21 results on '"Stapleton C"'
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2. Arterial compression syndromes at the shoulder. Part 1: an overview.
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Stapleton C
- Abstract
Arterial compression syndromes affectinq the subclavian artery, axillary artery and posterior humeral circumflex artery have been identified in younq, fit and healthy athletes. Specific to the third portion of the axillary artery, the overhead-throwinq motion in combination with excessive anterior translation of the humeral head has been implicated as a possible cause of vascular damaqe. This article briefly outlines the sites of potential arterial compression around the shoulder and summarises the effects of altered haemodynamics on the inner lininq of the artery. Part 2 will be published in the next issue (April 09) and focusses on diaqnostic arm manoevres used in physical examination, discusses some diaqnostic dilemmas and hiqhliqhts areas for research. [ABSTRACT FROM AUTHOR]
- Published
- 2009
3. Techniques de dépistage des sources de pollution microbiennes
- Author
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Gourmelon, M., Caprais, M.P., Kay, D., and Stapleton, C.
- Abstract
Afin d’améliorer la qualité sanitaire des eaux côtières, il est indispensable de mettre en place des mesures préventives et/ou correctives permettant de diminuer les apports d’origine fécale en amont du littoral. Aussi, des méthodes d’identification de l’origine de la contamination – traceurs de sources microbiennes (TSM); Microbial Source Tracking(MST) – ont été développées et/ou appliquées sur sites, en France et au Royaume-Uni, afin d’évaluer la pertinence de cette approche.Expérience en FranceÀ l’Ifremer, au laboratoire EMP de Brest, des marqueurs bactériens et viraux ont été ainsi sélectionnés :les Bacteroidales, bactéries anaérobies majoritaires de la flore intestinale, spécifiques de l’homme, des porcs ou des ruminants;un marqueur bactérien spécifique des oiseaux de bord de mer : Catellicoccus marimammalium;les bactériophages F ARN spécifiques.Tout d’abord, des développements méthodologiques ont été réalisés afin de disposer de marqueurs Bacteroidalesspécifiques d’un hôte. Ces marqueurs bactériens ont été validés en déterminant leur sensibilité et leur spécificité sur des fèces et effluents provenant de différents sites en France. Puis, la pertinence de ces marqueurs a été évaluée lors de simulations d’épandage de fumier de bovins et de lisier de porcs sur des parcelles expérimentales et de suivis de rejets dans des cours d’eau.Les marqueurs bactériens et viraux ont été appliqués sur des eaux et coquillages de la péninsule Guérande-Atlantique afin de tester ces marqueurs à l’échelle du bassin versant et de zones littorales. Un total de 63 échantillons d’eau et 80 lots de coquillages a été collecté de juin 2006 à octobre 2008 au niveau de sept affluents et de trois zones conchylicoles. Les marqueurs bactériens ont été recherchés par Polymerase Chain Reaction (PCR) – réaction en chaîne par polymérase –, en temps réel et les génogroupes humains et animaux des bactériophages par culture/génotypage.Cette étude a permis d’apporter des éléments importants pour identifier l’origine des pollutions fécales dans des affluents de cette péninsule. Elle a permis, entre autres, de mettre en évidence que la contamination au niveau des coquillages de l’îlot des Evens pouvait être attribuée, au moins en partie, aux oiseaux de mer nichant sur cet îlot. Toutefois, des développements méthodologiques sont encore indispensables et des données complémentaires concernant les relations entre ces marqueurs et les indicateurs de contamination fécale et les pathogènes sont encore à acquérir.Expérience au Royaume-UniAu Royaume-Uni, les méthodes TSM ont commencé à être utilisées afin de fournir des données scientifiques permettant de guider la prise de décisions sur les principales dépenses et/ou sur les actions correctives concernant les rejets des eaux usées dans ce pays. Cette étude présente une évaluation des méthodes TSM basées sur l’analyse génétique des micro-organismes du groupe Bacteroidalespar PCR en temps réel à l’échelle d’un bassin versant.Ce projet a permis d’acquérir des données de terrain afin d’évaluer l’intérêt opérationnel des données quantitatives concernant les marqueurs Bacteroidales, en les comparant avec les concentrations des indicateurs classiques de contaminations fécales dans les cours d’eau, les effluents et les eaux de baignades. De manière générale, les résultats obtenus par les marqueurs Bacteroidalessuggèrent une contamination des eaux de baignades principalement par des sources d’origine humaine, résultats globalement en accord avec les données sur les répartitions des sources obtenues lors d’une étude précédente. Cependant, il n’a pas été mis en évidence de corrélations