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Objective: This study aimed to investigate the effect of three-dimensional (3D) printed clear aligners (CA) with different designs on the extrusion of mandibular premolars using a force/moment measurement system and digital image correlation (DIC). Methods: The forces and moments applied to the mandibular canines, first and second premolars were measured using a multi-axis force/ moment transducer when an extrusion of 0.5 mm was planned, assuming the mandibular first premolars were intruded by 1 mm. In addition, displacement and strain changes in the CA were analyzed using the DIC method. CA designs were categorized based on the presence of first premolar attachment and subdivided into equigingival margins, 1-mm extended margins, equi-margins with 1-mm thickness and height, and equi-margins with 1-mm reduced buccolingual width. The CA was printed directly at a thickness of 0.5 mm, and the experiments were conducted at 37°C. Results: The results showed that attachment played an important role in the extrusion of first premolars in both the force/moment measurement system and the DIC method. Intrusion was observed without attachment, even though extrusion was planned. CA designs apply greater force to the cervical region by extending the margin or reducing the buccolingual width, thereby improving extrusion efficiency. Conclusions: Force and moment changes in direct 3D printed CA are complex and difficult to predict; however, modifying aligner designs, such as extending the margin or reducing buccolingual width, and using appropriate attachments could minimize unwanted tooth movement, optimize planned treatment, and increase treatment predictability. [ABSTRACT FROM AUTHOR]

Objective: Miniscrew-assisted maxillary expansion devices are frequently used for patients with calcified midpalatal sutures. This study aimed to evaluate the effects of two bone-borne maxillary expansion appliances on the cranial and circummaxillary sutures by comparing cone-beam computed tomography (CBCT) images before and after transverse maxillary expansion. Methods: A total of 81 patients (women = 58, men = 23) were treated with either a C-expander (n = 44) or an ATOZ expander (n = 37). CBCT images were obtained before (T0) and after (T1) maxillary expansion, and the widths of 10 circummaxillary sutures were measured in the sagittal, coronal, and axial planes. The Wilcoxon signed-rank test was used to compare the changes in suture width between the C-expander and ATOZ groups, and statistical significance was set at P < 0.05. Results: The frontonasal, frontomaxillary, pterygomaxillary, nasomaxillary, internasal, intermaxillary, and midpalatal suture widths increased significantly after maxillary expansion in both the ATOZ and C-expander groups (both P < 0.05). The frontozygomatic, zygomaticomaxillary, and temporozygomatic suture widths decreased in the C-expander group (P < 0.05), whereas the frontozygomatic suture width increased significantly in the ATOZ group (P < 0.05). The width changes of the frontozygomatic, zygomaticomaxillary, temporozygomatic, pterygomaxillary, internasal, intermaxillary, and midpalatal sutures differed significantly between the two groups (P < 0.05). Conclusions: Both the C- and ATOZ expanders affected the suture width in the naso-maxillozygomatic region. The C-expander decreased the circum-zygomatic suture widths, whereas the ATOZ expander widened the frontozygomatic suture with no effect on other circummaxillary sutures. [ABSTRACT FROM AUTHOR]

Objective: To correlate temporomandibular joint (TMJ) morphology and position with cone-beam computed tomography (CBCT) images, Joint Vibration Analysis (JVA), and Jaw Tracker (JT) to develop a radiation-free, dynamic method for screening and monitoring the TMJ in orthodontic patients. Methods: A total of 236 orthodontic patients without symptoms of TMJ disorders who had undergone CBCT were selected for the JVA and JT tests in this cross-sectional study. TMJ position and morphology were measured using a three-dimensional analysis software. JT measurements involved six opening-closing cycles, and JVA measurements were performed using a metronome to guide the mouth opening-closing movements of the patients. The correlations among the three measuring devices were evaluated. Results: Abnormalities in condylar surface morphology affected the mandibular range of motion. The cut-off value results show that when various measurement groups are within a certain range, abnormalities may be observed in morphology (area under the curve, 0.81; P < 0.001). A 300/< 300 Hz ratio = 0.09 suggested abnormal morphology (P < 0.05). Correlations were observed among the maximum opening velocity, maximum vertical opening position, and joint spaces in the JT measurements. Correlations were also observed between the > 300/< 300 Hz ratio, median frequency, total integral, integral < 300 Hz, and peak frequency with joint spaces in the JVA measurements. Conclusions: JT and JVA may serve as rapid, non-invasive, and radiation-free dynamic diagnostic tools for monitoring and screening TMJ abnormalities before and during orthodontic treatment. [ABSTRACT FROM AUTHOR]

