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20 results on '"Rojas, Lizbeth"'

2. Pesticide-Induced Alterations in Locomotor Activity, Anxiety, and Depression-like Behavior Are Mediated through Oxidative Stress-Related Autophagy: A Persistent Developmental Study in Mice

Author

Ommati, Mohammad Mehdi, Nozhat, Zahra, Sabouri, Samira, Kong, Xiangdong, Retana-Márquez, Socorro, Eftekhari, Aziz, Ma, Yanqin, Evazzadeh, Fatemeh, Juárez-Rojas, Lizbeth, Heidari, Reza, and Wang, Hong-Wei

Abstract

Chlorpyrifos (CPF), dichlorvos (DDV), and cypermethrin (CP), as commonly used pesticides, have been implicated in inducing neuropsychiatric disorders, such as anxiety, depression-like behaviors, and locomotor activity impairment. However, the exact molecular mechanisms of these adverse effects, particularly in both sexes and their next-generation effects, remain unclear. In this study, we conducted behavioral analysis, along with cellular assays (monodansylcadaverine staining) and molecular investigations (qRT-PCR and western blotting of mTOR, P62, and Beclin-1) to clear the potential role of autophagy in pesticide-induced behavioral alterations. For this purpose, 42 adult female and 21 male inbred ICR mice (F0) were distributed into seven groups. Maternal mice (F0) and 112 F1 offspring were exposed to 0.5 and 1 ppm of CPF, DDV, and CP through drinking water. F1 male and female animals were studied to assess the sex-specific effects of pesticides on brain tissue. Our findings revealed pronounced anxiogenic effects and impaired locomotor activity in mice. F1 males exposed to CPF (1 ppm) exhibited significantly elevated depression-like behaviors compared to other groups. Moreover, pesticide exposure reduced mTOR and P62 levels, while enhancing the Beclin-1 gene and protein expression. These changes in autophagy signaling pathways, coupled with oxidative and neurogenic damage in the cerebral cortex and hippocampus, potentially contribute to heightened locomotor activity, anxiety, and depression-like behaviors following pesticide exposure. This study underscores the substantial impact of pesticides on both physiological and behavioral aspects, emphasizing the necessity for comprehensive assessments and regulatory considerations for pesticide use. Additionally, the identification of sex-specific responses presents a crucial dimension for pharmaceutical sciences, highlighting the need for tailored therapeutic interventions and further research in this field.

Published
2024
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3. Inactivation of Mst/Nrf2/Keap1 signaling flexibly mitigates MAPK/NQO-HO1 activation in the reproductive axis of experimental fluorosis.

Author

Ommati, Mohammad Mehdi, Sabouri, Samira, Sun, Zilong, Zamiri, Mohammad Javad, Retana‑Marquez, Socorro, Nategh Ahmadi, Hassan, Zuo, Qiyong, Eftekhari, Aziz, Juárez-Rojas, Lizbeth, Asefi, Yaser, Lei, Lina, Cui, Shu-gang, Jadidi, Mohammad Hasan, Wang, Hong-wei, and Heidari, Reza

Subjects
GERM cells, FLUOROSIS, LEYDIG cells, SODIUM fluoride, CELL communication, MICROBIAL inactivation
Abstract

Fluoride induced reprotoxicity through oxidative stress-mediated reproductive cell death. Hence, the current study evaluated the importance of the MST/Nrf2/MAPK/NQO-HO1 signaling pathway in fluorosis-induced reproductive toxicity. For this purpose, the reproductive toxicity of sodium fluoride (NaF) at physiological, biochemical, and intracellular levels was evaluated. In-vivo, NaF at 100 mg/L instigated physiological dysfunction, morphological, stereological, and structural injuries in the gut-gonadal axis of fluorosis mice through weakening the antioxidant signaling, Nrf2/HO-1/NQO1signaling pathway, causing the gut-gonadal barrier disintegrated via oxidative stress-induced inflammation, mitochondrial damage, apoptosis, and autophagy. Similar trends were also observed in-vitro in the isolated Leydig cells (LCs) challenging with 20 mg/L NaF. Henceforth, activating the cellular antioxidant signaling pathway, Nrf2/HO-1/NQO1, inactivating autophagy and apoptosis, or attenuating lipopolysaccharide (LPS) can be the theoretical basis and valuable therapeutic targets for coping with NaF-induced reproductive toxicity. [Display omitted] • Fluoride causes a considerable decline in overall human fertility worldwide. • Fluoride caused reprotoxicity by inducing changes in the gut-gonadal-gamete axis and isolated Leydig cells. • Fluoride caused oxidative stress, mitochondrial impairment, inflammation, autophagy, apoptosis, and necrosis. • There is a close collaboration between Mst/Nrf2 axis and the MAPK/mTOR/HO-1/NQO1 axis in NaF-induced reprotoxicity. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Neuroendocrine disruption is associated to infertility in chronically stressed female rats

