29 results on '"Ribeiro, Sofia"'
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2. Development and characterisation of cytocompatible polyester substrates with tunable mechanical properties and degradation rate.
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Ribeiro, Sofia, Carvalho, Ana M., Fernandes, Emanuel M., Gomes, Manuela E., Reis, Rui L., Bayon, Yves, and Zeugolis, Dimitrios I.
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POLYESTERS ,POLYESTER films ,YOUNG'S modulus ,TENSILE strength ,GLASS transition temperature - Abstract
Although it has been repeatedly indicated the importance to develop implantable devices and cell culture substrates with tissue-specific rigidity, current commercially available products, in particular cell culture substrates, have rigidity values well above most tissues in the body. Herein, six resorbable polyester films were fabricated using compression moulding with a thermal presser into films with tailored stiffness by appropriately selecting the ratio of their building up monomers (e.g. lactide, glycolide, trimethylene carbonate, dioxanone, ε-caprolactone). Typical NMR and FTIR spectra were obtained, suggesting that the fabrication process did not have a negative effect on the conformation of the polymers. Surface roughness analysis revealed no apparent differences between the films as a function of polymer composition. Subject to polymer composition, polymeric films were obtained with glass transition temperatures from -52 °C to 61 °C; contact angles in water from 81 ° to 94 °; storage modulus from 108 MPa to 2,756 MPa and loss modulus from 8 MPa to 507 MPa (both in wet state, at 1 Hz frequency and at 37 °C); ultimate tensile strength from 8 MPa to 62 MPa, toughness from 23 MJ/m
3 to 287 MJ/m3 , strain at break from 3 % to 278 %, macro-scale Young's modulus from 110 MPa to 2,184 MPa (all in wet state); and nano-scale Young's modulus from 6 kPa to 15,019 kPa (in wet state). With respect to in vitro degradation in phosphate buffered saline at 37 °C, some polymeric films [e.g. poly(glycolide-lactide) 30 / 70] started degrading from day 7 (shortest timepoint assessed), whilst others [e.g. poly(glycolide-co-ε-caprolactone) 10 / 90] were more resilient to degradation up to day 21 (longest timepoint assessed). In vitro biological analysis using human dermal fibroblasts and a human monocyte cell line (THP-1) showed the potential of the polymeric films to support cell growth and controlled immune response. Evidently, the selected polymers exhibited properties suitable for a range of clinical indications. Image, graphical abstract [ABSTRACT FROM AUTHOR]- Published
- 2021
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3. Fasciite Necrotizante Rapidamente Progressiva causada por Photobacterium damselae: Um caso clínico.
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Ribeiro, Sofia Branco and Bento, Luís
- Abstract
Copyright of RPDI - Revista Portuguesa de Doenças Infecciosas is the property of Sociedade Portuguesa de Doencas Infecciosas e Microbiologia Clinica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
4. Aplicação da nota de transferência e do Paediatric Early Warning Score no serviço de emergência pediátrica do Hospital de Clínicas de Porto Alegre.
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Ribeiro, Sofia Panato, Vieira, Letícia Becker, Rodrigues Strada, Juliana Karine, Moreira Freitas, Cássio Amaro, de Almeida, Valmir Machado, and Wegner, Wiliam
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Copyright of Scientia Medica is the property of EDIPUCRS - Editora Universitaria da PUCRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
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5. A Strategy for the Promotion of Health Literacy in Portugal, Centered around the Life-Course Approach: The Importance of Digital Tools
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Silva Costa, Andreia, Arriaga, Miguel, Veloso Mendes, Rita, Miranda, Débora, Barbosa, Patrícia, Sakellarides, Constantino, Peralta, André, Ambrósio Lopes, Nuno, Roque, Célia, and Ribeiro, Sofia
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Applied to health, literacy enhances the capacity to make the decisions that are necessary for autonomous health management. With this position paper, we intend to defend the thesis that the conditions for creating a national strategy for health literacy in Portugal along the life course are strengthened by the modernization of the National Health Service (SNS). First, we conducted a scope review on health literacy, and then we collected data on the National Strategy for Health Literacy and the different actions around it. The Literacy Program in Health and Care Integration, aligned with the modernization program of the National Health Service “SNS + Proximidade,” has been developed based on a life course approach. On the other hand, the National Strategy for Health Literacy, in addition to encompassing different dimensions of health literacy, from the individual and community level to the health systems, also presents strategic opportunities for intervention in contexts associated with different determinants of health. The digital Health Literacy Library of the SNS Portal is the first tool to integrate this strategy, being a digital repository of resources to support the promotion of health literacy, accessible at all times. These resources include interactive digital health books and the “My Health Journal,” encouraging people to organize their health information and take control of their health throughout their lives. The strategy also includes plans to bring these resources to people in various everyday contexts, such as public libraries, schools, and day centers, enabling their activation. At the same time, the digital modernization of the SNS allows health information to be made available in the Citizen Area of the SNS Portal, for example, by facilitating each citizen’s access to their health information in a confidential way. The entire process of implementing the health literacy strategy is dynamic and aims to encourage all citizens to participate in its construction and evaluation, and consequently in its adaptation and continuous improvement.
