679 results on '"Peng, Jun"'
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2. Membrane Interactions of GET1 and GET2 Facilitate Fiber Cell Initiation through the Guided Entry of the TA Protein Pathway in Cotton
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Liu, Yang, Wei, Zhenzhen, Pei, Yanfei, Yang, Lu, Zou, Xianyan, Pei, Yayue, Zhang, Tianen, Miao, Pengfei, Gan, Lei, Liu, Ji, Yang, Zuoren, Peng, Jun, Li, Fuguang, and Wang, Zhi
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The guided entry of TA proteins (GET) pathway, which is responsible for the post-translational targeting and insertion of the tail-anchored (TA) protein into the endoplasmic reticulum (ER), plays an important role in physiological processes such as protein sorting, vesicle trafficking, cell apoptosis, and enzymatic reactions in which the GET1/2 complex is indispensable. However, a comprehensive study of the GET1and GET2genes and the GET pathway in cotton has not yet been carried out. Here, 12 GET1and 21 GET2genes were identified in nine representative plant species, and the phylogenetic relationships, gene structures, protein motifs, cis-regulatory elements (CREs), and temporal and spatial expression profiles were analyzed thoroughly. Our study indicated that GhGET1s and GhGET2s might be localized on ER membranes. According to expression profiling and CREs analysis, GhGET2-A02 was identified as a promising candidate for fiber cell development, interacting with two GhGET1s in the membrane, with a binding bias toward GhGET1-A06. Silencing of GhGET1-A06or GhGET2-A02reduced fiber initiation and elongation. In summary, our research provides important evidence for understanding the gene families and functions of GET1 and GET2 in cotton and provides clues for molecular breeding of high-quality cotton fiber varieties.
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- 2024
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3. Efficiency-Enhanced Dual-Input Transmitter Using Over-the-Air Combination for MIMO Systems
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Wu, Wenqi, Peng, Jun, He, Songbai, You, Fei, and Wang, Peng
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In this article, a dual-input transmitter (Tx) architecture with dual-power amplifier (PA) dual antennas is presented for multiple-input multiple-output (MIMO) systems. The baseband signal is split into two data streams with different peak-to-average power ratios (PAPRs) in the time domain, which are transmitted independently and recombined at the receiver antenna to boost Tx efficiency. An optimal PAPR and power-level configuration strategy is established, which is a constant threshold separation algorithm (CTSA), based on an efficiency prediction method and the distribution of modulation signals (MSs). In CTSA, the PAPR of the separated signal is correlated with the power level. Furthermore, a dynamic threshold separation algorithm (DTSA) is proposed to expand the solution space of the separated signal by decoupling the power from the PAPR of signals using an amplitude control factor. In addition, the spatial adjacent channel power ratio (ACPR) is utilized to evaluate the pollution to other systems in space by bandwidth expansion caused by signal separation. In DTSA, the optimal configuration strategy of PAPR and power under spatial ACPR constraints can be obtained. The Tx architecture is verified at 3.5 GHz with three different spatial ACPR requirements. For an MS with 8.4-dB PAPR, the optimal average efficiency of the Tx can be improved by
$1.2\times $ - Published
- 2024
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4. Study on the effect of rare earth Ce on the modification of sulfide inclusions in U71Mn heavy rail steel
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Zheng, Jie, Liu, Shuang, Yang, Fan, Liu, Lixia, Peng, Jun, and An, Shengli
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In this paper, the directional modification behavior of rare earth Ce on sulfide inclusions in steel is studied by thermodynamic calculation and experiment methods, and the mechanism of directional modification of rare earth Ce on sulfide inclusions in U71Mn heavy rail steel is proved. The results show that U71Mn heavy rail steel contained more large-sized inclusions and their distribution is more concentrated without the addition of rare earth Ce element. After the addition of rare earth Ce element, the average size of sulfur-containing inclusions in the steel decrease from 5.22 μm to 1.85 μm, and the number density of sulfur-containing inclusions in the steel increase from 83.65 mm−2to 217.68 mm−2, indicating that the number of sulfur-containing inclusions in the steel increases after the addition of Ce element, and more small-sized sulfur-containing inclusions will form in the steel. The addition of rare earth Ce element can effectively reduce the existence of large-sized inclusions in the steel and modify large-sized inclusions into small-sized inclusions.
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- 2024
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5. 20(S)-Ginsenoside Rh2 induces apoptosis and autophagy in melanoma cells via suppressing Src/STAT3 signaling
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Li, Jun-Kui, Jiang, Xiao-Li, Zhang, Zhu, Chen, Wen-Qing, Peng, Jun-Jie, Liu, Bin, Yung, Ken-Kin-Lam, and Zhu, Pei-Li
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20(S)-Ginsenoside Rh2 (GRh2) has been extensively studied for multifaceted health benefits. However, the anti-melanoma effect of GRh2 remains poorly understood. Herein, the anti-melanoma effects and underlying mechanisms of GRh2 were investigated.
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- 2024
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6. Eltrombopag plus diacerein vs eltrombopag in patients with ITP: a multicenter, randomized, open-label phase 2 trial
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Sun, Lu, Huang, Xiaoyang, Wang, Juan, Yuan, Chenglu, Zhao, Hongyu, Li, Daqi, Xu, Ruirong, Wang, Yan, Qin, Ping, Shi, Yan, Peng, Jun, Hou, Ming, and Hou, Yu
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•Eltrombopag plus diacerein is a potential salvage therapy for patients with ITP who were unresponsive to 14 days of eltrombopag at full dose.•Addition of diacerein to eltrombopag yields higher overall response rates and longer duration of response than eltrombopag alone.
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- 2024
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7. Risk Factors for Mortality in Critically Ill Patients with Coagulation Abnormalities: A Retrospective Cohort Study
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Guo, Qiu-yu, Peng, Jun, Shan, Ti-chao, and Xu, Miao
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Objective: Coagulation abnormalities are common and prognostically significant in intensive care units (ICUs) and are associated with increased mortality. This study aimed to explore the association between the levels of coagulation markers and the risk of mortality among ICU patients with coagulation abnormalities. Methods: This retrospective study investigated patients with coagulation abnormalities in the ICU between January 2021 and December 2022. The initial point for detecting hemostatic biomarkers due to clinical assessment of coagulation abnormalities was designated day 0. Patients were followed up for 28 days, and multivariate logistic regression analysis was utilized to identify risk factors for mortality. Results: Of the 451 patients analyzed, 115 died, and 336 were alive at the end of the 28-day period. Multivariate analysis revealed that elevated thrombin-antithrombin complex (TAT), tissue plasminogen activator inhibitor complex (tPAIC), prolonged prothrombin time, and thrombocytopenia were independent risk factors for mortality. For nonovert disseminated intravascular coagulation (DIC) patients, older age and thrombocytopenia were associated with increased risks of mortality, whereas elevated levels of plasmin α
2 -plasmin inhibitor complex (PIC) were found to be independent predictors of survival. In patients with overt DIC, elevated levels of tPAIC were independently associated with increased risks of mortality. Nevertheless, thrombocytopenia was independently associated with increased risks of mortality in patients with pre-DIC. Conclusion: Coagulation markers such as the TAT, tPAIC, PIC, and platelet count were significantly associated with mortality, underscoring the importance of maintaining a balance between coagulation and fibrinolysis. These findings highlight the potential for targeted therapeutic interventions based on specific coagulation markers to improve patient outcomes.- Published
- 2024
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8. Pectin methylesterase inhibitors GhPMEI53 and AtPMEI19 improve seed germination by modulating cell wall plasticity in cotton and Arabidopsis
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Pei, Yayue, Wang, Yakong, Wei, Zhenzhen, Liu, Ji, Li, Yonghui, Ma, Shuya, Wang, Ye, Li, Fuguang, Peng, Jun, and Wang, Zhi
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The germination process of seeds is influenced by the interplay between two opposing factors, pectin methylesterase (PME) and pectin methylesterase inhibitor (PMEI), which collectively regulate patterns of pectin methylesterification. Despite the recognized importance of pectin methylesterification in seed germination, the specific mechanisms that govern this process remain unclear. In this study, we demonstrated that the overexpression of GhPMEI53is associated with a decrease in PME activity and an increase in pectin methylesterification. This leads to seed cell wall softening, which positively regulates cotton seed germination. AtPMEI19, the homologue in Arabidopsis thaliana, plays a similar role in seed germination to GhPMEI53, indicating a conserved function and mechanism of PMEI in seed germination regulation. Further studies revealed that GhPMEI53 and AtPMEI19 directly contribute to promoting radicle protrusion and seed germination by inducing cell wall softening and reducing mechanical strength. Additionally, the pathways of abscicic acid (ABA) and gibberellin (GA) in the transgenic materials showed significant changes, suggesting that GhPMEI53/AtPMEI19-mediated pectin methylesterification serves as a regulatory signal for the related phytohormones involved in seed germination. In summary, GhPMEI53 and its homologs alter the mechanical properties of cell walls, which influence the mechanical resistance of the endosperm or testa. Moreover, they impact cellular phytohormone pathways (e.g., ABA and GA) to regulate seed germination. These findings enhance our understanding of pectin methylesterification in cellular morphological dynamics and signaling transduction, and contribute to a more comprehensive understanding of the PME/PMEI gene superfamily in plants.
