934 results on '"P. Force"'
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2. It's WINONA!
- Author
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LA FORCE, THESSALY
- Abstract
This article from Harper's Bazaar features an interview with actress Winona Ryder, who is currently filming the final season of Stranger Things in Atlanta. Ryder discusses her role in the upcoming Beetlejuice sequel and her admiration for actress Ruth Gordon. She reflects on her past relationships and personal struggles, as well as her current relationship with her boyfriend, Scott Mackinlay Hahn. The article also highlights Ryder's career and her unique style choices. Additionally, it explores the making of the film Beetlejuice and its impact on the careers of Ryder, Tim Burton, and Michael Keaton. The article provides insight into the casting process and the unique qualities that Ryder brought to her role as Lydia Deetz. It also touches on Ryder's experiences in the film industry and her thoughts on fame and social media. Overall, the article offers a glimpse into the making of a cult classic and the lasting influence of the film. [Extracted from the article]
- Published
- 2024
3. Real-world effectiveness and durability of dual antiretroviral therapy in HIV- infected patients.
- Author
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Pérez-Cordón, Laia, Sánchez, Azhara, Marin, Sergio, Force, Lluis, Serra-Prat, Mateu, Palomera, Elisabet, and Campins, Lluis
- Published
- 2024
- Full Text
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4. Periodontal Pocket Therapy Using a Class IV Dental Diode Laser in Dogs: A Retrospective Analysis.
- Author
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Zuckerman, Ilana, Force, Judy, Hanlon, Alexandra L., Lozano, Alicia J., Ji, Wenyan, and Anderson, Jamie G.
- Subjects
PERIODONTAL pockets ,SEMICONDUCTOR lasers ,LASER therapy ,DENTAL specialties ,VETERINARY dentistry ,RETROSPECTIVE studies - Abstract
Class IV dental diode lasers have been introduced as a nonsurgical therapy for periodontal pockets in veterinary and human dentistry. This retrospective case series evaluates the use of Class IV dental diode laser therapy for abnormal periodontal pockets in a specialty veterinary dental practice. A hypothesis that the Class IV diode dental laser is a useful adjuvant modality in canine periodontal pocket therapy in the reduction of clinical pocket depth was made. This article discusses and demonstrates diode laser use in periodontal pocket therapy in a specialty veterinary dental practice and reviews the current literature. Inclusion in this study was limited to client-owned dogs with noted periodontal pocketing on any tooth type between 3 and 6 mm, which were treated with closed root planing (RP/C) and laser therapy who returned in 6 to 7 months for recheck of the pockets from the years 2017 to 2020. Twelve patients met the inclusion criteria. A total of 128 periodontal pockets were included in the study. Each periodontal pocket was a case receiving therapy. The mean periodontal pocket depth before the treatment is measured as 3.35 mm. The mean pocket depth of the periodontal pockets following treatment was 0.59 mm. The mean improvement in periodontal pocket depths after diode laser therapy when considering patient and tooth number using linear mixed-effects modeling was 2.63 mm (95% confidence interval [CI]: 1.81-3.46, P <.0001). No statistically significant results were observed for pocket type, as P values were greater than.05. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
5. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
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Brauer, Michael, Roth, Gregory A, Aravkin, Aleksandr Y, Zheng, Peng, Abate, Kalkidan Hassen, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasi, Madineh Akram, Abbasian, Mohammadreza, Abbasifard, Mitra, Abbasi-Kangevari, Mohsen, Abd ElHafeez, Samar, Abd-Elsalam, Sherief, Abdi, Parsa, Abdollahi, Mohammad, Abdoun, Meriem, Abdulah, Deldar Morad, Abdullahi, Auwal, Abebe, Mesfin, Abedi, Aidin, Abedi, Armita, Abegaz, Tadesse M, Abeldaño Zuñiga, Roberto Ariel, Abiodun, Olumide, Abiso, Temesgen Lera, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Abualruz, Hasan, Abubakar, Bilyaminu, Abu-Gharbieh, Eman, Abukhadijah, Hana Jihad Jihad, Aburuz, Salahdein, Abu-Zaid, Ahmed, Adane, Mesafint Molla, Addo, Isaac Yeboah, Addolorato, Giovanni, Adedoyin, Rufus Adesoji, Adekanmbi, Victor, Aden, Bashir, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adha, Rishan, Adibi, Amin, Adnani, Qorinah Estiningtyas Sakilah, Adzigbli, Leticia Akua, Afolabi, Aanuoluwapo Adeyimika, Afolabi, Rotimi Felix, Afshin, Ashkan, Afyouni, Shadi, Afzal, Muhammad Sohail, Afzal, Saira, Agampodi, Suneth Buddhika, Agbozo, Faith, Aghamiri, Shahin, Agodi, Antonella, Agrawal, Anurag, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Noah, Ahmad, Shahzaib, Ahmad, Tauseef, Ahmed, Ali, Ahmed, Anisuddin, Ahmed, Ayman, Ahmed, Luai A, Ahmed, Muktar Beshir, Ahmed, Safoora, Ahmed, Syed Anees, Ajami, Marjan, Akalu, Gizachew Taddesse, Akara, Essona Matatom, Akbarialiabad, Hossein, Akhlaghi, Shiva, Akinosoglou, Karolina, Akinyemiju, Tomi, Akkaif, Mohammed Ahmed, Akkala, Sreelatha, Akombi-Inyang, Blessing, Al Awaidy, Salah, Al Hasan, Syed Mahfuz, Alahdab, Fares, AL-Ahdal, Tareq Mohammed Ali, Alalalmeh, Samer O, Alalwan, Tariq A, Al-Aly, Ziyad, Alam, Khurshid, Alam, Nazmul, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albakri, Almaza, AlBataineh, Mohammad T, Aldhaleei, Wafa A, 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Ismael R, Cao, Chao, Cao, Fan, Cao, Yubin, Capodici, Angelo, Cárdenas, Rosario, Carr, Sinclair, Carreras, Giulia, Carrero, Juan J, Carugno, Andrea, Carvalho, Felix, Carvalho, Márcia, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Catalá-López, Ferrán, Catapano, Alberico L, Cattaruzza, Maria Sofia, Caye, Arthur, Cederroth, Christopher R, Cegolon, Luca, Cenderadewi, Muthia, Cercy, Kelly M, Cerin, Ester, Chadwick, Joshua, Chakraborty, Chiranjib, Chakraborty, Promit Ananyo, Chakraborty, Sandip, Chan, Jeffrey Shi Kai, Chan, Raymond N C, Chandan, Joht Singh, Chandika, Rama Mohan, Chaturvedi, Pankaj, Chen, An-Tian, Chen, Catherine S, Chen, Haowei, Chen, Meng Xuan, Chen, Mingling, Chen, Simiao, Cheng, Ching-Yu, Cheng, Esther T W, Cherbuin, Nicolas, Chi, Gerald, Chichagi, Fatemeh, Chimed-Ochir, Odgerel, Chimoriya, Ritesh, Ching, Patrick R, Chirinos-Caceres, Jesus Lorenzo, Chitheer, Abdulaal, Cho, William C S, Chong, Bryan, Chopra, Hitesh, Chowdhury, Rajiv, Christopher, Devasahayam J, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Chung, Eric, Chung, Sheng-Chia, Chutiyami, Muhammad, Cioffi, Iolanda, Cogen, Rebecca M, Cohen, Aaron J, Columbus, Alyssa, Conde, Joao, Corlateanu, Alexandru, Cortese, Samuele, Cortesi, Paolo Angelo, Costa, Vera Marisa, Costanzo, Simona, Criqui, Michael H, Cruz, Jessica A, Cruz-Martins, Natália, Culbreth, Garland T, da Silva, Alanna Gomes, Dadras, Omid, Dai, Xiaochen, Dai, Zhaoli, Daikwo, Patience Unekwuojo, Dalli, Lachlan L, Damiani, Giovanni, D'Amico, Emanuele, D'Anna, Lucio, Darwesh, Aso Mohammad, Das, Jai K, Das, Subasish, Dash, Nihar Ranjan, Dashti, Mohsen, Dávila-Cervantes, Claudio Alberto, Davis Weaver, Nicole, Davitoiu, Dragos Virgil, De la Hoz, Fernando Pio, de la Torre-Luque, Alejandro, De Leo, Diego, Debopadhaya, Shayom, Degenhardt, Louisa, Del Bo', Cristian, Delgado-Enciso, Ivan, Delgado-Saborit, Juana Maria, Demoze, Chalachew Kassaw, Denova-Gutiérrez, Edgar, Dervenis, Nikolaos, Dervišević, Emina, Desai, Hardik 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Fitriana, Ida, Flavel, Joanne, Flohr, Carsten, Flood, David, Flor, Luisa S, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Force, Lisa M, Fortuna, Daniela, Foschi, Matteo, Franklin, Richard Charles, Freitas, Alberto, Friedman, Sara D, Fux, Blima, G, Sridevi, Gaal, Peter Andras, Gaihre, Santosh, Gajdács, Márió, Galali, Yaseen, Gallus, Silvano, Gandhi, Aravind P, Ganesan, Balasankar, Ganiyani, Mohammad Arfat, Garcia, Vanessa, Gardner, William M, Garg, Ravindra K, Gautam, Rupesh K, Gebi, Tilaye Gebru, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Gebremariam, Tesfay B B, Gebremeskel, Teferi Gebru, Gerema, Urge, Getacher, Lemma, Getahun, Genanew K a, Getie, Molla, Ghadirian, Fataneh, Ghafarian, Sadegh, Ghaffari Jolfayi, Amir, Ghailan, Khalid Yaser, Ghajar, Alireza, Ghasemi, MohammadReza, Ghasempour Dabaghi, Ghazal, Ghasemzadeh, Afsaneh, Ghassemi, Fariba, Ghazy, Ramy Mohamed, Gholami, Ali, Gholamrezanezhad, Ali, Gholizadeh, Nasim, Ghorbani, Mahsa, Gil, Artyom Urievich, Gil, Gabriela 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Halboub, Esam S, Halimi, Aram, Hall, Brian J, Haller, Sebastian, Halwani, Rabih, Hamadeh, Randah R, Hamdy, Nadia M, Hameed, Sajid, Hamidi, Samer, Hammoud, Ahmad, Hanif, Asif, Hanifi, Nasrin, Haq, Zaim Anan, Haque, Md Rabiul, Harapan, Harapan, Hargono, Arief, Haro, Josep Maria, Hasaballah, Ahmed I, Hasan, Ikramul, Hasan, Mohammad Jahid, Hasan, S M Mahmudul, Hasani, Hamidreza, Hasanian, Mohammad, Hashmeh, Nadim, Hasnain, Md Saquib, Hassan, Amr, Hassan, Ikrama, Hassan Zadeh Tabatabaei, Mahgol Sadat, Hassani, Shokoufeh, Hassanipour, Soheil, Hassankhani, Hadi, Haubold, Johannes, Havmoeller, Rasmus J, Hay, Simon I, Hebert, Jeffrey J, Hegazi, Omar E, Hegena, Tadele Yohannes, Heidari, Golnaz, Heidari, Mohammad, Helfer, Bartosz, Hemmati, Mehdi, Henson, Claire A, Herbert, Molly E, Herteliu, Claudiu, Heuer, Austin, Hezam, Kamal, Hinneh, Thomas Kwadwo, Hiraike, Yuta, Hoan, Nguyen Quoc, Holla, Ramesh, Hon, Julia, Hoque, Mohammad Enamul, Horita, Nobuyuki, Hossain, Sahadat, Hosseini, Seyed Ehsan, Hosseinzadeh, Hassan, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hoven, Hanno, Hsairi, Mohamed, Hsu, Johnathan M, Hu, Chengxi, Huang, Junjie, Huda, Md Nazmul, Hulland, Erin N, Hultström, Michael, Hushmandi, Kiavash, Hussain, Javid, Hussein, Nawfal R, Huynh, Chantal K, Huynh, Hong-Han, Ibitoye, Segun Emmanuel, Idowu, Oluwatope Olaniyi, Ihler, Audrey L, Ikeda, Nayu, Ikuta, Kevin S, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Imam, Mohammad Tarique, Immurana, Mustapha, Inbaraj, Leeberk Raja, Irham, Lalu Muhammad, Isa, Mustafa Alhaji, Islam, Md Rabiul, Ismail, Faisal, Ismail, Nahlah Elkudssiah, Iso, Hiroyasu, Isola, Gaetano, Iwagami, Masao, Iwu, Chidozie C D, Iwu-Jaja, Chinwe Juliana, J, Vinothini, Jaafari, Jalil, Jacob, Louis, Jacobsen, Kathryn H, Jadidi-Niaragh, Farhad, Jahankhani, Kasra, Jahanmehr, Nader, Jahrami, Haitham, Jain, Akhil, Jain, Nityanand, Jairoun, Ammar Abdulrahman, Jaiswal, Abhishek, Jakovljevic, Mihajlo, Jalilzadeh Yengejeh, Reza, Jamora, Roland Dominic G, Jatau, Abubakar Ibrahim, Javadov, Sabzali, Javaheri, Tahereh, Jayaram, Shubha, Jeganathan, Jayakumar, Jeswani, Bijay Mukesh, Jiang, Heng, Johnson, Catherine O, Jokar, Mohammad, Jomehzadeh, Nabi, Jonas, Jost B, Joo, Tamas, Joseph, Abel, Joseph, Nitin, Joshi, Vivek, Joshua, Charity Ehimwenma, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kaambwa, Billingsley, Kabir, Ali, Kabir, Zubair, Kadashetti, Vidya, Kahn, Ethan M, Kalani, Rizwan, Kaliyadan, Feroze, Kalra, Sanjay, Kamath, Rajesh, Kanagasabai, Thanigaivelan, Kanchan, Tanuj, Kandel, Himal, Kanmiki, Edmund Wedam, Kanmodi, Kehinde Kazeem, Kansal, Sushil Kumar, Kapner, Daniel John, Kapoor, Neeti, Karagiannidis, Efstratios, Karajizadeh, Mehrdad, Karakasis, Paschalis, Karanth, Shama D, Karaye, Ibraheem M, Karch, André, Karim, Asima, Karimi, Hanie, Karmakar, Shilpi, Kashoo, Faizan Zaffar, Kasraei, Hengameh, Kassahun, Woldeteklehaymanot Dagne, Kassebaum, Nicholas J, Kassel, Molly B, Katikireddi, Srinivasa Vittal, Kauppila, Joonas H, Kawakami, Norito, Kaydi, Neda, Kayode, Gbenga A, Kazemi, Foad, Keiyoro, Peter Njenga, Kemmer, Laura, Kempen, John H, Kerr, Jessica A, Kesse-Guyot, Emmanuelle, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khajuria, Himanshu, Khalaji, Amirmohammad, Khalil, Mariam, Khalilian, Alireza, Khamesipour, Faham, Khan, Asaduzzaman, Khan, M Nuruzzaman, Khan, Maseer, Khan, Mohammad Jobair, Khan, Moien AB, Khanmohammadi, Shaghayegh, Khatab, Khaled, Khatatbeh, Haitham, Khatatbeh, Moawiah Mohammad, Khatib, Mahalaqua Nazli, Khavandegar, Armin, Khayat Kashani, Hamid Reza, Khidri, Feriha Fatima, Khodadoust, Elaheh, Khormali, Moein, Khorrami, Zahra, Khosla, Atulya Aman, Khosrowjerdi, Mahmood, Khreis, Haneen, Khusun, Helda, Kifle, Zemene Demelash, Kim, Kwanghyun, Kim, Min Seo, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Adnan, Kisa, Sezer, Knibbs, Luke D, Knudsen, Ann Kristin Skrindo, Koh, David S Q, Kolahi, Ali-Asghar, Kompani, Farzad, Kong, Jianqiu, Koren, Gerbrand, Korja, Miikka, Korshunov, Vladimir 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Samer H, Murray, Christopher J L, and Gakidou, Emmanuela
- Abstract
Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensive estimates of exposure levels, relative health risks, and attributable burden of disease for 88 risk factors in 204 countries and territories and 811 subnational locations, from 1990 to 2021.
