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Heat extremes (ie, heatwaves) already have a serious impact on human health, with ageing, poverty, and chronic illnesses as aggravating factors. As the global community seeks to contend with even hotter weather in the future as a consequence of global climate change, there is a pressing need to better understand the most effective prevention and response measures that can be implemented, particularly in low-resource settings. In this Series paper, we describe how a future reliance on air conditioning is unsustainable and further marginalises the communities most vulnerable to the heat. We then show that a more holistic understanding of the thermal environment at the landscape and urban, building, and individual scales supports the identification of numerous sustainable opportunities to keep people cooler. We summarise the benefits (eg, effectiveness) and limitations of each identified cooling strategy, and recommend optimal interventions for settings such as aged care homes, slums, workplaces, mass gatherings, refugee camps, and playing sport. The integration of this information into well communicated heat action plans with robust surveillance and monitoring is essential for reducing the adverse health consequences of current and future extreme heat.

Hot ambient conditions and associated heat stress can increase mortality and morbidity, as well as increase adverse pregnancy outcomes and negatively affect mental health. High heat stress can also reduce physical work capacity and motor-cognitive performances, with consequences for productivity, and increase the risk of occupational health problems. Almost half of the global population and more than 1 billion workers are exposed to high heat episodes and about a third of all exposed workers have negative health effects. However, excess deaths and many heat-related health risks are preventable, with appropriate heat action plans involving behavioural strategies and biophysical solutions. Extreme heat events are becoming permanent features of summer seasons worldwide, causing many excess deaths. Heat-related morbidity and mortality are projected to increase further as climate change progresses, with greater risk associated with higher degrees of global warming. Particularly in tropical regions, increased warming might mean that physiological limits related to heat tolerance (survival) will be reached regularly and more often in coming decades. Climate change is interacting with other trends, such as population growth and ageing, urbanisation, and socioeconomic development, that can either exacerbate or ameliorate heat-related hazards. Urban temperatures are further enhanced by anthropogenic heat from vehicular transport and heat waste from buildings. Although there is some evidence of adaptation to increasing temperatures in high-income countries, projections of a hotter future suggest that without investment in research and risk management actions, heat-related morbidity and mortality are likely to increase.

Extensive flooding occurred during the winter of 2013–14 in England. Previous studies have shown that flooding affects mental health. Using data from the 2013–14 Public Health England National Study of Flooding and Health, we compared the prevalence of symptoms of depression, anxiety, and post-traumatic stress disorder between participants displaced by flooding and those flooded, but not displaced, 1 year after flooding.

Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Hyperglycemia- induced oxidative stress is a major risk factor for the development of micro-vascular pathogenesis in the diabetic myocardium, which results in myocardial cell death, hypertrophy, fibrosis, abnormalities of calcium homeostasis and endothelial dysfunction. Diabetes-mediated biochemical changes show cross-interaction and complex interplay culminating in the activation of several intracellular signaling molecules. Diabetic cardiomyopathy is characterized by morphologic and structural changes in the myocardium and coronary vasculature mediated by the activation of various signaling pathways. This review focuses on the oxidative stress and signaling pathways in the pathogenesis of the cardiovascular complications of diabetes, which underlie the development and progression of diabetic cardiomyopathy.

This article quantifies the impact of the heat wave, 4 to 13 August 2003, on mortality and emergency hospital admissions in England by region and age group. The August 2003 heat wave was associated with a large short-term increase in mortality, particularly in London. Overall in England there were 2,091 (17 per cent) excess deaths. Worst affected were those over the age of 75. The greatest increase of any region in England was in London in the over 75 age group with 522 excess deaths (59 per cent). Excess hospital admissions of 16 per cent were recorded in London for the over 75s. Temperatures in England were unusually hot. Ozone and particulate matter concentrations were also elevated during the heat wave. Estimated excess mortality was greater than for other recent heat waves in the UK. This article quantifies the impact of the heat wave, 4 to 13 August 2003, on mortality and emergency hospital admissions in England by region and age group. The August 2003 heat wave was associated with a large short-term increase in mortality, particularly in London. Overall in England there were 2,091 (17 per cent) excess deaths. Worst affected were those over the age of 75. The greatest increase of any region in England was in London in the over 75 age group with 522 excess deaths (59 per cent). Excess hospital admissions of 16 per cent were recorded in London for the over 75s. Temperatures in England were unusually hot. Ozone and particulate matter concentrations were also elevated during the heat wave. Estimated excess mortality was greater than for other recent heat waves in the UK. [ABSTRACT FROM AUTHOR]

More than 2000 deaths were attributed to the August 2003 heat wave in England and Wales. We analysed excess mortality in southern England during the heat wave by place of death. Excess mortality was 33 per cent in those aged 75 and over and 13.5 per cent in the under 75 age group during the 10 day heat wave. Among those aged 75 and over, deaths at home increased by 33 per cent and deaths in nursing homes increased by 42 per cent. Around one quarter of the heat wave attributable deaths occurred in care homes, but this is likely to be an underestimate as some residents may have been admitted to hospital before death. There is a need for further research to assess the risk of heat-related mortality in hospital in-patients and the residents of care homes in order to improve prevention strategies. [ABSTRACT FROM AUTHOR]

The heat wave that occurred in August 2003in Europe was unprecedented. The hugeimpact on the health of Europeans causedhealth policy makers to seriously considerthis environmental hazard, in many countriesfor the first time. As well as drivingsome changes in public health practice, theevent triggered a wealth of research on howheat waves and hot weather affect our health.As an increase in heat waves is one of themost certain impacts of climate change inEurope, the heatware research and practicehas also been engaged in the wider climatechange debate. Policy is often driven bydisasters and it is interesting to speculatewhat climate change actions would havebeen undertaken had the heat wave notoccurred. The articles in this journal onclimate change (1, 2) are timely, as we aresix years on from the European heat waveand climate change is now accepted as arisk to human health.

The article discusses research being done on the effects of weather and river flow on cryptosporidiosis. It references a study by Iain R. Lake and Graham Bentham, published in a 2005 issue of the "Journal of Water and Health." It has been established that about 92% of all cases of cryptosporidiosis are not associated with a particular outbreak. The researchers found an association between disease and a particular month's maximum river flow, consistent with the release of newborn, highly infectious animals onto the land.