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- 2019
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6. Linking the Modern Distribution of Biogenic Proxies in High Arctic Greenland Shelf Sediments to Sea Ice, Primary Production, and Arctic‐Atlantic Inflow
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Limoges, Audrey, Ribeiro, Sofia, Weckström, Kaarina, Heikkilä, Maija, Zamelczyk, Katarzyna, Andersen, Thorbjørn J., Tallberg, Petra, Massé, Guillaume, Rysgaard, Søren, Nørgaard‐Pedersen, Niels, and Seidenkrantz, Marit‐Solveig
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The eastern north coast of Greenland is considered to be highly sensitive to the ongoing Arctic warming, but there is a general lack of data on modern conditions and in particular on the modern distribution of climate and environmental proxies to provide a baseline and context for studies on past variability. Here we present a detailed investigation of 11 biogenic proxies preserved in surface sediments from the remote High Arctic Wandel Sea shelf, the entrance to the Independence, Hagen, and Danmark fjords. The composition of organic matter (organic carbon, C:N ratios, δ13C, δ15N, biogenic silica, and IP25) and microfossil assemblages revealed an overall low primary production dominated by benthic diatoms, especially at the shallow sites. While the benthic and planktic foraminiferal assemblages underline the intrusion of chilled Atlantic waters into the deeper parts of the study area, the distribution of organic‐walled dinoflagellate cysts is controlled by the local bathymetry and sea ice conditions. The distribution of the dinoflagellate cyst Polarella glacialismatches that of seasonal sea ice and the specific biomarker IP25, highlighting the potential of this species for paleo sea ice studies. The information inferred from our multiproxy study has important implications for the interpretation of the biogenic‐proxy signal preserved in sediments from circum‐Arctic fjords and shelf regions and can serve as a baseline for future studies. This is the first study of its kind in this area. A new multiproxy reference baseline is provided for assessing past changes in High Arctic fjord and shelf environmentsCysts of the ice‐dwelling dinoflagellate Polarella glacialisare tightly connected with seasonal sea ice and show promise as new paleo sea‐ice proxyBenthic diatoms and ice algae are the main primary producers in the shallower sites, whereas heterotrophic dinoflagellates and benthic foraminifera are indicative of Atlantic water intrusion and dominate at the deeper sites
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- 2018
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7. Late Holocene Sea Surface Instabilities in the Disko Bugt Area, West Greenland, in Phase With δ18O Oscillations at Camp Century
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Allan, Estelle, Vernal, Anne, Knudsen, Mads Faurschou, Hillaire‐Marcel, Claude, Moros, Matthias, Ribeiro, Sofia, Ouellet‐Bernier, Marie‐Michèle, and Seidenkrantz, Marit‐Solveig
- Abstract
Palynological analyses of sediment core MSM343310 from Disko Bugt (68°38′861°N, 53°49′493°W) document decadal‐ to centennial‐scale variability of sea surface conditions during the last ~3,600 years. Dinocyst fluxes (>104cysts/cm2yr−1) indicate a very high productivity. Dinocyst assemblages dominated by Islandinium minutum, Brigantediniumspp., Islandinium? cezare, and the cyst of Pentapharsodinium daleisuggest low surface salinity and marked shifts in summer sea surface temperature. The application of the modern analog technique to dinocyst assemblages, using an updated reference data set with new sites from the West Greenland margin, led to reconstruct decadal‐centennial‐scale variations in sea surface salinity and temperature, in phase with the δ18O variations in the Camp Century ice core. At ~1.5 ka BP, the seasonal sea ice cover records an important regime change, from winter‐only sea ice to more unstable conditions marked by successive cooling pulses with sea ice cover of up to 8 months/yr. The data suggest a close relationship between hydrographic conditions and regional climate over Greenland. Our record shows variations with a mean 200 years periodicity until ~2 ka BP, which supports the hypothesis of climate variations driven by solar variability. After 1.5 ka BP, our data show a variability characterized by a 60–70 year periodicity, which suggests linkages with the Atlantic Multidecadal Oscillation and southwestward migration of the atmospheric polar front. The most recent part of the record, from ~1900 CE to 2007 CE, is characterized by assemblages reflecting warmer surface conditions and reduced sea ice cover. Sea surface salinity changes are used as indicators of fresh‐meltwater events and sea ice cover as a diagnostic feature of regional climateChanging sea surface conditions from Disko Bugt are closely related with regional climate over GreenlandA marked change in surface waters at about 1.5 ka BP corresponds to enhanced sea ice cover and the onset of unstable conditions
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- 2018
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8. Increased risk for metachronous gastric adenocarcinoma following gastric MALT lymphoma—A US population-based study
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Palmela, Carolina, Fonseca, Cristina, Faria, Rita, Baptista, Rute Baeta, Ribeiro, Sofia, and Ferreira, Alexandre Oliveira
- Abstract
Background Gastric mucosa-associated lymphoid tissue lymphoma (gMALT) and gastric adenocarcinoma (GC) are long-term complications of chronic Helicobacter pylori(HP) gastritis. Treatment of HP infection induces remission in most patients with gMALT. Endoscopic follow-up is not currently endorsed after complete remission. However, the risk of GC in these patients is unclear.Objective The objective of this study is to estimate GC risk in gMALT patients.Methods The National Cancer Institute Surveillance, Epidemiology and End Results 13 (SEER) database-Nov 2014 Sub (1992–2012) was used to identify adult patients diagnosed with gMALT between 1992 and 2012. The standardized incidence ratio of second primary GC after a latency period of 12 months was calculated and compared to a reference SEER cohort of identical age, sex and time period. The risk of GC in these patients was also stratified by latency period (five years) and age.Results We identified 2195 cases of gMALT lymphoma, and 20 (0.91%) of them subsequently developed GC with a relative risk (RR) of 4.32 (95% CI 2.64–6.67) compared to the American population. The median latency time was five years and the risk was maintained afterward (RR 4.92, 95% CI 2.45–8.79). When stratified by age group the risk was highest for the 45–64 group (RR 14.04, 95% CI 5.64–28.93).Conclusion gMALT lymphoma is associated with an increased risk of metachronous gastric adenocarcinoma. The risk is still present after more than five years of follow-up. Further studies may clarify the most adequate follow-up strategy.
