Search

There is a direct relationship between bodyweight and risk of diabetes. Lorcaserin, a selective serotonin 2C receptor agonist that suppresses appetite, has been shown to facilitate sustained weight loss in obese or overweight patients. We aimed to evaluate the long-term effects of lorcaserin on diabetes prevention and remission.

L’objectif de cette étude était d’évaluer la fiabilité et la validité des variables céphalométriques obtenues grâce à MicroScribe-3DXL.

The aim of the study was to assess the reliability and validity of cephalometric variables from MicroScribe-3DXL.

Objective:The objective of this prospective, multicentre clinical study is to assess the application of MatriStem MicroMatrix (MSMM) and MatriStem Wound Matrix (MSWM) (porcine urinary bladder derived extracellular matrix) compared with Dermagraft (DG) (human fibroblast-derived dermal substitute) for the management of non-healing diabetic foot ulcers (DFUs).Method:A randomised, multicentre study was conducted at thirteen centers throughout the US. It was designed to evaluate the incidence of ulcer closure, rate of ulcer healing, wound characteristics, patient quality of life, cost-effectiveness, and recurrence. Those subjects whose DFUs decreased in size by ≤30% or increased by ≤50% during the standard of care (SOC) phase were randomised into the treatment phase of the study. The study evaluated complete wound closure by eight weeks with weekly device application. A two-week post treatment SOC phase followed the treatment phase for any wounds that did not heal by the end of eight weeks, and wound closure was also evaluated at the end of that period. Ulcer recurrence at 6 months post-treatment was evaluated in the subjects that showed wound healing by the end of the post-treatment SOC phase. Standard adjunctive therapy, including debridement, saline irrigation and foot off-loading, was provided to both arms during the four-week screening period, after which eligible subjects were randomised in a 1:1 ratio, to either the MatriStem (MS) or DG treatment arm. This study was developed to evaluate the hypothesis that the wound outcomes observed after wound management with MS were non-inferior to those of DG after eight weeks. The authors present the planned interim results of this study after one half of the projected enrolment was completed.Results:There were 95 subjects consented and entered into the SOC four-week screening phase of the trial and 56 were randomised into the treatment phase. At the planned interim analysis, there was a significantly lower cost per subject and significant improvement in patient quality of life for the subjects treated with MS compared with those managed with DG. However, there was not a statistically significant difference found during the analysis of the interim data between the two study groups for rate of wound healing or number of subjects with complete wound closure.Conclusion:The data from this interim analysis show that MSMM and MSWM provide results for healing DFUs that are similar to the results obtained for DG at a significant quality of life and economic advantage.

Objective:The objective of this prospective, multicentre clinical study is to assess the application of MatriStem MicroMatrix (MSMM) and MatriStem Wound Matrix (MSWM) (porcine urinary bladder derived extracellular matrix) compared with Dermagraft (DG) (human fibroblast-derived dermal substitute) for the management of non-healing diabetic foot ulcers (DFUs).Method:A randomised, multicentre study was conducted at thirteen centers throughout the US. It was designed to evaluate the incidence of ulcer closure, rate of ulcer healing, wound characteristics, patient quality of life, cost-effectiveness, and recurrence. Those subjects whose DFUs decreased in size by ≤30% or increased by ≤50% during the standard of care (SOC) phase were randomised into the treatment phase of the study. The study evaluated complete wound closure by eight weeks with weekly device application. A two-week post treatment SOC phase followed the treatment phase for any wounds that did not heal by the end of eight weeks, and wound closure was also evaluated at the end of that period. Ulcer recurrence at 6 months post-treatment was evaluated in the subjects that showed wound healing by the end of the post-treatment SOC phase. Standard adjunctive therapy, including debridement, saline irrigation and foot off-loading, was provided to both arms during the four-week screening period, after which eligible subjects were randomised in a 1:1 ratio, to either the MatriStem (MS) or DG treatment arm. This study was developed to evaluate the hypothesis that the wound outcomes observed after wound management with MS were non-inferior to those of DG after eight weeks. The authors present the planned interim results of this study after one half of the projected enrolment was completed.Results:There were 95 subjects consented and entered into the SOC four-week screening phase of the trial and 56 were randomised into the treatment phase. At the planned interim analysis, there was a significantly lower cost per subject and significant improvement in patient quality of life for the subjects treated with MS compared with those managed with DG. However, there was not a statistically significant difference found during the analysis of the interim data between the two study groups for rate of wound healing or number of subjects with complete wound closure.Conclusion:The data from this interim analysis show that MSMM and MSWM provide results for healing DFUs that are similar to the results obtained for DG at a significant quality of life and economic advantage.Declaration of interest:The opinions expressed are those of the authors and not necessarily those of the Department of Veterans Affairs or the United States Government. T.W. Gilbert is employed as the Chief Science Officer and is a stockholder in ACell, Inc., which commercializes MatriStem Wound Matrix and MicroMatrix. None of the other authors have a conflict of interest to declare.