- Published
- 2024
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6. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
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Ferrari, Alize J, Santomauro, Damian Francesco, Aali, Amirali, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbastabar, Hedayat, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdollahi, Arash, Abdullahi, Auwal, Abegaz, Kedir Hussein, Abeldaño Zuñiga, Roberto Ariel, Aboagye, Richard Gyan, Abolhassani, Hassan, Abreu, Lucas Guimarães, Abualruz, Hasan, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Ackerman, Ilana N, Addo, Isaac Yeboah, Addolorato, Giovanni, Adebiyi, Akindele Olupelumi, Adepoju, Abiola Victor, Adewuyi, Habeeb Omoponle, Afyouni, Shadi, Afzal, Saira, Afzal, Sina, Agodi, Antonella, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Shahzaib, Ahmed, Ali, Ahmed, Luai A, Ahmed, Muktar Beshir, Ajami, Marjan, Akinosoglou, Karolina, Akkaif, Mohammed Ahmed, Al Hasan, Syed Mahfuz, Alalalmeh, Samer O, Al-Aly, Ziyad, Albashtawy, Mohammed, Aldridge, Robert W, Alemu, Meseret Desalegn, Alemu, Yihun Mulugeta, Alene, Kefyalew Addis, Al-Gheethi, Adel Ali Saeed, Alharrasi, Maryam, Alhassan, Robert Kaba, Ali, Mohammed Usman, Ali, Rafat, Ali, Syed Shujait Shujait, Alif, Sheikh Mohammad, Aljunid, Syed Mohamed, Al-Marwani, Sabah, Almazan, Joseph Uy, Alomari, Mahmoud A, Al-Omari, Basem, Altaany, Zaid, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Alwafi, Hassan, Al-Wardat, Mohammad Sami, Al-Worafi, Yaser Mohammed, Aly, Safwat, Alzoubi, Karem H, Amare, Azmeraw T, Amegbor, Prince M, Ameyaw, Edward Kwabena, Amin, Tarek Tawfik, Amindarolzarbi, Alireza, Amiri, Sohrab, Amugsi, Dickson A, Ancuceanu, Robert, Anderlini, Deanna, Anderson, David B, Andrade, Pedro Prata, Andrei, Catalina Liliana, Ansari, Hossein, Antony, Catherine M, Anwar, Saleha, Anwar, Sumadi Lukman, Anwer, Razique, Anyanwu, Philip Emeka, Arab, Juan Pablo, Arabloo, Jalal, Arafat, Mosab, Araki, Daniel T, Aravkin, Aleksandr Y, Arkew, Mesay, Armocida, Benedetta, Arndt, Michael Benjamin, Arooj, Mahwish, Artamonov, Anton A, Aruleba, Raphael Taiwo, Arumugam, Ashokan, Ashbaugh, Charlie, Ashemo, 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Theo, and Murray, Christopher J L
- Abstract
Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to implement strategies that can mitigate diseases. It can also facilitate more rigorous monitoring of progress towards national and international health targets, such as the Sustainable Development Goals. For three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has filled that need. A global network of collaborators contributed to the production of GBD 2021 by providing, reviewing, and analysing all available data. GBD estimates are updated routinely with additional data and refined analytical methods. GBD 2021 presents, for the first time, estimates of health loss due to the COVID-19 pandemic.
- Published
- 2024
- Full Text
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7. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Author
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- Abstract
Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period.
- Published
- 2024
- Full Text
- View/download PDF
8. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021
- Author
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Vollset, Stein Emil, Ababneh, Hazim S, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasian, Mohammadreza, Abbastabar, Hedayat, Abd Al Magied, Abdallah H A, Abd ElHafeez, Samar, Abdelkader, Atef, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdi, Parsa, Abdollahi, Mohammad, Abdoun, Meriem, Abdullahi, Auwal, Abebe, Mesfin, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Absalan, Abdorrahim, Abualruz, Hasan, Abubakar, Bilyaminu, Abukhadijah, Hana Jihad Jihad, Addolorato, Giovanni, Adekanmbi, Victor, Adetunji, Charles Oluwaseun, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adha, Rishan, Adhikary, Ripon Kumar, Adnani, Qorinah Estiningtyas Sakilah, Adzigbli, Leticia Akua, Afrashteh, Fatemeh, Afzal, Muhammad Sohail, Afzal, Saira, Agbozo, Faith, Agodi, Antonella, Agrawal, Anurag, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahlstrom, Austin J, Ahmad, Aqeel, Ahmad, 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Luís Manuel Lopes Rodrigues, Silva, Soraia, Silva, Thales Philipe R, Simpson, Colin R, Simpson, Kyle E, Singh, Abhinav, Singh, Balbir Bagicha, Singh, Baljinder, Singh, Harmanjit, Singh, Jasbir, Singh, Paramdeep, Singh, Puneetpal, Skou, Søren T, Smith, Georgia, Sobia, Farrukh, Socea, Bogdan, Solanki, Shipra, Soleimani, Hamidreza, Soliman, Sameh S M, Song, Yi, Soyiri, Ireneous N, Spartalis, Michael, Spearman, Sandra, Sreeramareddy, Chandrashekhar T, Stanaway, Jeffrey D, Stanikzai, Muhammad Haroon, Starodubova, Antonina V, Stein, Dan J, Steiner, Caitlyn, Steiropoulos, Paschalis, Stockfelt, Leo, Stokes, Mark A, Straif, Kurt, Subedi, Narayan, Suliankatchi Abdulkader, Rizwan, Sultana, Abida, Sun, Jing, Sundström, Johan, Swain, Chandan Kumar, Szarpak, Lukasz, Szeto, Mindy D, Tabaee Damavandi, Payam, Tabarés-Seisdedos, Rafael, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabb, Karen M, Tabche, Celine, Tabish, Mohammad, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taiba, Jabeen, Talaat, Iman M, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tang, Haosu, Tat, Nathan Y, Tavakoli Oliaee, Razieh, Tavangar, Seyed Mohammad, Taveira, Nuno, Tbakhi, Abdelghani, Tehrani, Hadi, Temsah, Mohamad-Hani, Teramoto, Masayuki, Tesfaye, Behailu Terefe, Teye-Kwadjo, Enoch, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Thapar, Rekha, Thayakaran, Rasiah, Thirunavukkarasu, Sathish, Thomas, Nihal, Thygesen, Lau Caspar, Ticoalu, Jansje Henny Vera, Timalsena, Dinesh, Tiruye, Tenaw Yimer, Tiwari, Krishna, Tomo, Sojit, Tonelli, Marcello, Topor-Madry, Roman, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tran, An Thien, Tran, Jasmine T, Tran, Nghia Minh, Tran, Thang Huu, Trico, Domenico, Tromans, Samuel Joseph, Truyen, Thien Tan Tri Tai, Tsatsakis, Aristidis, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Turnock, Steven T, Udoh, Arit, Ullah, Atta, Ullah, Saeed, Ullah, Sana, Umakanthan, Srikanth, Umar, Muhammad, Umar, Shehu Salihu, Unim, Brigid, Unnikrishnan, Bhaskaran, Upadhyay, Era, Usman, Jibrin Sammani, Vahdati, Sanaz, Vaithinathan, Asokan Govindaraj, Vakili, Omid, Valizadeh, Rohollah, Van den Eynde, Jef, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vasic, Milena, Venketasubramanian, Narayanaswamy, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Vijayageetha, Mathavaswami, Villafañe, Jorge Hugo, Vinayak, Manish, Violante, Francesco S, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vo, Bay, Vohra, Karn, Vos, Theo, Wadood, Abdul Wadood, Waheed, Yasir, Wang, Fang, Wang, Shaopan, Wang, Shu, Wang, Yanqing, Wang, Yanzhong, Wang, Yuan-Pang, Wanjau, Mary Njeri, Waqas, Muhammad, Ward, Paul, Waris, Abdul, Wassie, Emebet Gashaw, Watson, Stefanie, Weaver, Marcia R, Weerakoon, Kosala Gayan, Weintraub, Robert G, Weldetinsaa, Haftom Legese Legese, Wells, Katherine M, Wen, Yi Feng, Westerman, Ronny, Wiangkham, Taweewat, Wickramasinghe, Dakshitha Praneeth, Widowati, Evi, Wojewodzic, Marcin W, Woldeyes, Dawit Habte, Wolf, Axel Walter, Wolfe, Charles D A, Wu, Chenkai, Wu, Dongze, Wu, Felicia, Wu, Jiayuan, Wu, Zenghong, Wulf Hanson, Sarah, Xiao, Hong, Xu, Suowen, Yadav, Rakesh, Yamagishi, Kazumasa, Yang, Danting, Yano, Yuichiro, Yarahmadi, Amir, Yazdani Nia, Iman, Ye, Pengpeng, Yesodharan, Renjulal, Yesuf, Subah Abderehim, Yezli, Saber, Yiğit, Arzu, Yiğit, Vahit, Yigzaw, Zeamanuel Anteneh, Yin, Dehui, Yip, Paul, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yu, Chuanhua, Yu, Elaine A, Yu, Yong, Yuan, Chun-Wei, Yusuf, Hadiza, Zafar, Uzma, Zafari, Nima, Zahid, Mondal Hasan, Zakham, Fathiah, Zaki, Nazar, Zerfu, Taddese Alemu, Zhang, Haijun, Zhang, Jingya, Zhang, Liqun, Zhang, Yunquan, Zhang, Zhiqiang, Zhao, Xiu-Ju George, Zhao, Yang, Zhao, Zhongyi, Zhong, Chenwen, Zhou, Bolun, Zhou, Juexiao, Zhou, Shangcheng, Zhu, Bin, Zhumagaliuly, Abzal, Zielińska, Magdalena, Zoghi, Ghazal, Zumla, Alimuddin, Zyoud, Sa'ed H, Zyoud, Samer H, Smith, Amanda E, and Murray, Christopher J L
- Abstract
Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternative scenarios assessing disease burden trajectories if selected sets of risk factors were eliminated from current levels by 2050.
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- 2024
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9. What PADMA Wants.
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LA FORCE, THESSALY
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- 2024
10. Periodontal Pocket Therapy Using a Class IV Dental Diode Laser in Dogs: A Retrospective Analysis
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Zuckerman, Ilana, Force, Judy, Hanlon, Alexandra L., Lozano, Alicia J., Ji, Wenyan, and Anderson, Jamie G.
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Class IV dental diode lasers have been introduced as a nonsurgical therapy for periodontal pockets in veterinary and human dentistry. This retrospective case series evaluates the use of Class IV dental diode laser therapy for abnormal periodontal pockets in a specialty veterinary dental practice. A hypothesis that the Class IV diode dental laser is a useful adjuvant modality in canine periodontal pocket therapy in the reduction of clinical pocket depth was made. This article discusses and demonstrates diode laser use in periodontal pocket therapy in a specialty veterinary dental practice and reviews the current literature. Inclusion in this study was limited to client-owned dogs with noted periodontal pocketing on any tooth type between 3 and 6 mm, which were treated with closed root planing (RP/C) and laser therapy who returned in 6 to 7 months for recheck of the pockets from the years 2017 to 2020. Twelve patients met the inclusion criteria. A total of 128 periodontal pockets were included in the study. Each periodontal pocket was a case receiving therapy. The mean periodontal pocket depth before the treatment is measured as 3.35 mm. The mean pocket depth of the periodontal pockets following treatment was 0.59 mm. The mean improvement in periodontal pocket depths after diode laser therapy when considering patient and tooth number using linear mixed-effects modeling was 2.63 mm (95% confidence interval [CI]: 1.81-3.46, P < .0001). No statistically significant results were observed for pocket type, as Pvalues were greater than .05.
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- 2024
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11. MATERIAL EVIDENCE.
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La Force, Thessaly
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This article explores the Manhattan apartment of fashion designer Emily Adams Bode Aujla and her husband, Aaron Aujla. The couple's apartment is filled with antique textiles, objects, and artworks that reflect their reverence for personal histories and storytelling. The article discusses how Emily incorporates elements from different eras into her clothing designs and how their apartment is a reflection of their unique aesthetic. The couple recently moved into their current apartment after outgrowing their previous rental. The article also mentions that the couple draws inspiration from the life of painter Everett Shinn, a member of the Ashcan School known for depicting scenes of urban life. The apartment features elements from the period of Shinn's occupancy, but some renovations have been made. Emily and Aaron have incorporated their own artistic touches, such as antique textiles and artwork, while also creating a space for their growing family. Emily is particularly interested in preserving and collecting family heirlooms and vintage pieces. [Extracted from the article]
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- 2024
12. Real-world effectiveness and durability of dual antiretroviral therapy in HIV-infected patients
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Pérez-Cordón, Laia, Sánchez, Azhara, Marin, Sergio, Force, Lluis, Serra-Prat, Mateu, Palomera, Elisabet, and Campins, Lluis
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Background and objectivesWhile randomised controlled trials in HIV-infected patients have shown that certain dual antiretroviral therapy (DAT) regimens are non-inferior in terms of efficacy compared with classical triple-drug regimens, few real clinical experiences have been described. The aim of the study was to investigate, in real clinical practice, DAT effectiveness, durability, and risk factors for treatment discontinuation.MethodsThis was a prospective cohort study that included HIV-infected patients treated with DAT (2015–2020). DAT was considered effective when patients achieved or maintained virological suppression and was assessed at 24 and 48 weeks. DAT durability was evaluated using the Kaplan-Meier method. Adherence and treatment cost were compared with patients’ previous antiretroviral regimens.Results51 patients were included, 27.5% with HIV-1 RNA ≥50 copies/mL at baseline, treated with a wide range of dual combinations. At 48 weeks follow-up, 83.8% and 50.0% of patients who started DAT with HIV-1 RNA <50 copies/mL and ≥50 copies/mL, respectively, were suppressed. 39 out of 51 patients (76.5%) maintained DAT for a mean treatment duration of 40.5±14.8 weeks. Full adherence was observed in 78.4% of patients compared with 70.2% in the previous regimen. Mean daily cost was €18.6±4.3 compared with €16.1±7.9 in the previous regimen (p=0.008).ConclusionDAT effectiveness and durability were higher in patients who were virologically suppressed at baseline. DAT is a possible alternative for virologically non-suppressed patients who cannot be treated with a triple-drug regimen.