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- 2017
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9. Increased risk for metachronous gastric adenocarcinoma following gastric MALT lymphoma—A US population-based study
- Author
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Palmela, Carolina, Fonseca, Cristina, Faria, Rita, Baptista, Rute Baeta, Ribeiro, Sofia, and Ferreira, Alexandre Oliveira
- Abstract
Gastric mucosa-associated lymphoid tissue lymphoma (gMALT) and gastric adenocarcinoma (GC) are long-term complications of chronic Helicobacter pylori(HP) gastritis. Treatment of HP infection induces remission in most patients with gMALT. Endoscopic follow-up is not currently endorsed after complete remission. However, the risk of GC in these patients is unclear. The objective of this study is to estimate GC risk in gMALT patients. The National Cancer Institute Surveillance, Epidemiology and End Results 13 (SEER) database-Nov 2014 Sub (1992–2012) was used to identify adult patients diagnosed with gMALT between 1992 and 2012. The standardized incidence ratio of second primary GC after a latency period of 12 months was calculated and compared to a reference SEER cohort of identical age, sex and time period. The risk of GC in these patients was also stratified by latency period (five years) and age. We identified 2195 cases of gMALT lymphoma, and 20 (0.91%) of them subsequently developed GC with a relative risk (RR) of 4.32 (95% CI 2.64–6.67) compared to the American population. The median latency time was five years and the risk was maintained afterward (RR 4.92, 95% CI 2.45–8.79). When stratified by age group the risk was highest for the 45–64 group (RR 14.04, 95% CI 5.64–28.93). gMALT lymphoma is associated with an increased risk of metachronous gastric adenocarcinoma. The risk is still present after more than five years of follow-up. Further studies may clarify the most adequate follow-up strategy.
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- 2017
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10. Streptococcus agalactiaeToxic Shock Syndrome: New Agent, New Challenges
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Meireles, Mariana, Ricardo, Miguel, Ribeiro, Sofia, and Correia, João Araújo
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Streptococcus agalactiaeis associated with an increasing burden of invasive disease. Its recognition as an agent of toxic shock-like syndrome can prevent casualties.Toxic shock syndrome is a rare life-threatening disease. The raising of new etiologic agent identification and antimicrobial therapy resistance poses new questions. We report a rare case of Streptococcus agalactiaetoxic shock–like syndrome and a literature review focusing on the presentation, current therapeutic challenges, and future approaches.
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- 2017
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11. CHARACTERIZATION OF TIMBER FRAME STRUCTURAL SYSTEM OF TABIQUE WALLS.
