality of fluid-solid coupling model and it can be an effective way for the temperature predictions of industrial products. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
4. Activated Two-Photon Near-Infrared Ratiometric Fluorescent Nanoprobe for ONOO– Detection and Early Diagnosis and Assessment of Liver Injury.
- Author
-
Xie, Can, Zhou, Yizhuang, Luo, Kun, Yang, Qiaomei, Tan, Libin, and Zhou, Liyi
- Published
- 2022
- Full Text
- View/download PDF
5. Rationally Constructed De NovoFluorescent Nanosensor for Nitric Oxide Detection and Imaging in Living Cells and Inflammatory Mice Models
- Author
-
Yang, Qiaomei, Zhou, Yizhuang, Tan, Libin, Xie, Can, Luo, Kun, Li, Xiaowen, Zeng, Miao, and Zhou, Liyi
- Abstract
For the early diagnosis and effective evaluation of treatment effects of inflammation, a de novobioanalytical method is urgently needed to monitor the metabolite nitric oxide (NO) associated with inflammatory diseases. However, developing a reliable detection method with excellent water solubility, biocompatibility, long retention time, and blood circulation is still challenging. In this work, we reported for the first time a de novohost–guest self-assembled nanosensor CTA for the quantitative detection and visualization of NO levels in inflammatory models. CTA mainly consists of two parts: (i) an adamantyl-labeled guest small-molecule RN-adH containing a classical response moiety o-phenylenediamine for a chemical-specific response toward NO and fluorophore rhodamine B with excellent optical properties as an internal reference for self-calibration and (ii) a remarkable water-soluble and biocompatible supramolecular β-cyclodextrin polymer (Poly-β-CD) host. In the presence of NO, the o-phenylenediamine unit was reacted with NO at a low pH value of ∼7.0, accompanied by changes in the intensity of the two emission peaks corrected for each other and the change in fluorescence color of the CTA solution from fuchsia to pink. Furthermore, CTA was an effective tool for NO detection with a fast response time (∼60 s), high selectivity, and sensitivity (LOD: 22.3 nM). Impressively, the CTA nanosensor has successfully achieved the targeted imaging of NO in living inflammatory RAW 264.7 cells and mice models with satisfactory results, which can provide a powerful molecular tool for the visualization and assessment of the occurrence and development of NO-related inflammatory diseases in complex biosystems.
- Published
- 2023
- Full Text
- View/download PDF
6. Computational fluid dynamics simulation and performance optimization of an electrical vehicle Air-conditioning system.
- Author
-
Tan, Libin and Yuan, Yuejin
- Subjects
AIR flow ,AIR conditioning ,RELATIVE velocity ,COMPUTATIONAL fluid dynamics ,AIR ducts ,TRAFFIC safety ,VISUAL fields - Abstract
In vehicles, air conditioning tends to offer efficient thermal conditioning and air circulation inside cabin for passenger comfort from different climate variation. The working performance of air conditioning system in vehicles is an essential factor for thermal comfort and driving safety of the passenger compartment of vehicles. Therefore, it is of great significance to construct a numerical simulation model for theoretical analysis and performance evaluation of vehicle air conditioning system. In current research, the air conditioning system of an electric vehicle is taken as the research subject. Internal flow field characteristics of air conditioning system is investigated by Computational Fluid Dynamics (CFD). Results show that the air flow in air-conditioning system is relatively smooth, and the velocity distribution in the front windshield A area and the driver's field of vision of the left and right windows is not ideal when the defrosting-demisting mode is on; the velocity and air quantity distribution of the two outlets in the middle air duct are not uniform under blowing mode. In view of the uneven distribution of velocity and air quantity, the corresponding optimization scheme is proposed. After optimization, the cell relative velocity of the front windshield is significantly improved, and velocity distribution of the side window glass is slightly increased and the defrosting-demisting performance meets the vehicle defrosting requirements of national standard; after optimization, the air quantity distribution of the air ducts at blowing mode is more uniform, which is conducive to the comfort of the passenger compartment. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
7. Rational Development of a New Reaction-Based Ratiometric Fluorescent Probe with a Large Stokes Shift for Selective Detection of Bisulfite in Tap Water, Real Food Samples, Onion Tissues, and Zebrafish
- Author
-
Yuan, Gangqiang, Zhou, Liyi, Yang, Qiaomei, Ding, Haiyuan, Tan, Libin, and Peng, Longpeng
- Abstract
Bisulfite (HSO3–) is usually widely added to tap water and food because it has antibacterial, bleaching, and antioxidant effects. However, its abnormal addition would cause a series of serious diseases related to it. Therefore, development of an effective method for HSO3–detection was of great significance to human health. In this work, a new reaction-based ratiometric fluorescent probe KQ–SO2was rationally designed, which could be used for the highly selective detection of HSO3–in tap water, real food samples, onion tissues, and zebrafish. Specifically, a positively charged benzo[e]indolium moiety and a carbazole group through a condensation reaction resulted in KQ–SO2, which displayed two well-resolved emission bands separated by 225 nm, fast response (1 min), and high selectivity and sensitivity toward HSO3–upon undergoing the Michael addition reaction, as well as low cytotoxicity in vitro. In addition, KQ–SO2has been successfully applied for the detection of HSO3–in tap water, real food samples, onion tissues, and zebrafish with satisfactory results. We predict that KQ–SO2could be used as a powerful tool to reveal the relationship between HSO3–and the human health.