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- 2024
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13. CHARACTERISTICS OF STUDIES EVALUATING VALUES AND PREFERENCES IN MODERATE-TO-SEVERE ASTHMA PATIENTS: A SYSTEMATIC REVIEW.
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Rayner, D., Ferri, D., Silang, I., Fernandes, A., Tse, S., Li, S., Chu, D., and Parameters, f. Force on Practice
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- 2024
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14. Hip crepitus is prevalent and severe in football players with hip/groin pain: Is it associated with early hip osteoarthritis features?
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Serighelli, F., Crossley, K.M., Scholes, M.J., Kemp, J.L., King, M.G., Lawrenson, P.R., Group, FORCe, Heerey, J.J., and de Oliveira Silva, D.
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- 2024
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15. Impacto psicológico del COVID-19 en los pacientes de Oncología Médica, Hemato-Oncología y Oncología Radioterápica de un hospital público en España.
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Force Castells, Elena, Toader, Irina Denisa, Carpio Moreno, Alberto, Narváez Arróspide, Almudena, García Valverde, Anhara, and Paz-Ares Rodríguez, Luis
- Abstract
Copyright of Psicooncologia is the property of Universidad Complutense de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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16. MAYA LIN's Monumental VISION.
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LA FORCE, THESSALY
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- 2023
17. The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories: A Systematic Analysis for the Global Burden of Disease Study 2019
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Cunha, Amanda Ramos da, Compton, Kelly, Xu, Rixing, Mishra, Rashmi, Drangsholt, Mark Thomas, Antunes, Jose Leopoldo Ferreira, Kerr, Alexander R., Acheson, Alistair R., Lu, Dan, Wallace, Lindsey E., Kocarnik, Jonathan M., Fu, Weijia, Dean, Frances E., Pennini, Alyssa, Henrikson, Hannah Jacqueline, Alam, Tahiya, Ababneh, Emad, Abd-Elsalam, Sherief, Abdoun, Meriem, Abidi, Hassan, Abubaker Ali, Hiwa, Abu-Gharbieh, Eman, Adane, Tigist Demssew, Addo, Isaac Yeboah, Ahmad, Aqeel, Ahmad, Sajjad, Ahmed Rashid, Tarik, Akonde, Maxwell, Al Hamad, Hanadi, Alahdab, Fares, Alimohamadi, Yousef, Alipour, Vahid, Al-Maweri, Sadeq Ali, Alsharif, Ubai, Ansari-Moghaddam, Alireza, Anwar, Sumadi Lukman, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Aravkin, Aleksandr Y., Aruleba, Raphael Taiwo, Asaad, Malke, Ashraf, Tahira, Athari, Seyyed Shamsadin, Attia, Sameh, Azadnajafabad, Sina, Azangou-Khyavy, Mohammadreza, Badar, Muhammad, Baghcheghi, Nayereh, Banach, Maciej, Bardhan, Mainak, Barqawi, Hiba Jawdat, Bashir, Nasir Z., Bashiri, Azadeh, Benzian, Habib, Bernabe, Eduardo, Bhagat, Devidas S., Bhojaraja, Vijayalakshmi S., Bjørge, Tone, Bouaoud, Souad, Braithwaite, Dejana, Briko, Nikolay Ivanovich, Calina, Daniela, Carreras, Giulia, Chakraborty, Promit Ananyo, Chattu, Vijay Kumar, Chaurasia, Akhilanand, Chen, Meng Xuan, Cho, William C. S., Chu, Dinh-Toi, Chukwu, Isaac Sunday, Chung, Eunice, Cruz-Martins, Natália, Dadras, Omid, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Daneshpajouhnejad, Parnaz, Darvishi Cheshmeh Soltani, Reza, Darwesh, Aso Mohammad, Debela, Sisay Abebe, Derbew Molla, Meseret, Dessalegn, Fikadu Nugusu, Dianati-Nasab, Mostafa, Digesa, Lankamo Ena, Dixit, Shilpi Gupta, Dixit, Abhinav, Djalalinia, Shirin, El Sayed, Iman, El Tantawi, Maha, Enyew, Daniel Berhanie, Erku, Daniel Asfaw, Ezzeddini, Rana, Fagbamigbe, Adeniyi Francis, Falzone, Luca, Fetensa, Getahun, Fukumoto, Takeshi, Gaewkhiew, Piyada, Gallus, Silvano, Gebrehiwot, Mesfin, Ghashghaee, Ahmad, Gill, Paramjit Singh, Golechha, Mahaveer, Goleij, Pouya, Gomez, Ricardo Santiago, Gorini, Giuseppe, Guimaraes, Andre Luiz Sena, Gupta, Bhawna, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Haj-Mirzaian, Arvin, Halboub, Esam S., Halwani, Rabih, Hanif, Asif, Hariyani, Ninuk, Harorani, Mehdi, Hasani, Hamidreza, Hassan, Abbas M., Hassanipour, Soheil, Hassen, Mohammed Bheser, Hay, Simon I., Hayat, Khezar, Herrera-Serna, Brenda Yuliana, Holla, Ramesh, Horita, Nobuyuki, Hosseinzadeh, Mehdi, Hussain, Salman, Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Isola, Gaetano, Jaiswal, Abhishek, Jani, Chinmay T., Javaheri, Tahereh, Jayarajah, Umesh, Jayaram, Shubha, Joseph, Nitin, Kadashetti, Vidya, Kandaswamy, Eswar, Karanth, Shama D., Karaye, Ibraheem M., Kauppila, Joonas H., Kaur, Harkiran, Keykhaei, Mohammad, Khader, Yousef Saleh, Khajuria, Himanshu, Khanali, Javad, Khatib, Mahalaqua Nazli, Khayat Kashani, Hamid Reza, Khazeei Tabari, Mohammad Amin, Kim, Min Seo, Kompani, Farzad, Koohestani, Hamid Reza, Kumar, G. Anil, Kurmi, Om P., La Vecchia, Carlo, Lal, Dharmesh Kumar, Landires, Iván, Lasrado, Savita, Ledda, Caterina, Lee, Yo Han, Libra, Massimo, Lim, Stephen S., Listl, Stefan, Lopukhov, Platon D., Mafi, Ahmad R., Mahumud, Rashidul Alam, Malik, Ahmad Azam, Mathur, Manu Raj, Maulud, Sazan Qadir, Meena, Jitendra Kumar, Mehrabi Nasab, Entezar, Mestrovic, Tomislav, Mirfakhraie, Reza, Misganaw, Awoke, Misra, Sanjeev, Mithra, Prasanna, Mohammad, Yousef, Mohammadi, Mokhtar, Mohammadi, Esmaeil, Mokdad, Ali H., Moni, Mohammad Ali, Moraga, Paula, Morrison, Shane Douglas, Mozaffari, Hamid Reza, Mubarik, Sumaira, Murray, Christopher J. L., Nair, Tapas Sadasivan, Narasimha Swamy, Sreenivas, Narayana, Aparna Ichalangod, Nassereldine, Hasan, Natto, Zuhair S., Nayak, Biswa Prakash, Negru, Serban Mircea, Nggada, Haruna Asura, Nouraei, Hasti, Nuñez-Samudio, Virginia, Oancea, Bogdan, Olagunju, Andrew T., Omar Bali, Ahmed, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pandey, Anamika, Pardhan, Shahina, Patel, Jay, Pezzani, Raffaele, Piracha, Zahra Zahid, Rabiee, Navid, Radhakrishnan, Venkatraman, Radhakrishnan, Raghu Anekal, Rahmani, Amir Masoud, Rahmanian, Vahid, Rao, Chythra R., Rao, Sowmya J., Rath, Goura Kishor, Rawaf, David Laith, Rawaf, Salman, Rawassizadeh, Reza, Razeghinia, Mohammad Sadegh, Rezaei, Nazila, Rezaei, Negar, Rezaei, Nima, Rezapour, Aziz, Riad, Abanoub, Roberts, Thomas J., Romero-Rodríguez, Esperanza, Roshandel, Gholamreza, S., Manjula, S. N., Chandan, Saddik, Basema, Saeb, Mohammad Reza, Saeed, Umar, Safaei, Mohsen, Sahebazzamani, Maryam, Sahebkar, Amirhossein, Salek Farrokhi, Amir, Samy, Abdallah M., Santric-Milicevic, Milena M., Sathian, Brijesh, Satpathy, Maheswar, Šekerija, Mario, Senthilkumaran, Subramanian, Seylani, Allen, Shafaat, Omid, Shahsavari, Hamid R., Shamsoddin, Erfan, Sharew, Mequannent Melaku, Sharifi-Rad, Javad, Shetty, Jeevan K., Shivakumar, K. M., Shobeiri, Parnian, Shorofi, Seyed Afshin, Shrestha, Sunil, Siddappa Malleshappa, Sudeep K., Singh, Paramdeep, Singh, Jasvinder A., Singh, Garima, Sinha, Dhirendra Narain, Solomon, Yonatan, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Taheri Abkenar, Yasaman, Talaat, Iman M., Tan, Ker-Kan, Tbakhi, Abdelghani, Thiyagarajan, Arulmani, Tiyuri, Amir, Tovani-Palone, Marcos Roberto, Unnikrishnan, Bhaskaran, Vo, Bay, Volovat, Simona Ruxandra, Wang, Cong, Westerman, Ronny, Wickramasinghe, Nuwan Darshana, Xiao, Hong, Yu, Chuanhua, Yuce, Deniz, Yunusa, Ismaeel, Zadnik, Vesna, Zare, Iman, Zhang, Zhi-Jiang, Zoladl, Mohammad, Force, Lisa M., and Hugo, Fernando N.
- Abstract
IMPORTANCE: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning. OBJECTIVE: To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates. EVIDENCE REVIEW: The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019. FINDINGS: In 2019, 370 000 (95% uncertainty interval [UI], 338 000-401 000) cases and 199 000 (95% UI, 181 000-217 000) deaths for LOC and 167 000 (95% UI, 153 000-180 000) cases and 114 000 (95% UI, 103 000-126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia. CONCLUSIONS AND RELEVANCE: In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts.
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- 2023
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18. TOPICAL CORTICOSTEROIDS FOR URTICARIA: SYSTEMATIC REVIEW AND BAYESIAN META-ANALYSIS INCORPORATING EXPERT INPUT
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Chu, A., Rayner, D., Chu, X., Chen, L., Dong, A., Chu, D., and Parameters, f. Force on Practice
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Topical corticosteroids (TCS) are widely used to treat urticaria, but clinicians and patients have noted varying degrees of benefit. We performed a systematic review and Bayesian meta-analysis informed by expert input.
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- 2024
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19. CHARACTERISTICS OF STUDIES EVALUATING VALUES AND PREFERENCES IN MODERATE-TO-SEVERE ASTHMA PATIENTS: A SYSTEMATIC REVIEW
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Rayner, D., Ferri, D., Silang, I., Fernandes, A., Tse, S., Li, S., Chu, D., and Parameters, f. Force on Practice
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Understanding patient values and preferences can inform optimal asthma care. We systematically summarized the evidence addressing patient and caregiver values and preferences regarding the management of severe asthma.
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- 2024
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20. THE JOY OF KØKKEN.
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La Force, Thessaly
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This article from Elle Decor discusses the transformation of a writer's kitchen in Brooklyn into a space that combines personal memories with Scandinavian design. The writer wanted a kitchen that was practical, economical, and possessed a simple kind of beauty. She drew inspiration from her Danish family and their kitchen, which held special memories of togetherness. The article also explores the concept of Scandinavian design and its influence on American interiors, emphasizing the idea of creating warm and inviting spaces. [Extracted from the article]
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- 2024
21. How Do High School Students Learn the Importance of Fats in the Diet? Analysis of the Fatty Acid Composition of Bakery Products.
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Clavijo-Bernal, Enrique J., Sánchez, Rosario, Villoslada-Valbuena, Mónica, DeAndrés-Gil, Cristina, Garcés, Rafael, Martínez-Force, Enrique, Salas, Joaquín J., and Venegas-Calerón, Mónica
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- 2023
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22. Recovery of Patient-reported Quality of Life After Esophagectomy.