Purpose: As people living with cancer increase in the aging society, cancer-related emergency department (ED) visits are also increasing. This study aimed to investigate the epidemiologic characteristics of non-emergent cancer-related ED visits using a nationwide ED database. Materials and Methods: A cross-sectional study was conducted using the National Emergency Department Information System (NEDIS) database. All cancer-related ED visits between 2016 and 2020 were included. The study outcome was non-emergent ED visits, defined as patients triaged into non-emergent condition at both the time of arrival at ED and discharge from ED and were discharged without hospitalization. Results: Among 1185871 cancer-related ED visits over 5 years, 19.0% (n=225491) were classified as non-emergent visits. While abdominal pain and fever are the top chief complaints in both emergent and non-emergent visits, non-emergent visits had high proportions of abdomen distension (4.8%), ascite (2.4%), and pain in lower limb (2.0%) compared with emergent visits. The cancer types with a high proportion of non-emergent visits were thyroid (32.4%) and prostate cancer (30.4%). Adults compared with children or older adults, female, medical aid insurance, urban/rural ED, direct-in compared with transfer-in, and weekend visit were associated with high odds for non-emergent visits. Conclusion: Approximately 20% of cancer-related ED visits may be potentially non-emergent. A significant number of non-emergent patients visited the ED due to cancer-related symptoms. To improve the quality of care for people living with cancer, the expansion of supportive care resources besides of ED, including active symptom control, is necessary. [ABSTRACT FROM AUTHOR]

We aimed to evaluate the antibacterial activity of phytochemicals with or without an experimental fluoride varnish against Porphyromonas gingivalis. Five phytochemicals, chrysophanol (CHR), emodin (EMO), anthrarufin (ANT), bavachalcone (BCC), and isobavachromene (IBC), were tested using agar diffusion, minimal inhibition concentration (MIC), and minimum bacterial concentration (MBC) assays. We also assessed the cell viability and cytotoxicity of phytochemicals. All phytochemicals showed clear inhibition zones in the agar diffusion test. The inhibition zones of all phytochemical-containing fluoride varnishes were similar to or larger than that of the positive control, excluding that of 1 mM EMO. With or without the fluoride varnish, BCC exhibited the lowest MIC and MBC levels. Cell viability was high in the presence of all phytochemicals except 200 μM EMO. In conclusion, BCC was most effective as a phytochemical alone, while all phytochemical-containing fluoride varnishes inhibited P. gingivalis growth without cytotoxicity. [ABSTRACT FROM AUTHOR]

In modern warfare, missiles play a pivotal role but typically spend the majority of their lifecycle in long-term storage or standby mode, making it difficult to detect failures. Preemptive detection of missiles that will fail is crucial to preventing severe consequences, including safety hazards and mission failures. This study proposes a contamination-based stacking ensemble model, employing the local outlier factor (LOF), to detect such missiles. The proposed model creates multiple base LOF models with different contamination values and combines their anomaly scores to achieve a robust anomaly detection. A comparative performance analysis was conducted between the proposed model and the traditional single LOF model, using production-related inspection data from missiles deployed in the military. The experimental results showed that, with the contamination parameter set to 0.1, the proposed model exhibited an increase of approximately 22 percentage points in accuracy and 71 percentage points in F1-score compared to the single LOF model. This approach enables the preemptive identification of potential failures, undetectable through traditional statistical quality control methods. Consequently, it contributes to lower missile failure rates in real battlefield scenarios, leading to significant time and cost savings in the military industry. [ABSTRACT FROM AUTHOR]

Objectives: Limited information is available concerning the epidemiology of stroke and acute myocardial infarction (AMI) in the Republic of Korea. This study aimed to develop a national surveillance system to monitor the incidence of stroke and AMI using national claims data. Methods: We developed and validated identification algorithms for stroke and AMI using claims data. This validation involved a 2-stage stratified sampling method with a review of medical records for sampled cases. The weighted positive predictive value (PPV) and negative predictive value (NPV) were calculated based on the sampling structure and the corresponding sampling rates. Incident cases and the incidence rates of stroke and AMI in the Republic of Korea were estimated by applying the algorithms and weighted PPV and NPV to the 2018 National Health Insurance Service claims data. Results: In total, 2,200 cases (1,086 stroke cases and 1,114 AMI cases) were sampled from the 2018 claims database. The sensitivity and specificity of the algorithms were 94.3% and 88.6% for stroke and 97.9% and 90.1% for AMI, respectively. The estimated number of cases, including recurrent events, was 150,837 for stroke and 40,529 for AMI in 2018. The age- and sex-standardized incidence rate for stroke and AMI was 180.2 and 46.1 cases per 100,000 person-years, respectively, in 2018. Conclusion: This study demonstrates the feasibility of developing a national surveillance system based on claims data and identification algorithms for stroke and AMI to monitor their incidence rates. [ABSTRACT FROM AUTHOR]

