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A recent study from the University of Kentucky College of Medicine explores the role of Scavenger Receptor BI (SR-BI) in sepsis, a life-threatening condition caused by a dysregulated host response to infection. The research suggests that SR-BI may protect against sepsis through various mechanisms, such as preventing cytotoxicity, promoting LPS clearance, and regulating cholesterol metabolism. This study highlights the potential of SR-BI as a target for developing effective therapies for sepsis. [Extracted from the article]

A recent study conducted by the National Institutes of Health explores the role of the class B scavenger receptor CD36 as a potential therapeutic target in inflammation induced by Danger-Associated Molecular Patterns (DAMPs). The research indicates that CD36 functions as a pattern recognition receptor for various pathogens and mediates pro-inflammatory effects of DAMPs. The findings suggest that CD36 plays a crucial role in the innate immune response and could be a promising target for treating inflammatory conditions associated with DAMPs. [Extracted from the article]

Researchers at the Salk Institute for Biological Studies in La Jolla, California, have identified a mechanism involving the scavenger receptor CD36 in tumor-associated macrophages (TAMs) that promotes cancer progression by suppressing type I interferon signaling. The study found that CD36 upregulation in TAMs was associated with immunosuppressive features, and its deletion reduced tumor growth while enhancing an inflammatory response. These findings suggest that CD36 plays a critical role in regulating TAM function and the tumor microenvironment, potentially offering new avenues for anti-tumor therapies. [Extracted from the article]

Researchers at the National Heart Lung and Blood Institute (NHLBI) in Bethesda, Maryland, have conducted a study on phagocytosis, focusing on the role of glia maturation factor-gamma (GMFG) in regulating the phagocytosis of beta-amyloid (A beta) in macrophages. The study found that GMFG plays a role in the uptake of A beta by macrophages through modulation of the type I class A scavenger receptor. This research may offer insights into potential therapeutic approaches for Alzheimer's disease. The study has been peer-reviewed and published in the Journal of Leukocyte Biology. [Extracted from the article]

Researchers from Shenyang Agricultural University in China have conducted a study on LDL receptors and their role in the toxicity of Binary toxins from Lysinibacillus sphaericus to Ag55 cells. The study focused on the scavenger receptor C1 (SCRC1) as a potential mediator of Bin toxin cytotoxicity. Through RNA interference knockdown experiments, the researchers found that SCRC1 plays a crucial role in the endocytosis of Bin toxin into Ag55 cells, facilitating its cytological activity. This research provides new insights into the mechanism of Bin toxin action and encourages further investigation into the transfer of Bin toxin within the cells. [Extracted from the article]

A recent study conducted at Zibo Central Hospital in China has found that the level of soluble CD163 (sCD163) is elevated in patients with lupus nephritis (LN), a kidney disease associated with systemic lupus erythematosus (SLE). The researchers analyzed 11 indices and found that sCD163 could be used to diagnose LN and predict its occurrence and prognosis. The study also revealed that higher levels of sCD163 were associated with a heavier SLE disease activity index and poorer response to treatment. These findings suggest that serum sCD163 could be a useful biomarker for LN. [Extracted from the article]

A study conducted by researchers at the College of Medicine in Iraq explores the role of scavenger receptor class B type I (SR-B1) in the aggressiveness and development of prostate cancer. The study involved 180 male participants and found that SR-B1 levels were significantly higher in prostate cancer patients compared to benign, tumor-treated, and control groups. The study suggests that SR-B1 could be used as a marker for the initial detection of prostate cancer. Further information on the study can be found in the Medical Journal of Babylon. [Extracted from the article]

A recent study conducted in Hangzhou, People's Republic of China, has found that alpha-ketoglutarate (alpha-KG) has the potential to modulate the inflammatory response in sepsis, a condition characterized by an uncontrolled inflammatory response triggered by infection or stress. The study showed that alpha-KG can mitigate inflammatory factors in the serum of septic mice and reduce tissue damage. It was also found that alpha-KG regulates the expression of the scavenger receptor (SR-A5) through m6A demethylation, playing a crucial role in inhibiting inflammation during sepsis. These findings provide valuable insights into the relationship between energy metabolism and inflammation regulation. [Extracted from the article]

