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Radioimmunotherapy (RIT) is a novel and promising cancer treatment method, with ongoing research focusing on RIT antibody selection, radionuclides, treatment options, and benefited patient groups. As we dive into the mechanisms of tumor biology, a deeper exploration of how RIT affects tumor tissue is needed to provide new ways to improve clinical treatment outcome and patient prognosis. We labeled the anti-PD-L1 monoclonal antibody atezolizumab with iodine-131 (131I), separated and purified the labeled mAb with Sephadex G-25 medium gel filtration resin, and tested product stability. We detected the in vivo activity of 131I-PD-L1 mAb by analyzing its in vivo biodistribution and performing SPECT imaging and then set different treatment groups to study the effect of 131I-atezolizumab on the survival of tumor-bearing mice. Western blot, real-time quantitative PCR, and immunohistochemistry were used to detect the expression level of Caspase8 and Nlrp3 in tumor. TUNEL fluorescence staining was used to detect the apoptosis in the tumor. The radiopharmaceutical molecular probe 131I-atezolizumab showed high stability and in vivo biological activity. The treatment regimen adopted had a positive effect on the survival of tumor-bearing mice. 131I internal irradiation upregulated Caspase8 in tumor and ultimately inhibited solid tumor growth by activating apoptosis pathways. We also found a significant increase in the expression of NLRP3, which plays an important role in the pyroptosis pathway, in tumor. In summary, our data demonstrated that radiopharmaceuticals combined with immunotherapy affected tumor tissue by modulating relevant biological pathways, thereby achieving better antitumor effects compared with single therapy and providing new insights for promoting better patient prognosis and combination treatment strategies.

Fe-Mn-Ce metal oxides (FeMC) were prepared by using a co-precipitation method for the removal of tetracycline (TC). The FeMC composite has a good adsorption performance, and the maximum adsorption capacity at 318 K is 307.692 mg/g. FeMC metal oxides maintain good stability, and the removal rate of TC still reaches 85.24% after 5 cycles. The structural characteristics and adsorption mechanism of FeMC adsorbent have been systematically studied. According to the study of adsorption kinetics and adsorption isotherms, the adsorption process conforms to the quasi-second-order kinetic model. Langmuir isotherm model is more suitable than Freundlich isotherm model to describe the adsorption equilibrium data. The Fourier-transform infrared spectrum shows that the adsorption between FeMC and TC is realized by the stretching vibration of C–H and the stretching vibrations of C–O or C–O–C.

Fe-Co-Ni-S (FCNS) nanocomposite is prepared through a hydrothermal method as a new efficient adsorbent to remove organic dyes in wastewater. The morphology, elemental composition and crystalline structure of the adsorbents have been studied by scanning electron microscopy, energy-dispersive X-ray spectroscopy and X-ray diffraction. The influence of the dosage of adsorbent and the pH value on the adsorption performance, the reusability of the nanocomposite, and effects of different anions are studied, which show that the adsorption rate of FCNS towards Rhodamine B (RhB) is as high as 99.63%. The adsorption kinetics of RhB on FCNS is described to pseudo-second-order model. At 318 K, the saturated adsorption capacity is 581.4 mg/g, which is consistent with the Langmuir isotherm. The kinetic results indicate that the adsorption process involves three steps, among which chemical adsorption and intraparticle diffusion play important roles. In addition, through the thermodynamic fitting of the adsorption process, it indicates that the adsorption of RhB by FCNS is spontaneous and accompanied by endothermic reaction. The FCNS nanocomposites has good adsorption performance under pH values ranging from 3 to 11. The FCNS has good reusability and adsorption performance after being reused 5 times. The Fourier-transform infrared spectrum indicates that hydrogen bonding is one of the main factors for influencing the adsorption. Compared with monometallic or bimetallic sulfides, the composite presented here has better adsorption performance and higher adsorption capacity, which will inspire some other emerging trimetallic sulfide composites for various advanced applications.

Fe-Co-S (FeCoS) nanomaterials with good recycling abilities were prepared by a hydrothermal method, and their adsorption properties twords Rhodamine B (RhB) were investigated. Scanning Electron Microscopy (SEM), Energy Dispersive Spectrometer (EDS), X-ray Diffraction (XRD), N2adsorption-desorption isotherms, Brunel Emmett Taylor (BET) surface area, and Fourier Transform Infrared Spectroscopy (FTIR) were used to characterize the materials and analyze their physicochemical properties. The effects of temperature, pH, and adsorbent dosage on the adsorption performance of FeCoS were also investigated. The results showed that the equilibrium time for the adsorption of rhodamine B by FeCoS was 150 min. The adsorption process followed the Langmuir isotherm with a pseudo-second-order kinetic model. It suggests that the adsorption is mainly controlled by chemisorption and belongs to homogeneous monolayer adsorption. The thermodynamic fitting of the adsorption process showed that the adsorption of RhB by FeCoS is spontaneous and accompanied by an endothermic reaction, and the maximum adsorption capacity reached 578.03 mg/g at 318 K with a removal rate of 98.3%. The removal rate of FeCoS was maintained at 89.95% after five cycles, which was of great potential for practical application in the treatment of dyestuff wastewater.