This article discusses a study published in the Korean Journal of Orthodontics that examined the pharyngeal airway space (PAS) in patients with anterior open bite (AOB) compared to those with normal occlusion. The study found that individuals with AOB had a narrower PAS and smaller volumes in certain pharyngeal segments, suggesting a different oral structure. However, there was no correlation between the amount of anterior overbite and changes in the PAS. The study acknowledges the need for further research and highlights the importance of evaluating the PAS in patients with AOB. [Extracted from the article]

This article explores the impact of diabetes on facial and skeletal development in rats, specifically focusing on the effects of a compound called 4-hexylresorcinol (4HR). The study found that diabetes impaired bone growth and reduced bone mass, but the administration of 4HR mitigated these effects and resulted in improved bone structure. Additionally, 4HR was found to have a protective effect on testes function in diabetic animals. However, the study had limitations, such as a small sample size and the use of growing animals, so further research is needed to fully understand the effects and mechanisms of 4HR. [Extracted from the article]

A diamond-like carbon (DLC) coating was deposited on the surface of 316L stainless steel using the arc ion plating (AIP) method to improve the life and efficiency of the metallic bipolar plate for polymer electrolyte membrane fuel cells (PEMFCs). The electrochemical characteristics and damage behaviour were investigated in an accelerating solution simulating the PEMFCs operation environment. A result of the experiment showed the corrosion current density of all specimens with DLC coatings was lower than that of the base metal. However, when the thickness of the DLC coating was 0.3 and 0.5 μm, the corrosion resistance was lower than that of the base metal. This is thought to be because defects on the coating surface result in crevice corrosion of the gap between the coating layer and the intermediate layer or between the coating layer and the base metal, further accelerating corrosion. [ABSTRACT FROM AUTHOR]

Objectives: This study aimed to classify coronavirus disease 2019 (COVID-19)-related deaths according to whether COVID-19 was listed as the cause of death, and to investigate the differences in demographic characteristics and risk factors for COVID-19 death classifications. Methods: A total of 5,625 deaths in South Korea among patients with confirmed COVID-19 from January 20, 2020 to December 31, 2021 were selected. Excluding false reports and unnatural deaths, 5,597 deaths were analyzed. Based on death report data, deaths were classified according to whether the cause of death was listed as COVID-19 (CD) or not (NCD). The epidemiological characteristics and causes of deaths were investigated using descriptive, univariate, and multivariate statistical analyses. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to analyze the risk factors. Results: The case fatality ratio was 0.89% and increased with age. Additionally, 96.4% of the subjects had an underlying disease, and 53.4% died in winter. The proportion of NCDs was 9.3%, of whom 19.1% died at home and 39.0% were confirmed to have COVID-19 after death. Malignant neoplasms (102/416 vs. 637/4,442; OR, 1.71; 95% CI, 1.36-2.16; p<0.001) were significantly associated with NCD. Conclusion: This is the first study to analyze risk factors by cause of death using COVID-19 death report data in South Korea. These results are expected to be used as evidence for establishing a death monitoring system that can collect timely information in a new infectious disease pandemic. [ABSTRACT FROM AUTHOR]

Background: The aim of the present study was to investigate the effect of horse-riding simulator (HRS) exercise on balance control ability and gait in the elderly with dementia. Material and Methods: This study was conducted on people aged 65 years or older living in D city (Korea) enrolled in the day care center with a diagnosis of dementia as documented by the Korean Ministry of Health andWelfare. The control group performed the same exercise therapy previously performed at the center for 30 minutes (per session), and the experimental group performed the conventional intervention (15 minutes per session) and HRS exercise (15 minutes per session). In both groups, intervention was performed 3 times a week for 8 weeks. Functional reach test (FRT), timed up-and-go (TUG), 10 MeterWalk Test (10MWT), and Short Form Berg Balance Scale (SFBBS) tests were used measured to evaluate balance control ability and gait ability before and after intervention to confirm its effect. Results: Pre-intervention no intergroup differences were found between FRT, TUG, 10MWT, or SFBBS results. (p > 0.05). However, post-intervention comparison, the experimental group had significantly better FRT, TUG, 10MWT, and SFBBS results (p < 0.05). Conclusion: We found HRS exercise and exercise therapy improved balance control ability and gait speed, and that HRS exercise produced better results than convention exercise. [ABSTRACT FROM AUTHOR]