A recent study conducted by researchers at Peking University in Beijing, China, has found that a combination of scavenger receptor-A (SR-A) and anti-cyclic citrullinated peptide antibody (anti-CCP) can improve the early diagnosis of rheumatoid arthritis (RA). The study involved 1,129 individuals from three different cohorts, including RA patients, healthy controls, and patients with other rheumatic diseases. The combination of SR-A and anti-CCP increased the sensitivity of anti-CCP by 13% in RA patients, while maintaining a specificity of 90%. In early RA patients, the combination increased the sensitivity of anti-CCP by 7% while maintaining a specificity of 94%. The researchers believe that this combination could potentially improve the prognosis and reduce mortality in RA patients. [Extracted from the article]

A patent application titled "Compositions, Kits, And Methods For Detecting Preclinical Alzheimer's Disease" has been made available online. The inventors have conducted a study on cell-surface leukocyte biomarkers and their association with cerebral amyloid beta (Ab) accumulation as potential biomarkers for Alzheimer's Disease (AD). They have identified several biomarkers, such as CD163, CD91, and MerTK, that show promise in diagnosing and prognosing AD. The patent application also describes methods for diagnosing AD and evaluating the efficacy of AD therapeutic candidates using these biomarkers. Panels of biomarkers and methods for measuring their relative expression are also discussed. This patent application describes methods and kits for detecting preclinical Alzheimer's disease (AD) in human patients. The methods involve obtaining blood samples from patients, reacting the samples with specific monoclonal antibodies conjugated with fluorophores, and measuring the concentration of bound biomarkers. Changes in biomarker concentration can be used to diagnose AD and determine the efficacy of AD therapeutic candidates. The kits include binding agents for specific biomarkers conjugated with detectable moieties. These methods and kits have potential applications in the diagnosis and treatment of AD. [Extracted from the article]

This patent application discusses the development of nucleic acid-derivatized therapeutics that can be used to treat various diseases by targeting macrophages. Macrophages are versatile cells that play a role in maintaining homeostasis and are associated with diseases such as cancer, obesity, and coronary heart disease. The application describes a composition that specifically targets the lysosomes of macrophages, potentially allowing for more effective treatment. The therapeutic agents can include small molecules, peptides, and inhibitors of specific enzymes. The application also mentions the use of labeling modules for imaging purposes and the inclusion of pharmaceutically acceptable carriers. The overall goal of this research is to develop new approaches for targeted drug delivery to macrophages and improve treatment outcomes for various diseases. [Extracted from the article]

A study conducted by investigators at the University of Tubingen in Germany has found that Staphylococcus aureus, a type of Gram-positive bacteria, uses wall teichoic acid (WTA) to attach to endothelial cells in blood vessels. The researchers discovered that the oxidized low-density lipoprotein receptor 1 (LOX-1) on endothelial cells interacts with S. aureus WTA, facilitating the binding of the bacteria to human endothelial cells. The study suggests that blocking LOX-1 could potentially prevent or treat severe endovascular infections caused by S. aureus. This research has been peer-reviewed and published in ACS Infectious Diseases. [Extracted from the article]

A recent preprint abstract discusses the role of the scavenger receptor Bez in lipid redistribution in Drosophila. While scavenger receptors have been studied in mammals, little is known about their function in invertebrates. The study found that Bez is involved in lipid export from Drosophila adipocytes and interacts with lipoproteins to transfer lipids from the fat body to the ovaries. This process contributes to the metabolic control of development. The research has not yet undergone peer review. [Extracted from the article]