significatives entre les marqueurs Bacteroidaleset les indicateurs fécaux au sein des différentes matrices étudiées.Par conséquent, les résultats acquis dans cette étude ne permettent pas de montrer que les proportions et/ou les pourcentages des contributions humaines et/ou des ruminants (basés sur la détermination du nombre de copies de gènes de Bacteroidales) apportent des données fiables pour décrire les contributions des indicateurs fécaux dans les non-conformités des eaux. L’étude a montré également :qu’il n’y avait pas de diminution significative du nombre de copies des gènes de Bacteroidaleslors du processus de désinfection par les UV;que l’analyse d’un seul ou d’un faible nombre d’échantillons d’eaux de baignades non conformes, de cours d’eau ou d’effluents par les marqueurs Bacteroidalesn’était pas suffisante pour caractériser l’importante variabilité du signal TSM observé.Au stade où en est cet outil au Royaume-Uni, il apparaît imprudent d’utiliser les pourcentages des contributions humaines et/ou des ruminants comme le seul ou principal élément constituant les données établies permettant de guider les décisions des principales dépenses et/ou des actions correctives.Des développements complémentaires pour ces méthodes sont donc encore nécessaires aussi bien en France qu’au Royaume-Uni.
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- 2010
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4. Steric Control over Molecular Structure and Supramolecular Association Exerted by Tin- and Ligand-Bound Groups in Diorganotin Carboxylates
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Dakternieks, D., Duthie, A., Smyth, D. R., Stapleton, C. P. D., and Tiekink, E. R. T.
- Abstract
Structural data (X-ray and solution and solid-state 119Sn NMR) show that skew-trapezoidal-bipyramidal diorganotin compounds of 2-quinaldate are invariably monomeric, owing to the steric bulk of the carboxylate ligand. In contrast, most of the analogous compounds of 2-picolinate (2-pic) can increase their coordination number by polymerization or the incorporation of solvent in their coordination sphere in the solid state. The exceptional compound is tBu
2 Sn(2-pic)2 (3 ), for which no increase in coordination number is apparent, a result that is correlated with the bulky tert-butyl groups. Thus, judicious choice of tin or ligand substituents can be exploited to dictate coordination number and/or the degree of supramolecular aggregation in the investigated systems.- Published
- 2003
5. Development of a modelling tool to quantify faecal indicator levels in Cardiff Bay
- Author
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Harris, E., Falconer, R. A., Kay, D., and Stapleton, C.
- Abstract
The growing trend towards urban regeneration, particularly around water bodies, has made it increasingly important to predict the quality of urban waters. Furthermore, concern regarding hydro-environmental pollution has resulted in a marked increase in the development of computer models to assist in environmental impact assessment studies. Details are given of models used for flow and water quality indicator predictions in coastal and inland hydraulic basins, together with the limitations and restrictions of both physical and numerical models. Such models are now used routinely by non-specialist engineers and scientists to assist in the planning and design of water quality related studies. The paper then goes on to describe the development and application of a refined three-dimensional layer-integrated hydro-environmental model to predict water elevations, layer-averaged velocity components and the distribution of water quality indicators within Cardiff Bay, Wales. The model includes the prediction of flushing through the bay of spillages from combined sewer overflows or riverine inputs. Details are also given of field measurements taken for a range of variables used to describe the role of environmental factors and the interaction of various parameters in predicting the survival rates of bacteria in the numerical model.
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- 2002
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6. Alcohol use by patients admitted to hospital emergency rooms for treatment of drug overdose and misuse.
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Kaplan, H L, Sellers, E M, Marshman, J A, Giles, H G, MacLeod, S M, Kapur, B M, Stapleton, C, Sealey, F, and Busto, U
- Abstract
Persons admitted to hospital emergency rooms for treatment of drug misuse with concomitant alcohol use were generally found to be heavy drinkers.
- Published
- 1980
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7. FMLP-induced enzyme release from neutrophils: a role for intracellular calcium
- Author
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Chandler, D., Meusel, G., Schumaker, E., and Stapleton, C.
