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Zinc sulphate (50 mg kg−1p.o.) did not modify basal gastric mucosal blood flow, as measured by [3H]aniline clearance, but inhibited its reduction by noradrenaline (3.5 μg kg−1min-1). Zinc sulphate also influenced gastric emptying of phenol red but its effects depended upon the dose; 30 mg kg−1caused no variation whereas 80 mg kg−1induced a significant delay. The nature of both actions is discussed and their implications in the development and prevention of gastric ulceration have been analysed.