Although exposure to cigarette smoke has been shown to be the main risk factor for COPD, the mechanisms underlying this association remain unclear as many smokers do not develop COPD. Keywords: Chronic Obstructive Pulmonary Disease; Epidemiology; Health and Medicine; Immunologic Receptors; LDL Receptors; Lung Diseases and Conditions; Membrane Proteins; Mortality; Pathogenesis; Risk and Prevention; Scavenger Receptors EN Chronic Obstructive Pulmonary Disease Epidemiology Health and Medicine Immunologic Receptors LDL Receptors Lung Diseases and Conditions Membrane Proteins Mortality Pathogenesis Risk and Prevention Scavenger Receptors 995 995 1 08/28/23 20230901 NES 230901 2023 SEP 1 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Letter on the CDC & FDA -- New study results on chronic obstructive pulmonary disease have been published. [Extracted from the article]

Agrochemicals, Bioinformatics, Biotechnology, Genetics, Immunologic Receptors, Information Technology, LDL Receptors, Membrane Proteins, Pesticides, Scavenger Receptors Based on the P. xylostella genome, we comprehensively analyzed the physicochemical properties, transmembrane structure, phylogenetic evolution, secondary and tertiary structure prediction, conserved protein motifs and phosphorylation site prediction of SR gene family. Keywords: Agrochemicals; Bioinformatics; Biotechnology; Genetics; Immunologic Receptors; Information Technology; LDL Receptors; Membrane Proteins; Pesticides; Scavenger Receptors EN Agrochemicals Bioinformatics Biotechnology Genetics Immunologic Receptors Information Technology LDL Receptors Membrane Proteins Pesticides Scavenger Receptors 1155 1155 1 07/17/23 20230721 NES 230721 2023 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- New research on bioinformatics is the subject of a new report. [Extracted from the article]

For more information on this research see: Macrophage Gpx4 Deficiency Aggravates Foam Cell Formation By Regulating the Expression of Scavenger Receptors, Abca1, and Abcg1. Keywords: Guangdong; People's Republic of China; Asia; Connective Tissue Cells; Drugs and Therapies; Foam Cells; Health and Medicine; Hemic and Immune Systems; Immunologic Receptors; Immunology; LDL Receptors; Lipid Research; Lipids; Lipoproteins; Macrophages; Membrane Proteins; Mononuclear Phagocyte System; Myeloid Cells; Phagocytes; Scavenger Receptors EN Guangdong People's Republic of China Asia Connective Tissue Cells Drugs and Therapies Foam Cells Health and Medicine Hemic and Immune Systems Immunologic Receptors Immunology LDL Receptors Lipid Research Lipids Lipoproteins Macrophages Membrane Proteins Mononuclear Phagocyte System Myeloid Cells Phagocytes Scavenger Receptors 157 157 1 07/10/23 20230714 NES 230714 2023 JUL 10 (NewsRx) -- By a News Reporter-Staff News Editor at Gene Therapy Weekly -- New research on Membrane Proteins - LDL Receptors is the subject of a report. [Extracted from the article]

"In some embodiments, the antibody that inhibits the function of a protein encoded by a cholesterol metabolism gene is an anti-SR-B1 antibody (i.e., an antibody that specifically binds to SR-B1. The method of any one of claims 1-9, wherein the agent that targets cholesterol metabolism is a synthetic HDL nanostructure, an inhibitory nucleic acid that targets a cholesterol metabolism gene, or an antibody that inhibits the function of a protein encoded by a cholesterol metabolism gene. "In some embodiments, the agent that targets cholesterol metabolism is a synthetic HDL nanostructure, an inhibitory nucleic acid (e.g., antisense RNA, siRNA, microRNA, shRNA) that targets a cholesterol metabolism gene, or an antibody that inhibits the function of a protein encoded by a cholesterol metabolism gene. [Extracted from the article]

