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Background and Aims: This study aims to investigate the clinicopathological profile of cervical lymphadenopathy in a tertiary referral centre. The findings will contribute to a deeper understanding of the disease spectrum, aid in accurate diagnosis, and help in improving patient treatment and outcomes.Methodology: This is a prospective study conducted in the Department of ENT, Head and Neck Surgery, Apollo Hospital, Chennai, between June 2022 and May 2023. The clinicopathological profile of all patients was analysed. The final histological diagnosis and the preoperative Fine Needle Aspiration Cytology (FNAC) were correlated. The primary tumour was identified in cases with metastatic secondary tumours in the neck.Results: Among the 80 patients in our study, 67% had a benign aetiology (most common was tuberculosis), and 33% had a malignant aetiology (most common was Hodgkin’s Lymphoma). Gender distribution was equal, with those between the ages of 35 and 60 more frequently affected. The nasopharynx (30%) was the most likely location of the occult primary, followed by the thyroid (20%) and larynx (20%). In detecting TB, FNAC had a sensitivity of 75.5% and a specificity of 98%; in detecting lymphomas, it was 64% and 100%; in detecting metastatic secondaries, it was 80% and 100%; and in detecting reactive lymphadenitis, it was 79% and 86%.Conclusion: Cervical lymphadenopathy is a common entity requiring careful evaluation and treatment. PET scans prove invaluable in detecting occult primary tumours. FNAC is an initial, cost-effective diagnostic tool. However, biopsy is indicated in specific conditions to obtain accurate diagnosis to enable prompt treatment.

Purpose: An increasingly popular concept in numerous fields is a digital twin, which is a virtual counterpart of an object. This technology is causing important advances for the benefit of patients in the context of healthcare. A digital twin is a computer-generated depiction of an actual product that mimics its information model, action, interaction processes, and product, as well as examines how they might be used to improve the organization of health care and the constraints linked to this innovative technology. This paper will investigate the utilization of Digital Twin systems, processes, and products, as well as examine how they might be used to improve the organization of health care and the constraints linked to this innovative technology. Methods: For research on Digital Twins and their use in healthcare published recently, a brief overview of the literature was reported. The databases of this study are published from 2002 to 2023 and the review was written in English. The Digital twin technology which does not support the Healthcare studies was excluded. This assessment is focused on their contribution to the Digital Twin, which aims to enhance user experience in healthcare from a system engineering and human aspects perspective. Results: The Digital Twin in healthcare has been growing since 2002 from 0 studies to 25 in 2023, with 15 studies available in 2023(N = 15 studies). The knowledge reported on the contributions or applications of each Digital Twin in healthcare, and its roles. The four main roles of digital twins in healthcare systems are health management and well-being promotion (n = 3), operational control (n = 12), information management (n = 5), and safety management (n = 4). The usage of digital twins in healthcare has the potential to stop unanticipated harm from occurring to patients while providing care. They may also be utilized to distinguish and manage the systemic concerns posed by crises. All stakeholders' access to real-time information and privacy are guaranteed by digital twins in the healthcare industry. Additionally, by enabling healthcare practices and fostering high levels of system efficiency by ensuring that healthcare facilities function properly and provide every patient with high-quality care, they help enhance self-care capacities. Conclusion: This assessment is focused on their contribution to the Digital Twin, which aims to enhance user experience in healthcare from a system engineering and human aspects perspective. This review explores and analyses opportunities for implementing digital twin technology in the Industrial Revolution 4.0 by considering various functionalities.

Polycrystalline Ca0.18Sr0.226Ba0.594Nb2O6(CSBN18) was synthesized via the solid-state reaction route. X-ray structural studies confirmed it belonged to the tetragonal tungsten bronze family. Rietveld refinement of the X-ray data has been carried out for CSBN18 where the atomic positions and site occupancy factors for A-sites have been determined. The dielectric properties of CSBN18 ceramic were studied as a function of temperature in the 100 Hz–1 MHz frequency range. The dielectric relaxation followed the Vogel–Fulcher relation wherein Ea= 37.4 meV; Tf= 131.5 °C and ?0= 4.31 × 109rad s-1. A high pyroelectric coefficient of ~ 250 µC m-2.K was obtained around the transition temperature (~150 °C). This is significantly higher than that reported for polycrystalline SrxBa1-xNb2O6(SBN). However, the piezoelectric coefficient (d33) of the title composition was as low as 6 pC N-1.