- Published
- 2021
- Full Text
- View/download PDF
8. Tumor Microenvironment Activatable Nanoprodrug System for In Situ Fluorescence Imaging and Therapy of Liver Cancer
- Author
-
Xie, Can, Peng, Yongbo, Zhang, Zhen, Luo, Kun, Yang, Qiaomei, Tan, Libin, and Zhou, Liyi
- Abstract
The development of new imaging and treatment nanoprodrug systems is highly demanded for diagnosis and therapy of liver cancer, a severe disease characterized by a high recurrence rate. Currently, available small molecule drugs are not possible for cancer diagnosis because of the fast diffusion of imaging agents and low efficacy in treatment due to poor water solubility and significant toxic side effects. In this study, we report the development of a tumor microenvironment activatable nanoprodrug system for the diagnosis and treatment of liver cancer. This nanoprodrug system can accumulate in the tumor site and be selectively activated by an excess of hydrogen peroxide (H2O2) in the tumor microenvironment, releasing near-infrared solid-state organic fluorescent probe (HPQCY-1) and phenylboronic acid-modified camptothecin (CPT) prodrug. Both HPQCY-1 and CPT prodrugs can be further activated in tumor sites for achieving more precise in situ near-infrared (NIR) fluorescence imaging and treatment while reducing the toxic effects of drugs on normal tissues. Additionally, the incorporation of hydrophilic multivalent chitosan as a carrier effectively improved the water solubility of the system. This research thus provides a practical new approach for the diagnosis and treatment of liver cancer.
- Published
- 2024
- Full Text
- View/download PDF
9. Collaborative optimization on cooling channel flow resistance and winding temperature for integrated cooling of motor and controller
- Author
-
Tan, Libin, Yuan, Yuejin, and Tang, Lin
- Abstract
The efficiency and working performance of the motor and controller system in micro-electric vehicles depends mainly on its thermal performance, which is contingent upon effective and active cooling. The working temperature of the motor and controller may be too high during operation, which properly causes motor power reduction or motor breakdowns. Therefore, it is crucial to design a good cooling channel for better cooling the integrated motor and controller system. This work proposes an integrated cooling channel of motor and controller, and the fluid-solid coupling analysis is applied for analyzing the velocity, pressure distributions of the cooling channel, and temperature distributions of motor solid components. Meanwhile, the collaborative optimization method based on the multi-island genetic algorithm (MIGA) is used to attain optimal design parameters of the integrated cooling channel of the motor and controller for obtaining a better cooling channel design with lower flow resistance and lower winding temperatures. Results show that the original cooling channel’s flow resistance and maximum winding temperature are 31.87 kPa and 120.04°C, respectively. The flow resistance and winding temperature are pretty significant. After optimization, the local vortex flow and zero velocity area in optimal cooling channel design are improved, the coolant flow velocity becomes more uniform, and the flow resistance is significantly reduced. The flow resistance and maximum winding temperature of the optimal cooling channel design are 12.5 kPa and 116.76°C, respectively, which are decreased compared with the original cooling channel structure, with a decrease of 39.4% and 2.7%, respectively. The research findings in this work can provide theoretical reference for solid components temperature evaluation of motor and give valuable data to cooling performance evaluation and optimization of integrated cooling channel for motor and controller system.
- Published
- 2024
- Full Text
- View/download PDF
10. Dynamic model and simulation of open innovation in product development
- Author
-
Tan, Libin, Tang, Dunbing, and Chen, Weifang
- Abstract
ABSTRACTIn order to meet the needs of customers and take advantage of the customer’s innovative resources, companies open up their design activities of products to customers. In contrast to the traditional product innovation, the primary characteristic of open innovation is the participation of a large number of autonomous individuals across organisational boundaries, and there is not a central authority. Hence, it is necessary to study the dynamic mechanism for obtaining a good decision. This paper first studies the evolution of individual interaction based on game theory and then studies the dynamic characteristics of large-scale interaction. According to the results of simulation, it is concluded that the opinions are convergent under various communication conditions, and he convergent velocity distribution of the product solution with payoffs as the independent variable is obtained. A case study is used to deeply understand the participant behaviour based on the game theory and verify the conclusion of dynamic analysis in this paper.