- Abstract
The ability of the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP) to stimulate beta-glucuronidase release and 45Ca2+ release from rabbit neutrophils was studied. FMLP stimulated enzyme release from cytochalasin B-treated cells either in the presence or the absence of extracellular calcium. Depletion of cell calcium, by exposure to either ethyleneglycol-bis(beta-aminoethylether)-N,N'-tetraacetic acid or the calcium ionophore A23187, blocked the ability of FMLP to stimulate enzyme release and 45Ca2+ release in the absence of extracellular calcium. The ability of A23187 to lower the 45Ca2+ content of neutrophils, to block FMLP-stimulated 45Ca2+ release, and to inhibit FMLP-stimulated enzyme release in the absence of calcium was dose dependent over the same concentration range (10(-8) to 10(-6) M A23187) for all three actions. In contrast, FMLP stimulated enzyme release from A23187-treated cells, provided that extracellular calcium was present. This secretory response was normal as judged by cell ultrastructure and FMLP dose-response relationships. It is concluded that A23187 depletes a pool of intracellular calcium usually released by FMLP and that release of calcium from this pool is necessary for initiation of enzyme secretion in the absence of extracellular calcium.
- Published
- 1983
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8. Radially shielded superconducting magnets for use in cryostats
- Author
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Stapleton, C. R., Echternach, P. M., Tang, Y-H., Hahn, Inseob, Boyd, S. T. P., Gould, C. M., and Bozler, H. M.
- Abstract
Three small superconducting magnets with active and passive shields that produce confined magnetic fields in low temperature cryostats have been designed and built. The design of these magnets uses both on and off-axis field calculations which are fed back to an optimization algorithm. These design principles and construction techniques are discussed.
- Published
- 1992
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9. Acute and Chronic Drug Abuse Emergencies in Metropolitan Toronto
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Sellers, E. M., Marshman, J. A., Kaplan, H. L., Giles, H. G., Kapur, B. M., Busto, U., Macleod, S. M., Stapleton, C., and Sealey, F.
- Abstract
From 3,548 drug overdose or abuse cases presenting at 21 Metropolitan Toronto hospitals' Emergency departments, data concerning demographic and medical characteristics, investigative and management procedures, drug analysis services, and disposition of patients were collected. Of the 3,548 cases, 2,723 (77%) were acute overdose and 816 (23%) were drug abuse. Drug overdose was more common than drug abuse for both sexes, but was more characteristic of females. The drugs most frequently alleged ingested were benzodiazepines (34%), ethanol (32%), salicylates (16%), and barbiturates (14%). The frequency with which particular classes of drugs are alleged in overdose corresponds closely to the frequency of prescribing these drugs in Ontario.
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- 1981
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10. Time optimal control of second-order systems with transport lag
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Ragg, B. C. and Stapleton, C. A.
- Abstract
The time optimal control of particular second-order systems with constant transport lags is determined by application of Pontryagin's Maximum Principle. A system with a delayed control and a system with a delayed state are considered. The optimal control for these systems is compared with the optimal control of a similar system which does not contain transport lag. It is found that the optimal control is essentially bang-bang but that it is non-unique under certain conditions.
- Published
- 1969
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11. A comprehensive classification of pseudo-random binary sequences using difference sets†
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Stapleton, C. A. and Hollo, P.
- Abstract
Pseudo-random binary sequences are shown to be perfectly analogous to cyclic difference sets and this is used to develop a programme to identify all such sequences. Residue, recursive and Hadamard sequences are shown to be describable by the properties of the respective difference set and a classification system is proposed.
- Published
- 1970
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12. The influence of Anterio-Posterior mobilisation at the cervical spine on vertebral artery blood flow.
- Author
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Lewis, M. and Stapleton, C.
