44 results on '"Schnaas, Lourdes"'
Search Results
2. Maternal FADS2 single nucleotide polymorphism modified the impact of prenatal docosahexaenoic acid (DHA) supplementation on child neurodevelopment at 5 years: Follow-up of a randomized clinical trial.
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Gonzalez Casanova, Ines, Schoen, Meriah, Tandon, Sonia, Stein, Aryeh D., Barraza Villarreal, Albino, DiGirolamo, Ann M., Demmelmair, Hans, Ramirez Silva, Ivonne, Feregrino, Raquel Garcia, Rzehak, Peter, Stevenson, India, Standl, Marie, Schnaas, Lourdes, Romieu, Isabelle, Koletzko, Berthold, and Ramakrishnan, Usha
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Variability in the FADS 2 gene, which codifies the Delta-6 Desaturases and modulates the conversion of essential n-3 and n-6 fatty acids into long-chain polyunsaturated fatty acids, might modify the impact of prenatal supplementation with n-3 docosahexaenoic acid (DHA) on neurodevelopment. To assess if maternal FADS2 single nucleotide polymorphisms (SNPs) modified the effect of prenatal DHA on offspring development at 5 years. We conducted a post-hoc interaction analysis of the POSGRAD randomized controlled trial (NCT00646360) of prenatal supplementation with algal-DHA where 1094 pregnant women originally randomized to 400 mg/day of preformed algal DHA or a placebo from gestation week 18–22 through delivery. In this analysis, we included offspring with information on maternal genotype and neurodevelopment at 5 years (DHA = 316; Control = 306) and used generalized linear models to assess interactions between FADS2 SNPs rs174602 or rs174575 and prenatal DHA on neurodevelopment at 5 years measured with McCarthy Scales of Children's Abilities (MSCA). Maternal and offspring characteristics were similar between groups. At baseline, mean (±standard deviation) maternal age was 26 ± 5 years and schooling was 12 ± 4 years. Forty-six percent (46%) of the children were female. Maternal minor allele frequencies were 0.37 and 0.33 for SNPs rs174602 and rs174575, respectively. There were significant variations by SNP rs174602 and intervention group (p for interactions <0.05) where children in the intervention group had higher MSCA scores on the quantitative (DHA: mean ± SEM = 22.6 ± 0.9 vs. Control = 19.1 ± 0.9, mean difference (Δ) = 3.45; p = 0.01) and memory (DHA = 27.9 ± 1.1 vs. Control = 23.7 ± 1.1, Δ = 4.26; p = 0.02) scales only among offspring of TT (minor allele homozygotes). Maternal FADS2 SNP rs174602 modified the effect of prenatal DHA on cognitive development at 5 years. Variations in the genetic make-up of target populations could be an important factor to consider for prenatal DHA supplementation interventions. [ABSTRACT FROM AUTHOR]
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- 2021
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3. Prenatal metal mixture concentrations and reward motivation in children
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de Water, Erik, Curtin, Paul, Gennings, Chris, Chelonis, John J., Paule, Merle, Bixby, Moira, McRae, Nia, Svensson, Katherine, Schnaas, Lourdes, Pantic, Ivan, Téllez-Rojo, Martha M., Wright, Robert O., and Horton, Megan. K.
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•We examined prenatal metal mixture concentrations and reward motivation in children.•Metal mixture concentrations were associated with increased reward motivation.•Contributions of different metals differed by trimester and child sex.
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- 2022
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4. Dietary fluoride intake during pregnancy and neurodevelopment in toddlers: A prospective study in the progress cohort
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Cantoral, Alejandra, Téllez-Rojo, Martha M., Malin, Ashley J., Schnaas, Lourdes, Osorio-Valencia, Erika, Mercado, Adriana, Martínez-Mier, E. Ángeles, Wright, Robert O., and Till, Christine
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•Mexican guidelines recommended a dietary reference intake for fluoride of 2.45 mg/d for adult and pregnant women.•Mexico has a salt fluoridation program.•High fluoride concentrations are neurotoxic.•Median fluoride intake through foods and beverages was estimated to be 1.01 mg/d (0.73, 1.32) in a Mexican pregnancy cohort.•Higher fluoride intake from foods and beverages during pregnancy is associated with lower cognitive neurodevelopment in male offspring.
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- 2021
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5. Associations between psychosocial stress, child's anxiety, and lung function in mid-childhood
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Rivera Rivera, Nadya Y., Lamadrid-Figueroa, Hector, Garcia, Adriana Mercado, Alcala, Cecilia Sara, Schnaas, Lourdes, Hernández-Chávez, Carmen, Téllez-Rojo, Martha M, Wright, Robert O., Wright, Rosalind J., Rosa, Maria José, and Tamayo-Ortiz, Marcela
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Reducing the risk of respiratory disease during the plasticstages of lung development could have long-term health impacts. Psychosocial stress has been previously linked to adverse childhood respiratory outcomes, but the influence of child's anxiety and sex differences has not been completely elucidated.
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- 2024
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6. OFFSPRING GENETIC PROFILE, PRENATAL DHA SUPPLEMENTATION, AND CHILD COGNITION AT AGE 5 YEARS.