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- 2024
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9. Proactive Bandwidth Allocation for V2X Networks With Multi-Attentional Deep Graph Learning
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Wang, Chenglong, Peng, Jun, Cai, Lin, Liu, Weirong, Li, Shuo, He, Hu, and Huang, Zhiwu
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The increasing number of connected vehicles exacerbates the scarcity of spectrum resources in vehicle-to-everything (V2X) communication. To optimize the utilization of wireless resources, it is crucial to allocate the limited spectrum blocks to each roadside unit (RSU) based on the real-time bandwidth demand of vehicles within their coverage. However, the complex mobility patterns of vehicles and dynamic traffic conditions make it challenging to accurately and promptly estimate the bandwidth demand. To address this issue, a spatial-temporal multi-attentional network (STMA-net) is designed to predict the future bandwidth demand of RSUs. Based on the predicted bandwidth demand, a prediction error-compensable proactive bandwidth allocation algorithm is proposed to adaptively allocate spectrum resources and narrow the discrepancy between predicted and actual demand. Experimental results with realistic traffic in Bologna demonstrate that the proposed STMA-net achieves 11.25% higher prediction accuracy compared to state-of-the-art methods. Furthermore, the proposed proactive bandwidth allocation method outperforms existing methods, providing the highest throughput and serving 5% more vehicles while reducing the service drop rate by an order of magnitude.
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- 2024
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10. Neoadjuvant savolitinib targeted therapy for stage IIIB-N3 lung adenocarcinoma harboring mesenchymal–epithelial transition exon 14 skipping mutation: a case report and literature review
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Chen, Lei, Chen, Jin-Feng, He, Jin-Tao, Rong, Hao, Zhuang, Xiang, and Peng, Jun
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Savolitinib is a selective inhibitor that specifically targets the phosphorylation of mesenchymal–epithelial transition (MET) kinase. It has demonstrated significant inhibitory effects on the proliferation of tumor cells with METex14 skipping mutation, making it a promising treatment option. While it is the first approved small-molecule inhibitor specifically targeting MET kinase in China, there is limited information about its efficacy as neoadjuvant therapy for patients with supraclavicular lymph node metastasis (N3). In this case report, we presented the successful outcome of a 48-year-old male patient who was diagnosed with stage IIIB (T2bN3M0) lung adenocarcinoma originating from the left upper lobe. The patient exhibited the METex14 skipping alteration. Following two months of neoadjuvant savolitinib treatment, the patient achieved partial remission, with a significant reduction in the size of the primary tumor and metastatic lymph nodes. Postoperative pathological confirmation revealed a pathological complete response, and subsequent imaging examinations, including computed tomography scan and circulating tumor DNA-based molecular residual disease detection, showed no sign of recurrence at 7 months after surgery. Based on this case, neoadjuvant and adjuvant savolitinib therapy may be considered as a favorable alternative to chemotherapy for marginally resectable nonsmall cell lung cancer patients with METex14 skipping mutation.
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- 2024
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11. Transcriptome data reveal beneficial effects of Rickettsia(Rickettsiales: Rickettsiaceae) on Bemisia tabaci(Hemiptera: Aleyrodidae)through nutritional factors and defense mechanisms
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Li, Yi-Han, Peng, Jing, Wu, Qing-Jun, Sun, Jing-Chen, Zhang, Peng-Jun, and Qiu, Bao-Li
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Whitefly Bemisia tabaci(Hemiptera: Aleyrodidae) is a destructive insect pest of many crops. Rickettsiainfection in different cryptic species of B. tabacihas been observed worldwide. Understanding the interactions between these 2 organisms is critical to developing Rickettsia-based strategies to control B. tabaciand thereby reduce the transmission of related vector-borne viruses. In this study, we investigated the effects of Rickettsiainfection on the biological characteristics of the Middle East Asia Minor 1 (MEAM1) strain of B. tabacithrough biological analysis of infected and uninfected individuals. The results of this study suggest that Rickettsiamay confer fitness benefits. These benefits include increased fertility, improved survival rates, accelerated development, and resulted in female bias. We also investigated the transcriptomics impact of Rickettsiainfection on B. tabaciby performing a comparative RNA-seq analysis of nymphs and adult females, both with and without the infection. Our analysis revealed 218 significant differentially expressed genes (DEGs) in infected nymphs compared to uninfected ones and 748 significant DEGs in infected female adults compared to their uninfected whiteflies. Pathway analysis further revealed that Rickettsiacan affect many important metabolic pathways in whiteflies. The results suggest that Rickettsiaplays an essential role in energy metabolism, and nutrient synthesis in the B. tabaciMEAM1, and depends on metabolites obtained from the host to ensure its survival. Overall, our findings suggest that Rickettsiahas beneficial effects on B. tabaciand offered insights into the potential molecular mechanisms governing the interactions between Rickettsiaand B. tabaciMEAM1.
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- 2024
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12. Improving the Stability of Li3HoBr6 on Metallic Lithium by Using a Double-Halogen Strategy.
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Li, Bo, Xian, Lei, Peng, Jun, and Kong, Ling-Bin
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- 2024
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13. Studying HT-MCSs in IEEE 802.11n Networks via Simulations.
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Peng, Jun
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MODULATION coding ,LINEAR network coding ,PERFORMANCE theory - Abstract
We study the High Throughput Modulation and Coding Schemes (HT-MCS) in IEEE 802.11n In networks in this paper. The HT-MCSs are designed to deal with various channel conditions in the networks. We used ns-3 simulations to study HT-MCS 0 to HT-MCS 31 under various radio propagation models. The simulation results are presented in this paper. In our simulations the HT-MCSs were tested in networks with Friis, Nakagami, and log-distance propagation models for studying their performance under various signal attenuation and fading effects. The HT-MCSs provided consistent performance under most channel conditions in our simulations. However, they showed significantly degraded performance under the log-distance propagation model when the communication distance was relatively long because of the high signal attenuation in such a case. Our simulations also showed that an increased number of radio beams increased the ability of the modulation and coding schemes in combating adverse channel conditions. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Effects of rare earth Ce on TiN inclusion modifications in 20CrMnTi steel under deoxygenation conditions of Si–Ca–Ba alloy
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Liu, Shuang, Yang, Fan, Liu, Lixia, Wang, Jian, Peng, Jun, Zhang, Fang, and An, Shengli
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20CrMnTi steel is widely used in the gear manufacturing field of engineering machinery. The addition of Ti element to steel can effectively improve its low-temperature impact toughness and enhance its mechanical properties. However, during the smelting process of 20CrMnTi, large-sized TiN inclusions are inevitably formed in the steel, which affects its service performance improvement. This paper focuses on the directional modification behaviors of TiN inclusions in 20CrMnTi gear steel by rare earth Ce under deoxygenation conditions of Si–Ca–Ba alloy. The results show that under the deoxygenation conditions of Si–Ca–Ba alone, there are composite inclusions in 20CrMnTi steel with CaAl12O19as the core and TiN wrapped around the periphery, all of which have sizes greater than 2 μm. This type of inclusion is square or diamond shaped, and the addition of Si–Ca–Ba deoxygenation alone has poor TiN modification effect on gear steel 20CrMnTi. Adding Ce element can effectively improve the nucleation core of inclusions. The CeAlO3–TiN and (CaAl12O19–Ba–Ce)–TiN composite inclusions are formed, and the TiN inclusions are modified in terms of morphology and size. The average size of inclusions decreases from 4.1 to 3.0 μm, which prevented the excessive growth of pure TiN inclusions to some extent.
