Search

Anise, or Pimpinella anisum, has a long history of usage in traditional and alternative medicine, as well as in the pharmaceutical sector.The species is native to Southwest Asia, the Middle East, and the Mediterranean region. The current studies have revealed that wild and cultivated P. anisumare rich in bioactive compounds, such as phenols, tannins, carotenoids, and fatty acids. Different parts of P. anisumplant are used treatment of diseases, the treatment of pathogens for antiviral, antibacterial, and antifungal purposes, and cosmetics. In this paper, we reviewed the current knowledge on geographical distribution, cultivation, chemical compounds, extraction methods, and agronomic and medicinal uses of Pimpinella anisum. Equally, we suggested guidelines for future research to fill the gap in less investigated issues. Data for this paper was gathered via electronic literature search on Google, Google Scholar, and databases counting, Science Direct, Scopus, Springer, PubMed, and Hindawi, from 1930 to 2022. Analyzed data show that Pimpinella anisumis currently recorded from Portugal on the Atlantic Ocean in the west to China in the East. With new extraction methods, such as Ultrasound-Assisted Extraction, scientists have explored the higher quantities of polyphenols, flavonoids, and antioxidants, and revealed new constituents such as trans-anethole and estragole found in essential oil fruits by gas chromatography-mass spectrometry (GC–MS). These compounds showed significant therapeutic benefits against diseases, pathogens, and cosmetic roles. However, with the current impacts of climate change on natural vegetation cover, more investigations are needed to understand how these affect the geographical distribution, metabolic aspects, and chemical properties of Pimpinella anisum.These are suggested to increase the value of the species and ensure its conservation.

AbstractContext:Cluster of differentiation 40 (CD40), and its ligand CD40L, are major co-stimulatory molecules whose interactions are important in both cellular and humoral immunity, and has been suggested to play a role in the pathogenesis of acute coronary syndrome.Objective:The aim of this study was to examine the association of CD40 polymorphisms (-1 C>T (rs1883832) and 945G>T (rs4810485)) and myocardial infarction (MI), and to test the association of CD40 gene haplotypes with MI in Tunisians.Materials and methods:Three hundred and fifty MI patients and 301 apparently healthy controls were included in the study. The polymorphisms of CD40 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results:There were significant differences in the genotype and allele frequencies of CD40 gene -1 C>T (rs1883832) polymorphism between cases and controls. Stratifying according to gender, the association between the TT genotype and MI was statistically significant in males, only. Haplotype analysis revealed that the C-T and T-G haplotypes were associated with an increased risk of MI (p = 0.012 and p < 0.001, respectively).Conclusions:Our work showed a significant association between the -1 C>T (rs1883832) polymorphism of the CD40 gene and MI in the Tunisians.