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[Display omitted] • A pre-balanced and positivity preserving scheme over bent pipe. • No complex treatment of source term is required to well preserve the steady states. • Better performance in modelling of the asymptotic flow behavior in bent circular pipes. • Local bed reconstruction at wetting and drying fronts. In urban drainage networks, steady free surface flows in circular-shaped pipes are commonly observed given low inflow discharges. Therefore, accurate computation of such steady states is of great practical significance, especially considering bent pipes. This requires numerical schemes to be capable of achieving a delicate balance between slope source terms and fluxes in the discrete framework. To this end, in the current study, a new method using pressure balanced Saint–Venant equations and positivity preserving Godunov-type finite volume scheme, is developed for 1D flow simulation in bent circular pipes. Using pressure balancing, a set of pre-balanced Saint–Venant equations is derived. The numerical discretization method uses an approximate Riemann solver and is capable of dealing with wetting–drying process stably in frictional pipes. As verified by several test cases, the proposed method shows better performances than existing methods in modelling the asymptotic flow behavior and preserving steady states in bent circular pipes. [ABSTRACT FROM AUTHOR]

Abstract: The cancer stem cell (CSC) theory is gaining increasing attention from researchers and has become an important focus of cancer research. According to the theory, a minority population of cancer cells is capable of self-renewal and generation of differentiated progeny, termed cancer stem cells (CSCs). Understanding the properties and characteristics of CSCs is key to future study on cancer research, such as the isolation and identification of CSCs, the cancer diagnosis, and the cancer therapy. Standard oncology treatments, such as chemotherapy, radiotherapy and surgical resection, can only shrink the bulk tumor and the tumor tends to relapse. Thus, therapeutic strategies that focus on targeting CSCs and their microenvironmental niche address the ineffectiveness of traditional cancer therapies to eradicate the CSCs that otherwise result in therapy resistance. The combined use of traditional therapies with targeted CSC-specific agents may target the whole cancer and offer a promising strategy for lasting treatment and even cure. [Copyright &y& Elsevier]