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- 2024
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15. 10‐4: Design and Analysis of Ln‐IZO TFTs For Electrophoretic Display Driving
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Zhou, Lei, Xu, Miao, Wu, Wei-Jing, and Peng, Jun-Biao
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In this paper, we presented an Electrophoretic display(EPD) based on high mobility Ln‐IZO thin film transistor (TFT) panel. The display panel has a 104 *212 pixel array with a diagonal size of 2.13inch. We discuss the relationship between charge rate versus TFT mobility, clock feed‐though effect versus TFT parasitic capacitance, charge retention versus leakage current. Ln‐IZO TFTs have advantages in EPD displays in terms of high mobility, low parasitic capacitance and low leakage current.
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- 2024
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16. Study on the effects of Al–Ce composite deoxidations on the modification behaviors of TiN inclusions in 20CrMnTi steel
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Liu, Shuang, Yang, Fan, Liu, Lixia, Wang, Jian, Peng, Jun, Zhang, Fang, and An, Shengli
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20CrMnTi gear steel has high low-temperature impact toughness and is widely used in the manufacturing of engineering machinery such as automotive transmission gears. The sizes and distributions of TiN inclusions have a significant impact on the service performances of 20CrMnTi gear steel. Controlling the growth behaviors and size distributions of TiN inclusions are the foundation for stable, high-quality, and efficient production of 20CrMnTi gear steel. This paper uses experimental and computational methods to study the effects of different ratios of Al–Ce composite deoxidizers on the modification behaviors of TiN inclusions in 20CrMnTi steel. The results show that the TiN inclusions in 20CrMnTi steel without Al–Ce composite deoxidizer are square in shape, with a size of approximately 4 μm. After Al–Ce composite deoxidation, a composite phase inclusion is formed in the steel, which has contracted edges and corners. The center is the nucleation core composed of elements such as Ce, Al, O, etc. The elements of Ti and N are wrapped around the periphery of the composite inclusion, reducing its size to 2 μm. When the ratio of Al and Ce in the Al–Ce composite deoxidizer is 7:3, the number of TiN inclusions in steel is the highest, accounting for 51.7% of the total amount of titanium inclusions. The average diameter of inclusions in the modified steel decreases to 2.4 μm. When the ratio of Al and Ce elements is 8:2 and 7:3, the final deoxygenation product is CeAlO3, which is more conducive to the modification of TiN inclusions in 20CrMnTi steel.
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- 2024
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17. Experimental and first-principles calculation of TiN growth mechanism on CeAlO3surface in steel
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He, Fei-hu, Peng, Jun, Zhang, Fang, Wang, Yong-bin, and Chang, Hong-tao
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Regular TiN is harmful to the toughness of steel, and its shape and size need to be controlled. Understanding the behavior of TiN precipitation on CeAlO3surfaces is critical for controlling the morphology and formation process of CeAlO3–TiN composite inclusions in the steel. Experimental results showed that TiN had a square morphology on the CeAlO3surface, and electron backscatter diffraction phase identification results revealed the orientation relationship between CeAlO3and TiN as follows: (001)CeAlO3//(1¯10)TiN, (100)CeAlO3//(001¯)TiN, and [010]CeAlO3//[110]TiN. The CeAlO3crystal structure was studied using the first-principles calculation method, and the adsorption and growth process of TiN on the CeAlO3surface were investigated from the atomic scale. The calculation results indicate that there is no metallic bonding present in the CeAlO3system. Among the low-index crystal planes of CeAlO3, the (110) planes terminated with O and CeAlO have the highest and lowest surface energies, respectively, with values of 0.373 and 0.051 eV/Å2. On the high surface energy plane of CeAlO3, the TiN atomic permutation structure is consistent with the arrangement of Ti and N atoms in TiN (100) or (110). For the low surface energy plane of CeAlO3, the Ti and N atoms are arranged in a ring-like structure.
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- 2024
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18. Evaluation of MgO on hematite swelling dynamics during CO-driven stepwise reduction
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Zhang, Fang, Peng, Jun, Liu, Shuang, Wang, Yong-bin, and Yang, Fan
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The significant effect of MgO in inhibiting the reduction swelling of iron ore pellets has been widely recognized. The swelling behaviors of pellets during the stepwise reduction by CO were assessed. The linear expansion of strip samples was measured using a linear dilatometer during the staged reduction process at a temperature of 900 °C. The existence states of MgO in hematite, magnetite, and wüstite were investigated through thermodynamic calculations. The magnetite strip samples were subjected to oxidizing roasting at 1250 °C for 30 min to produce hematite strip samples. The strip samples with 0.49, 1.49, 2.49, and 3.49 wt.% MgO were analyzed for length change. It was observed that the sample with 2.49 wt.% MgO exhibited the least significant length change. The lengths of the samples with the initial length being 20 mm before reduction changed during the reduction stages of Fe2O3→ Fe3O4, Fe3O4→ FeO, and FeO → Fe were 615, − 25, and − 378 μm, respectively. The volume expansion of hematite to magnetite was primarily attributed to the crystal transformation. During the reduction stage from wüstite to metallic iron, a substantial contraction occurred, while the slag phase was able to retain its original basic shape. The enclosed areas, as indicated by the expansion change curves of the samples with 0.49, 1.49, 2.49, and 3.49 wt.% MgO, were measured at 3.76 × 106, 3.23 × 106, 3.05 × 106, and 3.17 × 106μm s, respectively.
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- 2024
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19. Reflected Stochastic Burgers Equation with Jumps
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Qian, Hongchao, Peng, Jun, Li, Ruizhi, and Gui, Yewei
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This paper is concerned with the reflected stochastic Burgers equation driven both by the Brownian motion and by the Poisson random measure. The existence and uniqueness of solutions are established. The penalization method plays an important role.
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- 2024
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20. An Optimized Prediction Horizon Energy Management Method for Hybrid Energy Storage Systems of Electric Vehicles
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Wang, Zini, Huang, Zhiwu, Wu, Yue, Liu, Weirong, Li, Heng, and Peng, Jun
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Model predictive control is a real-time energy management method for hybrid energy storage systems, whose performance is closely related to the prediction horizon. However, a longer prediction horizon also means a higher computation burden and more predictive uncertainties. This paper proposed a predictive energy management strategy with an optimized prediction horizon for the hybrid energy storage system of electric vehicles. Firstly, the receding horizon optimization problem is formulated to minimize the battery degradation cost and traction electricity cost for the electric vehicle operation. Then, the optimal control sequence is solved to obtain the power allocation between the battery and the supercapacitor. Furthermore, the effect of different horizons on the optimization results is analyzed under diverse operating conditions, determining the optimal horizon to balance the system costs and computation burden. Compared with the short horizon, the optimal horizon can achieve 5.2%~8.5% performance improvement with the acceptable computation time approaching 1s.