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Pinto, Jorge, Ribeiro, Sofia, Cunha, Vítor, Cristelo, Nuno, Lousada, José, Paiva, Anabela, Padrão, José, Varum, Humberto, and Costa, Aníbal
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WOODEN-frame houses ,CONCRETE durability ,REINFORCED concrete buildings ,CONSTRUCTION materials ,DWELLINGS - Abstract
Tabique construction corresponds to a relevant Portuguese heritage. Urban and rural tabique constructions exist all over the country. This traditional building technique started to be in disuse after the massive introduction of the reinforced concrete. Therefore, tabique buildings are already aged and, in general, they show signs of degradation. Recent research works led to the conclusion that this degradation stage is essentially caused by the absence of a regular and proper maintenance. The fact that tabique buildings are mainly private property, that there are economical limitations and that there is still a lack of knowledge concerning this traditional building technique, have been the main reasons identified to its degradation. In order to contribute to solve this problem, this paper intends to give an input on the characterization of timber frame structural system of tabique walls. In fact, a tabique building element is a structural system formed by a timber frame coated with an earth render. Technical information related to distinct traditional structural solutions are given and may be helpful in future rehabilitation processes. [ABSTRACT FROM AUTHOR]
- Published
- 2015
12. Global prevalence, cascade of care, and prophylaxis coverage of hepatitis B in 2022: a modelling study
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Razavi-Shearer, Devin, Gamkrelidze, Ivane, Pan, Calvin, Jia, Jidong, Berg, Thomas, Gray, Richard, Lim, Young-Suk, Chen, Chien-Jen, Ocama, Ponsiano, Desalegn, Hailemichael, Abbas, Zaigham, Abdallah, Ayat, Aghemo, Alessio, Ahmadbekova, Sabohat, Ahn, Sang Hoon, Aho, Inka, Akarca, Ulus, Al Masri, Nasser, Alalwan, Abduljaleel, Alavian, Seyed, Al-Busafi, Said, Aleman, Soo, Alfaleh, Faleh, Alghamdi, Abdullah, Al-Hamoudi, Waleed, Aljumah, Abdulrahman, Al-Naamani, Khalid, Al-Rifai, Ahmad, Alserkal, Yousif, Altraif, Ibrahim, Amarsanaa, Jazag, Anderson, Motswedi, Andersson, Monique, Armstrong, Paige, Asselah, Tarik, Athanasakis, Kostas, Baatarkhuu, Oidov, Ben-Ari, Ziv, Bensalem, Aicha, Bessone, Fernando, Biondi, Mia, Bizri, Abdul Rahman, Blach, Sarah, Braga, Wornei, Brandão-Mello, Carlos, Brosgart, Carol, Brown, Kimberly, Brown, Robert, Jr, Bruggmann, Philip, Brunetto, Maurizia, Buti, Maria, Cabezas, Joaquin, Casanovas, Teresa, Chae, Chungman, Chan, Henry Lik Yuen, Cheinquer, Hugo, Chen, Pei-Jer, Cheng, Kent Jason, Cheon, Myeong-Eun, Chien, Cheng-Hung, Choudhuri, Gourdas, Christensen, Peer Brehm, Chuang, Wan-Long, Chulanov, Vladimir, Cisneros, Laura, Coffin, Carla, Contreras, Fernando, Coppola, Nicola, Cornberg, Markus, Cowie, Benjamin, Cramp, Matthew, Craxi, Antonio, Crespo, Javier, Cui, Fuqiang, Cunningham, Chris, Dalgard, Olav, De Knegt, Robert, De Ledinghen, Victor, Dore, Gregory, Drazilova, Sylvia, Duberg, Ann-Sofi, Egeonu, Steve, Elbadri, Mohammed, El-Kassas, Mohamed, El-Sayed, Manal, Estes, Chris, Etzion, Ohad, Farag, Elmobashar, Ferradini, Laurent, Ferreira, Paulo, Flisiak, Robert, Forns, Xavier, Frankova, Sona, Fung, James, Gane, Edward, Garcia, Virginia, García-Samaniego, Javier, Gemilyan, Manik, Genov, Jordan, Gheorghe, Liliana, Gholam, Pierre, Gish, Robert, Goleij, Pouya, Gottfredsson, Magnus, Grebely, Jason, Gschwantler, Michael, Guingane, Nanelin Alice, Hajarizadeh, Behzad, Hamid, Saeed, Hamoudi, Waseem, Harris, Aaron, Hasan, Irsan, Hatzakis, Angelos, Hellard, Margaret, Hercun, Julian, Hernandez, Javier, Hockicková, Ivana, Hsu, Yao-Chun, Hu, Ching-Chih, Husa, Petr, Janicko, Martin, Janjua, Naveed, Jarcuska, Peter, Jaroszewicz, Jerzy, Jelev, Deian, Jeruma, Agita, Johannessen, Asgeir, Kåberg, Martin, Kaita, Kelly, Kaliaskarova, Kulpash, Kao, Jia-Horng, Kelly-Hanku, Angela, Khamis, Faryal, Khan, Aamir, Kheir, Omer, Khoudri, Ibtissam, Kondili, Loreta, Konysbekova, Aliya, Kristian, Pavol, Kwon, Jisoo, Lagging, Martin, Laleman, Wim, Lampertico, Pietro, Lavanchy, Daniel, Lázaro, Pablo, Lazarus, Jeffrey