For more information on this research see: Scavenger receptor B2, a type III membrane pattern recognition receptor, senses LPS and activates the IMD pathway in crustaceans. Keywords: Bacterial Infections and Mycoses; Drugs and Therapies; Health and Medicine; Immunologic Receptors; LDL Receptors; Membrane Proteins; Pattern Recognition Receptors; Scavenger Receptors EN Bacterial Infections and Mycoses Drugs and Therapies Health and Medicine Immunologic Receptors LDL Receptors Membrane Proteins Pattern Recognition Receptors Scavenger Receptors 2123 2123 1 06/19/23 20230623 NES 230623 2023 JUN 23 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in bacterial infections and mycoses. [Extracted from the article]

Keywords: Connective Tissue Cells; Drugs and Therapies; Emerging Technologies; Health and Medicine; Immunologic Receptors; Immunology; LDL Receptors; Macrophages; Membrane Proteins; Mononuclear Phagocyte System; Myeloid Cells; Nanoparticles; Nanotechnology; Phagocytes; Scavenger Receptors; Therapeutics; Therapy EN Connective Tissue Cells Drugs and Therapies Emerging Technologies Health and Medicine Immunologic Receptors Immunology LDL Receptors Macrophages Membrane Proteins Mononuclear Phagocyte System Myeloid Cells Nanoparticles Nanotechnology Phagocytes Scavenger Receptors Therapeutics Therapy 2686 2686 1 06/12/23 20230616 NES 230616 2023 JUN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in nanoparticles. Connective Tissue Cells, Drugs and Therapies, Emerging Technologies, Health and Medicine, Immunologic Receptors, Immunology, LDL Receptors, Macrophages, Membrane Proteins, Mononuclear Phagocyte System, Myeloid Cells, Nanoparticles, Nanotechnology, Phagocytes, Scavenger Receptors, Therapeutics, Therapy. [Extracted from the article]

Cancer, Connective Tissue Cells, Health and Medicine, Immunologic Receptors, Immunology, LDL Receptors, Macrophages, Membrane Proteins, Mononuclear Phagocyte System, Myeloid Cells, Oncology, Phagocytes, Scavenger Receptors Keywords for this news article include: Mayo Clinic, Scottsdale, Arizona, United States, North and Central America, Cancer, Oncology, Macrophages, LDL Receptors, Myeloid Cells, Membrane Proteins, Health and Medicine, Scavenger Receptors, Immunologic Receptors, Connective Tissue Cells, Mononuclear Phagocyte System. Keywords: Cancer; Connective Tissue Cells; Health and Medicine; Immunologic Receptors; Immunology; LDL Receptors; Macrophages; Membrane Proteins; Mononuclear Phagocyte System; Myeloid Cells; Oncology; Phagocytes; Scavenger Receptors EN Cancer Connective Tissue Cells Health and Medicine Immunologic Receptors Immunology LDL Receptors Macrophages Membrane Proteins Mononuclear Phagocyte System Myeloid Cells Oncology Phagocytes Scavenger Receptors 855 855 1 06/05/23 20230606 NES 230606 2023 JUN 6 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on cancer have been published. [Extracted from the article]

Keywords for this news article include: Daejeon, South Korea, Asia, Immunologic Receptors, LDL Receptors, Membrane Proteins, Scavenger Receptors, Chungnam National University. Keywords: Daejeon; South Korea; Asia; Immunologic Receptors; LDL Receptors; Membrane Proteins; Scavenger Receptors EN Daejeon South Korea Asia Immunologic Receptors LDL Receptors Membrane Proteins Scavenger Receptors 999 999 1 05/29/23 20230602 NES 230602 2023 JUN 2 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Data detailed on Membrane Proteins - LDL Receptors have been presented. [Extracted from the article]