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Chapnick, Melissa, Tandon, Sonia, Gonzalez Casanova, Ines, Rivera, Juan, Ramírez Silva, Ivonne, Schnaas, Lourdes, DiGirolamo, Ann M., Stein, Aryeh D., Koletzko, Berthold, and Ramakrishnan, Usha
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Background and Objective: Omega-3 polyunsaturated fatty acids are important for brain development and cognition. Maternal supplementation during pregnancy has shown mixed impacts on child cognitive performance. This study assessed whether offspring FADS genotype modified the impact of prenatal DHA supplementation on cognitive scores at age 5 years. Methods: POSGRAD (Prenatal Omega-3 Supplementation and Child Growth And Development) was a double-blind randomized controlled trial conducted in Mexico, in which 1094 women were randomly assigned at 18-22 weeks gestation to receive 400 mg/day algal docosahexaenoic acid (DHA) or placebo through delivery. We included children born to mothers enrolled in the original trial who had genetic data and cognitive outcomes at age 5 years assessed using the McCarthy Scales of Child Abilities (MSCA) which includes subscales for verbal, perceptual, quantitative, memory, and motor abilities. Generalized linear models were used to assess interactions between FADS1 and FADS2 SNPs (rs175446, rs174602, rs1535, rs174448, rs174583) and DHA supplementation on child cognitive outcomes at age 5 years. Results: 502 children (DHA= 254, placebo = 248) were included. Mean (SD) composite MSCA scores (sum of verbal, perceptual, quantitative) at age 5 years were 121.5 (22.5), and 121.0 (23.5) for the DHA and placebo groups, respectively. There were no significant differences by offspring FADs genotype (overall) on cognitive scores (all p > .05), neither was there evidence of effect modification of prenatal DHA supplementation (all p-interaction >.05). Conclusions: Variations in offspring FADS genotype appear not to influence child cognition at age 5 years and not to modify the impact of DHA on cognition. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Identification of novel loci associated with infant cognitive ability
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Sun, Ryan, Wang, Zhaoxi, Claus Henn, Birgit, Su, Li, Lu, Quan, Lin, Xihong, Wright, Robert O., Bellinger, David C., Kile, Molly, Mazumdar, Maitreyi, Tellez-Rojo, Martha Maria, Schnaas, Lourdes, and Christiani, David C.
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It is believed that genetic factors play a large role in the development of many cognitive and neurological processes; however, epidemiological evidence for the genetic basis of childhood neurodevelopment is very limited. Identification of the genetic polymorphisms associated with early-stage neurodevelopment will help elucidate biological mechanisms involved in neuro-behavior and provide a better understanding of the developing brain. To search for such variants, we performed a genome-wide association study (GWAS) for infant mental and motor ability at two years of age with mothers and children recruited from cohorts in Bangladesh and Mexico. Infant ability was assessed using mental and motor composite scores calculated with country-specific versions of the Bayley Scales of Infant Development. A missense variant (rs1055153) located in the gene WWTR1reached genome-wide significance in association with mental composite score (meta-analysis effect size of minor allele βmeta= −6.04; 95% CI: −8.13 to −3.94; P= 1.56×10−8). Infants carrying the minor allele reported substantially lower cognitive scores in both cohorts, and this variant is predicted to be in the top 0.3% of most deleterious substitutions in the human genome. Fine mapping and region-based association testing provided additional suggestive evidence that both WWTR1and a second gene, LRP1B, were associated with infant cognitive ability. Comparisons with recently conducted GWAS in intelligence and educational attainment indicate that our phenotypes do not possess a high genetic correlation with either adolescent or adult cognitive traits, suggesting that infant neurological assessments should be treated as an independent outcome of interest. Additional functional studies and replication efforts in other cohorts may help uncover new biological pathways and genetic architectures that are crucial to the developing brain.
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- 2020
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8. Maternal dietary intake of polyunsaturated fatty acids modifies association between prenatal DDT exposure and child neurodevelopment: A cohort study.
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Ogaz-González, Rafael, Mérida-Ortega, Ángel, Torres-Sánchez, Luisa, Schnaas, Lourdes, Hernández-Alcaraz, César, Cebrián, Mariano E., Rothenberg, Stephen J., García-Hernández, Rosa María, and López-Carrillo, Lizbeth
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MATERNAL nutrition ,UNSATURATED fatty acids in human nutrition ,DDT (Insecticide) ,POLLUTION ,MATERNAL exposure ,NEURAL development ,CHILD development - Abstract
Background Maternal 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) serum levels during pregnancy have been negatively linked to child neurodevelopment in contrast to intake of omega-3 and -6 (ω-3 and ω-6) fatty acids. Objectives To assess whether maternal dietary intake of ω-3 and ω-6 during pregnancy modifies the association between exposure to DDE and child neurodevelopment from age 42–60 months. Methods Prospective cohort study with 142 mother–child pairs performed in Mexico. DDE serum levels were determined by electron capture gas chromatography. Dietary ω-3 and ω-6 intake was estimated by questionnaire. Child neurodevelopment was assessed by McCarthy Scales. Results Docosahexaenoic (DHA) fatty acid intake significantly modified the association between DDE and motor component: increased maternal DDE was associated with lower motor development in children whose mothers had lower DHA intake (β log2DDE = −1.25; 95% CI: −2.62, 0.12), in contrast to the non-significant increase among children whose mothers had higher DHA intake (β log2DDE-motor = 0.50; 95% CI: 0.55, 1.56 ). Likewise, arachidonic fatty acid (ARA) intake modified the association between DDE and memory component: increased maternal DDE was associated with a significantly larger reduction in the memory component in children whose mothers had lower ARA intake (β log2DDE = −1.31; 95% CI: −2.29, −0.32) than children whose mothers had higher ARA intake (β log2DDE-memory = 0.17; 95% CI: −0.78, 1.11). Conclusions Dietary intake of DHA and ARA during pregnancy may protect against child neurodevelopment damage associated with prenatal maternal DDE levels. [ABSTRACT FROM AUTHOR]
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- 2018
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9. Effects of a Parenting Program Among Women Who Began Childbearing as Adolescents and Young Adults.
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Kagawa, Rose M.C., Deardorff, Julianna, García-Guerra, Armando, Knauer, Heather A., Schnaas, Lourdes, Neufeld, Lynnette M., and Fernald, Lia C.H.