V, Lee, Alice, Lee, Mei-Hsuan, Liakina, Valentina, Lukšić, Boris, Malekzadeh, Reza, Malu, Abraham, Marinho, Rui, Mendes-Correa, Maria Cássia, Merat, Shahin, Meshesha, Berhane Redae, Midgard, Håvard, Mohamed, Rosmawati, Mokhbat, Jacques, Mooneyhan, Ellen, Moreno, Christophe, Mortgat, Laure, Müllhaupt, Beat, Musabaev, Erkin, Muyldermans, Gaëtan, Naveira, Marcelo, Negro, Francesco, Nersesov, Alexander, Nguyen, Van Thi Thuy, Ning, Qing, Njouom, Richard, Ntagirabiri, Rénovat, Nurmatov, Zuridin, Oguche, Stephen, Omuemu, Casimir, Ong, Janus, Opare-Sem, Ohene, Örmeci, Necati, Orrego, Mauricio, Osiowy, Carla, Papatheodoridis, George, Peck-Radosavljevic, Markus, Pessoa, Mário, Pham, Trang, Phillips, Richard, Pimenov, Nikolay, Pincay-Rodríguez, Loreley, Plaseska-Karanfilska, Dijana, Pop, Cora, Poustchi, Hossein, Prabdial-Sing, Nishi, Qureshi, Huma, Ramji, Alnoor, Rautiainen, Henna, Razavi-Shearer, Kathryn, Remak, William, Ribeiro, Sofia, Ridruejo, Ezequiel, Ríos-Hincapié, Cielo, Robalino, Marcia, Roberts, Lewis, Roberts, Stuart, Rodríguez, Manuel, Roulot, Dominique, Rwegasha, John, Ryder, Stephen, Sadirova, Shakhlo, Saeed, Umar, Safadi, Rifaat, Sagalova, Olga, Said, Sanaa, Salupere, Riina, Sanai, Faisal, Sanchez-Avila, Juan F, Saraswat, Vivek, Sargsyants, Narina, Sarrazin, Christoph, Sarybayeva, Gulya, Schréter, Ivan, Seguin-Devaux, Carole, Seto, Wai-Kay, Shah, Samir, Sharara, Ala, Sheikh, Mahdi, Shouval, Daniel, Sievert, William, Simojoki, Kaarlo, Simonova, Marieta, Sinn, Dong Hyun, Sonderup, Mark, Sonneveld, Milan, Spearman, C Wendy, Sperl, Jan, Stauber, Rudolf, Stedman, Catherine, Sypsa, Vana, Tacke, Frank, Tan, Soek-Siam, Tanaka, Junko, Tergast, Tammo, Terrault, Norah, Thompson, Alexander, Thompson, Peyton, Tolmane, Ieva, Tomasiewicz, Krzysztof, Tsang, Tak-Yin, Uzochukwu, Benjamin, Van Welzen, Berend, Vanwolleghem, Thomas, Vince, Adriana, Voeller, Alexis, Waheed, Yasir, Waked, Imam, Wallace, Jack, Wang, Cong, Weis, Nina, Wong, Grace, Wong, Vincent, Wu, Jaw-Ching, Yaghi, Cesar, Yesmembetov, Kakharman, Yip, Terry, Yosry, Ayman, Yu, Ming-Lung, Yuen, Man-Fung, Yurdaydin, Cihan, Zeuzem, Stefan, Zuckerman, Eli, and Razavi, Homie
- Abstract
The 2016 World Health Assembly endorsed the elimination of hepatitis B virus (HBV) infection as a public health threat by 2030; existing therapies and prophylaxis measures make such elimination feasible, even in the absence of a virological cure. We aimed to estimate the national, regional, and global prevalence of HBV in the general population and among children aged 5 years and younger, as well as the rates of diagnosis, treatment, prophylaxis, and the future burden globally.
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- 2023
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13. Pharmaceutical Targeting of Chemokine Receptors.
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Neve, Kim A., Harrison, Jeffrey K., Lukacs, Nicholas W., Ribeiro, Sofia, and Horuk, Richard
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In this chapter, we will give a perspective of in vitro assays used in drug discovery when targeting chemokine receptors. We outline the complexity of the chemokine system and give a historical perspective on the in vitro assays and types of assays used at different stages of discovery, followed by several examples of successes and failures in clinical trials. Finally, we discuss the rationale for continuing, after several failures, to target chemokine receptors and how screening may change with the increasing evidence of dimerization of chemokine receptors. [ABSTRACT FROM AUTHOR]
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- 2007
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14. Composition and spatial distribution of floating plastic debris along the estuarine ecocline of a subtropical coastal lagoon in the Western Atlantic.
