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1. Involvement of the Chemokine RANTES (CCL5) in Resistance to Experimental Infection with Leishmania major

Author

da Costa Santiago, Helton, Oliveira, Carolina Ferreira, Santiago, Luciana, Oliveira Ferraz, Fernanda, da Glória de Souza, Daniele, Rodrigues De-Freitas, Luiz Antônio, Crocco Afonso, Luís Carlos, Teixeira, Mauro Martins, Gazzinelli, Ricardo Tostes, and Vieira, Leda Quercia

Abstract

ABSTRACTThe expression and putative role of chemokines during infection with Leishmania majorin mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection. CCL5 is part of the cascade of events leading to efficient parasite control in L. majorinfection.

Published
2004
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