Recent disputes between the Republic of Korea and Japan over colonial compensation have dealt a severe blow to their bilateral relations. In 2018, the Supreme Court of Korea ordered two Japanese corporations to pay damages to Korean laborers who had been forced to work at their factories under Japanese rule. The judgments, which ran directly counter to the earlier rulings of the Japanese Supreme Court for the same parties, reflected longstanding disagreement over the legality of Japan's annexation of Korea in 1910 and differences of interpretation concerning the 1965 treaties that restored diplomatic relations. Examination of judicial decisions in South Korea over the years indicates that the forced-laborer compensation issue had consistently been viewed as an internal problem, until it became an issue in domestic and judicial politics. In early 2023, the South Korean government announced that it would no longer demand that Japanese companies compensate Korean plaintiffs, who would instead be paid from a government fund. The forced laborer litigation and its aftermath have revealed the limits of the judicial process in resolving historical problems surrounding South Korea-Japan relations in ways that may be relevant to efforts around the globe to redress past injustices through adjudication. [ABSTRACT FROM AUTHOR]

Epipericardial fat necrosis (EPFN) is a relatively rare cause of acute chest pain, with only five pediatric cases having been reported in the English-language medical literature to date. EPFN can be diagnosed based on the clinical symptoms of acute pleuritic chest pain and classic CT features of typically ovoid fatty lesions surrounded by a rim or capsule in the mediastinal or pericardial areas. Previous studies have reported that contrast-enhanced MRI can detect typical fat signal changes in adults with EPFN. We report a pediatric EPFN case diagnosed using gadolinium-enhanced MRI. Thus, contrast-enhanced MRI may be used to confirm EPFN in the differential diagnoses of the causes of acute chest pain. [ABSTRACT FROM AUTHOR]

Acute puerperal uterine inversion is a rare postpartum obstetric complication; however, without rapid diagnosis and appropriate management, it is life-threatening. Substantial bleeding hinders the verification of a partially inverted uterus, possibly delaying the treatment. Herein, we present the report of a 32-year-old female presenting with massive postpartum bleeding managed by uterine artery embolization. The peculiar course of the uterine artery bowing inferiorly along the inverted fundus during embolization could uncover the uterine inversion, which was not diagnosed by physical examination and CT. In conclusion, uterine artery embolization is not only an effective therapeutic strategy for postpartum hemorrhage but also a valuable tool for diagnosing uterine inversion. [ABSTRACT FROM AUTHOR]

Objective: To introduce newly structured and developed orofacial myofunctional therapy (OFMFT) protocols named Bio-Exercise (BioEx), and evaluate the treatment effect of this method, using lateral cephalometric analysis on malocclusion with low tongue posture in young patients. Methods: A retrospective preliminary study was performed using orthodontic records from 28 patients (mean age of 8.41±1.45-yearold, 13 males, 15 females) treated with BioEx therapy using tongue elevators for 18.14±9.04 months (range: 6 to 37 months). Pretreatment (T0) and post-BioEx therapy (T1) lateral cephalograms were subsequently analyzed for tongue posture changes by linear, anteroposterior and vertical measurements. The data were analyzed by paired t-test, considering a 5% significance level. Results: The tongue length (TGL) and tongue height (TGH) increased statistically significant between T0 and T1. The decrease of the dorsum of the tongue perpendicular to the palatal plane (Td-PP value) was statistically significant. The increase of the tip of the tongue perpendicular to the pterygomaxillary vertical line (TT-PMV) was not statistically significant. Conclusions: These preliminary cephalometric results indicate that BioEx can be an effective OFMFT modality in increasing the tonicity of the tongue muscles to establish more normalized tongue position at rest. [ABSTRACT FROM AUTHOR]

The document is a reader's forum from the Korean Journal of Orthodontics. The reader, Changbeom Kwon, asks several questions about a study on the pharyngeal airway space in patients with anterior open bite. The authors respond by explaining their methodology and rationale for excluding certain samples. They also discuss the clinical implications of their study for orthodontic treatment. The document includes references to other studies on the topic. [Extracted from the article]