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- 2024
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21. Dual-Mode Three-Way Doherty Power Amplifier With Extended High-Efficiency Range Against Load Mismatch
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Pang, Jingzhou, Han, Yujie, Peng, Jun, Li, Mingyu, Dai, Zhijiang, Shi, Weimin, Zhou, Xinyu, and Zhu, Anding
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This article presents theoretical analysis and design methodology of a dual-mode three-way Doherty power amplifier (DPA) with an extended high-efficiency range and robust load mismatch adaptability. A nonlinear current model for active devices is established and employed to analyze the impact of load mismatches in the three-way DPA and a novel output combiner is proposed to minimize the mismatch impact by reconfiguring the gate bias conditions and setting distinct loads at the control port of the combiner. To validate the proposed DPA architecture and design approach, a prototype using commercial Gallium Nitride (GaN) transistors operated at the center frequency of 2.0 GHz was designed and fabricated. Under the ideal condition with a matched
$50~\Omega $ - Published
- 2024
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22. A 65-dB SNDR Continuous-Time Delta-Sigma ADC Integrated by IZO Thin-Film Transistors
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Xu, Wen-Xing, Chen, Jun-Rong, Li, Fei-Fan, Zhou, Lei, Wei, Xiao-Qin, Xu, Miao, Wang, Lei, Wu, Wei-Jing, Liu, Yu-Rong, and Peng, Jun-Biao
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This brief presents a first-order continuous-time delta-sigma ADC in IZO TFT process. The presented ADC achieves 65 dB SNDR in 30-Hz bandwidth and 43-dB SNDR in 304-Hz bandwidth. For TFT analog building block, a 60-dB dc gain, 400-kHz unity-gain frequency operational amplifier (OPA) using hybrid Miller/feedthrough compensation is proposed. And a 3-
$\mu \text{s}$ - Published
- 2024
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23. Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial
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Yuan, Shu-Qiang, Nie, Run-Cong, Jin, Ying, Liang, Cheng-Cai, Li, Yuan-Fang, Jian, Rui, Sun, Xiao-Wei, Chen, Ying-Bo, Guan, Wen-Long, Wang, Zi-Xian, Qiu, Hai-Bo, Wang, Wei, Chen, Shi, Zhang, Dong-Sheng, Ling, Yi-Hong, Xi, Shao-Yan, Cai, Mu-Yan, Huang, Chun-Yu, Yang, Qiu-Xia, Liu, Zhi-Min, Guan, Yuan-Xiang, Chen, Yong-Ming, Li, Ji-Bin, Tang, Xiong-Wen, Peng, Jun-Sheng, Zhou, Zhi-Wei, Xu, Rui-Hua, and Wang, Feng
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Perioperative chemotherapy is the standard treatment for locally advanced gastric or gastro-esophageal junction cancer, and the addition of programmed cell death 1 (PD-1) inhibitor is under investigation. In this randomized, open-label, phase 2 study (NEOSUMMIT-01), patients with resectable gastric or gastro-esophageal junction cancer clinically staged as cT3-4aN + M0 were randomized (1:1) to receive either three preoperative and five postoperative 3-week cycles of SOX/XELOX (chemotherapy group, n= 54) or PD-1 inhibitor toripalimab plus SOX/XELOX, followed by toripalimab monotherapy for up to 6 months (toripalimab plus chemotherapy group, n= 54). The primary endpoint was pathological complete response or near-complete response rate (tumor regression grade (TRG) 0/1). The results showed that patients in the toripalimab plus chemotherapy group achieved a higher proportion of TRG 0/1 than those in the chemotherapy group (44.4% (24 of 54, 95% confidence interval (CI): 30.9%–58.6%) versus 20.4% (11 of 54, 95% CI: 10.6%–33.5%)), and the risk difference of TRG 0/1 between toripalimab plus chemotherapy group and chemotherapy group was 22.7% (95% CI: 5.8%–39.6%; P= 0.009), meeting a prespecified endpoint. In addition, a higher pathological complete response rate (ypT0N0) was observed in the toripalimab plus chemotherapy group (22.2% (12 of 54, 95% CI: 12.0%–35.6%) versus 7.4% (4 of 54, 95% CI: 2.1%–17.9%); P= 0.030), and surgical morbidity (11.8% in the toripalimab plus chemotherapy group versus 13.5% in the chemotherapy group) and mortality (1.9% versus 0%), and treatment-related grade 3–4 adverse events (35.2% versus 29.6%) were comparable between the treatment groups. In conclusion, the addition of toripalimab to chemotherapy significantly increased the proportion of patients achieving TRG 0/1 compared to chemotherapy alone and showed a manageable safety profile. ClinicalTrials.gov registration: NCT04250948.
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- 2024
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24. Synergistic treatment of blast furnace slag and basic oxygen furnace slag for efficient recovery of iron: Phase transformation and oxidation mechanisms
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Huang, Lan, An, Shengli, Zhang, Fang, Peng, Jun, Chen, Yuxin, Ping, Xin, and Liu, Chunheng
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In light of the steel industry's rapid advancements, the availability of high-quality mineral resources is diminishing. Therefore, the recovery of iron from BOF slag is of great significance to the sustainability development. Considering the compositional characteristics of BOF slag, the transformation of the iron-containing phase into (Mn,Mg)yFe3-yO4is the key step. Thus, a novel process for recovering iron resources by synergistic treatment of blast furnace slag (BFS) and BOF slag was proposed. This research employed FactSage thermodynamic simulation, XRD, SEM-EDS, XPS, and EPMA to analysis the impact of BFS addition (10–50 %), cooling methods (from water-cooling to furnace-cooling), and temperature (1400–1600 °C) on phase transformation and the RO oxidation mechanism, and the conditions of (Mn,Mg)yFe3-yO4generation and enrichment was obtained. The results show that at BFS addition of 30 %, reaction temperature 1400 °C and furnace-cooling, the iron-containing phase (Ca2Fe2O5and RO) was almost completely transformed into (Mn,Mg)yFe3-yO4. The oxidation mechanism of RO was formation of (Mn,Mg)yFe3-yO4by cation diffusion. Under optimal conditions, the iron recovery rate and the grade reached 65.74 % and 32.07 %, respectively, which can be used as raw material for ironmaking. Meanwhile, the main phase of the tailing slag was β-Ca2SiO4, without f-CaO, which has the potential to be used in the cement and concrete industries with the advantages of both low cost and eco-friendly. Therefore, the process with green, efficient and low cost was provided, which is a feasible idea for the comprehensive utilization of industrial solid waste.