Author

Retana-Márquez, Socorro, Juárez-Rojas, Lizbeth, Ávila-Quintero, Alejandra, Rojas-Maya, Susana, Perera, Gerardo, Casillas, Fahiel, Betancourt, Miguel, and Gómez-Quiroz, Luis

Abstract

Infertility is a growing worldwide public health problem, and stress is a main factor exerting detrimental effects on female reproduction. However, knowledge regarding the neuroendocrine changes caused by chronic stress in females is limited. Therefore, this study assessed the effects of stress on hormones that control female reproduction during the proestrus and diestrus stages of the estrous cycle, as well as its effects on fertility. Adult females were assigned to either a control or a stress group. Stress consisted of exposure, for 15 min, to cold-water immersion daily for 30 days. Estrous cyclicity, female sexual behavior, as well as hypothalamic kisspeptin, gonadotropin releasing hormone (GnRH) content, serum luteinizing hormone (LH), estradiol (E2), progesterone (P4), corticosterone (CORT) and fertility were assessed after chronic stress. The results show that chronically stressed females exhibited disrupted estrous cyclicity, decreased receptivity, low pregnancy rates and lower numbers of fetuses. The content of Kisspeptin and GnRH in the Anteroventral Periventricular/medial Preoptic Area decreased during proestrus, while Kisspeptin increased in the Arcuate nucleus in proestrus and diestrus. Serum LH decreased only during proestrus, whereas E2and P4concentrations decreased during proestrus and diestrus, with a concomitant increase in CORT levels in both stages. As a whole, these results indicate that chronic stress decreases Kisspeptin content in AVPV nucleus and GnRH in POA in females, and might induce disruption of the LH surge, consequently disrupting estrous cyclicity and fertility, leading to lower rates of pregnancy and number of fetuses.

Published
2020
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6. PROTOCOLO DE NUTRICIÓN ENTERAL EN PACIENTES POLITRAUMATIZADOS DE LA SALA DE TRAUMA SHOCK DEL INSTITUTO AUTÓNOMO HOSPITAL UNIVERSITARIO DE LOS ANDES. MÉRIDA VENEZUELA.

Author

Rosales, Yesenia, Vielma, Nancy, Altamiranda, Leidy, Rojas, Lizbeth, and Ávila, IraimaD'Jesús

Abstract

Copyright of MedULA is the property of Facultad de Medicina, Universidad de los Andes, Venezuela and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019

7. ESTADO NUTRICIONAL, CONSUMO DE LÁCTEOS Y DE CALCIO EN ESCOLARES DE MÉRIDA, VENEZUELA.

Author

Beatriz Da Silva, Glenda, Rojas, Lizbeth, Bastardo, Gladys, Sanz, Belquis, Quintero de Rivas, Yurimay, Angarita, Coromoto, and Prada Briceño, Maribel

Abstract

Copyright of MedULA is the property of Facultad de Medicina, Universidad de los Andes, Venezuela and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019

8. ADECUACIÓN DE ENERGÍA Y MACRONUTRIENTES Y CONOCIMIENTO SOBRE NUTRICIÓN EN ESTUDIANTES DE NUTRICIÓN Y DIETÉTICA.

Author

Molina, Glendis, Marina Calderón, Luz, Sanz, Belquis, Márquez, Juan, Rojas, Lizbeth, and Alejandra, María

Abstract

Copyright of MedULA is the property of Facultad de Medicina, Universidad de los Andes, Venezuela and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018

9. ADECUACIÓN NUTRICIONAL Y CALIDAD HIGIÉNICO-SANITARIA DE LOS ALIMENTOS EN LOA SERVICIOS DE ALIMENTACIÓN DE LA UNIVERSIDAD DE LOS ANDES, NÚCLEO MÉRIDA. RESULTADOS PRELIMINARES.

Author

Rojas, Lizbeth, Berríos, Marlyn, Díaz, Cándida, and Gil, Gisvell

Abstract

Copyright of MedULA is the property of Facultad de Medicina, Universidad de los Andes, Venezuela and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017

10. NIVEL DE SATISFACCIÓN LABORAL EN EL PERSONAL DE LOS SERVICIOS DE ALIMENTACIÓN DE LA UNIVERSIDAD DE LOS ANDES NÚCLEO MÉRIDA.

Author

Rojas, Lizbeth, Berríos, Marlyn, Gutiérrez, Yorfani, Sanz, Belquis, Prada, Maribel, Holod, Marisol, Bruce, Gauciry, Bravo, Milaidi, Rojas, Anatty, and Molina, Glendis

Abstract

Copyright of MedULA is the property of Facultad de Medicina, Universidad de los Andes, Venezuela and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017

11. CALIDAD DEL SERVICIO DEL CENTRO DE DIAGNÓSTICO DE INFERTILIDAD Y ENFERMEDADES GENÉTICAS DE LA UNIVERSIDAD DE LOS ANDES.

Author

Rojas, Lizbeth, Altuve, Fátima, and Berríos, Marlyn

Abstract

Copyright of MedULA is the property of Facultad de Medicina, Universidad de los Andes, Venezuela and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017

13. INFLUENCIA DE LA INGESTA DE CALCIO EN LOS VALORES DE DENSIDAD MINERAL ÓSEA DE LA POBLACIÓN FEMENINA, ADULTA, DE MÉRIDA, VENEZUELA.