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Bonanno, Alicia, Dixon, Meredith, Binongo, Jose, Force, Seth D., Sancheti, Manu S., Pickens, Allan, Kooby, David A., Staley, Charles A., Russell, Maria C., Cardona, Kenneth, Shah, Mihir M., Gillespie, Theresa W., Fernandez, Felix, and Khullar, Onkar
- Abstract
Esophagectomy is an important, but potentially morbid, operation used to treat benign and malignant conditions that may significantly impact patient quality of life (QOL). Patient-reported outcomes (PROs) are measures of QOL that come directly from patient self-report. This study characterizes patterns of change and recovery in PROs in the first year after esophagectomy. Longitudinal QOL scores measuring physical function, pain, and dyspnea were obtained from esophagectomy patients during all clinic visits. PRO scores were obtained using the National Institutes of Health–sponsored Patient-Reported Outcomes Measurement Information System from April 2018 to February 2021. Mean PRO scores over 100 days after surgery were compared with baseline PRO scores using mixed-effects modeling with compound symmetry correlational structure. One hundred three patients with PRO results were identified. Reasons for esophagectomy were malignancy (87.4%), achalasia (5.8%), stricture (5.8%), and dysplasia (1.0%). When comparing mean PRO scores at visits ≤ 50 days after surgery with preoperative PRO scores, physical function scores declined by 27.3% (P <.001), whereas dyspnea severity and pain interference scores had increased by 24.5% (P <.001) and 17.1% (P <.001), respectively. Although recovery occurred over the course of the 100 days after surgery, mean physical function scores and dyspnea scores were still 12.7% (P =.02) and 26.4% (P =.001) worse, respectively, than mean preoperative levels. Despite declines in QOL scores immediately after esophagectomy, recovery back toward baseline was observed during the first 100 days. These findings are of considerable importance when counseling patients regarding esophagectomy, tracking recovery, and implementing quality improvement initiatives. Further long-term follow-up is needed to determine recovery beyond 100 days. [ABSTRACT FROM AUTHOR]
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- 2023
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23. Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021
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Thomson, Azalea M, McHugh, Theresa A, Oron, Assaf P, Teply, Corey, Lonberg, Nikhil, Vilchis Tella, Victor, Wilner, Lauren B, Fuller, Kia, Hagins, Hailey, Aboagye, Richard Gyan, Aboye, Melka Biratu, Abu-Gharbieh, Eman, Abu-Zaid, Ahmed, Addo, Isaac Yeboah, Ahinkorah, Bright Opoku, Ahmad, Aqeel, AlRyalat, Saif Aldeen S, Amu, Hubert, Aravkin, Aleksandr Y, Arulappan, Judie, Atout, Maha Moh'd Wahbi, Badiye, Ashish D, Bagherieh, Sara, Banach, Maciej, Banakar, Morteza, Bardhan, Mainak, Barrow, Amadou, Bedane, Deriba Abera, Bensenor, Isabela M, Bhagavathula, Akshaya Srikanth, Bhardwaj, Pankaj, Bhardwaj, Prarthna V, Bhat, Ajay Nagesh, Bhutta, Zulfiqar A, Bilalaga, Mariah Malak, Bishai, Jessica Devin, Bitaraf, Saeid, Boloor, Archith, Butt, Muhammad Hammad, Chattu, Vijay Kumar, Chu, Dinh-Toi, Dadras, Omid, Dai, Xiaochen, Danaei, Bardia, Dang, Anh Kim, Demisse, Fitsum Wolde, Dhimal, Meghnath, Diaz, Daniel, Djalalinia, Shirin, Dongarwar, Deepa, Elhadi, Muhammed, Elmonem, Mohamed A, Esezobor, Christopher Imokhuede, Etaee, Farshid, Eyawo, Oghenowede, Fagbamigbe, Adeniyi Francis, Fatehizadeh, Ali, Force, Lisa M, Gardner, William M, Ghaffari, Kazem, Gill, Paramjit Singh, Golechha, Mahaveer, Goleij, Pouya, Gupta, Vivek Kumar, Hasani, Hamidreza, Hassan, Treska S, Hassen, Mohammed Bheser, Ibitoye, Segun Emmanuel, Ikiroma, Adalia I, Iwu, Chidozie C D, James, Peter Bai, Jayaram, Shubha, Jebai, Rime, Jha, Ravi Prakash, Joseph, Nitin, Kalantar, Farnaz, Kandel, Himal, Karaye, Ibraheem M, Kassahun, Woldeteklehaymanot Dagne, Khan, Imteyaz A, Khanmohammadi, Shaghayegh, Kisa, Adnan, Kompani, Farzad, Krishan, Kewal, Landires, Iván, Lim, Stephen S, Mahajan, Preetam Bhalchandra, Mahjoub, Soleiman, Majeed, Azeem, Marasini, Bishnu P, Meresa, Haftu Asmerom, Mestrovic, Tomislav, Minhas, Sonica, Misganaw, Awoke, Mokdad, Ali H, Monasta, Lorenzo, Mustafa, Ghulam, Nair, Tapas Sadasivan, Narasimha Swamy, Sreenivas, Nassereldine, Hasan, Natto, Zuhair S, Naveed, Muhammad, Nayak, Biswa Prakash, Noubiap, Jean Jacques, Noyes, Taylor, Nri-ezedi, Chisom Adaobi, Nwatah, Vincent Ebuka, Nzoputam, Chimezie Igwegbe, Nzoputam, Ogochukwu Janet, Okonji, Osaretin Christabel, Onikan, Adeyinka Omoniyi, Owolabi, Mayowa O, Patel, Jay, Pati, Siddhartha, Pawar, Shrikant, Petcu, Ionela-Roxana, Piel, Frédéric B, Qattea, Ibrahim, Rahimi, Mehran, Rahman, Mosiur, Rawaf, Salman, Redwan, Elrashdy Moustafa Mohamed, Rezaei, Nazila, Saddik, Basema, Saeed, Umar, Saheb Sharif-Askari, Fatemeh, Samy, Abdallah M, Schumacher, Austin E, Shaker, Elaheh, Shetty, Adithi, Sibhat, Migbar Mekonnen, Singh, Jasvinder A, Suleman, Muhammad, Sunuwar, Dev Ram, Szeto, Mindy D, Tamuzi, Jacques JL Lukenze, Tat, Nathan Y, Taye, Birhan Tsegaw, Temsah, Mohamad-Hani, Umair, Muhammad, Valadan Tahbaz, Sahel, Wang, Cong, Wickramasinghe, Nuwan Darshana, Yigit, Arzu, Yiğit, Vahit, Yunusa, Ismaeel, Zaman, Burhan Abdullah, Zangiabadian, Moein, Zheng, Peng, Hay, Simon I, Naghavi, Mohsen, Murray, Christopher J L, and Kassebaum, Nicholas J
- Abstract
Previous global analyses, with known underdiagnosis and single cause per death attribution systems, provide only a small insight into the suspected high population health effect of sickle cell disease. Completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, this study delivers a comprehensive global assessment of prevalence of sickle cell disease and mortality burden by age and sex for 204 countries and territories from 2000 to 2021.
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- 2023
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24. Clinical trials of self-replicating RNA-based cancer vaccines
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Morse, Michael A., Crosby, Erika J., Force, Jeremy, Osada, Takuya, Hobeika, Amy C., Hartman, Zachary C., Berglund, Peter, Smith, Jonathan, and Lyerly, H. Kim
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Therapeutic cancer vaccines, designed to activate immune effectors against tumor antigens, utilize a number of different platforms for antigen delivery. Among these are messenger RNAs (mRNA), successfully deployed in some prophylactic SARS-CoV2 vaccines. To enhance the immunogenicity of mRNA-delivered epitopes, self-replicating RNAs (srRNA) that markedly increase epitope expression have been developed. These vectors are derived from positive-strand RNA viruses in which the structural protein genes have been replaced with heterologous genes of interest, and the structural proteins are provided in trans to create single cycle viral replicon particles (VRPs). Clinical stage srRNA vectors have been derived from alphaviruses, including Venezuelan Equine Encephalitis (VEE), Sindbis, and Semliki Forest virus (SFV) and have encoded the tumor antigens carcinoembryonic antigen (CEA), human epidermal growth factor receptor 2 (HER2), prostate specific membrane antigen (PSMA), and human papilloma virus (HPV) antigens E6 and E7. Adverse events have mainly been grade 1 toxicities and minimal injection site reactions. We review here the clinical experience with these vaccines and our recent safety data from a study combining a VRP encoding HER2 plus an anti-PD1 monoclonal antibody (pembrolizumab). This experience with VRP-based srRNA supports recent development of fully synthetic srRNA technologies, where the viral structural proteins are replaced with protective lipid nanoparticles (LNP), cationic nanoemulsions or polymers.
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- 2023
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25. Routine Implementation of Patient-Reported Outcomes Assessment Into Thoracic Surgery Practice.
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Khullar, Onkar V., Perez, Aubriana, Dixon, Meredith, Binongo, Jose N., Sancheti, Manu S., Pickens, Allan, Gillespie, Theresa, Force, Seth D., and Fernandez, Felix G.
- Abstract
Patient-reported outcomes (PROs) assessment is a necessary component of surgical outcome assessment and patient care. This study examined the success of routine PROs assessment in an academic-based thoracic surgery practice. PROs, measuring pain intensity, physical function, and dyspnea, were routinely obtained using the National Institutes of Health-sponsored Patient-Reported Outcomes Measurement Information System (PROMIS) on all thoracic surgery patients beginning in April 2018 through January 2021. Questionnaires were administered electronically through a web-based platform at home or during the office visit. Completion rates and barriers were measured. A total of 9725 thoracic surgery office visits occurred during this time frame. PROs data were obtained in 6899 visits from a total of 3551 patients. The mean number of questions answered per survey was 22.4 ± 2.2. Overall questionnaire completion rate was 65.7%. A significant decline in survey completion was noted in April 2020, after which adjustments were made to allow for questionnaire completion through a mobile health platform. Overall monthly questionnaire completion rates ranged from 20% (April 2020) to 90% (October 2018). Mean T scores were dyspnea, 41.6 ± 12.3; physical function, 42.7 ± 10.5; and pain intensity, 52.8 ± 10.3. PROs can be assessed effectively in a thoracic surgery clinic setting, with minimal disruption of clinical activities. Future efforts should focus on facilitating PROs collection from disadvantaged patient populations and scaling implementation across programs. [ABSTRACT FROM AUTHOR]
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- 2023
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26. LAST: Latent Space-Assisted Adaptive Sampling for Protein Trajectories.
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Tian, Hao, Jiang, Xi, Xiao, Sian, La Force, Hunter, Larson, Eric C., and Tao, Peng
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- 2023
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27. The Local Vibrational Mode Theory and Its Place in the Vibrational Spectroscopy Arena.
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Kraka, Elfi, Quintano, Mateus, La Force, Hunter W., Antonio, Juliana J., and Freindorf, Marek
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- 2022
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28. Hip crepitus severity is associated with psychological features and pain in football players with hip/groin pain: A cross-sectional analysis of 184 footballers.
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Serighelli, F., Crossley, K.M., King, M.G., Scholes, M.J., Heerey, J.J., Kemp, J.L., Lawrenson, P.R., Group, FORCe, and de Oliveira Silva, D.
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- 2024
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29. How Do High School Students Learn the Importance of Fats in the Diet? Analysis of the Fatty Acid Composition of Bakery Products
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Clavijo-Bernal, Enrique J., Sánchez, Rosario, Villoslada-Valbuena, Mónica, DeAndrés-Gil, Cristina, Garcés, Rafael, Martínez-Force, Enrique, Salas, Joaquín J., and Venegas-Calerón, Mónica
- Abstract
The high level of consumption of processed foods has an effect on human health. The consumption of doughnuts, pastries, fried chicken, French fried potatoes, snack chips, and imitation cheese is high among teenagers. These foods are generally rich in fats, although the focus has often been on the quantity rather than the quality of these fats. These products often contain saturated and trans fatty acids, which have adverse effects on triglycerides and cholesterol levels and raise lipoprotein(a) levels in plasma. These modifications are associated with the risk of developing certain health conditions, such as heart disease, stroke, type 2 diabetes, and obesity. It is important to note that not all fats have this negative effect on health. Dietary fats are an essential part that cannot be substituted for a healthy diet. A diet rich in healthy fats, such as monounsaturated and polyunsaturated fats, has an important benefit in human health. For this reason, it is crucial to read, identify, and interpret food labels in processed food to identify the presence of saturated or trans fats and choose healthier alternatives. Therefore, in this workshop, students in the first year of baccalaureate extracted oils and fats from a range of processed foods, quantifying and characterizing their nature by analyzing their fatty acid composition by gas chromatography. Subsequently, students compared their results according to the information given on the food package label and the literature. Finally, the students gave a talk on the work done in the laboratory and the knowledge gained from the students in lower grades, third and fourth years of high school, to raise awareness among these students.
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- 2023
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30. An Analysis of the Worldwide Utilization of Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia
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Tokaz, Molly C., Baldomero, Helen, Cowan, Andrew J., Saber, Wael, Greinix, Hildegard, Koh, Mickey B.C., Kröger, Nicolaus, Mohty, Mohamad, Galeano, Sebastian, Okamoto, Shinichiro, Chaudhri, Naeem, Karduss, Amado J., Ciceri, Fabio, Colturato, Vergílio Antonio R., Corbacioglu, Selim, Elhaddad, Alaa, Force, Lisa M., Frutos, Cristóbal, León, Andrés Gómez-De, Hamad, Nada, Hamerschlak, Nelson, He, Naya, Ho, Aloysius, Huang, Xiao-jun, Jacobs, Ben, Kim, Hee-Je, Iida, Minako, Lehmann, Leslie, de Latour, Regis Peffault, Percival, Mary-Elizabeth M., Perdomo, Martina, Rasheed, Walid, Schultz, Kirk R., Seber, Adriana, Ko, Bor-Sheng, Simione, Anderson João, Srivastava, Alok, Szer, Jeff, Wood, William A., Kodera, Yoshihisa, Nagler, Arnon, Snowden, John A., Weisdorf, Daniel, Passweg, Jakob, Pasquini, Marcelo C., Sureda, Anna, Atsuta, Yoshiko, Aljurf, Mahmoud, and Niederwieser, Dietger
- Abstract
Acute myeloid leukemia (AML) has an aggressive course and a historically dismal prognosis. For many patients, hematopoietic stem cell transplantation (HSCT) represents the best option for cure, but access, utilization, and health inequities on a global scale remain poorly elucidated. We wanted to describe patterns of global HSCT use in AML for a better understanding of global access, practices, and unmet needs internationally. Estimates of AML incident cases in 2016 were obtained from the Global Burden of Disease 2019 study. HSCT activities were collected from 2009 to 2016 by the Worldwide Network for Blood and Marrow Transplantation through its member organizations. The primary endpoint was global and regional use (number of HSCT) and utilization of HSCT (number of HSCT/number of incident cases) for AML. Secondary outcomes included trends from 2009 to 2016 in donor type, stem cell source, and remission status at time of HSCT. Global AML incidence has steadily increased, from 102,000 (95% uncertainty interval: 90,200-108,000) in 2009 to 118,000 (104,000-126,000) in 2016 (16.2%). Over the same period, a 54.9% increase from 9659 to 14,965 HSCT/yr was observed globally, driven by an increase in allogeneic (64.9%) with a reduction in autologous (−34.9%) HSCT. Although the highest numbers of HSCT continue to be performed in high-resource regions, the largest increases were seen in resource-constrained regions (94.6% in Africa/East Mediterranean Region [AFR/EMR]; 34.7% in America-Nord Region [AMR-N]). HSCT utilization was skewed toward high-resource regions (in 2016: AMR-N 18.4%, Europe [EUR] 17.9%, South-East Asia/Western Pacific Region [SEAR/WPR] 11.7%, America-South Region [AMR-S] 4.5%, and AFR/EMR 2.8%). For patients <70 years of age, this difference in utilization was widened; AMR-N had the highest allogeneic utilization rate, increasing from 2009 to 2016 (30.6% to 39.9%) with continued low utilization observed in AFR/EMR (1.7% to 2.9%) and AMR-S (3.5% to 5.4%). Across all regions, total HSCT for AML in first complete remission (CR1) increased (from 44.1% to 59.0%). Patterns of donor stem cell source from related versus unrelated donors varied widely by geographic region. SEAR/WPR had a 130.2% increase in related donors from 2009 to 2016, and >95% HSCT donors in AFR/EMR were related; in comparison, AMR-N and EUR have a predilection for unrelated HSCT. Globally, the allogeneic HSCT stem cell source was predominantly peripheral blood (69.7% of total HSCT in 2009 increased to 78.6% in 2016). Autologous HSCT decreased in all regions from 2009 to 2016 except in SEAR/WPR (18.9%). HSCT remains a central curative treatment modality in AML. Allogeneic HSCT for AML is rising globally, but there are marked variations in regional utilization and practices, including types of graft source. Resource-constrained regions have the largest growth in HSCT use, but utilization rates remain low, with a predilection for familial-related donor sources and are typically offered in CR1. Further studies are necessary to elucidate the reasons, including economic factors, to understand and address these health inequalities and improve discrepancies in use of HSCT as a potentially curative treatment globally.