Purpose: Interleukin-37 (IL-37) is an anti-inflammatory cytokine that inhibits a broad spectrum of inflammatory responses in various human cells, including neutrophils, macrophages, and endothelial cells. The aim of this study was to identify the role of IL-37 in toll-like receptor 9 (TLR9) signaling in human macrophages. Materials and Methods: Human macrophage U937 cells treated with CpG-oligonucleotides (CpG-ODN), recombinant IL-37, or dexamethasone were used in an in vitro study. IL-37 small interfering RNA (siRNA) and TLR9 siRNA were used to silence endogenous IL-37 and TLR9, respectively. Expression levels of phosphorylated nuclear factor-κB (NF-κB), IκBα, IL-37, IL-1β, tumor necrosis factor-α (TNF-α), and IL-6 protein were assessed by real-time quantitative polymerase chain reaction and Western blotting. CpG-ODN-mediated IL-37 expression stimulated by dexamethasone was detected using immunofluorescent analysis. Results: U937 cells treated with CpG-ODN induced activation of the NF-κB pathway and increased the expression of the pro-inflammatory cytokines IL-1β, TNF-α, and IL-6, but reduced that of IL-37. Recombinant IL-37 attenuated phosphorylation of NF-κB and IκBα and the expression of IL-1β, TNF-α, and IL-6 stimulated by CpG-ODN. Human macrophages transfected with IL-37 siRNA augmented the expression of IL-1β, TNF-α, and IL-6 mRNA and protein in cells treated with CpG-ODN. Dexamethasone markedly inhibited expression of pro-inflammatory cytokines in U937 cells, whereas IL-37 expression was increased with the addition of dexamethasone. Inflammatory responses elicited by CpG-ODN were dependent on an MyD88-TRAF6 pathway. IL-37 inhibited CpG-ODN-induced ubiquitination of TRAF6 in U937 macrophages. Conclusion: IL-37 inhibits CpG-ODN-mediated inflammatory responses through regulation of a TRAF6- NF-κB pathway in human macrophages. [ABSTRACT FROM AUTHOR]

Background: This study was performed to establish the relationship between these diseases by analysing the prevalence of metabolic syndrome and its link to pulmonary dysfunction. Material and Methods: This study obtained data from the 6th Korea National Health and Nutrition Examination Survey (KNHANES, 2013-2015), a cross-sectional and nationally representative survey conducted by the Korean Centres forDiseases Control and Prevention. Results: Of the 8,156 participants included in this study, the prevalence rate of restrictive pattern in the subjects of this study was 8.71% and 14.39% in the obstructive pattern. The prevalence of metabolic syndrome was 29.38%. The results of the relationship between pulmonary function and metabolic syndrome throughlogistic regression analysis showed a significant difference in the restrictive pattern, but no difference in the obstructive pattern, in odds ratio corrected for variables that could affect metabolic syndrome and pulmonary dysfunction (restrictive: OR 1.308, 95% CI 1.024-1.671; obstructive: OR0.928, 95%CI0.739-1.166). Conclusion: The conclusion of this study found that, rather than obstructive pattern, the restrictive pattern was highly correlated with metabolic syndrome regardless of the confounding variables or riskfactors of various metabolic syndromes that could be mediated. [ABSTRACT FROM AUTHOR]

Central nervous system infections caused by free-living amoeba are very rare, but often fatal. The typical image findings of amebic meningoencephalitis are non-specific, showing ring-like enhancement. We report the first case of fulminant disseminating fatal granulomatous amebic encephalitis caused by Balamuthia mandrillaris in an immunocompetent patient in South Korea. Our case exhibited two interesting features: one was the unusual clinical course and the other was additional image findings. Magnetic resonance imaging revealed a rim-enhancing lesion with intralesional blooming dark signal intensity on susceptibility weighted imaging and low signal intensity on diffusion weighted images and on apparent diffusion coefficient maps. Differential diagnosis was started from a tumor or non-tumorous lesion, and diagnosis was difficult due to the rarity of the disease. Following the clinical and diagnostic courses of our case, we recommend inspecting image findings of granulomatous amebic encephalitis for early diagnosis. [ABSTRACT FROM AUTHOR]

