Search

Background: Angiogenesis is an essential pre-requisite for the growth of solid tumor. The number of microvessels during multi step stages of oral tumorigenesis can reflect angiogenesis. The level of angiogenesis during oral tumorigenesis is not yet studied. Objectives: Therefore, the purpose of present study is to evaluate the role of angiogenesis during multi step stages of oral tumorigenesis. Methods: The level of angiogenesis can be measured in a variety of methods. In this study, quantification of Microvessel density (MVD) was performed after staining capillaries with von Willebrand factor (vWF) associated antigen in the different stages of oral tumorigenesis. Results: Total fifty two cases were studied among which ten were control and rest 42 cases were of different stages of oral epithelial dysplasia. Highest MVD was observed in severe dysplasia stage and it is higher even than squamous cell carcinoma. Conclusion: Therefore, anti-angiogenic therapy in the stage of severe dysplesia might be a good alternative to treat oral premalignant lesion and thereby prevent oral carcinogenesis. [ABSTRACT FROM AUTHOR]

Background Detailed characterization of factors influencing post-periacetabular osteotomy (PAO) outcome could guide treatment offered. Methods Using a prospective, multicenter database of PAOs, 61 hips/patients (51 females) with lesser dysplasia (acetabular index < 15° and lateral center–edge angle > 15°) were case-control matched for age, gender, body mass index, Tönnis grade, and joint congruency ( P = .6-.9) with a “comparison group” of pronounced dysplasia (n = 183), aiming to assess whether severity of acetabular dysplasia has an effect on outcome following PAO and/or the ability to achieve desired acetabular correction. Results At 4 ± 1.5 years, no differences in complication or reoperation rates were detected between the groups ( P = .29). Lesser dysplastic hips had inferior Hip Disability and Osteoarthritis Outcome Score, both preoperatively (52 vs 59) and postoperatively (73 vs 78); however, similar improvements were seen. Among the lesser dysplastic hips, those that required a femoral osteochondroplasty at PAO had significantly inferior preoperative Hip Disability and Osteoarthritis Outcome Score (48 ± 18). Increased ability to achieve optimum correction was seen (80% vs 59%, P = .4) in lesser dysplasia. Conclusion A PAO is safe and efficacious in the treatment of lesser dysplasia. Further study on the identification of the optimum treatment modality for the mildly dysplastic hips with cam deformity is required. [ABSTRACT FROM AUTHOR]

Background: Detailed characterization of factors influencing post-periacetabular osteotomy (PAO) outcome could guide treatment offered.Methods: Using a prospective, multicenter database of PAOs, 61 hips/patients (51 females) with lesser dysplasia (acetabular index < 15° and lateral center-edge angle > 15°) were case-control matched for age, gender, body mass index, Tönnis grade, and joint congruency (P = .6-.9) with a "comparison group" of pronounced dysplasia (n = 183), aiming to assess whether severity of acetabular dysplasia has an effect on outcome following PAO and/or the ability to achieve desired acetabular correction.Results: At 4 ± 1.5 years, no differences in complication or reoperation rates were detected between the groups (P = .29). Lesser dysplastic hips had inferior Hip Disability and Osteoarthritis Outcome Score, both preoperatively (52 vs 59) and postoperatively (73 vs 78); however, similar improvements were seen. Among the lesser dysplastic hips, those that required a femoral osteochondroplasty at PAO had significantly inferior preoperative Hip Disability and Osteoarthritis Outcome Score (48 ± 18). Increased ability to achieve optimum correction was seen (80% vs 59%, P = .4) in lesser dysplasia.Conclusion: A PAO is safe and efficacious in the treatment of lesser dysplasia. Further study on the identification of the optimum treatment modality for the mildly dysplastic hips with cam deformity is required. [ABSTRACT FROM AUTHOR]