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Monteiro, Isabel B., Dantas, David V., Makrakis, Maristela C., Lorenzi, Luciano, Ribeiro, Sofia Alves, Pezzin, Ana Paula Testa, Silveira, Victória Fonseca, and Gentil, Eduardo
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PLASTIC marine debris ,PLASTIC scrap ,LAGOONS ,MARINE pollution ,MICROPLASTICS ,EDUCATIONAL attainment ,POLYESTERS - Abstract
With the objective of characterizing the composition and spatial distribution of plastic fragments in a subtropical lagoon system, five sample areas affected by various anthropogenic impacts were chosen in the southern part of the Estuarine Lagoon System in Laguna, Santa Catarina, Brazil. The total density of the floating meso- and microplastics encountered was 7.32/m
3 , with the greatest density in the access channel and external area of the lagoon. Plastic filament was the most abundant and mainly comprised polyester (PET), polypropylene (PP) and polyethylene (PE) from 0.05 to 0.71 mm2 . Fishing and urbanization were the main sources of the meso- and microplastics in the environment. This is the first study to evaluate contamination by meso- and microplastics in the southern part of the Estuarine Lagoon System and provides information about the nature and extent of contamination by plastics in this estuarine ecosystem. • Importance of investigating microplastics in transitional aquatic ecosystems • Poor management and educational level increase the marine pollution. • Hydrological and geomorphological processes influenced the transportation of MPs. • The plastic polymers found in the Santo Antônio dos Anjos lagoon were PE, PEsT and PP. [ABSTRACT FROM AUTHOR]- Published
- 2022
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15. Buried alive – germination of up to a century-old marine protist resting stages
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Lundholm, Nina, Ribeiro, Sofia, Andersen, Thorbjørn J., Koch, Trine, Godhe, Anna, Ekelund, Flemming, and Ellegaard, Marianne
- Abstract
LundholmN., RibeiroS., AndersenT.J., KochT., GodheA., EkelundF. andEllegaardM. 2011. Buried alive – germination of up to a century-old marine protist resting stages. Phycologia50: 629–640. DOI: 10.2216/11-16.1We report on the survival and germination of up to a century-old marine protist resting stages naturally preserved in sediments from Koljö Fjord on the west coast of Sweden. This work has focused on germination of dinoflagellate cysts, but diatom resting stages were also observed. We record the longest known survival of dormant dinoflagellate cells. We individually isolated more than 1200 cysts of the three most abundant dinoflagellate taxa: Pentapharsodinium dalei, Lingulodinium polyedrumand Scrippsiellaspp. Germination success decreased with core depth, and all successful germinations took place within the first 2 wk of incubation. Pentapharsodinium daleihad the highest germination success rate, with a maximum of up to 80% in 28-yr-old sediment, and could successfully germinate from core sediments dated to 1920 ± 12. Scrippsiellaspp. cysts with cell contents occurred down to c.90-yr-old sediment and could germinate from down to ca. 40-yr-old sediments, with a maximum germination rate of 50–60% in recent sediments. Cysts of L. polyedrumgerminated frequently down to 20 yr and rarely to c.80 yr, with a maximum of 20–50% germination success in recent sediments. Cyst isolation under cooled conditions rather than at room temperature resulted in a significantly higher germination success in P. dalei, while no effect was observed for L. polyedrum. The time elapsed since slicing of the core affected survival of L. polyedrumcysts negatively, most likely due to the effect of oxygen. The long-term survival potential of benthic resting stages that we report here has important implications, as viable resting stages accumulated in bottom sediments can be transported back to the water column by, for example, bioturbation and human-mediated sediment dredging. Hence, the sediment may to a higher degree than previously considered play a role as seed bank. This is important in a changing climate and might have particularly severe impacts in the case of harmful species.
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- 2011
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16. Protoperidinium minutum(Dinophyceae) from Portugal: cyst–theca relationship and phylogenetic position on the basis of single-cell SSU and LSU rDNA sequencing
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Ribeiro, Sofia, Lundholm, Nina, Amorim, Ana, and Ellegaard, Marianne
- Abstract
RibeiroS., LundholmN., AmorimA. andEllegaardM. 2010. Protoperidinium minutum(Dinophyceae) from Portugal: cyst–theca relationship and phylogenetic position on the basis of single-cell SSU and LSU rDNA sequencing. Phycologia49: 48–63. DOI: 10.2216/09-11.1Round brown spiny cysts are common elements of Recent and Quaternary dinoflagellate cyst records and are often used to infer past climate conditions. Echinidiniumand Islandinium, two cyst-based genera composed of round brown spiny cysts, are believed to have affinities within the Protoperidiniaceae. However, their biological counterparts are still virtually unknown. In this study, we examined the cyst–theca relationship of an Echinidinium-like cyst isolated from recent sediments of the Portuguese coast. The cysts (25–34 µm) had an intercalary theropylic archeopyle and numerous processes (4–9 µm) with tapered stems and minutely expanded tips. Germinated cells were identified as Protoperidinium minutumon the basis of theca morphology and tabulation. This taxon has a complicated taxonomic history and most likely represents a complex of species with very similar thecae but different cyst morphologies. To provide a first step in elucidating the phylogeny of P. minutumand its evolutionary relationship among the Protoperidiniaceae, we undertook the first molecular study of this taxon on the basis of small-subunit (SSU) and large-subunit (LSU) ribosomal (r)DNA genetic sequences obtained through single-cell polymerase chain reaction. On the basis of SSU rDNA analysis, P. minutumformed a clade together with the Diplopsaloideae, not grouping together with the other Protoperidiniumspecies. LSU rDNA-based phylogenies indicate P. minutumas early divergent within the Protoperidiniaceae. The evolutionary significance of round brown spiny cysts produced by P. minutum-like species and diplopsalids is discussed.