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Purpose The purpose of the study was to examine whether access to an at-scale, group-based parenting education program (“Educación Inicial”) had differential effects on parenting behaviors and child cognitive development according to mother's age at the birth of her first child, with a focus on adolescent mothers in rural Mexico. Methods This was a secondary analysis of a cluster-randomized controlled trial (n = 728 households, n = 106 communities). We conducted intent-to-treat analyses and examined the interaction between treatment group and mother's age at first birth. The primary outcomes were parenting behaviors (Family Care Indicators) and children's cognitive development (McCarthy Scales of Children's Abilities) at ages 3–5 years. Results We found that children of mothers who began childbearing in adulthood (20–30 years) scored higher on tests of cognitive development when randomized to weekly parenting support than their counterparts in the comparison group. Whereas, the children of mothers who began childbearing in adolescence (≤16 years) did not have higher scores associated with the parenting program (difference in magnitude of associations: Verbal = −8.19; 95% CI = −15.50 to −.88; p = .03; Memory = −7.22; 95% CI = −14.31 to −.14; p = .05). The higher scores among the children of mothers who began childbearing in adulthood were only significant when Educación Inical was supported by Prospera, the conditional cash transfer program. Conclusions Our study results suggest that the Educación Inicial parenting intervention did not adequately address the needs of women who began childbearing in adolescence. One reason may be that adolescent mothers are more socially marginalized and less able to benefit from parenting programs. [ABSTRACT FROM AUTHOR]
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- 2017
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10. Maternal antenatal stress has little impact on child sleep: results from a prebirth cohort in Mexico City
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Chatterjee, Avik, Thompson, Jennifer W., Svensson, Katherine, Tamayo y Ortiz, Marcela, Wright, Robert, Wright, Rosalind, Tellez-Rojo, Martha, Baccarelli, Andrea, Cantoral, Alejandra, Schnaas, Lourdes, and Oken, Emily
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Maternal antenatal stress may influence offspring development and behavior, but any association with child sleep is unknown.
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- 2018
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11. Prenatal Lead Exposure Modifies the Impact of Maternal Self-Esteem on Children's Inattention Behavior.
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Xu, Jian, Hu, Howard, Wright, Rosalind, Sánchez, Brisa N., Schnaas, Lourdes, Bellinger, David C., Park, Sung Kyun, Martínez, Sandra, Hernández-Avila, Mauricio, Téllez-Rojo, Martha Maria, and Wright, Robert O.
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Objective: To prospectively evaluate the association of maternal self-esteem measured when their offspring were toddlers with the subsequent development of attention deficit hyperactivity disorder (ADHD)-like behavior in their school-age offspring and the potential modifying effects of prenatal lead exposure.Study Design: We evaluated a subsample of 192 mother-child pairs from a long-running birth-cohort project that enrolled mothers in Mexico from 1994-2011. Prenatal lead exposure was assessed using cord blood lead and maternal bone lead around delivery (tibia and patella lead, measured by K-x-ray-fluorescence). When children were 2 years old, maternal self-esteem was measured using the Coopersmith Self-Esteem Inventory. When children were 7-15 years old, children's blood lead levels and ADHD symptoms were assessed, and Conners' Parent Rating Scale-Revised and Behavior Rating Inventory of Executive Function-Parent Form were used as measures of ADHD-like behavior.Results: Adjusting for family economic status, marital status, maternal education and age, child's age and sex, and children's current blood lead levels, increased maternal self-esteem was associated with reduced child inattention behavior. Compared with those among high prenatal lead exposure (P25-P100), this association was stronger among low prenatal lead exposure groups (P1-P25, P values for the interaction effects between prenatal lead exposure and maternal self-esteem levels of <.10). Each 1-point increase in maternal self-esteem scores was associated with 0.6- to 1.3-point decrease in Conners' Parent Rating Scale-Revised and Behavior Rating Inventory of Executive Function-Parent Form T-scores among groups with low cord blood lead and patella lead (P1-P25).Conclusions: Children experiencing high maternal self-esteem during toddlerhood were less likely to develop inattention behavior at school age. Prenatal lead exposure may play a role in attenuating this protective effect. [ABSTRACT FROM AUTHOR]- Published
- 2015
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12. Prediction of Serum Zinc Levels in Mexican Children at 2 Years of Age Using a Food Frequency Questionnaire and Different Zinc Bioavailability Criteria.
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Cantoral, Alejandra, Téllez-Rojo, Martha, Shamah-Levy, Teresa, Schnaas, Lourdes, Hernández-Ávila, Mauricio, Peterson, Karen E., and Ettinger, Adrienne S.
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Background: The 2006 Mexican National Health and Nutrition Survey documented a prevalence of zinc deficiency of almost 30% in children under 2 years of age. Objective: We sought to validate a food frequency questionnaire (FFQ) for quantifying dietary bioavailable zinc intake in 2-year-old Mexican children accounting for phytic acid intake and using serum zinc as a reference. Methods: This cross-sectional study was nested within a longitudinal birth cohort of 333 young children in Mexico City. Nonfasting serum zinc concentration was measured and dietary zinc intake was calculated on the basis of a semiquantitative FFQ administered to their mothers. The relationship between dietary zinc intake and serum zinc was assessed using linear regression, adjusting for phytic acid intake, and analyzed according to two distinct international criteria to estimate bioavailable zinc. Models were stratified by zinc deficiency status. Results: Dietary zinc, adjusted for phytic acid intake, explained the greatest proportion of the variance of serum zinc. For each milligram of dietary zinc intake, serum zinc increased on average by 0.95 μg/dL (0.15 μmol/L) (p = .06). When stratified by zinc status, this increase was 0.74 μg/dL (p = .12) for each milligram of zinc consumed among children with adequate serum zinc (n = 276), whereas among those children with zinc deficiency (n = 57), serum zinc increased by only 0.11 μg/dL (p = .82). Conclusions: A semiquantitative FFQ can be used for predicting serum zinc in relation to dietary intake in young children, particularly among those who are zinc-replete, and when phytic acid or phytate intake is considered. Future studies should be conducted accounting for both zinc status and dietary zinc inhibitors to further elucidate and validate these findings. [ABSTRACT FROM AUTHOR]
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- 2015
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13. Prediction of Serum Zinc Levels in Mexican Children at 2 Years of Age Using a Food Frequency Questionnaire and Different Zinc Bioavailability Criteria
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Cantoral, Alejandra, Téllez-Rojo, Martha, Shamah-Levy, Teresa, Schnaas, Lourdes, Hernández-Ávila, Mauricio, Peterson, Karen E., and Ettinger, Adrienne S.