Keywords for this news article include: Little Rock, Arkansas, United States, North and Central America, Bone Research, Connective Tissue Cells, Health and Medicine, Immunologic Receptors, LDL Receptors, Lipid Research, Lipids, Lipoproteins, Macrophages, Membrane Proteins, Myeloid Cells, Osteoblasts, Osteoclasts, Scavenger Receptors, University of Arkansas for Medical Sciences. Keywords: Little Rock; State:Arkansas; United States; North and Central America; Bone Research; Connective Tissue Cells; Health and Medicine; Immunologic Receptors; LDL Receptors; Lipid Research; Lipids; Lipoproteins; Macrophages; Membrane Proteins; Myeloid Cells; Osteoblasts; Osteoclasts; Scavenger Receptors EN Little Rock State:Arkansas United States North and Central America Bone Research Connective Tissue Cells Health and Medicine Immunologic Receptors LDL Receptors Lipid Research Lipids Lipoproteins Macrophages Membrane Proteins Myeloid Cells Osteoblasts Osteoclasts Scavenger Receptors 2177 2177 1 05/02/23 20230505 NES 230505 2023 MAY 5 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on Membrane Proteins - LDL Receptors are discussed in a new report. [Extracted from the article]

"Suitable biomarkers for diagnosis of AD and evaluation of AD drug efficacy include CD11c, CD59, and CD163, in one panel, for example. Keywords: Alzheimer Disease; Antibodies; Biomarkers; Blood Proteins; Diagnostics and Screening; Drug Candidates; Drug Development; Drugs and Therapies; Health and Medicine; Immunoglobulins; Immunologic Receptors; Immunology; LDL Receptors; Membrane Proteins; Neurodegenerative Diseases and Conditions; Patent Application; Proteins; Scavenger Receptors; Therapeutics; Therapy EN Alzheimer Disease Antibodies Biomarkers Blood Proteins Diagnostics and Screening Drug Candidates Drug Development Drugs and Therapies Health and Medicine Immunoglobulins Immunologic Receptors Immunology LDL Receptors Membrane Proteins Neurodegenerative Diseases and Conditions Patent Application Proteins Scavenger Receptors Therapeutics Therapy 3266 3266 1 03/23/23 20230317 NES 230317 2023 MAR 17 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- A patent application by the inventors Doecke, James (Tamborine, AU); Fowler, Christopher (Mooroolbark, AU); Gu, Baijun (Mernda, AU); Huang, Xin (Mernda, AU); Li, Yihan (Parkville, AU); Masters, Colin L. (Clifton Hill, AU), filed on August 8, 2022, was made available online on February 23, 2023, according to news reporting originating from Washington, D.C., by NewsRx correspondents. Those biomarkers have been found to be diminished or increased (down-regulated or up-regulated) in AD patients and MCI patients, relative to CN patients, showing their usefulness in diagnosing and prognosing AD, alone or in combination with one or more other biomarkers. [Extracted from the article]

The isolated antibody of claim 1, wherein the VH chain sequence consists of the VH sequence shown in SEQ ID NO: 434; and the VL chain sequence consists of the VL sequence shown in SEQ ID NO: 439. The isolated antibody of claim 1, wherein the VH sequence consists of the VH sequence set forth in SEQ ID NO: 111; and the and the VL sequence consists of the VL sequence set forth in SEQ ID NO: 116. The isolated antibody of claim 1, wherein the VH sequence consists of the VH sequence set forth in SEQ ID NO: 61; and the VL sequence consists of the VL sequence set forth in SEQ ID NO: 66. The isolated antibody claim 1, wherein the VH sequence consists of the VH sequence selected from the sequences set forth in SEQ ID NO: 1, 11, 21, 31, 41, 51, 61, 71, 81, 91, 101, 111, 121, 131, 434, 444, or 474; and the VL sequence consists of the VL sequence selected from the sequences set forth in SEQ ID NOs: 6, 16, 26, 36, 46, 57, 66, 76, 86, 96, 106, 116, 126, 136, 439, 449, or 479. [Extracted from the article]

Reports on the study which found that heparin-binding EGF-like growth factor induces expression of lectin-like oxidized LDL receptor-1 in vascular smooth muscle cells. Examination of the proinflammatory cytokines; Evaluation of the advanced atherosclerotic plaques in vivo; Analysis of the cultured bovine aortic smooth muscle cells.