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- 2010
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17. Infiltrative Skin Lesion as First Sign of Lung Cancer: Case Report and Brief Review
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Pereira, Cláudia, Ribeiro, Sofia, Lima, Benedita, and Mendonça, Teresa
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- 2016
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18. Elucidation of Binding Sites of Dual Antagonists in the Human Chemokine Receptors CCR2 and CCR5
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Hall, Spencer E., Mao, Allen, Nicolaidou, Vicky, Finelli, Mattea, Wise, Emma L., Nedjai, Belinda, Kanjanapangka, Julie, Harirchian, Paymann, Chen, Deborah, Selchau, Victor, Ribeiro, Sofia, Schyler, Sabine, Pease, James E., Horuk, Richard, and Vaidehi, Nagarajan
- Abstract
Design of dual antagonists for the chemokine receptors CCR2 and CCR5 will be greatly facilitated by knowledge of the structural differences of their binding sites. Thus, we computationally predicted the binding site of the dual CCR2/CCR5 antagonist N-dimethyl-N-[4-[[[2-(4-methylphenyl)-6,7-dihydro-5H-benzohepten-8-yl] carbonyl]amino]benzyl]tetrahydro-2H-pyran-4-aminium (TAK-779), and a CCR2-specific antagonist N-(carbamoylmethyl)-3-trifluoromethyl benzamido-parachlorobenzyl 3-aminopyrrolidine (Teijin compound 1) in an ensemble of predicted structures of human CCR2 and CCR5. Based on our predictions of the protein-ligand interactions, we examined the activity of the antagonists for cells expressing thirteen mutants of CCR2 and five mutants of CCR5. The results show that residues Trp982.60and Thr2927.40contribute significantly to the efficacy of both TAK-779 and Teijin compound 1, whereas His1213.33and Ile2636.55contribute significantly only to the antagonistic effect of Teijin compound 1 at CCR2. Mutation of residues Trp862.60and Tyr1083.32adversely affected the efficacy of TAK-779 in antagonizing CCR5-mediated chemotaxis. Y49A1.39and E291A7.39mutants of CCR2 showed a complete loss of CCL2 binding and chemotaxis, despite robust cell surface expression, suggesting that these residues are critical in maintaining the correct receptor architecture. Modeling studies support the hypothesis that the residues Tyr491.39, Trp982.60, Tyr1203.32, and Glu2917.39of CCR2 form a tight network of aromatic cluster and polar contacts between transmembrane helices 1, 2, 3, and 7.
- Published
- 2009
19. Arterial thrombosis in COVID-19: keep in mind to stay vigilant
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Ribeiro, Sofia Branco, Domingos, Liliana Fidalgo, and Moreno, Javier
- Published
- 2022
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20. Middle aortic syndrome: high index of suspicion should be kept in mind
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Ribeiro, Sofia Branco, Pereira, Isabel Jesus, and Nuñez, Daniel
- Published
- 2022
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21. In vitroscreening for chemokine antagonists
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Ribeiro, Sofia and Horuk, Richard
- Abstract
Background: Chemokines play an important role in host defense coordinating the migration of immune cells. They do this by activating G-protein-coupled receptors and these proteins have attracted a huge investment in research and development by the pharmaceutical industry with the promise of new therapeutics for treating inflammatory diseases. Objective: Here, we provide a brief perspective of the in vitroassays that have been used in drug discovery for identifying potent and specific chemokine receptor antagonists. We outline the complexity of the chemokine system, give a historical perspective on the in vitroassays and types of assays used at different stages of discovery, followed by several examples of successes and failures in the clinic. Conclusion: We discuss the rationale for continuing, after several failures, targeting chemokine receptors and how screening may change with the increasing evidence of dimerization of chemokine receptors.
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- 2009
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22. Identification and Characterization of a Potent, Selective Nonpeptide Agonist of the CC Chemokine Receptor CCR8
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Haskell, Christopher A., Horuk, Richard, Liang, Meina, Rosser, Mary, Dunning, Laura, Islam, Imadul, Kremer, Leonor, Gutiérrez, Julio, Marquez, Gabriel, Martinez-A., Carlos, Biscone, Mark J., Doms, Robert W., and Ribeiro, Sofia
- Abstract
In this study, we report the first example of a nonpeptide chemokine receptor agonist, 2-{2-[4-(3-phenoxybenzyl)piperazin-1-yl]ethoxy}ethanol (ZK 756326), for the CC chemokine receptor CCR8. ZK 756326 inhibited the binding of the CCR8 ligand I-309 (CCL1), with an IC50 value of 1.8 µM. Furthermore, ZK 756326 was a full agonist of CCR8, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1. In addition, ZK 756326 stimulated extracellular acidification in cells expressing human CCR8. The ability of ZK 756326 to induce a response was receptor-specific and mediated through Gαi, because it could be blocked by treatment with pertussis toxin. The CCR8 agonist activated cells expressing murine CCR8, eliciting their chemotaxis and inducing phosphorylation of extracellular signal-regulated kinase ERK1/2. Like CCL1, ZK 756326 inhibited human immunodeficiency virus (HIV) fusion of cells expressing CD4 and CCR8. Finally, unlike mCCL1, ZK 756326 bound to and activated a form of mCCR8 that was mutated to eliminate O-linked sulfation at tyrosines 14 and 15. Therefore, ZK 756326 is most probably not binding in the same manner as CCL1 but can activate the switch mechanism involved in transducing signaling events. In summary, we have identified a nonpeptide agonist of CCR8. This compound may be useful in evaluating the physiological role of CCR8 in HIV infection, as well as in the general study of CCR8 biology without the constraints inherent to the use of protein agonists such as its natural ligand.
- Published
- 2006
23. Production, purification and analysis of an experimental DNA vaccine against rabies
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Diogo, Maria M., Ribeiro, Sofia C., Queiroz, João A., Monteiro, Gabriel A., Tordo, Noel, Perrin, Pierre, and Prazeres, Duarte M. F.