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Background: The 2006 Mexican National Health and Nutrition Survey documented a prevalence of zinc deficiency of almost 30% in children under 2 years of age.Objective: We sought to validate a food frequency questionnaire (FFQ) for quantifying dietary bioavailable zinc intake in 2-year-old Mexican children accounting for phytic acid intake and using serum zinc as a reference.Methods: This cross-sectional study was nested within a longitudinal birth cohort of 333 young children in Mexico City. Nonfasting serum zinc concentration was measured and dietary zinc intake was calculated on the basis of a semiquantitative FFQ administered to their mothers. The relationship between dietary zinc intake and serum zinc was assessed using linear regression, adjusting for phytic acid intake, and analyzed according to two distinct international criteria to estimate bioavailable zinc. Models were stratified by zinc deficiency status.Results: Dietary zinc, adjusted for phytic acid intake, explained the greatest proportion of the variance of serum zinc. For each milligram of dietary zinc intake, serum zinc increased on average by 0.95 µg/dL (0.15 µmol/L) (p= .06). When stratified by zinc status, this increase was 0.74 µg/dL (p= .12) for each milligram of zinc consumed among children with adequate serum zinc (n = 276), whereas among those children with zinc deficiency (n = 57), serum zinc increased by only 0.11 µg/dL (p= .82).Conclusions: A semiquantitative FFQ can be used for predicting serum zinc in relation to dietary intake in young children, particularly among those who are zinc-replete, and when phytic acid or phytate intake is considered. Future studies should be conducted accounting for both zinc status and dietary zinc inhibitors to further elucidate and validate these findings.
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- 2015
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14. Windows of Lead Exposure Sensitivity, Attained Height, and Body Mass Index at 48 Months.
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Afeiche, Myriam, Peterson, Karen E., Sánchez, Brisa N., Schnaas, Lourdes, Cantonwine, David, Ettinger, Adrienne S., Solano-González, Maritsa, Hernández-Avila, Mauricio, Hu, Howard, and Téllez-Rojo, Martha M.
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Objective: To examine longitudinal associations of prenatal, infancy, and early childhood lead exposure during sensitive periods with height and body mass index (BMI). Study design: A total of 773 participants were recruited between 1994 and 2005 in Mexico City. Lead exposure history categories were constructed for the prenatal period (maternal patellar lead concentration) and for infancy and childhood (mean child blood lead concentration at birth to 24 months and 30-48 months, respectively). Linear regression models were used to study lead exposure history with height and BMI at 48 months. Results: Mean height at age 48 months was significantly lower in children with a blood lead level exceeding the median during infancy (−0.84 cm; 95% CI, −1.42 to −0.25) than in children with a level below the median. Prenatal lead exposure was not associated with height at 48 months. Results for attained BMI generally trended in the same direction as for height. Conclusion: Our findings suggest an effect of lead exposure early in life on height attainment at 48 months, with the exposure window of greatest sensitivity in infancy. [ABSTRACT FROM AUTHOR]
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- 2012
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15. A Dopamine Receptor (DRD2) but Not Dopamine Transporter (DAT1) Gene Polymorphism is Associated with Neurocognitive Development of Mexican Preschool Children with Lead Exposure.
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Kordas, Katarzyna, Ettinger, Adrienne S., Bellinger, David C., Schnaas, Lourdes, Téllez Rojo, Martha María, Hernández-Avila, Mauricio, Hu, Howard, and Wright, Robert O.
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Objective: To investigate the effects of prenatal and postnatal lead exposure and polymorphisms in dopamine metabolism genes on neurocognitive development of Mexican children at 24 months (n = 220) and 48 months (n = 186) of age. Study design: We genotyped the dopamine transporter gene (DAT1; SLC6A3) variable nucleotide tandem repeat and the dopamine receptor D2 (DRD2) Taq1A single nucleotide polymorphism. Children were assessed at 24 months with Bayley Scales of Infant Development (Mental Development Index and Psychomotor Development Index) and at 48 months with McCarthy Scales of Children’s Abilities. Results: Blood lead concentration (BLL) in umbilical cord was 6.6 ± 3.3 μg/dL (measured in 1995-96), 8.1 ± 4.4 μg/dL at 24 months, and 8.1 ± 3.6 μg/dL at 48 months. Cord BLL was negatively associated with Mental Development Index (P < .01) and Psychomotor Development Index (P < .1), but not McCarthy scores. The 48-month BLL, but not the 24-month BLL, was negatively associated with children’s scores. Children with DRD2 TT genotype (variant) scored higher than children with CC genotype (wild type) on the Mental Development Index and McCarthy memory scale. Neither polymorphism modified the relationship between BLL (either prenatal or postnatal) and neurocognitive development. Conclusion: Lead exposure was adversely associated with neurocognitive measures, whereas the DRD2 Taq1A TT variant was positively associated with neurocognitive measures. We found no evidence of gene-environment interactions on developmental outcomes in early childhood. [Copyright &y& Elsevier]
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- 2011
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16. Early postnatal blood manganese levels and children's neurodevelopment.
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Claus Henn, Birgit, Ettinger, Adrienne S., Schwartz, Joel, Téllez-Rojo, Martha María, Lamadrid-Figueroa, Héctor, Hernández-Avila, Mauricio, Schnaas, Lourdes, Amarasiriwardena, Chitra, Bellinger, David C., Hu, Howard, and Wright, Robert O.
