5 results on '"Salim, Hamza Adel"'
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2. Assessment of Thrombectomy versus Combined Thrombolysis and Thrombectomy in Patients with Acute Ischemic Stroke and Medium Vessel Occlusion
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Dmytriw, Adam A., Ghozy, Sherief, Salim, Hamza Adel, Musmar, Basel, Siegler, James E., Kobeissi, Hassan, Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Regenhardt, Robert W., Cancelliere, Nicole M., El Naamani, Kareem, Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Kühn, Anna Luisa, Puri, Ajit S., Dyzmann, Christian, Kan, Peter T., Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Marotta, Thomas R., Stapleton, Christopher J., Rabinov, James D., Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard L. L., Tan, Benjamin Y. Q., Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Adeeb, Nimer, Cuellar-Saenz, Hugo H., Tjoumakaris, Stavropoula I., Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., Möhlenbruch, Markus A., Jesser, Jessica, Costalat, Vincent, Schiphorst, Adrien ter, Yedavalli, Vivek, Harker, Pablo, Chervak, Lina M., Aziz, Yasmin, Gory, Benjamin, Stracke, Christian Paul, Hecker, Constantin, Kadirvel, Ramanathan, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Thomas, Ajith J., Hsieh, Cheng-Yang, Liebeskind, David S., Radu, Răzvan Alexandru, Alexandre, Andrea M., Tancredi, Illario, Faizy, Tobias D., Fahed, Robert, Weyland, Charlotte S., Lubicz, Boris, Patel, Aman B., Pereira, Vitor Mendes, and Guenego, Adrien
- Abstract
This international multicenter study found that adjunctive intravenous thrombolysis may not provide benefit to mechanical thrombectomy in patients with acute ischemic stroke caused by distal and medium vessel occlusion.
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- 2024
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3. Endovascular therapy versus medical management in isolated posterior cerebral artery acute ischemic stroke: A multinational multicenter propensity score-weighted study
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Salim, Hamza Adel, Pulli, Benjamin, Yedavalli, Vivek, Musmar, Basel, Adeeb, Nimer, Lakhani, Dhairya, Essibayi, Muhammed Amir, El Naamani, Kareem, Henninger, Nils, Sundararajan, Sri Hari, Kühn, Anna Luisa, Khalife, Jane, Ghozy, Sherief, Scarcia, Luca, Grewal, Inayat, Tan, Benjamin YQ, Regenhardt, Robert W, Heit, Jeremy J, Cancelliere, Nicole M, Bernstock, Joshua D, Rouchaud, Aymeric, Fiehler, Jens, Sheth, Sunil, Puri, Ajit S, Dyzmann, Christian, Colasurdo, Marco, Barreau, Xavier, Renieri, Leonardo, Filipe, João Pedro, Harker, Pablo, Radu, Răzvan Alexandru, Abdalkader, Mohamad, Klein, Piers, Marotta, Thomas R, Spears, Julian, Ota, Takahiro, Mowla, Ashkan, Jabbour, Pascal, Biswas, Arundhati, Clarençon, Frédéric, Siegler, James E, Nguyen, Thanh N, Varela, Ricardo, Baker, Amanda, Altschul, David, Gonzalez, Nestor R, Möhlenbruch, Markus A, Costalat, Vincent, Gory, Benjamin, Stracke, Christian Paul, Aziz-Sultan, Mohammad Ali, Hecker, Constantin, Shaikh, Hamza, Griessenauer, Christoph J, Liebeskind, David S, Pedicelli, Alessandro, Alexandre, Andrea M, Tancredi, Illario, Faizy, Tobias D, Kalsoum, Erwah, Lubicz, Boris, Patel, Aman B, Pereira, Vitor Mendes, Wintermark, Max, Guenego, Adrien, and Dmytriw, Adam A
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Background: Despite the proven effectiveness of endovascular therapy (EVT) in acute ischemic strokes (AIS) involving anterior circulation large vessel occlusions, isolated posterior cerebral artery (PCA) occlusions (iPCAo) remain underexplored in clinical trials. This study investigates the comparative effectiveness and safety of EVT against medical management (MM) in patients with iPCAo.Methods: This multinational, multicenter propensity score-weighted study analyzed data from the Multicenter Analysis of primary Distal medium vessel occlusions: effect of Mechanical Thrombectomy (MAD-MT) registry, involving 37 centers across North America, Asia, and Europe. We included iPCAo patients treated with either EVT or MM. The primary outcome was the modified Rankin Scale (mRS) at 90 days, with secondary outcomes including functional independence, mortality, and safety profiles such as hemorrhagic complications.Results: A total of 177 patients were analyzed (88 MM and 89 EVT). EVT showed a statistically significant improvement in 90-day mRS scores (OR = 0.55, 95% CI = 0.30–1.00, p= 0.048), functional independence (OR = 2.52, 95% CI = 1.02–6.20, p= 0.045), and a reduction in 90-day mortality (OR = 0.12, 95% CI = 0.03–0.54, p= 0.006) compared to MM. Hemorrhagic complications were not significantly different between the groups.Conclusion: EVT for iPCAo is associated with better neurological outcomes and lower mortality compared to MM, without an increased risk of hemorrhagic complications. Nevertheless, these results should be interpreted with caution due to the study’s observational design. The findings are hypothesis-generating and highlight the need for future randomized controlled trials to confirm these observations and establish definitive treatment guidelines for this patient population.