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- 2024
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25. A multi-factor coupled acid-etching fracture conductivity prediction model study
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Fan, Yu, Peng, Jun Liang, Li, Qin, Min, Jian, and Wang, Zhouyang
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Starting from the perspective of dynamic dissolution of acid rock reaction, we use fractal dimension and spatial curvature to research the influencing factors and changing rules of acid-etching crack morphology. Under the condition of considering the filtration loss, the relationship between fracture morphology and inflow capacity is investigated, and a multi-factor coupled acid-erosion fracture inflow capacity prediction model is established. The model explores the effects of mineral content, porosity, permeability, rock mechanical properties, acid-rock reaction, and effective distance of acid action on fracture conductivity. The model shows that: dolomite content and calcite content are positively correlated with the hydraulic conductivity; non-carbonate rock mineral content is negatively correlated with the hydraulic conductivity; porosity is positively correlated with the hydraulic conductivity; and permeability is significantly positively correlated with the hydraulic conductivity. Young's modulus is positively correlated with the hydraulic conductivity. Poisson's ratio is negatively correlated with the hydraulic conductivity; and through the comparative analysis, we found that the main controlling factor is the permeability. [Received: July 31, 2023; Accepted: October 15, 2023]
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- 2024
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26. Dopant-additive synergism enhances perovskite solar modules
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Ding, Bin, Ding, Yong, Peng, Jun, Romano-deGea, Jan, Frederiksen, Lindsey E. K., Kanda, Hiroyuki, Syzgantseva, Olga A., Syzgantseva, Maria A., Audinot, Jean-Nicolas, Bour, Jerome, Zhang, Song, Wirtz, Tom, Fei, Zhaofu, Dörflinger, Patrick, Shibayama, Naoyuki, Niu, Yunjuan, Hu, Sixia, Zhang, Shunlin, Tirani, Farzaneh Fadaei, Liu, Yan, Yang, Guan-Jun, Brooks, Keith, Hu, Linhua, Kinge, Sachin, Dyakonov, Vladimir, Zhang, Xiaohong, Dai, Songyuan, Dyson, Paul J., and Nazeeruddin, Mohammad Khaja
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Perovskite solar cells (PSCs) are among the most promising photovoltaic technologies owing to their exceptional optoelectronic properties1,2. However, the lower efficiency, poor stability and reproducibility issues of large-area PSCs compared with laboratory-scale PSCs are notable drawbacks that hinder their commercialization3. Here we report a synergistic dopant-additive combination strategy using methylammonium chloride (MACl) as the dopant and a Lewis-basic ionic-liquid additive, 1,3-bis(cyanomethyl)imidazolium chloride ([Bcmim]Cl). This strategy effectively inhibits the degradation of the perovskite precursor solution (PPS), suppresses the aggregation of MACl and results in phase-homogeneous and stable perovskite films with high crystallinity and fewer defects. This approach enabled the fabrication of perovskite solar modules (PSMs) that achieved a certified efficiency of 23.30% and ultimately stabilized at 22.97% over a 27.22-cm2aperture area, marking the highest certified PSM performance. Furthermore, the PSMs showed long-term operational stability, maintaining 94.66% of the initial efficiency after 1,000 h under continuous one-sun illumination at room temperature. The interaction between [Bcmim]Cl and MACl was extensively studied to unravel the mechanism leading to an enhancement of device properties. Our approach holds substantial promise for bridging the benchtop-to-rooftop gap and advancing the production and commercialization of large-area perovskite photovoltaics.
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- 2024
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27. Effect of Mo on acicular ferrite transformation and interphase precipitation of Nb–V–N microalloyed steel during a continuous cooling process
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Zhang, Jing, Xin, Wen-bin, Hou, Deng-yun, Peng, Jun, Zhao, Zhi-bo, and Tong, Yang
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The substantial influences of Mo contents varying from 0 to 0.26 and 0.50 wt.% on the microstructural evolution and MX (M = Nb, V and Mo; X = C and N) precipitation characteristics of Nb–V–N microalloyed steels processed by hot deformation and continuous cooling were studied using a Gleeble 3800 thermomechanical simulator. Metallographic analysis showed that the ferrite microstructure transformed from polygonal ferrite (PF) in 0Mo steel to both acicular ferrite (AF) and PF in 0.26Mo and 0.50Mo steels, and AF content first increased and then decreased. The thermodynamic calculations and the experimental results proved that the quantity of solid solution of Mo in austenite obviously increased, which reduced the austenite (γ) to ferrite (α) transformation temperature, consequently promoting AF formation in 0.26Mo steel and bainite transformation in 0.50Mo steel. Moreover, the submicron Nb-rich MX particles that precipitated at the temperature of the austenite region further induced AF heterogeneous nucleation with an orientation relationship of (011)MX//(100)Ferriteand [11¯1]MX//[001]Ferrite. The interphase precipitation of the nanosized V-rich MX particles with Mo partitioning that precipitated during γ → α transformation exhibited a Baker–Nutting orientation relationship of 100MX//100Ferriteand 001MX//011¯Ferritewith respect to the ferrite matrix. With increasing Mo content from 0 to 0.26 and 0.50 wt.%, the sheet spacing decreased from 46.9–49.0 to 34.6–38.6 and 25.7–28.0 nm, respectively, which evidently hindered dislocation movement and greatly enhanced precipitation strengthening. Furthermore, facilitating AF formation and interphase precipitation was beneficial to improving steel properties, and the optimal Mo content was 0.26 wt.%.
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- 2024
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28. Low Computational Complexity Delay Estimation Algorithm for Digital Predistortion
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Zhong, Tianyang, Peng, Jun, He, Songbai, You, Fei, Guo, Junfu, Wang, Xinyu, Tang, Yijie, and He, Guo
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In practical scenarios, digital predistortion (DPD) systems are typically deployed on hardware platforms. However, the current time delay alignment algorithm, a critical component of DPD processing, requires substantial hardware resource allocation. Consequently, this brief introduces a novel delay estimation algorithm aimed at simplifying the time alignment segment, including both integer and fractional elements. The integer alignment method is established on an adaptive filter framework, while the fractional component leverages a recursive least square (RLS) algorithm, based on a Farrow structure, to circumvent extensive matrix calculations. The complexity analysis, coupled with experimental results show that the proposed methods not only preserve high accuracy but also substantially diminish computational resource demands by 88.7% and 87.8%, respectively, when compared with two prevailing delay estimation techniques. This enhancement notably augments the performance of hardware-based DPD systems.
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- 2024
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29. Resource Reservation Coordination for Vehicle Platooning in C-V2X Networks
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Gu, Xin, Peng, Jun, Cai, Lin, Liu, Weirong, Zhang, Xiaoyong, and Huang, Zhiwu
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High-reliability and low-latency communication is essential for timely information exchange in vehicle platooning. As a key enabler of this, the cellular vehicular-to-everything (C-V2X) network uses a sensing-based semi-persistent scheduling (SPS) protocol, where radio resources are reserved for a number of transmissions with reduced resource re-allocation and control overhead. However, consecutive access collisions may be caused by reservation conflict, which leads to long delay and threatens platoon’s stability and safety. In this paper, a coordinating resource reservation (CRR) protocol is proposed for vehicle platooning. By implementing error detection with coordination among platoon vehicles, the resource reservation is improved for reduced collisions and delay. Specifically, packet reception/loss information is sent out by platoon vehicles through their own packets. Such information is shared with transmitters and guides them to reserve new resources when access collision occurs. As a result, long delay is avoided while no extra feedback packet is introduced. Furthermore, Markov analysis is presented to evaluate the performance of SPS and the proposed CRR for vehicle platooning, providing the quantified performance gains. Finally, simulation results demonstrate the superiority of the proposed CRR in reducing packet loss and latency, compared with the legacy SPS and other state-of-the-art solutions.
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- 2024
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30. Maximizing Weighted Sum-Rate Over Gaussian Broadcast Channels
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Wan, Peng-Jun and Chen, Pengpeng
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A power assignment over Gaussian broadcast channels splits the power budget at the access point among all user-channel pairs subject to per-channel upper-bounds on the sum-power, and is optimal if it maximizes the weighted sum-rate (WSR). In this paper we first present a geometric algorithm for computing an optimal power assignment over single Gaussian broadcast channel, which has linear complexity if all users are presorted either by weight or by noise. We also provide an intuitively appealing water-filling interpretation of this geometric algorithm. By leveraging such water-filling interpretation, we develop a water-filling algorithm for computing an optimal power assignment over parallel Gaussian broadcast channels, whose complexity is linear in the number of user-channel pairs if all users are presorted by weight. From these algorithmic studies, we derive clean and simple expressions of the maximum WSR in both integral forms and sum forms. By exploiting the rich property of those forms, we further give a linear-complexity algorithm for computing a power budget at the access point, subject to a given upper bound, which maximizes the difference between the maximum WSR and a linear cost of the power budget. The algorithmic studies in this paper also reveal that a single Gaussian broadcast channel can be decomposed into parallel Gaussian single-user channels which preserve the maximum WSR.