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- 2023
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31. Trauma-Informed Radiation Therapy: Implementation and Evaluation of a Sensitive Practice Tool for Female Patients Undergoing Radiotherapy for Breast Cancer.
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Marshall, Deborah, Green, Sheryl, Jones, Brianna M., Starrs, Clodagh, Montgomery, Guy H., Minassian, Kevin, Wunder, Bruce, Force, James, and Schnur, Julie B.
- Abstract
Purpose: For childhood sexual abuse survivors, cancer care can be retraumatizing because of perceived similarities to the original sexual violence. The authors' group designed and implemented a sensitive practice tool (SPT) and evaluated the feasibility of the tool in female patients receiving breast radiation.Methods: The SPT was offered as a "universal precaution" to patients with breast cancer as part of standard clinical care. Patients were given the SPT, which included an instructional video about radiotherapy and a survey about triggers and preferences. The survey results were provided to radiation therapists and used to personalize patients' care. A retrospective chart review and quality improvement survey of therapists were performed.Results: Of 739 eligible patients, 493 (66.7%) completed the SPT from November 2013 to June 2019. Among respondents, 281 (57.0%) reported potential triggers, 395 (80.1%) reported distress management preferences, and 59 (12.0%) requested psychosocial referrals. Mean patient satisfaction was high, and a majority of patients were likely to recommend the SPT to other patients (85.3%). Among radiation therapists (n = 13), 100% reported that the SPT made it easier to customize or individualize patient care. Trauma disclosure was not significantly associated with increased frequency of trigger endorsement (P = .07) but was associated with increased endorsement of distress management preferences (P = .02) and psychosocial referral requests (P < .001).Conclusions: The reported experience with the SPT in the breast radiotherapy setting demonstrated that potential triggers and distress management preferences among patients are common and that patient satisfaction with the SPT is high, yielding clinically meaningful and actionable sensitive practice information. [ABSTRACT FROM AUTHOR]- Published
- 2022
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32. Consensus for Thoracoscopic Lower Lobectomy: Essential Components and Targets for Simulation.
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Erwin, Philip A., Lee, Andy C., Ahmad, Usman, Antonoff, Mara, Arndt, Andrew, Backhus, Leah, Berry, Mark, Birdas, Thomas, Cassivi, Stephen D., Chang, Andrew C., Cooke, David T., Crabtree, Traves, DeCamp, Malcolm, Donington, Jessica, Fernandez, Felix, Force, Seth, Gaissert, Henning, Hofstetter, Wayne, Huang, James, and Kent, Michael
- Abstract
Despite demonstration of its clear benefits relative to open approaches, a video-assisted thoracic surgery technique for pulmonary lobectomy has not been universally adopted. This study aims to overcome potential barriers by establishing the essential components of the operation and determining which steps are most useful for simulation training. After randomly selecting experienced thoracic surgeons to participate, an initial list of components to a lower lobectomy was distributed. Feedback was provided by the participants, and modifications were made based on anonymous responses in a Delphi process. Components were declared essential once at least 80% of participants came to an agreement. The steps were then rated based on cognitive and technical difficulty followed by listing the components most appropriate for simulation. After 3 rounds of voting 18 components were identified as essential to performance of a video-assisted thoracic surgery for lower lobectomy. The components deemed the most difficult were isolation and division of the basilar and superior segmental branches of the pulmonary artery, isolation and division of the lower lobe bronchus, and dissection of lymphovascular tissue to expose the target bronchus. The steps determined to be most amenable for simulation were isolation and division of the branches of the pulmonary artery, the lower lobe bronchus, and the inferior pulmonary vein. Using a Delphi process a list of essential components for a video-assisted thoracic surgery for lower lobectomy was established. Furthermore 3 components were identified as most appropriate for simulation-based training, providing insights for future simulation development. [ABSTRACT FROM AUTHOR]
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- 2022
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33. Glass Platform for Co-Packaged Optics
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Brusberg, Lars, Grenier, Jason R., Zakharian, Aramais R., Yeary, Lucas W., Seok, Seong-Ho, Noh, Jung-Hyun, Kim, Young-Gon, Matthies, Jurgen, Terwilliger, Chad C., Paddock, Barry J., Bellman, Robert A., Levesque, Daniel W., Force, Robin M., Sutton, Clifford G., Clark, Jeffrey S., and Johnson, Betsy J.
- Abstract
Placing the electrical and photonic chiplets in a single package leads to significant power reduction. Chiplets are connected by fine-line electrical routing over a length of a few millimeters and optical interconnects in the package connect photonic chips with optical fibers for off-package communication. A packaging substrate made of glass with optical waveguides, through glass vias and electrical redistribution layers inside a single-sided cavity enables lower-cost assembly. A single-sided 50 μm deep cavity was etched in glass, and electrical copper lines with 5 μm in height and width were deposited on the floor of the cavity. Ion-exchange (IOX) waveguides with propagation loss of <0.1 dB/cm were fabricated below the glass surface. For flip-chip assembly of photonic chips and optical coupling with the IOX waveguides at the top surface of the glass, all electrical interconnects were located inside the cavity. Photonic chips with silicon nitride waveguides were optically coupled to glass waveguides with a minimum loss of 0.5 dB, achieved by fiducial-aligned flip-chip photonic assembly. A low-profile fiber connector with height of 4.4 mm connects the integrated ion-exchanged waveguides with the optical fibers. Average connector loss of 0.83 dB was demonstrated with physical contact between fibers and IOX glass waveguides.
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- 2023
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34. The Local Vibrational Mode Theory and Its Place in the Vibrational Spectroscopy Arena
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Kraka, Elfi, Quintano, Mateus, La Force, Hunter W., Antonio, Juliana J., and Freindorf, Marek
- Abstract
This Feature Article starts highlighting some recent experimental and theoretical advances in the field of IR and Raman spectroscopy, giving a taste of the breadth and dynamics of this striving field. The local mode theory is then reviewed, showing how local vibrational modes are derived from fundamental normal modes. New features are introduced that add to current theoretical efforts: (i) a unique measure of bond strength based on local mode force constants ranging from bonding in single molecules in different environments to bonding in periodic systems and crystals and (ii) a new way to interpret vibrational spectra by pinpointing and probing interactions between particular bond stretching contributions to the normal modes. All of this represents a means to work around the very nature of normal modes, namely that the vibrational motions in polyatomic molecules are delocalized. Three current focus points of the local mode analysis are reported, demonstrating how the local mode analysis extracts important information hidden in vibrational spectroscopy data supporting current experiments: (i) metal–ligand bonding in heme proteins, such as myoglobin and neuroglobin; (ii) disentanglement of DNA normal modes; and (iii) hydrogen bonding in water clusters and ice. Finally, the use of the local mode analysis by other research groups is summarized. Our vision is that in the future local mode analysis will be routinely applied by the community and that this Feature Article serves as an incubator for future collaborations between experiment and theory.
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- 2022
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35. The Cynthia & Heywood Fralin Collection.
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Fralin, Cynthia and Force, Debra J.
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- 2022
36. A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial
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Landman, Roland, de Truchis, Pierre, Assoumou, Lambert, Lambert, Sidonie, Bellet, Jonathan, Amat, Karine, Lefebvre, Bénédicte, Allavena, Clotilde, Katlama, Christine, Yazdanpanah, Yazdan, Molina, Jean-Michel, Petrov-Sanchez, Ventzislava, Gibowski, Séverine, Alvarez, Jean-Claude, Leibowitch, Jacques, Capeau, Jacqueline, Fellahi, Soraya, Duracinsky, Martin, Morand-Joubert, Laurence, Costagliola, Dominique, Girard, Pierre-Marie, LAMAURY, Isabelle, BANI-SADR, Firouzé, FORCE, Gilles, CHABROL, Amélie, CABY, Fabienne, PATEY, Olivier, FRESARD, Anne, GAGNEUX-BRUNON, Amandine, CHIROUZE, Catherine, DUVIVIER, Claudine, LOURENCO, Jérémie, TOLSMA, Violaine, JANSSEN, Cécile, LEROLLE, Nathalie, CATALAN, Pilartxo, RAMI, Agathe, DE PONTHAUD, Lucile, PICHANCOURT, Gilles, NASRI, Safa, LANDOWSKI, Stéphanie, BOTTERO, Julie, MFUTILA KAYKAY, Flory, PIALOUX, Gilles, BOUCHAUD, Olivier, ABGRALL, Sophie, GATEY, Caroline, WEISS, Laurence, PAVIE, Juliette, SALMON-CERON, Dominique, ZUCMAN, David, LELIEVRE, Jean-Daniel, PALICH, Romain, SIMON, Anne, MEYOHAS, Marie-Caroline, GRAS, Julien, CABIE, André, PIRCHER, Mathilde, MORLAT, Philippe, HESSAMFAR, Mojgam, NEAU, Didier, CAZENAVE, Charles, GENET, Claire, FAUCHER, Jean-François, MAKHLOUFI, Djamila, BOIBIEUX, André, BREGIGEON-RONOT, Sylvie, LAROCHE, Hélène, SAUTEREAU, Aurélie, REYNES, Jacques, MAKINSON, Alain, RAFFI, François, BOLLENGIER-STRAGIER, Olivier, NAQVI, Alissa, CUA, Eric, ROSENTHAL, Eric, ARVIEUX, Cédrick, BUZELE, Rodolphe, REY, David, BATARD, Marie-Laure, BERNARD, Louis, DELOBEL, Pierre, PIFFAUT, Marie, VERDON, Renaud, PIROTH, Lionel, BLOT, Mathieu, LECLERCQ, Pascale, SIGNORI-SCHMUCK, Anne, HULEUX, Thomas, MEYBECK, Agnès, MAY, Thierry, MIAILHES, Patrick, PERPOINT, Thomas, GREDER-BELAN, Alix, ELHARRAR, Brigitte, KHUONG, Marie-Aude, POUPARD, Marie, BLUM, Laurent, MICHAU, Christophe, PRAZUCK, Thierry, PHILIBERT, Patrick, SLAMA, Laurence, HIKOMBO, Hitoto, DARASTEANU, Iuliana, GIRARD, Pierre-Marie, ALVAREZ, Jean-Claude, MATHEZ, Dominique, DE TRUCHIS, Pierre, LANDMAN, Roland, MEYNARD, Jean-Luc, MORAND-JOUBERT, Laurence, LAMBERT, Sidonie, LE DU, Damien, PERRONNE, Christian, ASSOUMOU, Lambert, COSTAGLIOLA, Dominique, MELCHIOR, Jean-Claude, DURACINSKI, Martin, PETROV-SANCHEZ, Ventzislava, AMAT, Karine, BENALYCHERIF, Aïda, SYLLA, Babacar, GELLEY, Ambre, GIBOWSKI, Séverine, LE MEUT, Guillaume, THIEBAUT, Rodolphe, CLUMECK, Nathan, LECLERCQ, Vincent, CECCHERINI-SILBERSTEIN, Francesca, DECOSTER, Laurent, LAMAURY, Isabelle, BANI-SADR, Firouzé, FORCE, Gilles, CHABROL, Amélie, CABY, Fabienne, PATEY, Olivier, FRESARD, Anne, GAGNEUX-BRUNON, Amandine, CHIROUZE, Catherine, DUVIVIER, Claudine, LOURENCO, Jérémie, TOLSMA, Violaine, JANSSEN, Cécile, LEROLLE, Nathalie, CATALAN, Pilartxo, RAMI, Agathe, DE PONTHAUD, Lucile, PICHANCOURT, Gilles, NASRI, Safa, LANDOWSKI, Stéphanie, BOTTERO, Julie, MFUTILA KAYKAY, Flory, PIALOUX, Gilles, BOUCHAUD, Olivier, ABGRALL, Sophie, GATEY, Caroline, WEISS, Laurence, PAVIE, Juliette, SALMON-CERON, Dominique, ZUCMAN, David, LELIEVRE, Jean-Daniel, PALICH, Romain, SIMON, Anne, MEYOHAS, Marie-Caroline, GRAS, Julien, CABIE, André, PIRCHER, Mathilde, MORLAT, Philippe, HESSAMFAR, Mojgam, NEAU, Didier, CAZENAVE, Charles, GENET, Claire, FAUCHER, Jean-François, MAKHLOUFI, Djamila, BOIBIEUX, André, BREGIGEON-RONOT, Sylvie, LAROCHE, Hélène, SAUTEREAU, Aurélie, REYNES, Jacques, MAKINSON, Alain, RAFFI, François, BOLLENGIER-STRAGIER, Olivier, NAQVI, Alissa, CUA, Eric, ROSENTHAL, Eric, ARVIEUX, Cédrick, BUZELE, Rodolphe, REY, David, BATARD, Marie-Laure, BERNARD, Louis, DELOBEL, Pierre, PIFFAUT, Marie, VERDON, Renaud, PIROTH, Lionel, BLOT, Mathieu, LECLERCQ, Pascale, SIGNORI-SCHMUCK, Anne, HULEUX, Thomas, MEYBECK, Agnès, MAY, Thierry, MIAILHES, Patrick, PERPOINT, Thomas, GREDER-BELAN, Alix, ELHARRAR, Brigitte, KHUONG, Marie-Aude, POUPARD, Marie, BLUM, Laurent, MICHAU, Christophe, PRAZUCK, Thierry, PHILIBERT, Patrick, SLAMA, Laurence, HIKOMBO, Hitoto, DARASTEANU, Iuliana, GIRARD, Pierre-Marie, ALVAREZ, Jean-Claude, MATHEZ, Dominique, DE TRUCHIS, Pierre, LANDMAN, Roland, MEYNARD, Jean-Luc, MORAND-JOUBERT, Laurence, LAMBERT, Sidonie, LE DU, Damien, PERRONNE, Christian, ASSOUMOU, Lambert, COSTAGLIOLA, Dominique, MELCHIOR, Jean-Claude, DURACINSKI, Martin, PETROV-SANCHEZ, Ventzislava, AMAT, Karine, BENALYCHERIF, Aïda, SYLLA, Babacar, GELLEY, Ambre, GIBOWSKI, Séverine, LE MEUT, Guillaume, THIEBAUT, Rodolphe, CLUMECK, Nathan, LECLERCQ, Vincent, CECCHERINI-SILBERSTEIN, Francesca, and DECOSTER, Laurent
- Abstract
Intermittent (on 4 days per week) antiretroviral therapy (ART) for patients with HIV-1 might be more convenient, better tolerated, and cheaper than continuous treatment. We aimed to establish the efficacy and safety of a 4-days-on and 3-days-off (intermittent) maintenance regimen versus a standard 7 day (continuous) maintenance regimen.