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- 2024
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4. Predictive value of follow-up infarct volume on functional outcomes in middle cerebral artery M2 segment vessel occlusion stroke treated with mechanical thrombectomy
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Yedavalli, Vivek, Salim, Hamza Adel, Musmar, Basel, Adeeb, Nimer, El Naamani, Kareem, Henninger, Nils, Sundararajan, Sri Hari, Kühn, Anna Luisa, Khalife, Jane, Ghozy, Sherief, Scarcia, Luca, Tan, Benjamin YQ, Regenhardt, Robert W, Heit, Jeremy J, Cancelliere, Nicole M, Bernstock, Joshua D, Rouchaud, Aymeric, Fiehler, Jens, Sheth, Sunil, Puri, Ajit S, Dyzmann, Christian, Colasurdo, Marco, Barreau, Xavier, Renieri, Leonardo, Filipe, João Pedro, Harker, Pablo, Radu, Răzvan Alexandru, Abdalkader, Mohamad, Klein, Piers, Marotta, Thomas R, Spears, Julian, Ota, Takahiro, Mowla, Ashkan, Jabbour, Pascal, Biswas, Arundhati, Clarençon, Frédéric, Siegler, James E, Nguyen, Thanh N, Varela, Ricardo, Baker, Amanda, Essibayi, Muhammed Amir, Altschul, David, Gonzalez, Nestor R, Möhlenbruch, Markus A, Costalat, Vincent, Gory, Benjamin, Stracke, Christian Paul, Aziz-Sultan, Mohammad Ali, Hecker, Constantin, Shaikh, Hamza, Liebeskind, David S, Pedicelli, Alessandro, Alexandre, Andrea M, Tancredi, Illario, Faizy, Tobias D, Kalsoum, Erwah, Lubicz, Boris, Patel, Aman B, Pereira, Vitor Mendes, Guenego, Adrien, and Dmytriw, Adam A
- Abstract
Background: Medium vessel occlusion (MeVO) strokes, particularly affecting the M2 segment of the middle cerebral artery, represent a critical proportion of acute ischemic strokes, posing significant challenges in management and outcome prediction. The efficacy of mechanical thrombectomy (MT) in MeVO stroke may warrant reliable predictors of functional outcomes. This study aimed to investigate the prognostic value of follow-up infarct volume (FIV) for predicting 90-day functional outcomes in MeVO stroke patients undergoing MT.Methods: This multicenter, retrospective cohort study analyzed data from the Multicenter Analysis of primary Distal medium vessel occlusions: effect of Mechanical Thrombectomy (MAD-MT) registry, covering patients with acute ischemic stroke due to M2 segment occlusion treated with MT. We examined the relationship between 90-day functional outcomes, measured by the modified Rankin Scale (mRS), and follow-up infarct volume (FIV), assessed through CT or MRI within 12–36 h post-MT.Results: Among 130 participants, specific FIV thresholds were identified with high specificity and sensitivity for predicting outcomes. A FIV ⩽5 ml was highly specific for predicting favorable and excellent outcomes. The optimal cut-off for both prognostications was identified at ⩽15 ml by the Youden Index, with significant reductions in the likelihood of favorable outcomes observed above a 40 ml threshold. Receiver Operator Curve (ROC) analyses confirmed FIV as a superior predictor of functional outcomes compared to traditional recanalization scores, such as final modified thrombolysis in cerebral infarction score (mTICI). Multivariable analysis further highlighted the inverse relationship between FIV and positive functional outcomes.Conclusions: FIV within 36 h post-MT serves as a potent predictor of 90-day functional outcomes in patients with M2 segment MeVO strokes. Establishing FIV thresholds may aid in the prognostication of stroke outcomes, suggesting a role for FIV in guiding post intervention treatment decisions and informing clinical practice. Future research should focus on validating these findings across diverse patient populations and exploring the integration of FIV measurements with other clinical and imaging markers to enhance outcome prediction accuracy.