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- 2024
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31. Neural radiance fields-based multi-view endoscopic scene reconstruction for surgical simulation
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Qin, Zhibao, Qian, Kai, Liang, Shaojun, Zheng, Qinhong, Peng, Jun, and Tai, Yonghang
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Purpose: In virtual surgery, the appearance of 3D models constructed from CT images lacks realism, leading to potential misunderstandings among residents. Therefore, it is crucial to reconstruct realistic endoscopic scene using multi-view images captured by an endoscope. Methods: We propose an Endoscope-NeRF network for implicit radiance fields reconstruction of endoscopic scene under non-fixed light source, and synthesize novel views using volume rendering. Endoscope-NeRF network with multiple MLP networks and a ray transformer network represents endoscopic scene as implicit field function with color and volume density at continuous 5D vectors (3D position and 2D direction). The final synthesized image is obtained by aggregating all sampling points on each ray of the target camera using volume rendering. Our method considers the effect of distance from the light source to the sampling point on the scene radiance. Results: Our network is validated on the lung, liver, kidney and heart of pig collected by our device. The results show that the novel views of endoscopic scene synthesized by our method outperform existing methods (NeRF and IBRNet) in terms of PSNR, SSIM, and LPIPS metrics. Conclusion: Our network can effectively learn a radiance field function with generalization ability. Fine-tuning the pre-trained model on a new endoscopic scene to further optimize the neural radiance fields of the scene, which can provide more realistic, high-resolution rendered images for surgical simulation.
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- 2024
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32. AI-Enabled Spatial-Temporal Mobility Awareness Service Migration for Connected Vehicles
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Wang, Chenglong, Peng, Jun, Cai, Lin, Peng, Hui, Liu, Weirong, Gu, Xin, and Huang, Zhiwu
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In the future 6G intelligent transportation system, the edge server will bring great convenience to the timely computing service for connected vehicles. To guarantee the quality of service, the time-critical services need to be migrated according to the future location of the vehicle. However, predicting vehicle mobility is challenging due to the time-varying of road traffic and the complex mobility patterns of vehicles. To address this issue, a spatial-temporal awareness proactive service migration strategy is proposed in this paper. First, a spatial-temporal neural network is designed to obtain accurate mobility by using gated recurrent units and graph convolutional layers extracting features from spatial road traffic and multi-time scales driving data. Then a proactive migration method is proposed to guarantee the reliability of services and reduce energy consumption. Considering the reliability of services and the real-time workload of servers, the migration problem is modeled as a multi-objective optimization problem, and the Lyapunov optimization method is utilized to obtain utility-optimal migration decisions. Extensive simulations based on real-world datasets are performed to validate the performance of the proposed method. The results show that the proposed method achieved 6% higher prediction accuracy, 10% lower dropping rate, and 10% lower energy consumption compared to state-of-the-art methods.
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- 2024
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33. Experimental and Theoretical Studies on Two Dual-Functional Organic–Inorganic Hybrids Based on [V4O12]4– Clusters.
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Zhou, Wanli, Zhao, Ziqi, Li, Jinyang, Zheng, Yanping, Lv, Ying, Chen, Xiao, Fu, Lihai, and Peng, Jun
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- 2023
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34. Telaprevir Improves Memory and Cognition in Mice Suffering Ischemic Stroke via Targeting MALT1-Mediated Calcium Overload and Necroptosis.
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Zhang, Yi-Yue, Peng, Jing-Jie, Chen, Di, Liu, Hui-Qi, Yao, Bi-Feng, Peng, Jun, and Luo, Xiu-Ju
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- 2023
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35. Predictive Set Point Modulation Control for Supercapacitor Storage Systems of Catenary-Free Trams
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Li, Heng, Zhang, Yu, Gao, Dianzhu, Li, Wenyun, Dai, Xiaokang, Huang, Zhiwu, and Peng, Jun
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Supercapacitors have been considered as a promising choice for public transportation electrification, e.g., catenary-free trams, as the only power source. Due to the frequent stops and drastic load changes of trams, the DC bus of supercapacitor storage systems exhibits significant voltage fluctuations, which degrades the reliable operation of trams. In this article, we propose a predictive set point modulation control method for supercapacitors storage systems, where the reference voltage is regulated in real time based on the prediction of DC bus voltage, which can effectively suppress the voltage fluctuations. We first model the supercapacitor storage systems based on the averaging method. Then, a cascade control framework is designed to regulate the DC bus voltage. A predictive set point modulation control method is designed to suppress the voltage fluctuations without changing the closed-loop system structure. We built a laboratory hardware platform to illustrate the performance of the proposed method. Both simulation and experiment results verify that the proposed method can effectively suppress the voltage fluctuations of the DC bus when compared with classical methods.
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- 2023
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36. Value Analysis, Realistic Examination and Approach Analysis of Artificial Intelligence into Physical Education.
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LIU Wei, PENG Jun, and ZHOU Boyu
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With the continuous maturity of artificial intelligence technologies such as ChatGPT, virtual reality, and machine learning,how to integrate artificial intelligence into physical education has become a new topic of education reform. By using the methods of literature and logical analysis, this paper expounds the value, problems and approaches of integrating artificial intelligence into physical education. It finds that the integration of artificial intelligence into physical education is conducive to promoting the liberalization of physical education field, the modernization of evaluation, the personalization of programs,the intelligence of management, and the low-risk process. Its process faces four dilemmas:teaching orientation, technical adaptation, educational data and model popularization. The approaches of integrating artificial intelligence into physical education: changing the role orientation of teachers and students to highlight the tool attributes of artificial intelligence, optimizing the technology research and development process to enhance the adaptability of artificial intelligence physical education products, improving the governance of physical education data to consolidate the base of artificial intelligence application, and strengthening equipment and personnel support to dispel barriers to artificial intelligence applications. [ABSTRACT FROM AUTHOR]
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- 2023
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37. RNA binding motif protein 45-mediated phosphorylation enhances protein stability of ASCT2 to promote hepatocellular carcinoma progression
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Du, Danyu, Qin, Mengyao, Shi, Li, Liu, Chan, Jiang, Jingwei, Liao, Zhengguang, Wang, Hongxv, Zhang, Zhibo, Sun, Li, Fan, Hui, Liu, Zhengrui, Yu, Hong, Li, Hongyang, Peng, Jun, Yuan, Shengtao, Yang, Mei, and Xiong, Jing
- Abstract
Targeting metabolic remodeling represents a potentially promising strategy for hepatocellular carcinoma (HCC) therapy. In-depth understanding on the regulation of the glutamine transporter alanine-serine-cysteine transporter 2 (ASCT2) contributes to the development of novel promising therapeutics. As a developmentally regulated RNA binding protein, RBM45 is capable to shuttle between nucleus and cytoplasm, and directly interacts with proteins. By bioinformatics analysis, we screened out that RBM45 was elevated in the HCC patient specimens and positively correlated with poor prognosis. RBM45 promoted cell proliferation, boosted xenograft tumorigenicity and accelerated HCC progression. Using untargeted metabolomics, it was found that RBM45 interfered with glutamine metabolism. Further results demonstrated that RBM45 positively associated with ASCT2 in human and mouse specimens. Moreover, RBM45 enhanced ASCT2 protein stability by counteracting autophagy-independent lysosomal degradation. Significantly, wild-type ASCT2, instead of phospho-defective mutants, rescued siRBM45-suppressed HCC cell proliferation. Using molecular docking approaches, we found AG-221, a mutant isocitrate dehydrogenase 2 (mIDH2) inhibitor for acute myeloid leukemia therapy, pharmacologically perturbed RBM45-ASCT2 interaction, decreased ASCT2 stability and suppressed HCC progression. These findings provide evidence that RBM45 plays a crucial role in HCC progression via interacting with and counteracting the degradation of ASCT2. Our findings suggest a novel alternative structural sites for the design of ASCT2 inhibitors and the agents interfering with RBM45-ASCT2 interaction may be a potential direction for HCC drug development.