- Published
- 2016
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13. P-019 Role of collateral circulation in branch vessel occlusion from flow diversion
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Raymond, S, Koch, M, Stapleton, C, Torok, C, and Patel, A
- Abstract
Introduction/PurposeFlow diversion with the Pipeline Embolization Device (PED) often necessitates covering branch vessels. A number of studies suggest a low rate of branch vessel occlusion with only rare clinical complications from these occlusions. We and others hypothesize that branch vessel occlusion is generally clinically silent due to collateral circulation from ECA to ICA anastomoses (e.g. in the case of the ophthalmic artery) or via the circle of Willis.Materials and MethodsWe reviewed a consecutive retrospective cohort of 64 patients from 2011–2016, who had branch vessel coverage associated with aneurysm flow diversion. Immediate post-treatment angiography and interval follow-up angiography was evaluated for branch vessel opacification. Branch vessels demonstrated either normal, slow, or absent contrast opacification. Collateral circulation was assessed for all branch vessels with slow or absent flow when selective angiography was available.ResultsIn our cohort, we identified 106 branch vessels covered by the PED construct in 64 patients. These were primarily anterior circulation branches (99 of 106) and of those, most were ophthalmic arteries (56 of 99). Slow flow was seen in 11 of 106 branches (10%), only 1 of which progressed on follow up to full occlusion. Angiographic occlusion was seen in 11 vessels (10%). Seven patients had new or worsening neurologic deficits, two of which were associated with stent thrombosis. Three patients had new visual deficits although the covered ophthalmic artery remained patent; two patients had new or worsening 6th nerve palsy related to mass effect from coils and/or the thrombosed aneurysm.The majority of branch vessels with altered flow (slow or absent) had angiographic evidence of collateral circulation (15 of 22, 68%). Altered branch vessel flow was not associated with new or worsening neurologic deficit. In the subset of branch vessels with altered flow, lack of collateral circulation was associated with new or worsening neurologic deficit (p<0.03, Fisher exact test), which in all cases occurred in the setting of PED construct thrombosis. Altered branch vessel flow was not associated with the use of adjunctive coils or the use of more than one PED construct.ConclusionBranch vessel occlusion is a well-known ramification from flow diversion, but rarely results in clinical deficits. Most patients with altered branch vessel flow (either slow or absent) have distal supply via collateral circulation. In our cohort with altered branch vessel flow, new or worsening neurologic symptoms were associated with absent collateral circulation.DisclosuresS. Raymond:None. M. Koch:None. C. Stapleton:None. C. Torok:None. A. Patel:2; C; Medtronic, Penumbra.
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- 2017
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14. E-039 Comparison of predictive grading systems for procedural risk in endovascular treatment of brain arteriovenous malformations – analysis of 104 consecutive patients
- Author
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Pulli, B, Stapleton, C, Koch, M, and Patel, A
- Abstract
IntroductionEndovascular embolization of brain arteriovenous malformations (AVMs) is widely utilized, often used in conjunction with micro- and/or radiosurgery. Grading systems to assess procedural risks of endovascular embolization have been proposed, but none has been independently validated. We sought to validate and compare these grading systems in 104 consecutive patients with brain AVMs who underwent endovascular embolization between 2003 and 2016 at our tertiary academic referral center.MethodsClinical and demographic data were obtained from the medical records. Cerebral angiograms were reviewed and Buffalo, AVM Neuroendovascular (AVMN), and Spetzler-Martin (SM) grades determined. Clinical outcomes and complications were collected. Receiver operating characteristics (ROC) curve analysis was performed, and areas under the curve (AUCs) for different grading systems compared with DeLong’s test.ResultsForty-five (43.3%) patients were females, with an average age at presentation of 43.2±16.2 years. Forty-nine patients (47.1%) presented with hemorrhage. Fifty-five (52.9%) AVMs were located on the left side, 40 (38.5%) were in an eloquent brain region, and mean AVM size was 3.4±1.4 cm. There were 10 major and 17 minor complications in 25 patients (vessel rupture: 9; retained/fractured microcatheter: 5; off-target embolization: 4; extension of embolic cast into venous outflow: 2; artery dissection: 1; ischemic stroke presumed to be related to embolization: 6). Arterial pedicle size (p=0.002) and number of arterial pedicles (p=0.04) were predictors of complications, while AVM side, location in/near an eloquent brain region, patient age, AVM size, or venous drainage pattern were not. The Buffalo score was predictive of complications (p=0.004), but AVMN (p=0.23) and SM grades (p=0.35) were not (Table). ROC curve analysis revealed an area under the curve (AUC) of 0.68±0.05 for the Buffalo score, significantly better than AVMN (AUC 0.58±0.06, p=0.04) and SM grades (AUC 0.56±0.06, p=0.05, Figure).ConclusionOur independent analysis of 104 patients with brain AVMs treated with endovascular embolization validates the predictive capacity of the Buffalo score, but not AVMN or SM grades, for endovascular embolization procedural risk. This will allow for better stratification of brain AVM patients by procedural risk, and will ultimately result in safer care of these patients.Complications(n=25)No complications(n=79)P-valueAge ± SD 46.0±16.9 42.3±15.9 0.33 Female gender, N (%) 7 (28) 38 (48) 0.12 Left side, N (%) 14 (56) 41 (52) 0.90 Spetzler-Martin grade, median (IQR) 3 (2–3) 2 (2–3) 0.35 Number of arterial pedicles, N ± SD 4.8±1.6 4.0±1.8 0.04 Arterial pedicle size<1 mm, N (%) 18 (72) 27 (34) 0.002 Buffalo score, median (IQR) 4 (3–4) 3 (2–4) 0.004 Fistulous component, N (%) 11 (44) 22 (28) 0.21 AVMN grade, median (IQR) 3 (2–4) 3 (2–3.5) 0.23 [Figure]DisclosuresB. Pulli:None. C. Stapleton:None. M. Koch:None. A. Patel:2; C; Penumbra, Medtronic.