Author

Márquez, Darleny, Vielma, Nancy, D`Jesús Ávila, Iraima, and Rojas, Lizbeth

Abstract

Copyright of MedULA is the property of Facultad de Medicina, Universidad de los Andes, Venezuela and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2015

14. ESTADO NUTRICIONAL, CONDICIÓN SOCIOECONÓMICA Y PARASITOSIS INTESTINAL EN NIÑOS EN EDAD PRE-ESCOLAR DEL ESTADO BARINAS, VENEZUELA.

Author

Holod, Marisol, Bruce, Gauciry, Prada, Maribel, Rojas, Lizbeth, and Quintero, Yurimay

Abstract

Copyright of MedULA is the property of Facultad de Medicina, Universidad de los Andes, Venezuela and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2014

15. Reproductive disruption in adult female and male rats prenatally exposed to mesquite pod extract or daidzein

Author

Solano, Floriberta, Hernández, Eunice, Juárez-Rojas, Lizbeth, Rojas-Maya, Susana, López, Gabriela, Romero, Carlos, Casillas, Fahiel, Betancourt, Miguel, López, Alma, Heidari, Reza, Ommati, Mohammad Mehdi, and Retana-Márquez, Socorro

Abstract

Phytoestrogens are considered to be endocrine disruptors, since they can alter the endocrine system, thus disturbing many reproductive events. The intake of diets containing a high content of phytoestrogens has increased worldwide in human populations and in domestic animals. Phytoestrogens in maternal blood can pass through the placenta to the fetus in high amounts and can have long-term organizational effects. Mesquite (Prosopis sp) is a leguminous plant widely used to feed several livestock species, and is also used in the human diet. In this study we assessed the effects of exposure to mesquite pod extract during the periconception and pregnancy periods on the reproduction of male and female descendants. The females of three experimental groups received one of the following treatments: 1) vehicle injection; 2) mesquite pod extract or 3) the isoflavone daidzein during the periconception and pregnancy periods. Estrous cyclicity, sexual behavior and hormones, as well as uterine and vaginal epithelia were evaluated in the female descendants. In the males, sexual behavior and hormones, apoptosis in testicular cells and sperm quality were evaluated. In females the following was observed: alterations in estrous cycles, decreased sexual behavior, estradiol and progesterone levels, increased uterine and vaginal epithelia. In males, we observed a decrease in sexual behavior, testosterone and sperm quality, and apoptosis increased in testicular cells. All these effects were similar to those caused by daidzein. These results indicate that prenatal exposure to mesquite pod extract or daidzein, administered to females before and during pregnancy, can disrupt normal organizational-activational programming of reproductive physiology in female and male descendants.

Published
2022
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17. PERFIL MOTIVACIONAL DEL TALENTO HUMANO DE LA ESCUELA DE NUTRICIÓN Y DIETÉTICA. UNIVERSIDAD DE LOS ANDES.

Author

Rojas, Lizbeth, Berríos, Marlyn, Sanz, Belquis, and Prada, Maribel

Abstract

Copyright of MedULA is the property of Facultad de Medicina, Universidad de los Andes, Venezuela and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2013

18. NIVEL DE CONOCIMIENTO SOBRE MEDIDAS DE BIOSEGURIDAD Y SU APLICACIÓN POR EL PERSONAL MÉDICO Y DE ENFERMERÍA DE UN AMBULATORIO URBANO TIPO I. MÉRIDA, VENEZUELA.

Author

Rojas, Lizbeth, Flores, Marlene, Berríos, Marlyn, and Briceño, Indira

Abstract

Copyright of MedULA is the property of Facultad de Medicina, Universidad de los Andes, Venezuela and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2013

19. Seguridad alimentaria como indicador de calidad de vida en un entorno agroproductivo Un estudio comparative.

Author

E., Angarita R. Coromoto, Gladys, Bastardo, Yurimay, Quintero, Rojas, Lizbeth, C., Rodríguez Luis, and B., Da Silva Glenda

Subjects
RURAL conditions, COUNTRY life, BASIC needs, SOCIOLOGY of rural development, NUTRITION research
Abstract

Copyright of Fermentum: Revista Venezolana de Sociologia y Antropologia is the property of Universidad de Los Andes and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2008

20. CONSUMO DE HIERRO Y OTROS NUTRIENTES EN LA DIETA DE PREESCOLARES RESIDENTES EN APARTADEROS, ESCAGÜEY Y PUEBLO LLANO (MÉRIDA, VENEZUELA).

Author

Bastardo, Gladys, Angarita, Coromoto, Quintero, Yurimay, Rojas, Lizbeth, Rodríguez, Luís Carlos, and Márquez, Juan Leonardo

Abstract

Copyright of MedULA is the property of Facultad de Medicina, Universidad de los Andes, Venezuela and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2008

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