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CHILD development ,COMPARATIVE studies ,LONGITUDINAL method ,MANGANESE ,MASS spectrometry ,NEUROPSYCHOLOGICAL tests ,RESEARCH methodology ,MEDICAL cooperation ,PSYCHOLOGY of movement ,REGRESSION analysis ,RESEARCH ,RESEARCH funding ,ENVIRONMENTAL exposure ,EVALUATION research - Abstract
Background: Recent evidence suggests that low-level environmental exposure to manganese adversely affects child growth and neurodevelopment. Previous studies have addressed the effects of prenatal exposure, but little is known about developmental effects of early postnatal exposure.Methods: We studied 448 children born in Mexico City from 1997 through 2000, using a longitudinal study to investigate neurotoxic effects of early-life manganese exposure. Archived blood samples, collected from children at 12 and 24 months of age, were analyzed for manganese levels using inductively coupled plasma mass spectrometry. Mental and psychomotor development were scored using Bayley Scales of Infant Development at 6-month intervals between 12 and 36 months of age.Results: At 12 months of age, the mean (SD) blood manganese level was 24.3 (4.5)microg/L and the median was 23.7 microg/L; at 24 months, these values were 21.1 (6.2) microg/L and 20.3 microg/L, respectively. Twelve- and 24-month manganese concentrations were correlated (Spearman correlation = 0.55) and levels declined over time ([beta] = -5.7 [95% CI = -6.2 to -5.1]). We observed an inverted U-shaped association between 12-month blood manganese and concurrent mental development scores (compared with the middle 3 manganese quintiles, for the lowest manganese quintile, [beta] = -3.3 [-6.0 to -0.7] and for the highest manganese quintile, [beta] = -2.8 [-5.5 to -0.2]). This 12-month manganese effect was apparent but diminished with mental development scores at later ages. The 24-month manganese levels were not associated with neurodevelopment.Conclusions: These results suggest a possible biphasic dose-response relationship between early-life manganese exposure at lower exposure levels and infant neurodevelopment. The data are consistent with manganese as both an essential nutrient and a toxicant. [ABSTRACT FROM AUTHOR]- Published
- 2010
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17. Early Postnatal Blood Manganese Levels and Children's Neurodevelopment
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Claus Henn, Birgit, Ettinger, Adrienne S., Schwartz, Joel, Téllez-Rojo, Martha María, Lamadrid-Figueroa, Héctor, Hernández-Avila, Mauricio, Schnaas, Lourdes, Amarasiriwardena, Chitra, Bellinger, David C., Hu, Howard, and Wright, Robert O.
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Recent evidence suggests that low-level environmental exposure to manganese adversely affects child growth and neurodevelopment. Previous studies have addressed the effects of prenatal exposure, but little is known about developmental effects of early postnatal exposure.
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- 2010
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18. Erythrocyte cell membrane phospholipid levels compared against reported dietary intakes of polyunsaturated fatty acids in pregnant Mexican women
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Parra, Maria-Socorro, Schnaas, Lourdes, Meydani, Mohsen, Perroni, Estela, Mart?anez, Sandra, and Romieu, Isabelle
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AbstractObjective:To evaluate the validity of a food-frequency questionnaire (FFQ) for assessment of the dietary intakes of polyunsaturated fatty acids (PUFAs) against a biochemical marker of fat intake, erythrocyte cell membrane phospholipid levels, during pregnancy.Design:Cross-sectional analysis.Setting:Developmental Neurobiology Department, National Institute of Perinatology, Mexico City.Subjects:One hundred forty-six healthy pregnant women during the last trimester of pregnancy. Among women enrolled, the first 35 pregnant women (24%) had their erythrocytes analysed for fatty acid status.Methods:We administered an FFQ and compared intakes of PUFAs against their erythrocyte cell membrane concentrations, processed by gas chromatography.Results:Pearson correlation coefficients among ?-linolenic acid (ALN), docosahexaenoic acid (DHA) and eicosapentaenoic acid in erythrocyte cell membranes against their crude dietary counterparts were 0.32, 0.35 and 0.36 (each P< 0.05). In a simple linear regression, erythrocyte DHA and arachidonic acid (AA) were significantly related to their respective dietary intakes (? = 0.30, 95% confidence interval (CI): 0.007?0.60, P= 0.045 for DHA; ? = 0.49, 95% CI: 0.010?0.98, P= 0.044 for AA). Erythrocyte cell membrane ALN concentration (%/total) was only marginally related to ALN dietary intake (mg day?1) (? = 0.52, 95% CI: ?0.020?1.10, P= 0.061). However, after adjustment for long-chain n?3 PUFA/AA, this association reached significance (? = 0.44, 95% CI: 0.026?0.825, P= 0.038). Main dietary sources for n?3 PUFAs were canned tuna fish and fresh catfish; for n?6 these were eggs and cow's milk. The use of this FFQ in these pregnant Mexican women provided estimates of average long-term intakes of PUFAs and correlated reasonably well with their erythrocyte cell membrane phospholipid status. However, we need to consider that, during pregnancy, there is a faster turnover of PUFAs from fat storage that may modify the profile of erythrocyte PUFAs and lower the correlation between dietary intake and erythrocyte PUFAs.
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- 2002
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19. Effect of Maternal Bone Lead on Length and Head Circumference of Newborns and 1-Month-Old Infants
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Hernandez-Avila, Mauricio, Peterson, Karen, Gonzalez-Cossio, Teresa, Sanin, Luz, Aro, Antonio, Schnaas, Lourdes, and Hu, Howard
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The authors evaluated the effects that maternal bone lead stores have in anthropometry at birth in 223 mother-infant pairs. The participants were recruited between April and November 1994. Anthropometric data were collected within the first 12 hr following delivery. Maternal information was obtained 1 mo after delivery occurred. Bone lead burden was determined with in-vivo K-x-ray fluorescence of the tibia (cortical bone) and the patella (trabecular bone). The authors transformed anthropometric measurements to an ordinal 5-category scale, and the association of measurements with other factors was evaluated with ordinal logistic-regression models. Mean bone lead levels were 9.8 μg/gm bone mineral and 14.4 μg/gm bone mineral for the tibia and patella, respectively. Birth length of newborns decreased as tibia lead levels increased. Compared with women in the lower quintiles of the distribution of tibia lead, those in the upper quintile had a 79% increase in risk of having a lower birth length newborn (odds ratio = 1.79; 95% confidence interval = 1.10, 3.22). The authors adjusted by birth weight, and the effect was attenuated—but nonetheless significant. Patella lead was positively and significantly related to the risk of a low head circumference score; this score remained unaffected by inclusion of birth weight. The authors estimated the increased risk to be 1.02 per μg lead/gm bone mineral (95% confidence interval = 1.01, 1.04 per μg lead/gm bone mineral). Odds ratios did not vary substantially after the authors adjusted for birth weight and other important determinants of head circumference.