- Published
- 2019
- Full Text
- View/download PDF
11. Open Design Pattern, Method, and its Self-organization Mechanism.
- Author
-
Tan, Libin, Tang, Dunbing, Wang, Qi, and Yang, Jun
- Abstract
As the consumer individualization is becoming stronger and the customer demand is changing more frequently, the traditional manufacture-active design pattern cannot meet the demands of the present age. It is widely acknowledged by experts that the individualization can be really realized if the consumer could participate in the product design process. At present, the consumer participation in product design process through Internet is quite prevalent, but the design methodology and theoretical foundation have never been concerned by previous studies. This paper proposes the concept of Open Design and then investigates related design pattern, method and self-organization mechanism to enable efficient implementation of consumer participation. Aiming at the increasingly complexity and variety with random consumer participation, a reference framework of Internet Open Design which based on social network is established to realize self-organization. Meanwhile, a dynamic function model tool and a knowledge fusion method are proposed to enable efficient and effective consumer participation online. The effectiveness of proposed model, theory and method are validated by simulation. This research on the Internet Open Design Pattern, Method and its Self-organization Mechanism extends the current product design methodology. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
12. An optimization model for low carbon oriented modular product platform planning (MP3)
- Author
-
Wang, Qi, Tang, Dunbing, Yin, Leilei, Ullah, Inayat, Tan, Libin, and Zhang, Tao
- Abstract
Consumers, industry, and government entities put more focus on the global warming. With this point in view, enterprises have started to take into account of the low carbon idea to develop products. Recently, lots of firms are using the Modular Product Platform Planning (MP3) between product generations for the rapid update of products with lesser production costs and time to market. Traditionally, MP3mainly concerns on module sharing between product generations in modular planning, but pays no attention to the environmental concern which becomes an important design criterion due to the rising awareness of environmental protection. In this paper, an optimization model for low carbon oriented MP3is presented. To support low carbon oriented MP3, this article proposed a probability approach to evaluate the scheme of modular planning for MP3. Meanwhile, a measurement method for low carbon performance of modular planning is provided. Then, an optimization model for low carbon oriented MP3 is formulated to determine the modular planning in pursuit of maximizing the low carbon performance of the product with controlling the implementation probability of MP3. Furthermore, an Adaptive Memetic Algorithm (AMA) is developed for solving the optimization problem. Finally, a case study is proposed to validate the effectiveness of the proposed approach.
- Published
- 2018
- Full Text
- View/download PDF
13. Activated Two-Photon Near-Infrared Ratiometric Fluorescent Nanoprobe for ONOO–Detection and Early Diagnosis and Assessment of Liver Injury
- Author
-
Xie, Can, Zhou, Yizhuang, Luo, Kun, Yang, Qiaomei, Tan, Libin, and Zhou, Liyi
- Abstract
Liver injury poses a serious threat to human health and growing evidence suggests that it is closely associated with a biomarker (peroxynitrite, ONOO–). Therefore, considering that the relationship of ONOO–levels with the occurrence and development of liver injury disease remains a challenge, an urgent need exists to develop a reliable and robust tool for its visual rapid diagnosis and assessment. Herein, a two-photon near-infrared (TP-NIR) ratiometric fluorescent nanoprobe (NTC) based on a fluorescence resonance energy transfer (FRET) strategy was designed, synthesized, and characterized, which had the advantages of good water solubility, low background interference, deep tissue penetration, and high imaging resolution. Specially, NTCwas constructed by self-assembly of an alkynyl group of a small-molecule fluorescent probe (NR) via click chemistry grafting onto azide chitosan (natural polymeric nanomaterial). NR contained acceptor 1(NIR fluorophore) and donor 3(D–π–Astructure of naphthalimide derivative fluorophore) with outstanding TP properties that could be activated by ONOO–for the ratiometric detection of ONOO–. Furthermore, in the presence of ONOO–, NTCexhibited a short response time (∼10 s) and high selectivity and sensitivity toward ONOO–with an excellent detection limit as low as 15.3 nM over other reactive oxygen/nitrogen species. Notably, NTChas been successfully employed for ONOO–detection and imaging in living HepG2 cells, liver injury mice tissues, and mice models with satisfactory results. Thus, the construction of this NTCnanoprobe can provide a robust molecule tool for enabling early diagnosis and assessment of liver injury in the future.
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.