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Copyright of Afyon Kocatepe University Journal of Science & Engineering / Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi is the property of Afyon Kocatepe University, Faculty of Science & Literature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkish Culture & Haci Bektas Veli Research Quarterly is the property of Turkish Cultur & Haci Bektas Veli Research Quarterly and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The effects of alpha-pinene (AP), a monoterpenoid, known for its antioxidant, anti-inflammatory, and anti-apoptotic properties, on methotrexate (MTX)-induced cardiac and hepatic damage were investigated in this study. Male Sprague-Dawley rats were divided into Control, Vehicle, AP, MTX, and AP+MTX groups (n=7). AP (50 mg/kg/day, 14 days) was applied subcutaneously in the AP and AP+MTX groups. MTX (20 mg/kg) was injected three days before sacrification. Serum CK-MB, troponin T, ALT, and AST levels, as well as cardiac and hepatic MDA, GSH, caspase-3, and p53 levels, were measured by ELISA. Histological changes in tissues were evaluated by scoring in terms of tissue damage and cellular degeneration parameters after hematoxylin-eosin staining. MTX caused significant increase in serum CK-MB, troponin T, ALT, and AST levels, hepatic and cardiac lipid peroxidation, GSH depletion, and caspase-3 level. However, tissue levels of p53 did not change significantly. MTX-induced histological deterioration was observed in both tissues. These MTX-induced changes were significantly reduced in the AP+MTX group. Present results show that MTX-induced cardiac and hepatic damage is prevented by AP pretreatment. This protection can be attributed to the antioxidant and anti-apoptotic properties of AP. Considering the importance of MTX in cancer treatment, AP appears to have highly promising potential as a cardioprotective and hepatoprotective agent in anti-tumoral therapy. [ABSTRACT FROM AUTHOR]

The principle of similitude put forward by Hahnemann has challenging practical consequences in the selection of the right homeopathic medicine for a patient. According to this principle, only the medicines that best fit the totality of the symptoms of a given patient are supposed to really cure: this greatly depends on the homeopath's clinical analysis. In addition, a patient's illness may be more or less curable, depending on the characteristics of the disease. In their daily practice, homeopaths typically apply Bayesian reasoning to deal with uncertainty associated with both medicine and disease. We suggest that clinical research on homeopathy would gain by integrating this kind of prior estimation of (1) the probability of a given medicine being effective for that particular patient and (2) the probability of the patient's disease (or symptoms) being curable. We therefore suggest that future trials of N-of-1 design may gain (1) by testing a small number of "best candidate" medicines (instead of one) for a given patient facing a given disease, and (2) by including careful prior estimations of the probabilities that (a) each selected medicine will be efficient for that patient and (b) the patient's disease will be reversible with the medicine. [ABSTRACT FROM AUTHOR]

Nuclear energy is an important alternative energy source. However, construction of nuclear power plants (NPPs) requires the consideration of environmental, economic, socioeconomic, health, and safety factors since using such an energy source involves some risks during the operation lifetime of a NPP. Accordingly, the selection of the most suitable site for a NPP yields a multicriteria decision making (MCDM) problem. Natural hazards, health hazards, environmental conditions, population density, and the availability of water resources are among the main factors that should be considered. To demonstrate the application of the proposed methodology, two previously identified NPP sites in Turkey, specifically, Mersin-Akkuyu and Sinop-Abalı, are compared utilizing the multicriteria utility functions. In the comparison of these two sites, seismic hazard, tsunami hazard; extreme wind hazard; distance to facilities; population density; proximity to the city center; existence of forests, natural parks, nature conservation areas, and natural monuments; biodiversity; and immovable cultural heritage have been identified as the most important critical criteria and are evaluated concerning the utility functions developed for each criterion. The optimal site is selected within the framework of the MCDM rules, and is recommended as the output of the study. [ABSTRACT FROM AUTHOR]

