3 results on '"Slieker MG"'
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2. Association of the CLCA1p.S357N Variant With Meconium Ileus in European Patients With Cystic Fibrosis
- Author
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Doef, HPJ, Slieker, MG, Staab, D, Alizadeh, BZ, Seia, M, Colombo, C, Ent, CK, Nickel, R, Witt, H, and Houwen, RHJ
- Abstract
In Cftr−/− mice that mostly die because of intestinal obstruction, intestinal expression of Clca3is decreased, whereas upregulation of Clca3results in amelioration of intestinal disease. The aim of the study was to investigate whether the p.S357N variant in CLCA1, the human orthologue of Clca3, acts as a modifier gene in a cohort of 682 European patients with cystic fibrosis (CF)–99 patients with meconium ileus. The 357SS genotype was significantly overrepresented in both patients with meconium ileus and also with a severe CFTRgenotype (P= 0.009) and in p.F508del homozygotes (P= 0.002). This suggests that CLCA1has similar important functions in CF‐related intestinal obstruction in humans as in Cftr−/− mice.
- Published
- 2010
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3. Club35 Poster Session Thursday 12 December: 12/12/2013, 08:30-18:00 * Location: Poster area
- Author
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Montoro Lopez, M, Iniesta Manjavacas, AM, Mori Junco, R, Pena Conde, L, Pons De Antonio, I, Garcia Blas, S, Lopez Fernandez, T, Moreno Gomez, R, Moreno Yanguela, M, Lopez Sendon, JL, Carro, A, Kiotsekoglou, A, Andoh, J, Brown, S, Kaski, JC, Imamura, Y, Arai, K, Uematsu, S, Fukushima, K, Hoshi, H, Ashihara, K, Takagi, A, Hagiwara, N, Gillis, K, Bala, G, Roosens, B, Remory, I, Droogmans, S, Van Camp, G, Cosyns, B, Van De Heyning, CM, Magne, J, Pierard, LA, Bruyere, PJ, Davin, L, De Maeyer, C, Paelinck, BP, Vrints, CJ, Lancellotti, P, Borowiec, A, Dabrowski, R, Kowalik, I, Firek, B, Chwyczko, T, Janas, J, Szwed, H, Tufaro, V, Fragasso, G, Ingallina, G, Marini, C, Fisicaro, A, Loiacono, F, Margonato, A, Agricola, E, Ferreira, F, Pereira, TS, Abreu, J, Labandeiro, J, Fiarresga, A, Ferreira, AM, Galrinho, A, Branco, LM, Timoteo, AT, Ferreira, RC, Marmol, R, Gomez, M, Garcia, K, Sanmiguel, D, Cabades, C, Monteagudo, M, Nunez, C, Fernandez, C, Diez, JL, Roldan, I, Kolesnyk, MY, Borowiec, A, Dabrowski, R, Kowalik, I, Firek, B, Chwyczko, T, Janas, J, Szwed, H, Marini, C, Tufaro, V, Ancona, MB, Fisicaro, A, Oppizzi, M, Margonato, A, Agricola, E, Krestjyaninov, M, Razin, VA, Gimaev, RH, Carminati, MC, Piazzese, C, Tsang, W, Lang, RM, Caiani, EG, Goncalves, S, Ramalho, A, Placido, R, Marta, L, Cortez Dias, N, Magalhaes, A, Menezes, M, Martins, S, Almeida, A, Nunes Diogo, A, Stokke, T M, Ruddox, V, Sarvari, S I, Otterstad, J E, Aune, E, Edvardsen, T, Pirone, D, De Francesco, V, Marino, F, Gervasi, F, Demartini, C, Goffredo, C, Bono, MC, Mega, S, Chello, M, Di Sciascio, G, Martin Hidalgo, M, Seoane Garcia, T, Carrasco Avalos, F, Mesa Rubio, MD, Delgado Ortega, M, Ruiz Ortiz, M, Mazuelos Bellido, F, Suarez De Lezo Herrero De Tejada, J, Pan Alvarez De Osorio, M, Suarez De Lezo Cruz Conde, J, Seoane Garcia, T, Martin Hidalgo, M, Carrasco Avalos, F, Mesa Rubio, MD, Ruiz Ortiz, M, Delgado Ortega, M, Lopez Granados, A, Romero Moreno, M, Pan Alvarez-Ossorio, M, Suarez De Lezo Cruz Conde, J, Menichetti, F, Bongiorni, MG, Ferro, B, Segreti, L, Bertini, P, Mariotti, R, Baldassarri, R, Di Cori, A, Zucchelli, G, Guarracino, F, Santoro, A, Federco Alvino, FA, Giovanni Antonelli, GA, Raffaella De Vito, RDV, Roberta Molle, RM, Sergio Mondillo, SM, Mahmoud, Y, Abdel-Kader, M, Guindy, R, Elzahwy, S, Dijkema, EJ, Molenschot, MC, Slieker, MG, Oliveira Da Silva, C, Sahlen, A, Winter, R, Back, M, Ruck, A, Settergren, M, Manouras, A, Shahgaldi, K, Krestjyaninov, MV, and Ruzov, VI
- Abstract
Purpose: The coexistence of mitral regurgitation (MR) and severe aortic stenosis is a common problem in elderly patients that limits the indication for percutaneous aortic prosthesis (TAVI). However, recent publications indicate a decrease in MR after TAVI because of the improvement of left ventricle (LV) hemodynamic conditions. The aim of our study was to investigate clinical and echocardiographic predictors of MR after TAVI. Methods: We included patients undergoing TAVI from May 2008 to November 2012. It was performed a 3D transesophageal echocardiogram during the procedure and a transthoracic echocardiogram before discharge and 12 months after implantation. We studied the etiology of MR before procedure, LV ejection fraction, chambers volume, pulmonary hypertension and tricuspid regurgitation, as well as clinical and technical variables related to the procedure. Results: 90 patients underwent TAVI successfully (Table). At the beginning, 21% of patients had MR at least grade III/IV. After TAVI, 84.4% of patients showed no change in MR degree, 12.2% improved and only 3.3% worsened. Variables related with MR worsening were rheumatic MR etiology, history of atrial fibrillation (AF) and the coexistence of significant tricuspid regurgitation (TR) in the baseline study (p <0.04, p <0.01; p <0.03, respectively). Conclusions: In patients undergoing TAVI, the rheumatic etiology of MR, the previous history of AF and significant TR coexistence were factors related to MR worsening after the procedure.
Baseline characteristics. N = 90 Age 81.9 ± 6.9 Women 49 (54.4%) LVEF 56 % ± 11.6 Previous stroke 16 (18%) Previous AF 36 (42.4%) Baseline creatinine serum level 1.3 mg/dl ± 0.5 EuroSCORE 16.8 ± 9.2 Transfemoral approach 71 (79.8%) Transapical approach 18 (20.2%) LVEF: ejection fraction of the left ventricle. AF: atrial fibrillation - Published
- 2013
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