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- 2022
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37. An Analysis of the Worldwide Utilization of Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia
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Tokaz, Molly, Baldomero, Helen, Cowan, Andrew J, Saber, Wael, Greinix, Hildegard T., Koh, Mickey, Kröger, Nicolaus, Mohty, Mohamad, Galeano, Sebastian, Okamoto, Shinichiro, Chaudhri, Naeem A., Karduss, Amado J, Ciceri, Fabio, Colturato, Vergilio Rensi, Corbacioglu, Selim, Elhaddad, Alaa M., Force, Lisa, Frutos Ortiz, Cristobal Augusto, Gomez-De Leon, Andres, Hamad, Nada, Hamerschlak, Nelson, He, Naya, Ho, Aloysius YL, Huang, Xiao-Jun, Jacobs, Benjamin, Kim, Heeje, Iida, Minako, Lehmann, Leslie E., Peffault de Latour, Régis, Percival, Mary-Elizabeth M., Rasheed, Walid, Schultz, Kirk R., Seber, Adriana, Ko, Bor-Sheng, Simione, Anderson, Srivastava, Alok, Szer, Jeff, Wood, William A., Kodera, Yoshihisa, Nagler, Arnon, Snowden, John A, Weisdorf, Daniel J., Passweg, Jakob R., Pasquini, Marcelo C, Sureda, Anna, Atsuta, Yoshiko, Aljurf, Mahmoud, Niederwieser, Dietger, and Perdomo, Martina
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- 2022
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38. An Analysis of the Worldwide Utilization of Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia
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Tokaz, Molly, Baldomero, Helen, Cowan, Andrew J, Saber, Wael, Greinix, Hildegard T., Koh, Mickey, Kröger, Nicolaus, Mohty, Mohamad, Galeano, Sebastian, Okamoto, Shinichiro, Chaudhri, Naeem A., Karduss, Amado J, Ciceri, Fabio, Colturato, Vergilio Rensi, Corbacioglu, Selim, Elhaddad, Alaa M., Force, Lisa, Frutos Ortiz, Cristobal Augusto, Gomez-De Leon, Andres, Hamad, Nada, Hamerschlak, Nelson, He, Naya, Ho, Aloysius YL, Huang, Xiao-Jun, Jacobs, Benjamin, Kim, Heeje, Iida, Minako, Lehmann, Leslie E., Peffault de Latour, Régis, Percival, Mary-Elizabeth M., Rasheed, Walid, Schultz, Kirk R., Seber, Adriana, Ko, Bor-Sheng, Simione, Anderson, Srivastava, Alok, Szer, Jeff, Wood, William A., Kodera, Yoshihisa, Nagler, Arnon, Snowden, John A, Weisdorf, Daniel J., Passweg, Jakob R., Pasquini, Marcelo C, Sureda, Anna, Atsuta, Yoshiko, Aljurf, Mahmoud, Niederwieser, Dietger, and Perdomo, Martina
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- 2022
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39. SOUNDING Off.
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LA FORCE, THESSALY
- Abstract
As the critic Sophie Gilbert wrote in The Atlantic, "Ratajkowski so clearly wants to have it all: ultimate control over the sale of her image; power; money, yes; but also kudos for being more than an object, for being able to lucidly communicate how much she's suffered because of a toxic system - and is still suffering because of her ongoing participation. It is a rainy afternoon in New York's West Village when I see that Emily Ratajkowski is already waiting for me at a small outdoor cafe table at Buvette, the popular French-inspired bistro. Lena Dunham, who is a friend of Ratajkowski's, has this to say of her literary talents: "Emily observes from a distance yet somehow is at the center of the stories, making her personal experience feel somehow universal. Singer Robin Thicke cast Ratajkowski in the video for his 2013 Pharrell-produced track after seeing a nude photograph of her on the cover of a niche erotic magazine called Treats!. [Extracted from the article]
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- 2022
40. A Novel Staging System for De Novo Metastatic Breast Cancer Refines Prognostic Estimates.
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Plichta, Jennifer K. MS, Thomas, Samantha M. MS, Sergesketter, Amanda R., Greenup, Rachel A., Rosenberger, Laura H. MS, Fayanju, Oluwadamilola M. S, Kimmick, Gretchen MS, Force, Jeremy DO, Hyslop, Terry, and Hwang, E. Shelley
- Abstract
Objective: We aim to identify prognostic groups within a de novo metastatic cohort, incorporating both anatomic and biologic factors. Background: Staging for breast cancer now includes anatomic and biologic factors, although the guidelines for stage IV disease do not account for how these factors may influence outcomes. Methods: Adults with de novo metastatic breast cancer were selected from the National Cancer DataBase (2010-2013). Recursive partitioning analysis was used to group patients with similar overall survival (OS) based on clinical T/N stage, tumor grade, ER, PR, HER2, number of metastatic sites, and presence of bone-only metastases. Categories were created by amalgamating homogeneous groups based on 3-year OS rates (stage IVA: >50%, stage IVB: 30%-50%, stage IVC: <30%). Results: 16,187 patients were identified; median follow-up was 32 months. 65.2% had 1 site of distant metastasis, and 42.9% had bone-only metastases. Recursive partitioning analysis identified the number of metastatic sites (1 vs >1) as the first stratification point, and ER status as the second stratification point for both resulting groups. Additional divisions were made based on HER2 status, PR status, cT stage, tumor grade, and presence of bone-only metastases. After bootstrapping, significant differences in 3-year OS were noted between the 3 groups [stage IVB vs IVA: HR 1.58 (95% confidence interval 1.50-1.67), stage IVC vs IVA: HR 3.54 (95% confidence interval 3.33-3.77)]. Conclusions: Both anatomic and biologic factors yielded reliable and reproducible prognostic estimates among patients with metastatic disease. These findings support formal stratification of de novo stage IV breast cancer into 3 distinct prognosis groups. [ABSTRACT FROM AUTHOR]
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- 2022
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41. Eumelanin-Inspired Antimicrobial with Biocidal Activity against Methicillin-Resistant Staphylococcus aureus.
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Adhikari, Santosh, Essandoh, Martha A., Starr, William C., Sah, Prakash, Force, Colleen N. La, Eleshy, Rawan G., Lutter, Erika I., and Nelson, Toby L.
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- 2022
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42. The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019
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Tran, Khanh Bao, Lang, Justin J, Compton, Kelly, Xu, Rixing, Acheson, Alistair R, Henrikson, Hannah Jacqueline, Kocarnik, Jonathan M, Penberthy, Louise, Aali, Amirali, Abbas, Qamar, Abbasi, Behzad, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abbastabar, Hedayat, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdelwahab, Ahmed Abdelwahab, Abdoli, Gholamreza, Abdulkadir, Hanan Abdulkadir, Abedi, Aidin, Abegaz, Kedir Hussein, Abidi, Hassan, Aboagye, Richard Gyan, Abolhassani, Hassan, Absalan, Abdorrahim, Abtew, Yonas Derso, Abubaker Ali, Hiwa, Abu-Gharbieh, Eman, Achappa, Basavaprabhu, Acuna, Juan Manuel, Addison, Daniel, Addo, Isaac Yeboah, Adegboye, Oyelola A, Adesina, Miracle Ayomikun, Adnan, Mohammad, Adnani, Qorinah Estiningtyas Sakilah, Advani, Shailesh M, Afrin, Sumia, Afzal, Muhammad Sohail, Aggarwal, Manik, Ahinkorah, Bright Opoku, Ahmad, Araz Ramazan, Ahmad, Rizwan, Ahmad, Sajjad, Ahmad, Sohail, Ahmadi, Sepideh, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Muktar Beshir, Ahmed Rashid, Tarik, Aiman, Wajeeha, Ajami, Marjan, Akalu, Gizachew Taddesse, Akbarzadeh-Khiavi, Mostafa, Aklilu, Addis, Akonde, Maxwell, Akunna, Chisom Joyqueenet, Al Hamad, Hanadi, Alahdab, Fares, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alessy, Saleh Ali, Algammal, Abdelazeem M, Al-Hanawi, Mohammed Khaled, Alhassan, Robert Kaba, Ali, Beriwan Abdulqadir, Ali, Liaqat, Ali, Syed Shujait, Alimohamadi, Yousef, Alipour, Vahid, Aljunid, Syed Mohamed, Alkhayyat, Motasem, Al-Maweri, Sadeq Ali Ali, Almustanyir, Sami, Alonso, Nivaldo, Alqalyoobi, Shehabaldin, Al-Raddadi, Rajaa M, Al-Rifai, Rami H Hani, Al-Sabah, Salman Khalifah, Al-Tammemi, Ala'a B, Altawalah, Haya, Alvis-Guzman, Nelson, Amare, Firehiwot, Ameyaw, Edward Kwabena, Aminian Dehkordi, Javad Javad, Amirzade-Iranaq, Mohammad Hosein, Amu, Hubert, Amusa, Ganiyu Adeniyi, Ancuceanu, Robert, Anderson, Jason A, Animut, Yaregal Animut, Anoushiravani, Amir, Anoushirvani, Ali Arash, Ansari-Moghaddam, Alireza, Ansha, Mustafa Geleto, Antony, Benny, Antwi, Maxwell Hubert, Anwar, Sumadi Lukman, Anwer, Razique, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Arab-Zozani, Morteza, Aremu, Olatunde, Argaw, Ayele Mamo, Ariffin, Hany, Aripov, Timur, Arshad, Muhammad, Artaman, Al, Arulappan, Judie, Aruleba, Raphael Taiwo, Aryannejad, Armin, Asaad, Malke, Asemahagn, Mulusew A, Asemi, Zatollah, Asghari-Jafarabadi, Mohammad, Ashraf, Tahira, Assadi, Reza, Athar, Mohammad, Athari, Seyyed Shamsadin, Atout, Maha Moh'd Wahbi, Attia, Sameh, Aujayeb, Avinash, Ausloos, Marcel, Avila-Burgos, Leticia, Awedew, Atalel Fentahun, Awoke, Mamaru Ayenew, Awoke, Tewachew, Ayala Quintanilla, Beatriz Paulina, Ayana, Tegegn Mulatu, Ayen, Solomon Shitu, Azadi, Davood, Azadnajafabad, Sina, Azami-Aghdash, Saber, Azanaw, Melkalem Mamuye, Azangou-Khyavy, Mohammadreza, Azari Jafari, Amirhossein, Azizi, Hosein, Azzam, Ahmed Y Y, Babajani, Amirhesam, Badar, Muhammad, Badiye, Ashish D, Baghcheghi, Nayereh, Bagheri, Nader, Bagherieh, Sara, Bahadory, Saeed, Baig, Atif Amin, Baker, Jennifer L, Bakhtiari, Ahad, Bakshi, Ravleen Kaur, Banach, Maciej, Banerjee, Indrajit, Bardhan, Mainak, Barone-Adesi, Francesco, Barra, Fabio, Barrow, Amadou, Bashir, Nasir Z, Bashiri, Azadeh, Basu, Saurav, Batiha, Abdul-Monim Mohammad, Begum, Aeysha, Bekele, Alehegn Bekele, Belay, Alemayehu Sayih, Belete, Melaku Ashagrie, Belgaumi, Uzma Iqbal, Bell, Arielle Wilder, Belo, Luis, Benzian, Habib, Berhie, Alemshet Yirga, Bermudez, Amiel Nazer C, Bernabe, Eduardo, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhandari, Bharti Bhandari, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhattacharyya, Krittika, Bhojaraja, Vijayalakshmi S, Bhuyan, Soumitra S, Bibi, Sadia, Bilchut, Awraris Hailu, Bintoro, Bagas Suryo, Biondi, Antonio, Birega, Mesfin Geremaw Birega, Birhan, Habitu Eshetu, Bjørge, Tone, Blyuss, Oleg, Bodicha, Belay Boda Abule, Bolla, Srinivasa Rao, Boloor, Archith, Bosetti, Cristina, Braithwaite, Dejana, Brauer, Michael, Brenner, Hermann, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Buchanan, Christina