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To investigate levels of nickel and chromium in gingival crevicular fluid from subjects undergoing orthodontic treatment with and without using fluoridated toothpaste and mouthwash over a 6-month period. Sixty subjects divided into two groups of 30 each served as the experimental group with and without using fluoride agents for oral hygiene care along with fixed appliance treatment. Gingival crevicular fluid was collected in fluoridated and nonfluoridated groups before, and at 7 days, 30 days, and 6 months after commencing orthodontic treatment. Levels of nickel, chromium, titanium, and manganese were evaluated using inductively coupled plasma mass spectrometry. No changes in metal levels at any time were observed in the untreated control group. Nickel levels were elevated to 101.78 μg/L in the fluoridated group at 30 days posttreatment, indicating heavy leaching from nickel-titanium archwires (Friedman P < 0.001). Results returned to baseline in both groups at 6 months. Mean differences for chromium, titanium, and manganese ion release were not statistically significant at 30 days. Titanium showed elevated levels at 30 days in both tested groups, but levels were lesser than nickel. Archwires are susceptible to corrosion when exposed to fluoride agents during orthodontic therapy causing release of metal ions into the mouth with the possibility of systemic absorption. Long-term consequences of metal ion release into the oral cavity require further investigation. • Nickel and chromium ions are released into gingival crevicular fluid during orthodontic treatment. • Fluorides cause greater amounts of metal release due to their corrosive effects on metals. • Maximum levels of nickel and titanium are noticed 30 days after commencing treatment. • Fluoride agents should be used with caution in orthodontic patients undergoing treatment with metal fixed appliances. [ABSTRACT FROM AUTHOR]