The aim of this study is to examine the relationship between childhood trauma and psychological resilience in the Turkish Cypriot community and to identify the predictors of psychological resilience. The research was conducted with 354 individuals in a web-based online environment in Northern Cyprus. Data were collected using a "Personal Information Form", the "Adverse Childhood Events Scale", and the "Resilience Scale for Adults". Percentage, mean, standard deviation, and Pearson's correlation analysis were used in the data analysis. In the study, 16.67 % of the participants were exposed to war or conflict when they were young and 10.17 % had a mental illness. In addition, it was determined that there were statistically significant and negative correlations between the Adverse Childhood Events Scale scores and the scores they got from the Adult Resilience Scale and the sub-dimensions of the scale. Female gender and education level predicted the scores on the Resilience Scale for Adults positively, and the presence of mental disease and the scores on the Adverse Childhood Events Scale negatively predicted the scores on the Resilience Scale for Adults. İn this study, gender, educational status, presence of mental illness, and the total score on the Adverse Childhood Events Scale were determined to be predictive variables affecting resilience. Considering the research findings, it is recommended that nurses plan studies for the protection of the mental health of children and adolescents and the groups exposed to trauma should be psychologically supported to raise individuals with high resilience. • Negative life events experienced in childhood affect resilience negatively. • Gender, education level, presence of mental illness are predictive variables affecting resilience. • Nurses should identify high-risk children, and provide holistic training by using their investigative and educational roles. [ABSTRACT FROM AUTHOR]

Locating the screw channel in a cement-retained implant-supported crown is challenging. This article describes a fully digital workflow for fabricating a 3D printed template which can accurately guide the dentist to find the screw channel. A definitive implant cast from the patient and an implant planning software program are used in the workflow. This technique provides precise guidance for finding the location and angulation of the abutment screw access hole. [ABSTRACT FROM AUTHOR]

The subject of stains and stain removal has great importance to the professional lives of textile researchers and the daily lives of the public. Therefore, stain removal characteristics of five different types of 100% cotton knitted fabrics (single-jersey, piquet, 3-thread fleece, 1x1 rib, and interlock) commonly used for casual wear were investigated in this study. Samples were stained with three types of common stains, and the effects of various fabric properties on stain removal characteristics were investigated. The stain removal performance was evaluated both objectively via a spectrophotometer and subjectively by Grey Scale grading. According to the results, fabric structure had a significant effect on stain removal characteristics. 1x1 rib and single jersey were the most difficult structures for stain removal, whereas, piquet fabric was the most convenient. Additionally, tomato paste was the most difficult stain to remove, whereas chocolate milk was the easiest. [ABSTRACT FROM AUTHOR]

Sportswear, the clothing including footwear, worn during sports or physical exercise, has an increasing demand and the sports apparel with improved comfort properties have become more popular than ever. Enhancing the wearer's comfort is possible by engineering fabric structures by incorporating suitable fibers. For doing so, in this study, bilayered spacer fabric samples were produced from sustainable fibers namely, recycled PA66 and PA6-Umorfil yarns, together with 44 dtex elastane. A PA6 FDY monofilament yarn was employed as the spacer yarn. The results showed that comfort properties of sports apparel can be improved by using recycled and Umorfil poliamide fibers in different parts of the garments depending on the intended use and purposes. Use of such sustainable fibers in the fabric structure is not only suitable for achieving active sportswear comfort but also is respectful to the environment. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the influence of the polymerization distance of monowave and polywave light curing units (LCUs) on the measured irradiance relative to the value reported by the manufacturer in relation to the physical properties of resin-based composites (RBCs). Methods: Four LCUs were used: one monowave and three polywave. The irradiance was measured with a digital radiometer. Depth of cure (DC) and flexural strength (FS) tests were performed according to ISO 4049:2019 at polymerization distances of 0 mm and 5 mm. Results: The irradiance of all LCUs was higher than that reported by the manufacturer (>25-64%). The irradiance of the four LCUs was reduced when polymerization was performed at between 0 to 5 mm (paired t-test, P < 0.001). The DC at 0 mm was similar in all groups but was significantly decreased at 5 mm distance (ANOVA P < 0.001). FS showed differences among the LCUs at 0 mm (ANOVA P < 0.001) and was affected by the polymerization distance. The elastic modulus was unaffected by the LCU used or the distance (ANOVA P > 0.001). Conclusions: The LCU must be positioned as near as possible to RBCs during the polymerization process, as increased distance negatively affects the depth of cure and flexural strength. [ABSTRACT FROM AUTHOR]

Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

We aimed to develop a basic, easily applicable nomogram to improve the survival prediction of the patients with stage II/III gastric cancer (GC) and to select the best candidate for postoperative radiotherapy (RT). In this multicentric trial, we retrospectively evaluated the data of 1597 patients with stage II/III GC after curative gastrectomy followed by postoperative RT ± chemotherapy (CT). Patients were divided into a training set (n = 1307) and an external validation set (n = 290). Nomograms were created based on independent predictors identified by Cox regression analysis in the training set. The consistency index (C-index) and the calibration curve were used to evaluate the discriminative ability and accuracy of the nomogram. A nomogram was created based on the predictive model and the identified prognostic factors to predict 5-year cancer-specific survival (CSS) and progression-free survival (PFS). The multivariate Cox model recognized lymph node (LN) involvement status, lymphatic dissection (LD) width, and metastatic LN ratio as covariates associated with CSS. Depth of invasion, LN involvement status, LD width, metastatic LN ratio, and lymphovascular invasion were the factors associated with PFS. Calibration of the nomogram predicted both CSS and PFS corresponding closely with the actual results. In our validation set, discrimination was good (C-index, 0.76), and the predicted survival was within a 10% margin of ideal nomogram. In our relatively large cohort, we created and validated both CSS and PFS nomograms that could be useful for underdeveloped or developing countries rather than Korea and Japan, where the D2 gastrectomy is routinely performed. This could serve as a true map for oncologists who must make decisions without an experienced surgeon and a multidisciplinary tumor board. [ABSTRACT FROM AUTHOR]

Background: Hymenoptera venom allergy (HVA) is among the most common causes of severe allergic reactions worldwide. Objective: To investigate clinical features and factors that affect the severity of HVA and to determine the alterations in immunologic biomarkers after venom immunotherapy (VIT). Methods: Seventy-six adults and 36 children were prospectively investigated. We analyzed specific immunoglobulin E (sIgE) and sIgG4 levels of venom extracts and components (rApi m1, rApi m10, rVes v1, rVes v5, rPol d5) before and after the first year of VIT. Results: Although cardiovascular symptoms were more common in adults (p < 0.001), the skin was the most affected organ in children (p = 0.009). Serum basal tryptase (sBT) levels were higher in the adults than the children (p < 0.001). The absence of urticaria (odds ratio [OR] 4.208 [95% confidence interval {CI}, 1.395–12.688]; p = 0.011) and sBT ≥ 5.2 ng/mL (OR 11.941 [95% CI, 5.220–39.733]; p < 0.001) were found as the risk factors for grade IV reactions. During VIT, changes in sIgE levels were variable. In the Apis VIT group, we observed remarkable increases in sIgG4 levels in Apis extract and rApi m1 but not in Api m10. Vespula extract, rVes v1, and rVes v5 sIgG4 levels were significantly increased in Vespula VIT group, we also detected significant increases in the Polistes extract and rPol d5 sIgG4 levels, which were not observed in the Apis VIT group. In the patients who received both Apis and Vespula VIT, increases in sIgG4 levels were observed for both venoms. Conclusion: Adults and children can have different clinical patterns. After 1 year, VIT induced a strong IgG4 response. Although Apis immunotherapy (IT) induced Apis sIgG4, excluding Api m10, Vespula IT induced both Vespula and Polistes sIgG4 [ABSTRACT FROM AUTHOR]

This article examines the resilience of the rural cultural landscape (RCL) shaped by hazelnut production in the Eastern Black Sea Region of Türkiye. Addressing the cultural landscapes shaped by agricultural production with their economic dimensions constitutes the original aspect of the article. In the study, the resilience of RCLs is discussed in the context of the socio- ecological resilience approach. The main aim is to evaluate the resilience of the RCL of the region by identifying causal relationships between socio-cultural, economic, and institutional dynamics in the Giresun-Ordu Subregion. In the study, historical profiling, which enables the provision of context-specific detailed information, has been adopted. Within the scope of the article, the effects of the historical change and development of socio-cultural, economic, and institutional dynamics in the Giresun-Ordu sub-region on the RCL of the region are analyzed comparatively in three periods. This comparison has been carried out through agricultural production mode-method- economy, social structure and culture, and physical space features. The changing, unchanging, and evolving characteristics of the rural cultural landscape of the region were identified. As a result of the method followed and the evaluations made, migration and demographic changes in the region have brought about adaptations in the agricultural production style, method, and economy. These adaptations have transformed the way of life by making migration permanent and continuous. It is possible to say that the rural cultural landscape of the region, which can continue its traditional economic and social structure by adapting to all these changes and transformations, is resilient. [ABSTRACT FROM AUTHOR]