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- 2002
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20. Blood Lead Secular Trend in a Cohort of Children in Mexico City. II. 1990–1995
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Rothenberg, Stephen, Schnaas, Lourdes, Perroni, Estela, Hernández, Reyna, and Ortega, Juan
- Abstract
The authors determined the secular trend in blood lead levels in a cohort of 91 children born in Mexico City between 1987 and the beginning of 1993. The authors grouped children by calendar year in which they reached 36 mo of age (i.e., 1990–1995), and their blood lead levels were measured every 6 mo during a 66-mo period. The overall geometric mean blood lead level was 8.6 μmlg/dl (range = 1.0–61.0 μmlg/dl). A repeated measures analysis of variance revealed a significant downward linear trend in blood lead levels by year (p < .001)—from an estimated marginal geometric mean of 14.2 μmlg/dl in 1990 to 6.3 μmlg/dl in 1995. There was also a significant linear age effect (p < .001); blood lead levels generally fell during the 36th-66th mo. Family use of lead-glazed pottery significantly elevated blood lead levels (p = .006), and the effect magnified as age increased (Age x Pottery Interaction [p = .014]). Although the overall downward trend in blood lead levels during the time period described corresponded to a reduction in various sources of lead exposure, there was no alteration in production, distribution, or use of leaded pottery. Currently, use of lead-glazed ceramic pottery is one of the most profound sources of lead exposure in the Mexican population.
- Published
- 2000
- Full Text
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21. Lead-Glazed Ceramic Ware and Blood Lead Levels of Children in the City of Oaxaca, Mexico
- Author
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Azcona-cruz, Maria, Rothenberg, Stephen, Schnaas, Lourdes, Zamora-Muñoz, Jose, and Romero-placeres, Manuel
- Abstract
Although Mexico substantially reduced use of leaded gasoline during the 1990s, lead-glazed pottery remains a significant source of population exposure. Most previous studies of lead in nonoccupationally exposed groups in Mexico have been conducted in the Mexico City metropolitan area. Oaxaca, a poor southern state of Mexico, has a centuries-old tradition of use of low temperature lead-glazed ceramic ware manufactured mainly by small family businesses. We measured blood lead levels in 220 8–10-y-old children (i.e., not from pottery-making families) who were students in the innercity of Oaxaca and in the mothers of all children. The geometric mean blood lead level of the children was 10.5 μmlg/dl (+7.0/–4.3 μmlg/dl standard deviation; range = 1.3–35.5 μmlg/dl). The corresponding mean value for the mothers was 13.4 (+9.0/–5.4 μmlg/dl standard deviation; range = 2.8–45.3 μmlg/dl). We used cutoffs that were greater than or equal to 10 μmlg/dl, 20 μmlg/dl, and 30 μmlg/dl, and we determined that 54.9%, 10.3%, and 3.0% of the children were at or above the respective criteria. We accounted for 25.2% of the variance in blood lead levels of the children, using maternal responses to a questionnaire that assessed possible lead sources in a linear multiple-regression model. The most important factors related to lead levels were family use of lead-glazed pottery, use of animal fat in cooking, and family income. The addition of maternal blood lead level to the model increased accounted variance in blood lead to 48.0%. In logistic-regression modeling of children's blood lead levels, we used a cutoff of greater than or equal to 10 μmlg/dl, and we found that use of lead-glazed pottery was the most important of all questionnaire items that were predictive of blood lead levels (odds ratio = 2.98). In Oaxaca, as is the case elsewhere in Mexico, lead-glazed ceramic ware remains a significant risk factor for elevated blood lead levels in children.
- Published
- 2000
- Full Text
- View/download PDF
22. Secular Trend in Blood Lead Levels in a Cohort of Mexico City Children
- Author
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Rothenberg, Stephen, Schnaas, Lourdes, Perroni, Estela, Hernandez, Reyna, and Karchmer, Samuel
- Abstract
We determined the secular trend in blood lead levels in a cohort of 104 children born in Mexico City between 1987 and 1993. We grouped children by the calendar year in which they reached 6 mo of age and measured blood lead levels every 6 mo until they attained 36 mo of age. The overall geometric mean blood lead level was 9.6 μg/dl (range = 1.5–59.5 μg/dl). A repeated measures analysis of variance revealed a highly significant linear trend in blood lead level with year (p < .001); there was a maximum decrease of 7.6 μg/dl between 1989 and 1993. There was a highly significant quadratic age effect (p < .001); blood lead levels rose between 6 and 18 mo of age and decreased thereafter. There was a marginally significant interaction between age of the child and year. Family use of lead-glazed pottery significantly elevated blood lead levels (p = .028). The downward trend in blood lead levels during the time period of study corresponded to the reduction in various sources of lead exposure.
- Published
- 1998
- Full Text
- View/download PDF
23. Prenatal particulate matter exposure and wheeze in Mexican children: Effect modification by prenatal psychosocial stress.
- Author
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Rosa, Maria José, Just, Allan C., Kloog, Itai, Pantic, Ivan, Schnaas, Lourdes, Lee, Alison, Bose, Sonali, Chiu, Yueh-Hsiu Mathilda, Hsu, Hsiao-Hsien Leon, Coull, Brent, Schwartz, Joel, Cohen, Sheldon, Téllez Rojo, Martha María, Wright, Robert O., and Wright, Rosalind J.
