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1. Role of Substance P and Bradykinin in Acute Pancreatitis Induced by Secretory Phospholipase A2

Author

Camargo, Enilton A., Ferreira, Tatiane, Ribela, Maria Teresa C.P., de Nucci, Gilberto, Landucci, Elen C.T., and Antunes, Edson

Abstract

Secretory phospholipases A2(sPLA2s) induce acute pancreatitis when injected into the common bile duct of rats. Substance P via neurokinin 1 (NK-1) receptors and bradykinin via B2receptors are described to play important roles in the pathophysiology of acute pancreatitis. This study was undertaken to evaluate the role of substance P and bradykinin in the sPLA2-induced pancreatitis.

Published
2008
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