- Abstract
The basic and applied research efforts devoted to the development of DNA vaccines must be accompanied by manufacturing processes capable of being scaled up and delivering a clinical-grade product. This work describes a rapid process of this kind, based on hydrophobic interaction chromatography (HIC) for the production of milligram quantities of an experimental DNA rabies vaccine. Its properties and protective activity are tested in comparison with the same plasmid DNA purified with a commercial kit. The experimental DNA vaccine encoding the rabies virus glycoprotein was amplified in vivo in Escherichia coli. The plasmid was isolated by alkaline lysis, pre-purified and concentrated by isopropanol and (NH
4 )2 SO4 precipitation, and purified by HIC and dialysis. Product quality was controlled by using high-performance liquid chromatography (HPLC), Southern slot blotting, agarose gel electrophoresis, the kinetic-QCL Limulus amoebocyte lysate assay, and protein assays. The expression of the rabies virus glycoprotein was tested in vitro in neuroblastoma cells. The production of rabies-virus-neutralising antibodies and the protection against an intracerebral virus challenge were tested in mice. One hundred and forty-two milligrams of the plasmid, with an HPLC purity greater than 99% were obtained from 4.5 l medium. Control analysis showed that the vaccine conforms to specifications in terms of impurities (endotoxins, genomic DNA, RNA, proteins). Furthermore, the final experimental vaccine induces rabies-virus-neutralising antibodies and protects mice against a rabies virus challenge. This study demonstrates that the method developed for the purification of milligram amounts of plasmid delivers an endotoxin-free, experimental rabies DNA vaccine, with protective activity similar to that obtained with the vaccine purified using a commercial kit. Copyright © 2001 John Wiley & Sons, Ltd.- Published
- 2001
- Full Text
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24. Production, purification and analysis of an experimental DNA vaccine against rabies
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Diogo, Maria M., Ribeiro, Sofia C., Queiroz, João A., Monteiro, Gabriel A., Tordo, Noel, Perrin, Pierre, and Prazeres, Duarte M. F.
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- 2001
- Full Text
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25. HIV encephalitis in chronic infection: An acute presentation.
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Ribeiro, Sofia, Gomes, Ana, Santos, Ernestina, França, Margarida, and Vasconcelos, Carlos
- Abstract
Abstract: The acute neurologic syndromes in the setting of HIV infection have been frequently associated with acute retroviral syndrome. However, some conditions like HIV encephalitis may be present in chronic disease. This case describes a 65-year-old man, with a 1-week history of progressive mixed aphasia, without clinical signs of personality or behavioral impairment. This patient's clinical picture was consistent with HIV encephalitis after exclusion of other possible causes of mental status change. The clinical and radiological resolution, after initiation antiretroviral therapy, favored this diagnosis. With the presentation of this clinical case the authors highlight the importance of HIV infection exclusion in the differential diagnosis of acute neurological disorders. [Copyright &y& Elsevier]
- Published
- 2013
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26. Paralisia unilateral do nervo hipoglosso como única manifestação de dissecção espontânea de carótida interna associada com a variante da artéria faríngea ascendente
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de Sá Júnior, Antenor Tavares, Peleja, Sebastião Berquó, Schoepfer Junior, Jean Louis, Venâncio, Isabella Mesquita, Rosa, Eduardo Augusto Silva, Bittar, Nathalia Aidar, Peleja, Mariana Berquó, Perazolo, Patricia Montini, Beze, Rodrigo Santos, and Ribeiro, Sofia Rosa
- Published
- 2018
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27. Mo1150 Increased Risk for Metachronous Gastric Adenocarcinoma Following Gastric MALT Lymphoma.
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Ferreira, Alexandre O., Palmela, Carolina, Fonseca, Cristina, Faria, Rita, Baptista, Rute, and Ribeiro, Sofia
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- 2016
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28. Students' reflections on the World Health Summit
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Ribeiro, Sofia, Schürmann, Christopher, Kraef, Christian, and Munzert, Philipp
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- 2014
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29. A century-long genetic record reveals that protist effective population sizes are comparable to those of macroscopic species
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Watts, Phillip C., Lundholm, Nina, Ribeiro, Sofia, and Ellegaard, Marianne
- Abstract
Effective population size (Ne) determines the rate of genetic drift and the relative influence of selection over random genetic changes. While free-living protist populations characteristically consist of huge numbers of cells (N), the absence of any estimates of contemporary Neraises the question whether protist effective population sizes are comparably large. Using microsatellite genotype data of strains derived from revived cysts of the marine dinoflagellate Pentapharsodinium daleifrom sections of a sediment record that spanned some 100 years, we present the first estimates of contemporary Nefor a local population in a free-living protist. The estimates of Neare relatively small, of the order of a few 100 individuals, and thus are similar in magnitude to values of Nereported for multicellular animals: the implications are that Neof P. daleiis of many orders of magnitude lower than the number of cells present (Ne/N∼ 10−12) and that stochastic genetic processes may be more prevalent in protist populations than previously anticipated.
- Published
- 2013
- Full Text
- View/download PDF
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