- Published
- 2017
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15. Book reviews.
- Author
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Mould D, McLoughlin B, Leong K, Reid D, Hayward PC, Carbis L, Stapleton C, Dunford H, Sweeney L, Keks F, and Johanesen D
- Published
- 2010
16. Book reviews.
- Author
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Cuthbert M, Michael R, Michael G, Barfoed S, Stapleton C, Leong K, Lewis S, and van der Veer K
- Published
- 2009
17. P11.16 Evaluation of three air decontamination devices as part of the smart solutions for healthcare associated infections programme.
- Author
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Williams, K., Griffiths, B., Bassett, P., Stapleton, C., and James, E.
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- 2010
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18. (1366) Proposal to conserve the name Thyrsostachys siamensisagainst T. regia (Poaceae, Bambusoideae)
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Stapleton, C. M. A.
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- 1998
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19. Mid-latency auditory evoked response during propofol and alfentanil anaesthesia
- Author
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Tooley, M. A., Stapleton, C. L., Greenslade, G. L., and Prys-Roberts, C.
- Abstract
Background. Propofol has been shown to affect the mid‐latency auditory evoked response (MLAER) in a dose‐dependant manner. Few studies have investigated the addition of alfentanil. Myogenic responses, such as the post‐auricular responses (PAR), can confound the MLAER but there has been little investigation as to which electrode site reduces this interference. Methods. We studied the MLAER in 27 women. They received an infusion of alfentanil 15 µg kg–1 h–1, followed by either a high or low infusion regimen of propofol (final infusion rates 6 and 3 mg kg–1 h–1). We compared the results with those of our study using propofol alone. We collected the data from two electrode sites: vertex–inion and vertex–mastoid. We evaluated the occurrence of the PAR and the shape of the MLAER at each electrode site. Results. The infusion rate of propofol associated with loss of the eyelash response in 50% of subjects was 3.3 mg kg–1 h–1. This was significantly lower than using propofol alone (5.8 mg kg–1 h–1). Nb latency was the best MLAER discriminator of unconsciousness (sensitivity 94%, specificity 88%), with a threshold of 46 ms (propofol alone was 53 ms). The addition of alfentanil did not alter the relationship between propofol infusion rate and MLAER. The vertex–inion electrode site gave the best protection against PAR in awake subjects (P=0.0003), and after 30 min of propofol infusion (P=0.06). The magnitude of the MLAER obtained from the vertex–mastoid electrodes was larger than from the other site, although the increase was not consistent throughout the waveform (brain stem 100%, Nb 14%). Conclusions. Addition of alfentanil lowers the propofol infusion rate required to produce unconsciousness and the Nb latency that predicts it. The better of the two sites to reduce the incidence of PAR is the vertex–inion electrode site. Br J Anaesth 2004; 92: 25–32
- Published
- 2004
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20. Risk of breast cancer is also increased among retired US female airline cabin attendants.
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Wartenberg, D and Stapleton, C P
- Published
- 1998
21. Random Noise Techniques in Nuclear Reactor Systems
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Uhrig, R. E. and Stapleton, C. A.
- Published
- 1975
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