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- 2023
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38. Detrimental effect of arsenic on hot ductility of copper-bearing steel
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Xin, Wen-bin, Liang, Yu-yu, Zhang, Jing, Meng, Qing-yang, Peng, Jun, Deng, Yong-chun, and Jiang, Yin-ju
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The effect of As content on the hot ductility of steel with 0.17 wt.% Cu was investigated at 700–1100 °C using a Gleeble-3800 thermal–mechanical simulator. The results showed that increasing the As content from 0 to 0.15 wt.% obviously widened the hot ductility trough and pushed the trough into the high-temperature regime. Meanwhile, when the As content exceeded 0.10 wt.%, significant hot ductility deterioration was found. In the ferrite + austenite two-phase regions of 700–800 °C, the fracture appearance changed from dimple ductile to intergranular ductile or from intergranular ductile to intergranular decohesion with increasing As content. The inhibition formation of proeutectoid ferrite and austenite grain coarsening were responsible for the slight hot ductility deterioration by As in the two-phase region. In the austenite single-phase region above 850 °C, the fracture appearance changed from dimple ductile to intergranular decohesion with increasing As content, especially at 850–950 °C. Suppression of dynamic recrystallization and grain boundary segregation of As resulted in serious damage of the hot ductility and widened the ductility trough in the single-phase region.
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- 2023
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39. Substation location and capacity planning based on multi-source heterogeneous data and mutational imperialist competition algorithm
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Shakir Md Saat, Mohd, Bin Ibne Reaz, Mamun, Wang, Bin, Wang, Li, Xue, Yi, Wang, Yuxiang, and Peng, Jun
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- 2023
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40. Experimental and Theoretical Studies on Two Dual-Functional Organic–Inorganic Hybrids Based on [V4O12]4–Clusters
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Zhou, Wanli, Zhao, Ziqi, Li, Jinyang, Zheng, Yanping, Lv, Ying, Chen, Xiao, Fu, Lihai, and Peng, Jun
- Abstract
Two new bimetallic organic–inorganic hybrids based on [V4O12]4–polyanion, [Cu(dpy)(V2O6)]·H2O (1) and [Cu2(tpy)2(V4O12)] (2) [dpy = 2,6-di(pyrazol-1-yl) pyrazine; tpy = 4′-(pyrrol-3-yl)-2,2′:6′,2″-terpyridine], were synthesized under gentle solvothermal conditions. Hybrid 1has a 1D {−V4O12–Cu2–V4O12}ncircle-connecting-circle chain with [V4O12]4–clusters and [Cu(dpy)]2+fragments, and hybrid 2possesses a discrete structure assembled from [Cu2(tpy)]4+motifs and [V4O12]4–clusters. We studied dual-functional electrocatalytic activities of the two hybrids for nitrite reduction and oxidation of ascorbic acid. Hybrid 1shows superior electrocatalytic activity toward oxidation–reduction reactions with electrocatalytic efficiencies of 680 and 128%, respectively. Also, density functional theory calculations including the molecular electrostatic potential and the frontier molecular orbital were adopted to study the electron structure and charge distribution.
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- 2023
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41. Forrestiacids E–K: Further [4 + 2]-Type Triterpene–Diterpene Hybrids as Potential ACL Inhibitors from the Vulnerable Conifer Pseudotsuga forrestii.
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Zhou, Peng-Jun, Huang, Ting, Ma, Guang-Lei, Tong, Ying-Peng, Chen, Wen-Xue, Zang, Yi, Xiong, Juan, Li, Jia, and Hu, Jin-Feng
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- 2023
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42. Enhanced Thermoelectric Performance and Low Thermal Conductivity in Cu2GeTe3 with Identified Localized Symmetry Breakdown.
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Qin, Feiyu, Hu, Lei, Zhu, Yingcai, Li, Yushan, Wang, Haitao, Wu, Haijun, Peng, Jun, Shi, Wen, Aydemir, Umut, and Ding, Xiangdong
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- 2023
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43. Study of Spatial Reuse in IEEE 802.11ax Networks over Propagation Models.
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Peng, Jun and Miller, Paola
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WIRELESS Internet ,LITERATURE - Abstract
The paper studies the spatial reuse in IEEE 802.11ax networks over propagation models in ns3. The propagation models used in the study include the Friis model, the Nakagami model, and the combination of the two models. The results show that not all access points in an area benefit from the spatial reuse, and some even lose throughput. These results introduce the question of how to justify the spatial reuse for those access points who lose throughput, although the total throughput of the access points in the area benefits from the spatial reuse in general. The results also show that the total throughput gains heavily depend on the physical environment of the networks as the environment determines the signal propagation in the networks. The results show that an environment of significant attenuation plus multipath fading offers significant throughput gains for the access points as a whole. Our main contributions in the paper are the results of the ns3 simulations which were not found in the literature. [ABSTRACT FROM AUTHOR]
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- 2023
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44. Process and property optimization of ceramsite preparation by Bayan Obo tailings and blast furnace slag
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Chai, Yi-fan, Hu, Wen-xian, Zhang, Yun-hao, Wang, Yi-ci, Peng, Jun, and An, Sheng-li
- Abstract
The ceramsite was prepared by using Bayan Obo tailings and blast furnace slag of Baotou Steel as the main raw materials and coal gangue as pore-forming agent, and the process system and the performance of ceramsite were optimized. The phase transformation rules of the ceramsite prepared by multi-source solid waste in sintering method were clarified. The influence of sintering process parameters on ceramsite performance and the purification effect of ceramsite on ammonia nitrogen wastewater were revealed. The results show that the reasonable proportion of raw materials for preparing ceramsite is 60% tailings, 35% blast furnace slag and 5% coal gangue. The reasonable preparation process of ceramsite is preheating at 350 °C for 12 min, increasing the temperature to 750 °C and holding for 60 min, then increasing the temperature to 1130 °C and roasting for 20 min. The cooling method is to cool down with the furnace. The prepared ceramsite has compressive strength of 1.89 MPa, porosity of 51.31%, water absorption of 31.42%, and bulk density of 1.94 g/cm3. When the ceramsite is used to treat ammonia nitrogen wastewater, the removal rate of ammonia nitrogen is 47.33%.
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- 2023
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45. Improvement of plant tolerance to drought stress by cotton tubby-like protein 30 through stomatal movement regulation.