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- 2024
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5. Creation of a predictive calculator to determine adequacy of occlusion of the woven endobridge (WEB) device in intracranial aneurysms—A retrospective analysis of the WorldWide WEB Consortium database
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Musmar, Basel, Adeeb, Nimer, Gendreau, Julian, Horowitz, Melanie Alfonzo, Salim, Hamza Adel, Sanmugananthan, Praveen, Aslan, Assala, Brown, Nolan J, Cancelliere, Nicole M, McLellan, Rachel M, Algin, Oktay, Ghozy, Sherief, Dibas, Mahmoud, Orscelik, Atakan, Senol, Yigit Can, Lay, Sovann V, Guenego, Adrien, Renieri, Leonardo, Carnevale, Joseph, Saliou, Guillaume, Mastorakos, Panagiotis, El Naamani, Kareem, Shotar, Eimad, Premat, Kevin, Möhlenbruch, Markus, Kral, Michael, Doron, Omer, Chung, Charlotte, Salem, Mohamed M, Lylyk, Ivan, Foreman, Paul M, Vachhani, Jay A, Shaikh, Hamza, Župančić, Vedran, Hafeez, Muhammad U, Catapano, Joshua, Waqas, Muhammad, Tutino, Vincent M, Gokhan, Yuce, Imamoglu, Cetin, Bayrak, Ahmet, Rabinov, James D, Ren, Yifan, Schirmer, Clemens M, Piano, Mariangela, Kühn, Anna L, Michelozzi, Caterina, Elens, Stéphanie, Starke, Robert M, Hassan, Ameer E, Ogilvie, Mark, Nguyen, Anh, Jones, Jesse, Brinjikji, Waleed, Nawka, Marie T, Psychogios, Marios, Ulfert, Christian, Bengzon Diestro, Jose Danilo, Pukenas, Bryan, Burkhardt, Jan-Karl, Huynh, Thien, Martinez-Gutierrez, Juan Carlos, Essibayi, Muhammed Amir, Sheth, Sunil A, Spiegel, Gary, Tawk, Rabih, Lubicz, Boris, Panni, Pietro, Puri, Ajit S, Pero, Guglielmo, Nossek, Erez, Raz, Eytan, Killer-Oberfalzer, Monika, Griessenauer, Christoph J, Asadi, Hamed, Siddiqui, Adnan, Brook, Allan L, Altschul, David, Ducruet, Andrew F, Albuquerque, Felipe C, Regenhardt, Robert W, Stapleton, Christopher J, Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Boddu, Srikanth, Knopman, Jared, Aziz-Sultan, Mohammad A, Tjoumakaris, Stavropoula I, Clarençon, Frédéric, Limbucci, Nicola, Bydon, Mohamad, Hasan, David, Cuellar-Saenz, Hugo H, Jabbour, Pascal M, Pereira, Vitor Mendes, Patel, Aman B, and Dmytriw, Adam A
- Abstract
Background Endovascular treatment with the woven endobridge (WEB) device has been widely utilized for managing intracranial aneurysms. However, predicting the probability of achieving adequate occlusion (Raymond–Roy classification 1 or 2) remains challenging.Objective Our study sought to develop and validate a predictive calculator for adequate occlusion using the WEB device via data from a large multi-institutional retrospective cohort.Methods We used data from the WorldWide WEB Consortium, encompassing 356 patients from 30 centers across North America, South America, and Europe. Bivariate and multivariate regression analyses were performed on a variety of demographic and clinical factors, from which predictive factors were selected. Calibration and validation were conducted, with variance inflation factor (VIF) parameters checked for collinearity.Results A total of 356 patients were included: 124 (34.8%) were male, 108 (30.3%) were elderly (≥65 years), and 118 (33.1%) were current smokers. Mean maximum aneurysm diameter was 7.09 mm (SD 2.71), with 112 (31.5%) having a daughter sac. In the multivariate regression, increasing aneurysm neck size (OR 0.706 [95% CI: 0.535–0.929], p= 0.13) and partial aneurysm thrombosis (OR 0.135 [95% CI: 0.024–0.681], p= 0.016) were found to be the only statistically significant variables associated with poorer likelihood of achieving occlusion. The predictive calculator shows a c-statistic of 0.744. Hosmer–Lemeshow goodness-of-fit test indicated a satisfactory model fit with a p-value of 0.431. The calculator is available at: https://neurodx.shinyapps.io/WEBDEVICE/.Conclusion The predictive calculator offers a substantial contribution to the clinical toolkit for estimating the likelihood of adequate intracranial aneurysm occlusion by WEB device embolization.
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- 2024
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