While using the internet services, users tend to frequently experience the inconvenience in service due to buffering caused by overloads in the domain service server. If there are some margins for availabilities for the service server, the above issue does not occur, so it is possible to remove the inconvenience. In each time period of the domain that provides the service, the peak traffic data is collected to configure the data set, and the peak traffic data in each time period within the configured data set is summed up. After that, in this newly proposed model, the cumulative hourly peak traffic data is checked in terms of whether it exceeds the availability threshold set by an operator, and if it does, it is transferred to other pool group (pool N). The test results for the proposed model indicates that in the past, it normally took 2 hours to analyze the domain traffic data and 10 to 20 minutes to apply the analysis results, but in the newly proposed model, it takes only less than 5 minutes to analyze and apply results. System load frequency is reduced from 13 times a month to 1 time per month, and also the number of times to use the reserved server is reduced from 18 times to 2 times. The CPU margin rate is increased from 27% to 71%, which indicates that the usage rate is decreased. Overall, the operator's resource is reduced, and thus it is possible to achieve server stability as well. [ABSTRACT FROM AUTHOR]

Purpose To compare the recurrence pattern, disease-free survival (DFS), and overall survival (OS) after curative surgery for pancreatic ductal adenocarcinoma (PDAC) in patients who underwent preoperative evaluation with CT alone or in combination with MRI, and to compare the prognosis according to the first recurrence site. Materials and Methods We retrospectively evaluated 152 patients who underwent R0 resection of PDAC. Preoperative CT or combined CT and MRI were performed for 103 and 49 patients, respectively. Two radiologists recorded the location and date of the first recurrence in consensus. The recurrence pattern, DFS, and OS were compared between the two groups. OS was analyzed according to the first recurrence site. Results In both groups, liver metastasis was the most common recurrence pattern. DFS (p = 0.247) or OS (p = 0.067) showed no significant difference between the two groups. OS according to the first recurrence site was the lowest for liver metastasis, followed by locoregional recurrence (p < 0.001). Conclusion There were no significant differences in the recurrence pattern, DFS, or OS between patients evaluated with preoperative CT alone or with CT and MRI after curative resection of PDAC. Liver metastasis was the most common tumor recurrence pattern with the lowest OS. [ABSTRACT FROM AUTHOR]

Atherectomy has become a promising treatment option for peripheral artery disease caused by diabetes mellitus or end-stage renal disease. Atherectomy refers to the removal of atheromatous tissue by mechanical method, resulting in an enlarged lumen of the treated blood vessel. Based on this method, the term is limited to the percutaneous minimally invasive approach, and there are currently two types of atherectomy devices available in Korea. The increased prevalence of atherectomy has led to the concept of “vascular preparation” and a new treatment concept of “leave nothing behind.” Various studies have proven the safety and effectiveness of atherectomy; however, there are some limitations. We need to remain focused on patient selection and subsequent large-scale research. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the inhibitory effects of Colocasia antiquorum var. esculenta (CA) on Porphyromonas gingivalis (P. gingivalis) growth, inflammation, and osteoclastogenesis. CA was effective in inhibiting the growth of P. gingivalis when applied together with an experimental fluoride varnish. CA also significantly decreased the release of interleukin-6, tumor necrosis factor-a, and nitric oxide from lipopolysaccharide-induced RAW 264.7 cells. No significant differences in viability were noted between the cells treated with CA and the controls. In addition, CA significantly attenuated osteoclast differentiation on bone marrow macrophages. In conclusion, CA inhibited the growth of P. gingivalis and showed anti-inflammatory and anti-osteoclastogenic effects. Therefore, CA may have the potential to act as a novel natural agent for preventing periodontitis. [ABSTRACT FROM AUTHOR]

Purpose: To describe adverse drug reactions (ADRs) to carbamazepine (CBZ) and oxcarbazepine (OXC), including severe cutaneous ADRs, at a tertiary care hospital over a 10-year period. Materials and Methods: The frequency and clinical features of ADRs caused by CBZ and OXC were analyzed using the pharmacovigilance database and spontaneous ADR reporting data of Yonsei University Severance Hospital & Dental Hospital (Seoul, Korea) from January 1, 2010 to January 31, 2020. Results: Among 10419 cases prescribed CBZ and OXC, 204 ADR cases were reported. The incidences of ADRs were 1.8% and 2.2% for CBZ and OXC respectively, with no significant difference (p=0.169). The most common clinical presentations were skin disorders. Female patients had relatively more frequent ADRs than male patients. Although mild skin ADRs were more frequent with OXC, nervous system disorders, general disorders, and hepatobiliary disorders occurred more often with CBZ. There were six reports of severe cutaneous adverse reactions to CBZ, while OXC had none. Both CBZ and OXC caused ADRs at daily doses lower than the recommended initial dose. Conclusion: Due to lower incidence of severe ADRs with OXC than CBZ, we suggest OXC as a first-line prescription. [ABSTRACT FROM AUTHOR]