Abstract: Stored product insect pests of Morocco Over a period of 3 years stored product insects pests were collected from markets, storage places, houses etc., identified, and their economic importance estimated. 48 Lepidoptera and Coleoptera species were detected, 17 of which play an important econmic role. No mites were encountered, probably due to prolonged high temperature in summer.

It was found from plan-view transmission electron microscopy (TEM) observations that c-oriented YBa2Cu3O7−δ(YBCO) films on LaAlO3, prepared by the magnetron sputtering technique had a single crystalline-like YBCO matrix, but always contained some precipitates of impurity phases. A large number of highly defective twin boundaries were also observed in all of these epitaxial films. Such highly defective twin boundaries are thought to be flux pinning centres and also paths for the diffusion of water into YBCO films. Therefore the films need to be passivated against attack from humid air.

AbstractRearing of Diabrotica balteataLeConte is possible throughout the year at temperatures between 10? and 30 ?C. Adults feed on a very large variety of host plants. Good edibility combined with pronounced oviposition and egg viability are found in Cucurbitaceae, Leguminosae, Rosaceae, and Cruciferae. However, cases of good edibility with no oviposition are also established in several families. Optimal adult longevity lies between 17? and 24 ?C and oviposition indicates two high peaks within the female life span.Temperatures below 0 ?C are detrimental to all stages and those between 0? and 4 ?C mainly to larval and pupal stages. No diapause is found in any stage and this explains the limited distribution within warmer regions of the Americas. Precautions not to introduce this species into other continents should be taken.

Zusammenfassung: Die wichtigsten Milben von wirtschaftlicher Bedeutung im Libanon, Jordanien und der südlichen Türkei werden aufgeführt. Es handelt sich auf Äpfeln um:Tetranychus urticae, Metatetranychus ulmi, Tetranychus cinnabarinus, Bryobia rubrioculus; aufCitrus sp. um:Phyllocoptruta oleivora, Aceria sheldoni ,Eutetranychus orientalis, Brevipalpus obovatus, T. cinnabarinus: auf Gemüsearten um:Tetranychus urticae, T. cinnabarinus; auf Wein um:Eriophyes vitis; auf Granatäpfeln um:Eriophyes granati.Die Orte und Daten der Befunde werden angegeben.

The growth of thin films of Pb-doped BiSrCaCuO by laser ablation is described. We use for the first time, the laser ablation technique to ablate multilayers of both doped BiPbSrCaCuO and PbO. In common with other BiPbSrCaCuO films grown by alternative routes, the layers produced still require an ex situ annealing step, although in our case the presence of a nearby Pb-rich solid was not required. We find a mixture of both 2223 and 2212 phases in the films, exhibiting Tonset of 110K and Tzero of 81K.

Background Despite the increased dissemination of tuberculosis among HIV infected patients, the diagnosis is difficult to establish. Traditional microbiological methods lack satisfactory sensitivity. We have developed a highly sensitive and specific nested polymerase chain reaction (PCR) capable of detecting Mycobacterium tuberculosis DNA in urine specimens and have used this test to examine urine specimens from HIV patients with active pulmonary tuberculosis. Methods Urine specimens from 13 HIV infected patients with microbiologically proven active pulmonary tuberculosis, 10 AIDS patients with non-tuberculous mycobacterial infection (documented by blood culture), 53 AIDS patients with no evidence of mycobacterial disease, and 80 healthy subjects (25 with positive skin test to purified protein derivative) were tested for M tuberculosis using PCR, acid fast staining (AFS), and culture. Results Of the urine specimens from patients with active tuberculosis, all tested positive by PCR, two by culture, and none by AFS. No reactivity was observed in urine specimens from patients with non-tuberculous mycobacterial infection. Of the 53 AIDS patients without mycobacterial infection, one had a positive urine PCR. Normal subjects were all negative. Conclusions Urine based nested PCR for M tuberculosis may be a useful test for identifying HIV patients with pulmonary tuberculosis.

Zusammenfassung: Drei Phosphorsäureester-bodeninsektizide mit geringerer Persistenz im Boden als Chlorkohlenwasserstoffinsektizide wurden vergleichend zu Lindan bei der Bekämpfung vonCapnodis tenebrionis L. in einer Krischbaumanlage geprüft. Die Ergebnisse zeigen, daß Isofenphos die besten Ergebnisse erbrachte und Lindan ersetzen kann.

Zusammenfassung: 10 Tage alte, jungfräuliche Weibchen vonTetranychus urticae Koch können noch begattet und ihre Eier befruchtet werden; einzelne Männchen konnten bis zu 7 Weibchen im Verlauf von 8 Tagen begatten. Weibchen erwiesen sich als 20mal so giftwiderstandsfähig wie Männchen; beide Geschlechter besaßen gleiche Heterogenität in der Population.

The description and development of the various stages of Tetranychus yusti McGregor are presented. The female requires 9-10 days and the male 8½-9½ days to develop at 25.5. On an average a female lays 4.5 eggs per day and lives 21 days, but it can lay up to 158 eggs and live up to 35 days. More than 85 plant species were tested as host plants, and representatives of the Leguminosae, Malacca, Gramineae, and Compositae proved most suitable. The chances of this spider mite to become economically important are discussed.