- Published
- 2017
- Full Text
- View/download PDF
24. Maternal Bone Lead Levels Are Prospectively Associated With Increased Blood Pressure in Female Offspring.
- Author
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Zhang, Aimin, Hu, Howard, Sánchez, Brisa, Park, Sung Kyun, Schnaas, Lourdes, Wright, Robert, Ettinger, Adrienne, Lamadrid-Figueroa, Hector, and Tellez-Rojo, Martha Maria
- Published
- 2011
- Full Text
- View/download PDF
25. Prenatal and postnatal stress and wheeze in Mexican children: Sex-specific differences.
- Author
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Rosa, Maria José, Just, Allan C., Tamayo y Ortiz, Marcela, Schnaas, Lourdes, Svensson, Katherine, Wright, Robert O., Téllez Rojo, Martha María, and Wright, Rosalind J.
- Published
- 2016
- Full Text
- View/download PDF
26. Prenatal particulate matter exposure and wheeze in Mexican children
- Author
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Rosa, Maria José, Just, Allan C., Kloog, Itai, Pantic, Ivan, Schnaas, Lourdes, Lee, Alison, Bose, Sonali, Chiu, Yueh-Hsiu Mathilda, Hsu, Hsiao-Hsien Leon, Coull, Brent, Schwartz, Joel, Cohen, Sheldon, Téllez Rojo, Martha María, Wright, Robert O., and Wright, Rosalind J.
- Abstract
Air pollution exposure in childhood is associated with greater incidence and exacerbation of asthma, particularly in children whose parents report high levels of psychological stress. However, this interaction has not been completely elucidated in pregnancy.
- Published
- 2017
- Full Text
- View/download PDF
27. Maternal Bone Lead Levels Are Prospectively Associated With Increased Blood Pressure in Female Offspring
- Author
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Zhang, Aimin, Hu, Howard, Sánchez, Brisa, Park, Sung Kyun, Schnaas, Lourdes, Wright, Robert, Ettinger, Adrienne, Lamadrid-Figueroa, Hector, and Tellez-Rojo, Martha Maria
- Published
- 2011
- Full Text
- View/download PDF
28. Prenatal and postnatal stress and wheeze in Mexican children
- Author
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Rosa, Maria José, Just, Allan C., Tamayo y Ortiz, Marcela, Schnaas, Lourdes, Svensson, Katherine, Wright, Robert O., Téllez Rojo, Martha María, and Wright, Rosalind J.
- Abstract
Increasing evidence links early-life exposure to psychosocial stress with adverse childhood respiratory outcomes. The influence of exposure timing has not been completely elucidated.
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- 2016
- Full Text
- View/download PDF
29. P-411.
- Author
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Zhang, Aimin, Hu, Howard, Sanchez, Brisa N, Ettinger, Adrienne S, Park, Sung Kyun, Cantonwine, David, Schnaas, Lourdes, Wright, Robert O., Lamadrid-Figueroa, Hector, and Tellez-Rojo, Martha Maria
- Published
- 2012
- Full Text
- View/download PDF
30. P-273.
- Author
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Vazquez-Salas, Ruth Argelia, Torres-Sanchez, Luisa, Menezes-Filho, Jose Antonio, López Carrillo, Lizbeth, Rothenberg, Stephen J, Schnaas, Lourdes, and Cebrian, Mariano E
- Published
- 2012
- Full Text
- View/download PDF
31. P-072.
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Osorio, Erika, Torres-Sánchez, Luisa, del Carmen Hernández, María, López-Carrillo, Lizbeth, Schnaas, Lourdes, and Cebriàn, Mariano
- Published
- 2012
- Full Text
- View/download PDF
32. E-023.
- Author
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XU, Jian, Jian, Xu, Cao, Sirui, Sánchez, Brisa N., Schnaas, Lourdes, Bellinger, David, Park, Sung Kyun, Wright, Robert O., Lamadrid-Figueroa, Hector, Hernandez-Avila, Mauricio, Hu, Howard, Tellez-Rojo, Martha Maria, and Martisa, Solano-González
- Published
- 2012
- Full Text
- View/download PDF
33. Modification of Lead Exposure on the Association Between Patterns of Physical Growth and Neuromotor Functions Development.
- Author
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Huang, Siying, Hu, Howard, Tellez-Rojo, Mara, Peterson, Karen, Sanchez, Brisa, Bellinger, David, Park, Sung Kyun, Schnaas, Lourdes, LaMadrid-Figueroa, Hector, and Hernandez-Avila, Mauricio
- Published
- 2011
- Full Text
- View/download PDF
34. Neonatal Neurodevelopment and Prenatal p,p’-DDE Exposure: Evaluation by Three Different Tests.
- Author
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Bahena-Medina, Lilia Araceli, Torres-Sanchez, Luisa, Schnaas, Lourdes, del Carmen Hernandez Chavez, Maria, Valencia, Erika Osorio, Cebrián-García, Mariano E, Hernández, Rosa María García, and Lopez-Carrillo, Lizbeth
- Published
- 2009
- Full Text
- View/download PDF
35. In-Utero p,p'-DDE Exposure and Child Neurodevelopment at 48 Months of Age: A Mexican Cohort.
- Author
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Gutierrez, Analucia, Torres-Sanchez, Luisa, Schnaas, Lourdes, del Carmen Hernandez, Maria, Osorio, Erika, Cebrian Garcia, Mariano E, Garcia Hernandez, Rosa Maria, and Lopez-Carrillo, Lizbeth
- Published
- 2009
- Full Text
- View/download PDF
36. Secondary Hyperparathyroidism Induced by Plateletpheresis in Donors As a Result of Divalent Cationic Chelation by Citrate.