Maree, Bulamu, Norma B, Bustamante-Teixeira, Maria Teresa, Butt, Muhammad Hammad, Butt, Nadeem Shafique, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cámera, Luis Alberto, Cao, Chao, Cao, Yin, Carreras, Giulia, Carvalho, Márcia, Cembranel, Francieli, Cerin, Ester, Chakraborty, Promit Ananyo, Charalampous, Periklis, Chattu, Vijay Kumar, Chimed-Ochir, Odgerel, Chirinos-Caceres, Jesus Lorenzo, Cho, Daniel Youngwhan, Cho, William C S, Christopher, Devasahayam J, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Cohen, Aaron J, Conde, Joao, Cortés, Sandra, Costa, Vera Marisa, Cruz-Martins, Natália, Culbreth, Garland T, Dadras, Omid, Dagnaw, Fentaw Teshome, Dahlawi, Saad M A, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Daneshpajouhnejad, Parnaz, Danielewicz, Anna, Dao, An Thi Minh, Darvishi Cheshmeh Soltani, Reza, Darwesh, Aso Mohammad, Das, Saswati, Davitoiu, Dragos Virgil, Davtalab Esmaeili, Elham, De la Hoz, Fernando Pio, Debela, Sisay Abebe, Dehghan, Azizallah, Demisse, Biniyam, Demisse, Fitsum Wolde, Denova-Gutiérrez, Edgar, Derakhshani, Afshin, Derbew Molla, Meseret, Dereje, Diriba, Deribe, Kalkidan Solomon, Desai, Rupak, Desalegn, Markos Desalegn, Dessalegn, Fikadu Nugusu, Dessalegni, Samuel Abebe A, Dessie, Gashaw, Desta, Abebaw Alemayehu, Dewan, Syed Masudur Rahman, Dharmaratne, Samath Dhamminda, Dhimal, Meghnath, Dianatinasab, Mostafa, Diao, Nancy, Diaz, Daniel, Digesa, Lankamo Ena, Dixit, Shilpi Gupta, Doaei, Saeid, Doan, Linh Phuong, Doku, Paul Narh, Dongarwar, Deepa, dos Santos, Wendel Mombaque, Driscoll, Tim Robert, Dsouza, Haneil Larson, Durojaiye, Oyewole Christopher, Edalati, Sareh, Eghbalian, Fatemeh, Ehsani-Chimeh, Elham, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, Ekwueme, Donatus U, El Tantawi, Maha, Elbahnasawy, Mostafa Ahmed, Elbarazi, Iffat, Elghazaly, Hesham, Elhadi, Muhammed, El-Huneidi, Waseem, Emamian, Mohammad Hassan, Engelbert Bain, Luchuo, Enyew, Daniel Berhanie, Erkhembayar, Ryenchindorj, Eshetu, Tegegne, Eshrati, Babak, Eskandarieh, Sharareh, Espinosa-Montero, Juan, Etaee, Farshid, Etemadimanesh, Azin, Eyayu, Tahir, Ezeonwumelu, Ifeanyi Jude, Ezzikouri, Sayeh, Fagbamigbe, Adeniyi Francis, Fahimi, Saman, Fakhradiyev, Ildar Ravisovich, Faraon, Emerito Jose A, Fares, Jawad, Farmany, Abbas, Farooque, Umar, Farrokhpour, Hossein, Fasanmi, Abidemi Omolara, Fatehizadeh, Ali, Fatima, Wafa, Fattahi, Hamed, Fekadu, Ginenus, Feleke, Berhanu Elfu, Ferrari, Allegra Allegra, Ferrero, Simone, Ferro Desideri, Lorenzo, Filip, Irina, Fischer, Florian, Foroumadi, Roham, Foroutan, Masoud, Fukumoto, Takeshi, Gaal, Peter Andras, Gad, Mohamed M, Gadanya, Muktar A, Gaipov, Abduzhappar, Galehdar, Nasrin, Gallus, Silvano, Garg, Tushar, Gaspar Fonseca, Mariana, Gebremariam, Yosef Haile, Gebremeskel, Teferi Gebru, Gebremichael, Mathewos Alemu, Geda, Yohannes Fikadu, Gela, Yibeltal Yismaw, Gemeda, Belete Negese Belete, Getachew, Melaku, Getachew, Motuma Erena, Ghaffari, Kazem, Ghafourifard, Mansour, Ghamari, Seyyed-Hadi, Ghasemi Nour, Mohammad, Ghassemi, Fariba, Ghimire, Ajnish, Ghith, Nermin, Gholamalizadeh, Maryam, Gholizadeh Navashenaq, Jamshid, Ghozy, Sherief, Gilani, Syed Amir, Gill, Paramjit Singh, Ginindza, Themba G, Gizaw, Abraham Tamirat T, Glasbey, James C, Godos, Justyna, Goel, Amit, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Golitaleb, Mohamad, Gorini, Giuseppe, Goulart, Bárbara Niegia Garcia, Grosso, Giuseppe, Guadie, Habtamu Alganeh, Gubari, Mohammed Ibrahim Mohialdeen, Gudayu, Temesgen Worku, Guerra, Maximiliano Ribeiro, Gunawardane, Damitha Asanga, Gupta, Bhawna, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Gurara, Mekdes Kondale, Guta, Alemu, Habibzadeh, Parham, Haddadi Avval, Atlas, Hafezi-Nejad, Nima, Hajj Ali, Adel, Haj-Mirzaian, Arvin, Halboub, Esam S, Halimi, Aram, Halwani, Rabih, Hamadeh, Randah R, Hameed, Sajid, Hamidi, Samer, Hanif, Asif, Hariri, Sanam, Harlianto, Netanja I, Haro, Josep Maria, Hartono, Risky Kusuma, Hasaballah, Ahmed I, Hasan, S M Mahmudul, Hasani, Hamidreza, Hashemi, Seyedeh Melika, Hassan, Abbas M, Hassanipour, Soheil, Hayat, Khezar, Heidari, Golnaz, Heidari, Mohammad, Heidarymeybodi, Zahra, Herrera-Serna, Brenda Yuliana, Herteliu, Claudiu, Hezam, Kamal, Hiraike, Yuta, Hlongwa, Mbuzeleni Mbuzeleni, Holla, Ramesh, Holm, Marianne, Horita, Nobuyuki, Hoseini, Mohammad, Hossain, Md Mahbub, Hossain, Mohammad Bellal Hossain, Hosseini, Mohammad-Salar, Hosseinzadeh, Ali, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Huang, Junjie, Hugo, Fernando N, Humayun, Ayesha, Hussain, Salman, Hussein, Nawfal R, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Iftikhar, Pulwasha Maria, Ikuta, Kevin S, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Immurana, Mustapha, Innos, Kaire, Iranpour, Pooya, Irham, Lalu Muhammad, Islam, Md Shariful, Islam, Rakibul M, Islami, Farhad, Ismail, Nahlah Elkudssiah, Isola, Gaetano, Iwagami, Masao, J, Linda Merin, Jaiswal, Abhishek, Jakovljevic, Mihajlo, Jalili, Mahsa, Jalilian, Shahram, Jamshidi, Elham, Jang, Sung-In, Jani, Chinmay T, Javaheri, Tahereh, Jayarajah, Umesh Umesh, Jayaram, Shubha, Jazayeri, Seyed Behzad, Jebai, Rime, Jemal, Bedru, Jeong, Wonjeong, Jha, Ravi Prakash, Jindal, Har Ashish, John-Akinola, Yetunde O, Jonas, Jost B, Joo, Tamas, Joseph, Nitin, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Ali, Kacimi, Salah Eddine Oussama, Kadashetti, Vidya, Kahe, Farima, Kakodkar, Pradnya Vishal, Kalankesh, Laleh R, Kalankesh, Leila R, Kalhor, Rohollah, Kamal, Vineet Kumar, Kamangar, Farin, Kamath, Ashwin, Kanchan, Tanuj, Kandaswamy, Eswar, Kandel, Himal, Kang, HyeJung, Kanno, Girum Gebremeskel, Kapoor, Neeti, Kar, Sitanshu Sekhar, Karanth, Shama D, Karaye, Ibraheem M, Karch, André, Karimi, Amirali, Kassa, Bekalu Getnet, Katoto, Patrick DMC, Kauppila, Joonas H, Kaur, Harkiran, Kebede, Abinet Gebremickael, Keikavoosi-Arani, Leila, Kejela, Gemechu Gemechu, Kemp Bohan, Phillip M, Keramati, Maryam, Keykhaei, Mohammad, Khajuria, Himanshu, Khan, Abbas, Khan, Abdul Aziz Khan, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khan, Md Nuruzzaman, Khan, Moien AB, Khanali, Javad, Khatab, Khaled, Khatatbeh, Moawiah Mohammad, Khatib, Mahalaqua Nazli, Khayamzadeh, Maryam, Khayat Kashani, Hamid Reza, Khazeei Tabari, Mohammad Amin, Khezeli, Mehdi, Khodadost, Mahmoud, Kim, Min Seo, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Klugar, Miloslav, Klugarová, Jitka, Kolahi, Ali-Asghar, Kolkhir, Pavel, Kompani, Farzad, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Yuvaraj, Kucuk Bicer, Burcu, Kugbey, Nuworza, Kulimbet, Mukhtar, Kumar, Akshay, Kumar, G Anil, Kumar, Narinder, Kurmi, Om P, Kuttikkattu, Ambily, La Vecchia, Carlo, Lahiri, Arista, Lal, Dharmesh Kumar, Lám, Judit, Lan, Qing, Landires, Iván, Larijani, Bagher, Lasrado, Savita, Lau, Jerrald, Lauriola, Paolo, Ledda, Caterina, Lee, Sang-woong, Lee, Shaun Wen Huey, Lee, Wei-Chen, Lee, Yeong Yeh, Lee, Yo Han, Legesse, Samson Mideksa, Leigh, James, Leong, Elvynna, Li, Ming-Chieh, Lim, Stephen S, Liu, Gang, Liu, Jue, Lo, Chun-Han, Lohiya, Ayush, Lopukhov, Platon D, Lorenzovici, László, Lotfi, Mojgan, Loureiro, Joana A, Lunevicius, Raimundas, Madadizadeh, Farzan, Mafi, Ahmad R, Magdeldin, Sameh, Mahjoub, Soleiman, Mahmoodpoor, Ata, Mahmoudi, Morteza, Mahmoudimanesh, Marzieh, Mahumud, Rashidul Alam, Majeed, Azeem, Majidpoor, Jamal, Makki, Alaa, Makris, Konstantinos Christos, Malakan Rad, Elaheh, Malekpour, Mohammad-Reza, Malekzadeh, Reza, Malik, Ahmad Azam, Mallhi, Tauqeer Hussain, Mallya, Sneha Deepak, Mamun, Mohammed A, Manda, Ana Laura, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Martini, Santi, Martorell, Miquel, Masoudi, Sahar, Masoumi, Seyedeh Zahra, Matei, Clara N, Mathews, Elezebeth, Mathur, Manu Raj, Mathur, Vasundhara, McKee, Martin, Meena, Jitendra Kumar, Mehmood, Khalid, Mehrabi Nasab, Entezar, Mehrotra, Ravi, Melese, Addisu, Mendoza, Walter, Menezes, Ritesh G, Mengesha, SIsay Derso, Mensah, Laverne G, Mentis, Alexios-Fotios A, Mera-Mamián, Andry Yasmid Mera, Meretoja, Tuomo J, Merid, Mehari Woldemariam, Mersha, Amanual Getnet, Meselu, Belsity Temesgen, Meshkat, Mahboobeh, Mestrovic, Tomislav, Miao Jonasson, Junmei, Miazgowski, Tomasz, Michalek, Irmina Maria, Mijena, Gelana Fekadu Worku, Miller, Ted R, Mir, Shabir Ahmad, Mirinezhad, Seyed Kazem, Mirmoeeni, Seyyedmohammadsadeq, Mirza-Aghazadeh-Attari, Mohammad, Mirzaei, Hamed, Mirzaei, Hamid Reza, Misganaw, Abay Sisay, Misra, Sanjeev, Mohammad, Karzan Abdulmuhsin, Mohammadi, Esmaeil, Mohammadi, Mokhtar, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mohammed, Arif, Mohammed, Shafiu, Mohan, Syam, Mohseni, Mohammad, Moka, Nagabhishek, Mokdad, Ali H, Molassiotis, Alex, Molokhia, Mariam, Momenzadeh, Kaveh, Momtazmanesh, Sara, Monasta, Lorenzo, Mons, Ute, Montasir, Ahmed Al, Montazeri, Fateme, Montero, Arnulfo, Moosavi, Mohammad Amin, 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Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Odukoya, Oluwakemi Ololade, Oghenetega, Onome Bright, Ogunsakin, Ropo Ebenezer, Oguntade, Ayodipupo Sikiru, Oh, In-Hwan, Okati-Aliabad, Hassan, Okekunle, Akinkunmi Paul, Olagunju, Andrew T, Olagunju, Tinuke O, Olakunde, Babayemi Oluwaseun, Olufadewa, Isaac Iyinoluwa, Omer, Emad, Omonisi, Abidemi E Emmanuel, Ong, Sokking, Onwujekwe, Obinna E, Orru, Hans, Otstavnov, Stanislav S, Oulhaj, Abderrahim, Oumer, Bilcha, Owopetu, Oluwatomi Funbi, Oyinloye, Babatunji Emmanuel, P A, Mahesh, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pakbin, Babak, Pakshir, Keyvan, Pakzad, Reza, Palicz, Tamás, Pana, Adrian, Pandey, Anamika, Pandey, Ashok, Pant, Suman, Pardhan, Shahina, Park, Eun-Cheol, Park, Eun-Kee, Park, Seoyeon, Patel, Jay, Pati, Siddhartha, Paudel, Rajan, Paudel, Uttam, Paun, Mihaela, Pazoki Toroudi, Hamidreza, Peng, Minjin, Pereira, Jeevan, Pereira, Renato B, Perna, Simone, Perumalsamy, Navaraj, Pestell, Richard G, Pezzani, Raffaele, 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- Abstract
Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally.
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- 2022
- Full Text
- View/download PDF
43. Community Size and Lung Cancer Resection Outcomes: Studying The Society of Thoracic Surgeons Database.
- Author
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Melvan, John Nicholas, Khullar, Onkar, Vemulapalli, Sreekanth, Kosinski, Andrzej S., Pickens, Allan, Force, Seth D., Zhang, Shuaiqi, and Sancheti, Manu S.