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Li, Zhanshuai, Liu, Ji, Kuang, Meng, Zhang, Chaojun, Ma, Qifeng, Huang, Longyu, Wang, Huiying, Fan, Shuli, and Peng, Jun
- Abstract
[Display omitted] • GhTULP30 transcription in cotton was induced by drought and salt stress. • Ectopic GhTULP30 expression significantly improved yeast cell tolerance to drought and salt. • GhTULP30 overexpression increased the tolerance of Arabidopsis to drought and salt stress. • Silencing GhTULP30 affected stomatal movement and decreased tolerance to drought stress. • Protein experiments exhibited the interaction of GhTULP30 with GhSKP1B and GhXERICO. Cotton is a vital industrial crop that is gradually shifting to planting in arid areas. However, tubby-like proteins (TULPs) involved in plant response to various stresses are rarely reported in cotton. The present study exhibited that GhTULP30 transcription in cotton was induced by drought stress. The present study demonstrated the improvement of plant tolerance to drought stress by GhTULP30 through regulation of stomatal movement. GhTULP30 response to drought and salt stress was preliminarily confirmed by qRT-PCR and yeast stress experiments. Ectopic expression in Arabidopsis and endogenous gene silencing in cotton were used to determine stomatal movement. Yeast two-hybrid and spilt-luciferase were used to screen the interacting proteins. Ectopic expression of GhTULP30 in yeast markedly improved yeast cell tolerance to salt and drought. Overexpression of GhTULP30 made Arabidopsis seeds more resistant to drought and salt stress during seed germination and increased the stomata closing speed of the plant under drought stress conditions. Silencing of GhTULP30 in cotton by virus-induced gene silencing (VIGS) technology slowed down the closure speed of stomata under drought stress and decreased the length and width of the stomata. The trypan blue and diaminobenzidine staining exhibited the severity of leaf cell necrosis of GhTULP30 -silenced plants. Additionally, the contents of proline, malondialdehyde, and catalase of GhTULP30 -silenced plants exhibited significant variations, with obvious leaf wilting. Protein interaction experiments exhibited the interaction of GhTULP30 with GhSKP1B and GhXERICO. GhTULP30 participates in plant response to drought stress. The present study provides a reference and direction for further exploration of TULP functions in cotton plants. [ABSTRACT FROM AUTHOR]
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- 2022
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46. Forrestiacids E–K: Further [4 + 2]-Type Triterpene–Diterpene Hybrids as Potential ACL Inhibitors from the Vulnerable Conifer Pseudotsuga forrestii
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Zhou, Peng-Jun, Huang, Ting, Ma, Guang-Lei, Tong, Ying-Peng, Chen, Wen-Xue, Zang, Yi, Xiong, Juan, Li, Jia, and Hu, Jin-Feng
- Abstract
Seven [4 + 2]-type triterpene–diterpene hybrids derived from a rearranged or a normal lanostane unit (dienophile) and an abietane moiety (diene), forrestiacids E–K (1–7, respectively), were further isolated and characterized from Pseudotsuga forrestii(a vulnerable conifer endemic to China). The intriguing molecules were revealed with the guidance of an LC-MS/MS-based molecular ion networking strategy combined with conventional phytochemical procedures. Their chemical structures with absolute configurations were established by spectroscopic data, chemical transformation, electronic circular dichroism calculations, and single-crystal X-ray diffraction analysis. They all contain a rare bicyclo[2.2.2]octene motif. Both forrestiacids J (6) and K (7) represent the first examples of this unique class of [4 + 2]-type hybrids that arose from a normal lanostane-type dienophile. Some isolates remarkably inhibited ATP-citrate lyase (ACL), with IC50values ranging from 1.8 to 11 μM. Docking studies corroborated the findings by highlighting the interactions between the bioactive compounds and the ACL enzyme (binding affinities: −9.9 to −10.7 kcal/mol). The above findings reveal the important role of protecting plant species diversity in support of chemical diversity and potential sources of new therapeutics.
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- 2023
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47. Flexible solar cells based on foldable silicon wafers with blunted edges
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Liu, Wenzhu, Liu, Yujing, Yang, Ziqiang, Xu, Changqing, Li, Xiaodong, Huang, Shenglei, Shi, Jianhua, Du, Junling, Han, Anjun, Yang, Yuhao, Xu, Guoning, Yu, Jian, Ling, Jiajia, Peng, Jun, Yu, Liping, Ding, Bin, Gao, Yuan, Jiang, Kai, Li, Zhenfei, Yang, Yanchu, Li, Zhaojie, Lan, Shihu, Fu, Haoxin, Fan, Bin, Fu, Yanyan, He, Wei, Li, Fengrong, Song, Xin, Zhou, Yinuo, Shi, Qiang, Wang, Guangyuan, Guo, Lan, Kang, Jingxuan, Yang, Xinbo, Li, Dongdong, Wang, Zhechao, Li, Jie, Thoroddsen, Sigurdur, Cai, Rong, Wei, Fuhai, Xing, Guoqiang, Xie, Yi, Liu, Xiaochun, Zhang, Liping, Meng, Fanying, Di, Zengfeng, and Liu, Zhengxin
- Abstract
Flexible solar cells have a lot of market potential for application in photovoltaics integrated into buildings and wearable electronics because they are lightweight, shockproof and self-powered. Silicon solar cells have been successfully used in large power plants. However, despite the efforts made for more than 50 years, there has been no notable progress in the development of flexible silicon solar cells because of their rigidity1–4. Here we provide a strategy for fabricating large-scale, foldable silicon wafers and manufacturing flexible solar cells. A textured crystalline silicon wafer always starts to crack at the sharp channels between surface pyramids in the marginal region of the wafer. This fact enabled us to improve the flexibility of silicon wafers by blunting the pyramidal structure in the marginal regions. This edge-blunting technique enables commercial production of large-scale (>240 cm2), high-efficiency (>24%) silicon solar cells that can be rolled similarly to a sheet of paper. The cells retain 100% of their power conversion efficiency after 1,000 side-to-side bending cycles. After being assembled into large (>10,000 cm2) flexible modules, these cells retain 99.62% of their power after thermal cycling between −70 °C and 85 °C for 120 h. Furthermore, they retain 96.03% of their power after 20 min of exposure to air flow when attached to a soft gasbag, which models wind blowing during a violent storm.
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- 2023
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48. Effects of a Dry-Mass Conserving Dynamical Core on the Simulation of Tropical Cyclones
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Li, Shaoying, Peng, Jun, Zhang, Weimin, Wu, Jianping, Yao, Qiang, Yang, Xiangrong, and Luo, Tengling
- Abstract
The accurate forecasting of tropical cyclones (TCs) is a challenging task. The purpose of this study was to investigate the effects of a dry-mass conserving (DMC) hydrostatic global spectral dynamical core on TC simulation. Experiments were conducted with DMC and total (moist) mass conserving (TMC) dynamical cores. The TC forecast performance was first evaluated considering 20 TCs in the West Pacific region observed during the 2020 typhoon season. The impacts of the DMC dynamical core on forecasts of individual TCs were then estimated. The DMC dynamical core improved both the track and intensity forecasts, and the TC intensity forecast improvement was much greater than the TC track forecast improvement. Sensitivity simulations indicated that the DMC dynamical core-simulated TC intensity was stronger regardless of the forecast lead time. In the DMC dynamical core experiments, three-dimensional winds and warm and moist cores were consistently enhanced with the TC intensity. Drier air in the boundary inflow layer was found in the DMC dynamical core experiments at the early simulation times. Water vapor mixing ratio budget analysis indicated that this mainly depended on the simulated vertical velocity. Higher updraft above the boundary layer yielded a drier boundary layer, resulting in surface latent heat flux (SLHF) enhancement, the major energy source of TC intensification. The higher DMC dynamical core-simulated updraft in the inner core caused a higher net surface rain rate, producing higher net internal atmospheric diabatic heating and increasing the TC intensity. These results indicate that the stronger DMC dynamical core-simulated TCs are mainly related to the higher DMC vertical velocity.
- Published
- 2023
- Full Text
- View/download PDF
49. Transitional wave configurations between Type III and Type IV oblique-shock/bow-shock interactions
- Author
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PENG, Jun, LI, Shuai, YANG, Fan, LIN, Mingyue, HAN, Guilai, and HU, Zongmin
- Abstract
The interactions of oblique/bow shock waves are the key flow phenomena restricting the design and aerothermodynamic performance of high-speed vehicles. Type III and Type IV Shock/Shock Interactions(SSIs) have been extensively investigated, as such interactions can induce abnormal aerodynamic heating problems in hypersonic flows of vehicles. The transition process between these two distinct types of shock/shock interactions remains unclear. In the present study, a subclass of shock/shock interaction configuration is revealed and defined as Type IIIa. Type IIIa interaction can induce much more severe aerodynamic heating than a Type IV interaction which was ever reported to be the most serious in literature. The intense aerodynamic heating observed in this configuration highlights a new design point for the thermal protection system of hypersonic vehicles. A secondary Mach interaction between shock waves in the supersonic flow path of a Type III configuration is demonstrated to be the primary mechanism for such a subclass of shock/shock interaction configuration.
- Published
- 2023
- Full Text
- View/download PDF
50. Three New Difunctional Electrocatalysts Built from Polyoxometalates and Cu–Tpy Units: Experimental and Theoretical Study.
- Author
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Zhou, Wanli, Guan, Yuecen, Zheng, Yanping, Chen, Xiao, Li, Jinyang, Liu, Xuekun, and Peng, Jun
- Published
- 2022
- Full Text
- View/download PDF
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