- Author
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Sanchez-Guerrero, Sergio, Zapata-Canto, Nidia, Tolentino-Dolores, Maricruz, Barbosa-Ibarra, Arlette, Volkow-Fernandez, Patricia, Juan, Labardini, Zamora-Sanchez, Lizbeth, Alonso-Lopez, Alma, Rivas-Pichon, Eloisa, Buendia-Gomez, Leticia, Damian-Yañez, Delfina, Ortiz, Claudia Angel, Samano-Samano, Reyna, Morales, Rosa M, and Schnaas, Lourdes
- Abstract
Apheresis is an efficient method to collect specific blood components such as platelets, leukocytes, plasma and stem cells. Its advantages include: the collection of standardized and high-quality blood products and a higher collection frequency. However, apheresis is usually accompanied by acute metabolic changes (specially in serum calcium and magnesium concentrations) due to citrate infusion during the whole procedure.To compare pre and post-plateletpheresis serum level concentrations of calcium, magnesium, zinc, copper and parathyroid hormone among donors and correlate these levels with symptoms that donors may experience during the procedure performance.This is a prospective study including 105 healthy plateletpheresis donors who attended the National Cancer Institute. Basal and post-procedure serum levels of parathyroid hormone (PTH), calcium (Ca), magnesium (Mg), zinc (Zn) and copper (Cu) were measured by ion selective potentiometry (Ca), final dot (Mg), atomic absorption (Cu, Zn) and solid phase two site chemoluminiscence (PTH) methods. In case of adverse reactions, a blood sample was drawn immediately in order to analyze concentrations of such hormone and minerals. We intended to correlate both, diet and adverse reactions with serum levels of aforementioned elements. Statistical analysis was performed by chi-square and ANOVA. Protocol was approved by the institutional ethical and research committee.One hundred and five consecutive donors were included in the study conducted from June 28th through July 27th, 2012. There were 68 males and 37 females. Median age was 31 years (range 18–56). Pre and post-apheresis PTH, Ca, Mg, Zn and Cu serum levels are shown in table 1. Furthermore we found significant differences in women older than 30 years but did not find any relationship between donors' symptoms and diet.Plateletpheresis induced a secondary hyperparathyroidism state resulting from chelation of calcium and magnesium. We demonstrated that Cu was also chelated by citrate. These results urges us to assess the kinetics of these metabolic changes as well as to follow a cohort of donors with bone densitometry in order to assure that frequent and chronic infusion of citrate during plateletpheresis donations does not become a long-term risk for osteopenia and osteoporosis as already suggested by some authors1,2. If such a risk is demonstrated other preventive measures must be implemented like: 1.- To restrict the number of apheresis donations per person and 2.- To develop new and safer anticoagulants to be used during the apheresis procedures.No relevant conflicts of interest to declare.
- Published
- 2012
- Full Text
- View/download PDF
37. Secondary Hyperparathyroidism Induced by Plateletpheresis in Donors As a Result of Divalent Cationic Chelation by Citrate.
- Author
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Sanchez-Guerrero, Sergio, Zapata-Canto, Nidia, Tolentino-Dolores, Maricruz, Barbosa-Ibarra, Arlette, Volkow-Fernandez, Patricia, Juan, Labardini, Zamora-Sanchez, Lizbeth, Alonso-Lopez, Alma, Rivas-Pichon, Eloisa, Buendia-Gomez, Leticia, Damian-Yañez, Delfina, Ortiz, Claudia Angel, Samano-Samano, Reyna, Morales, Rosa M, and Schnaas, Lourdes
- Abstract
Abstract 2284
- Published
- 2012
- Full Text
- View/download PDF
38. P-411
- Author
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Zhang, Aimin, Hu, Howard, Sanchez, Brisa N, Ettinger, Adrienne S, Park, Sung Kyun, Cantonwine, David, Schnaas, Lourdes, Wright, Robert O., Lamadrid-Figueroa, Hector, and Tellez-Rojo, Martha Maria
- Published
- 2012
- Full Text
- View/download PDF
39. P-273
- Author
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Vazquez-Salas, Ruth Argelia, Torres-Sanchez, Luisa, Menezes-Filho, Jose Antonio, López Carrillo, Lizbeth, Rothenberg, Stephen J, Schnaas, Lourdes, and Cebrian, Mariano E
- Published
- 2012
- Full Text
- View/download PDF
40. P-072
- Author
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Osorio, Erika, Torres-Sánchez, Luisa, del Carmen Hernández, María, López-Carrillo, Lizbeth, Schnaas, Lourdes, and Cebriàn, Mariano
- Published
- 2012
- Full Text
- View/download PDF
41. E-023
- Author
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XU, Jian, Jian, Xu, Cao, Sirui, Sánchez, Brisa N., Schnaas, Lourdes, Bellinger, David, Park, Sung Kyun, Wright, Robert O., Lamadrid-Figueroa, Hector, Hernandez-Avila, Mauricio, Hu, Howard, Tellez-Rojo, Martha Maria, and Martisa, Solano-González
- Published
- 2012
- Full Text
- View/download PDF
42. Modification of Lead Exposure on the Association Between Patterns of Physical Growth and Neuromotor Functions Development
- Author
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Huang, Siying, Hu, Howard, Tellez-Rojo, Mara, Peterson, Karen, Sanchez, Brisa, Bellinger, David, Park, Sung Kyun, Schnaas, Lourdes, LaMadrid-Figueroa, Hector, and Hernandez-Avila, Mauricio
- Published
- 2011
- Full Text
- View/download PDF
43. In-Utero p,p'-DDE Exposure and Child Neurodevelopment at 48 Months of Age A Mexican Cohort
- Author
-
Gutierrez, Analucia, Torres-Sanchez, Luisa, Schnaas, Lourdes, del Carmen Hernandez, Maria, Osorio, Erika, Garcia, Mariano E Cebrian, Hernandez, Rosa Maria Garcia, and Lopez-Carrillo, Lizbeth
- Published
- 2009
- Full Text
- View/download PDF
44. Neonatal Neurodevelopment and Prenatal p,p’-DDE Exposure Evaluation by Three Different Tests
- Author
-
Bahena-Medina, Lilia Araceli, Torres-Sanchez, Luisa, Schnaas, Lourdes, del Carmen Hernandez Chavez, Maria, Valencia, Erika Osorio, Cebrián-García, Mariano E, Hernández, Rosa María García, and Lopez-Carrillo, Lizbeth
- Published
- 2009
- Full Text
- View/download PDF
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