- Abstract
Socioeconomic factors play key roles in surgical outcomes. Socioeconomic data within The Society of Thoracic Surgeons (STS) General Thoracic Surgery Database (GTSD) are limited. Therefore, we utilized community size as a surrogate to understand socioeconomic differences in lung cancer resection outcomes. We retrospectively reviewed all lung cancer resections from January 2012 to January 2017 in the STS GTSD. This captured 68,722 patients from 286 centers nationwide. We then linked patient zip codes with 2013 Rural-Urban Continuum Codes to understand the association between community size and postoperative outcomes. Demographic and clinical variables were evaluated for relationships with 30-day mortality, major morbidity, and readmission. Zip codes were included in 47.2% of patients. Zip-coded patients were older, were more comorbid, had less advanced disease, and were more commonly treated with minimally invasive approaches than were those without zip code classification. For geocoded patients, multivariable analyses demonstrated that sex, insurance payor, and hospital region were associated with all 3 major endpoints. Community size, based on Rural-Urban Continuum Codes coding, was not associated with any primary endpoint. Invasive mediastinal staging was related to morbidity, greater pathological stage predicted mortality, and worsened clinical stage was associated with readmission. More invasive surgery and greater extent of lung resection were associated with all primary endpoints. Incomplete data capture can promote selection bias within the STS GTSD and skew outcomes reporting. Moreover, community size is an insufficient surrogate, compared with sex, insurance payor, hospital region, for understanding socioeconomic differences in lung cancer resection outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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44. A Novel Staging System for De Novo Metastatic Breast Cancer Refines Prognostic Estimates
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Plichta, Jennifer K., Thomas, Samantha M., Sergesketter, Amanda R., Greenup, Rachel A., Rosenberger, Laura H., Fayanju, Oluwadamilola M., Kimmick, Gretchen, Force, Jeremy, Hyslop, Terry, and Hwang, E. Shelley
- Published
- 2022
- Full Text
- View/download PDF
45. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019
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Kocarnik, Jonathan M., Compton, Kelly, Dean, Frances E., Fu, Weijia, Gaw, Brian L., Harvey, James D., Henrikson, Hannah Jacqueline, Lu, Dan, Pennini, Alyssa, Xu, Rixing, Ababneh, Emad, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd-Elsalam, Sherief M., Abdoli, Amir, Abedi, Aidin, Abidi, Hassan, Abolhassani, Hassan, Adedeji, Isaac Akinkunmi, Adnani, Qorinah Estiningtyas Sakilah, Advani, Shailesh M., Afzal, Muhammad Sohail, Aghaali, Mohammad, Ahinkorah, Bright Opoku, Ahmad, Sajjad, Ahmad, Tauseef, Ahmadi, Ali, Ahmadi, Sepideh, Ahmed Rashid, Tarik, Ahmed Salih, Yusra, Akalu, Gizachew Taddesse, Aklilu, Addis, Akram, Tayyaba, Akunna, Chisom Joyqueenet, Al Hamad, Hanadi, Alahdab, Fares, Al-Aly, Ziyad, Ali, Saqib, Alimohamadi, Yousef, Alipour, Vahid, Aljunid, Syed Mohamed, Alkhayyat, Motasem, Almasi-Hashiani, Amir, Almasri, Nihad A., Al-Maweri, Sadeq Ali Ali, Almustanyir, Sami, Alonso, Nivaldo, Alvis-Guzman, Nelson, Amu, Hubert, Anbesu, Etsay Woldu, Ancuceanu, Robert, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Antwi, Maxwell Hubert, Anvari, Davood, Anyasodor, Anayochukwu Edward, Aqeel, Muhammad, Arabloo, Jalal, Arab-Zozani, Morteza, Aremu, Olatunde, Ariffin, Hany, Aripov, Timur, Arshad, Muhammad, Artaman, Al, Arulappan, Judie, Asemi, Zatollah, Asghari Jafarabadi, Mohammad, Ashraf, Tahira, Atorkey, Prince, Aujayeb, Avinash, Ausloos, Marcel, Awedew, Atalel Fentahun, Ayala Quintanilla, Beatriz Paulina, Ayenew, Temesgen, Azab, Mohammed A., Azadnajafabad, Sina, Azari Jafari, Amirhossein, Azarian, Ghasem, Azzam, Ahmed Y., Badiye, Ashish D., Bahadory, Saeed, Baig, Atif Amin, Baker, Jennifer L., Balakrishnan, Senthilkumar, Banach, Maciej, Bärnighausen, Till Winfried, Barone-Adesi, Francesco, Barra, Fabio, Barrow, Amadou, Behzadifar, Masoud, Belgaumi, Uzma Iqbal, Bezabhe, Woldesellassie M. 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B., Khang, Young-Ho, Khater, Amir M., Khayamzadeh, Maryam, Kim, Gyu Ri, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Kissimova-Skarbek, Katarzyna, Kopec, Jacek A., Koteeswaran, Rajasekaran, Koul, Parvaiz A., Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Kucuk Bicer, Burcu, Kugbey, Nuworza, Kumar, G. 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Emmanuel, Ong, Sokking, Onwujekwe, Obinna E., Orru, Hans, Ortega-Altamirano, Doris V., Otstavnov, Nikita, Otstavnov, Stanislav S., Owolabi, Mayowa O., P A, Mahesh, Padubidri, Jagadish Rao, Pakshir, Keyvan, Pana, Adrian, Panagiotakos, Demosthenes, Panda-Jonas, Songhomitra, Pardhan, Shahina, Park, Eun-Cheol, Park, Eun-Kee, Pashazadeh Kan, Fatemeh, Patel, Harsh K., Patel, Jenil R., Pati, Siddhartha, Pattanshetty, Sanjay M., Paudel, Uttam, Pereira, David M., Pereira, Renato B., Perianayagam, Arokiasamy, Pillay, Julian David, Pirouzpanah, Saeed, Pishgar, Farhad, Podder, Indrashis, Postma, Maarten J., Pourjafar, Hadi, Prashant, Akila, Preotescu, Liliana, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Radhakrishnan, Raghu Anekal, Radhakrishnan, Venkatraman, Rafiee, Ata, Rahim, Fakher, Rahimzadeh, Shadi, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rajai, Nazanin, Rajesh, Aashish, Rakovac, Ivo, Ram, Pradhum, Ramezanzadeh, Kiana, Ranabhat, Kamal, Ranasinghe, Priyanga, Rao, Chythra R., Rao, Sowmya J., Rawassizadeh, Reza, Razeghinia, Mohammad Sadegh, Renzaho, Andre M. N., Rezaei, Negar, Rezaei, Nima, Rezapour, Aziz, Roberts, Thomas J., Rodriguez, Jefferson Antonio Buendia, Rohloff, Peter, Romoli, Michele, Ronfani, Luca, Roshandel, Gholamreza, Rwegerera, Godfrey M., S, Manjula, Sabour, Siamak, Saddik, Basema, Saeed, Umar, Sahebkar, Amirhossein, Sahoo, Harihar, Salehi, Sana, Salem, Marwa Rashad, Salimzadeh, Hamideh, Samaei, Mehrnoosh, Samy, Abdallah M., Sanabria, Juan, Sankararaman, Senthilkumar, Santric-Milicevic, Milena M., Sardiwalla, Yaeesh, Sarveazad, Arash, Sathian, Brijesh, Sawhney, Monika, Saylan, Mete, Schneider, Ione Jayce Ceola, Sekerija, Mario, Seylani, Allen, Shafaat, Omid, Shaghaghi, Zahra, Shaikh, Masood Ali, Shamsoddin, Erfan, Shannawaz, Mohammed, Sharma, Rajesh, Sheikh, Aziz, Sheikhbahaei, Sara, Shetty, Adithi, Shetty, Jeevan K., Shetty, Pavanchand H., Shibuya, Kenji, Shirkoohi, Reza, Shivakumar, K. M., Shivarov, Velizar, Siabani, Soraya, Siddappa Malleshappa, Sudeep K., Silva, Diego Augusto Santos, Singh, Jasvinder A., Sintayehu, Yitagesu, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Soeberg, Matthew J., Sofi-Mahmudi, Ahmad, Sotoudeh, Houman, Steiropoulos, Paschalis, Straif, Kurt, Subedi, Ranjeeta, Sufiyan, Mu'awiyyah Babale, Sultan, Iyad, Sultana, Saima, Sur, Daniel, Szerencsés, Viktória, Szócska, Miklós, Tabarés-Seisdedos, Rafael, Tabuchi, Takahiro, Tadbiri, Hooman, Taherkhani, Amir, Takahashi, Ken, Talaat, Iman M., Tan, Ker-Kan, Tat, Vivian Y., Tedla, Bemnet Amare A., Tefera, Yonas Getaye, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Tesfay, Fisaha Haile, Tessema, Gizachew Assefa, Thapar, Rekha, Thavamani, Aravind, Thoguluva Chandrasekar, Viveksandeep, Thomas, Nihal, Tohidinik, Hamid Reza, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Traini, Eugenio, Tran, Bach Xuan, Tran, Khanh Bao, Tran, Mai Thi Ngoc, Tripathy, Jaya Prasad, Tusa, Biruk Shalmeno, Ullah, Irfan, Ullah, Saif, Umapathi, Krishna Kishore, Unnikrishnan, Bhaskaran, Upadhyay, Era, Vacante, Marco, Vaezi, Maryam, Valadan Tahbaz, Sahel, Velazquez, Diana Zuleika, Veroux, Massimiliano, Violante, Francesco S., Vlassov, Vasily, Vo, Bay, Volovici, Victor, Vu, Giang Thu, Waheed, Yasir, Wamai, Richard G., Ward, Paul, Wen, Yi Feng, Westerman, Ronny, Winkler, Andrea Sylvia, Yadav, Lalit, Yahyazadeh Jabbari, Seyed Hossein, Yang, Lin, Yaya, Sanni, Yazie, Taklo Simeneh Yazie, Yeshaw, Yigizie, Yonemoto, Naohiro, Younis, Mustafa Z., Yousefi, Zabihollah, Yu, Chuanhua, Yuce, Deniz, Yunusa, Ismaeel, Zadnik, Vesna, Zare, Fariba, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zhang, Jianrong, Zhong, Chenwen, Zhou, Linghui, Zhu, Cong, Ziapour, Arash, Zimmermann, Ivan R., Fitzmaurice, Christina, Murray, Christopher J. L., and Force, Lisa M.
- Abstract
IMPORTANCE: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.
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- 2022
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46. Preoperative Lung Function Is Associated With Patient-Reported Outcomes After Lung Cancer Surgery.
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Khullar, Onkar V., Wei, Jane W., Wagh, Kaustabh, Binongo, Jose N., Pickens, Allan, Sancheti, Manu S., Force, Seth D., Gillespie, Theresa W., and Fernandez, Felix G.
- Abstract
Patient quality of life (QOL) is a critical outcomes measure in lung cancer surgery. Patient-reported outcomes (PROs) provide valuable insight into the patient experience and allow measurement of preoperative and postoperative QOL. Our objective was to determine which clinical factors predict differences in QOL, as measured by patient-reported physical function and pain intensity among patients undergoing minimally invasive lung cancer surgery. PRO surveys assessing physical function and pain intensity were conducted using instruments from the National Institutes of Health Patient-Reported Outcomes Measurement Information System. PRO surveys were administered to patients undergoing minimally invasive lung cancer resections at preoperative, 1-month, and 6-month postoperative time points, in an academic institution. Linear mixed-effects regression models were constructed to assess the association between clinical variables on PRO scores over time. A total of 123 patients underwent a thoracoscopic lung resection for cancer. Mean age of the cohort was 67 ± 9.6 years, 43% were male, and 80% were White. When comparing clinical variables with PRO scores after surgery, lower diffusing capacity of the lungs for carbon monoxide (D lco) was associated with significantly worse physical function (P <.01) and greater pain intensity scores (P <.01) at 6 months, with no differences identified at 1 month. No other studied clinical factor was associated with significant differences in PRO scores. Low preoperative D lco was associated with significant decreases in PRO after minimally invasive lung cancer surgery. D lco may be of utility in identifying patients who experience greater decline in QOL after surgery and for guiding surgical decision making. [ABSTRACT FROM AUTHOR]
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- 2021
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47. Context Is (Almost) Everything: Academic Historians and Digital Archival Collections.
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Force, Donald and Wiles, Bradley
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- 2021
48. Association Between Patient Physical Function and Length of Stay After Thoracoscopic Lung Cancer Surgery.
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Valsangkar, Nakul, Wei, Jane W., Binongo, Jose N., Pickens, Allan, Sancheti, Manu S., Force, Seth D., Gillespie, Theresa W., Fernandez, Felix G., and Khullar, Onkar V.
- Abstract
Patient-reported outcomes (PRO) are an ideal method for measuring patient functional status. We sought to evaluate whether preoperative PRO were associated with resource utilization. We hypothesize that higher preoperative physical function PRO scores, measured via the NIH-sponsored Patient Reported Outcome Measurement Information System (PROMIS), are associated with shorter length of stay (LOS). Preoperative physical function scores were obtained using NIH PROMIS in a prospective observational study of patients undergoing minimally invasive surgery for lung cancer. Poisson regression models were constructed to estimate the association between the length of stay and PROMIS physical function T-score, adjusting for extent of resection, age, gender, and race. Due to the significant interaction between postoperative complications and physical function T-score, the relationship between physical function and LOS was described separately for each complication status. A total of 123 patients were included; 88 lobectomy, 35 sublobar resections. Mean age was 67 years, 35% were male, 65% were Caucasian. Among patients who had a postoperative complication, a lower preoperative physical function T-score was associated with progressively increasing LOS (P value = 0.006). In particular, LOS decreased by 18% for every 10-point increase in physical function T-score. Among patients without complications, T-score was not associated with LOS (P = 0.86). Preoperative physical function measured via PRO identifies patients who are at risk for longer LOS following thoracoscopic lung cancer surgery. In addition to its utility for preoperative counseling and planning, these data may be useful in identifying patients who may benefit from risk-reduction measures. [ABSTRACT FROM AUTHOR]
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- 2021
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49. Comparison of procedural outcomes between morning and afternoon colonoscopies performed by colorectal surgeons
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Modi, Shrey, Picado, Omar, Fiser, Caroline, Lubarsky, Maya, Giri, Bhuwan, Hui, Vanessa, Force, Luanne, Marchetti, Floriano, Sands, Laurence R., and Paluvoi, Nivedh V.
- Abstract
Background and objective: Colonoscopy is a common procedure performed by colorectal surgeons for screening, diagnosis, and surveillance of various colorectal diseases. Existing literature has conflicting data on quality outcomes of colonoscopies performed in the afternoon and the morning schedules and only includes colonoscopies performed by gastroenterologists. We sought to analyze procedural outcomes between morning and afternoon colonoscopies performed by colorectal surgeons. Data sources and main outcome measures: A retrospective chart review of colonoscopies performed by colorectal surgeons at a tertiary care center from October 2018 through July 2020 was performed. Complete colonoscopies with documented times were included. Patients with colonic resection and incomplete colonoscopy were excluded. Main outcome measures adenoma and polyp detection rates and colonoscopy time variables were compared between morning and afternoon colonoscopies. Results: A total of 781 patients were analyzed. Colonoscopies were evenly distributed during shifts (49% morning and 51% afternoon). The overall polyp and adenoma detection rates were 46% and 29%, respectively. There were no significant differences in adenoma and polyp detection rates and colonoscopy duration between morning and afternoon colonoscopies. Multivariate analysis demonstrated that history of prior polypectomy was an independent predictor of adenoma detection rate (OR: 2.17, 95% CI 1.33–3.54, p= 0.002) and was associated with significantly increased colonoscopy times in afternoon shift. Conclusion: There were no differences in quality outcomes of adenoma and polyp detection rates between morning and afternoon colonoscopies performed by colorectal surgeons. In addition to known predictors, cecal intubation time and history of polypectomy were also independent predictors of adenoma detection rate. Patients with prior polypectomy had increased colonoscopy times in afternoon shift. Since colorectal surgeons perform higher proportion of diagnostic and surveillance colonoscopies, these patients may be better suited for colonoscopies in morning shift.
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- 2022
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50. Modular Synthesis of 9,10-Dihydroacridines through an ortho-C Alkenylation/Hydroarylation Sequence between Anilines and Aryl Alkynes in Hexafluoroisopropanol.
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Wang, Shengdong, Force, Guillaume, Carpentier, Jean-François, Sarazin, Yann, Bour, Christophe, Gandon, Vincent, and Lebœuf, David
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- 2021
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