Copyright of Turk Psikiyatri Dergisi is the property of Turk Psikiyatri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkish Journal of Psychiatry is the property of Turk Psikiyatri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Output markets usually respond asymmetrically to input price changes, with prices rising faster than they fall; this phenomenon is known as the rockets and feathers pattern. This pattern has not yet been tested for a joint production process despite strong connections among markets. We fill this gap by using a vector error correction quantile framework and apply our model to soybean meal and oil, which are jointly produced by crushing soybeans. We find that output prices respond more to input price increases when their own market is bullish but the other market is bearish, confirming the rockets and feathers pattern at the extremes of price distributions. [ABSTRACT FROM AUTHOR]

Background. Pulmonary Langerhans cell histiocytosis (pLCH) is a rare disease, mostly a component of multisystemic LCH. We aimed to investigate the clinical features and treatment results in children with pLCH. Methods. We retrospectively reviewed the clinical, radiological, and treatment data of 37 patients with pLCH, diagnosed from 1974 to 2022. Results. 10% (n=37) of 367 patients with LCH had lung involvement. The median age was 1.8 years (range: 0.4 & 17.7) with a male-to-female ratio of 2.3. At admission 29.7% (n=11) presented with respiratory symptoms. Imaging showed a spectrum from nodular opacities to multiple cysts. All but one patient had multisystem disease. Twenty-nine received vinblastine-containing therapy. Ten-year event-free (EFS) and overall survival (OS) rates were 47.8% and 63.3%, respectively. In children younger and older than two years of age, the 10-year EFS was 53.3% vs. 40.2% and the 10-year OS was 58.7% vs. 68.8%, respectively. In children with and without risk organ involvement, 10-year EFS was 51.9% vs. 46.3% and 10-year OS was 51.9% vs. 73.7%. Conclusions. Lung and multisystem involvement are significant concerns in LCH, highlighting the need for careful management to reduce morbidity and mortality. [ABSTRACT FROM AUTHOR]

Background Opioid exposure after surgery increases risk of persistent opioid use. Here, we characterize at- home use of opioid rescue medication during 1-2 days after outpatient surgery (N=270) in a postoperative opioid-sparing context at a Norwegian hospital. Methods The postsurgical pain management plan included non-steroidal anti-inflammatory drugs and up to six pills of 5 mg oxycodone as rescue analgesics. In this observational study we assessed risk factors for taking rescue opioids after surgery, by comparing patients who did, with those who did not. Results Only 35% (N=228) of patients reported taking rescue opioids 1-2 days after discharge. Patients taking rescue opioids after surgery (opioid-takers) differed from non-takers by prevalence of preoperative chronic pain (>3 months; 74% vs 48%), higher pain severity and interference before and after surgery, reporting lower ability to cope with postsurgical pain, higher nervousness about the surgery, being younger, and having received more opioid analgesics in the recovery room. Exploratory predictive modeling identified opioid administration in the recovery room as the most important predictor of athome rescue medication use. Follow-up after >4 months indicated low acute pain levels (mean±SD = 1.1±1.8), with only four patients (2%, N=217) reporting opioid analgesic use. Conclusion Factors related to at-home rescue medication use closely mirrored known risk factors for persistent opioid use after surgery, such as prior chronic pain, prior substance use, affective disturbances, and pain severity before surgery. These findings are potential targets in patient-centered care. Nevertheless, and reassuringly, findings are consistent with the idea that opioid-sparing postsurgical care can prevent large-scale chronic opioid use. [ABSTRACT FROM AUTHOR]

• Telerehabilitation is an important option for healthcare professionals and patients during epidemics and natural disasters. Telerehabilitation is used for many conditions, including psychiatric conditions (such as anxiety and depression). • Evidence suggests that nursing students experience stress during their first clinical experience. • In this study, the positive effects of using telerehabilitation were observed in nursing students who switched to distance learning after the earthquake. To investigate the effect of telerehabilitation on stress levels experienced by nursing students during their first clinical experience. For nursing students, the first clinical experience can cause stress and anxiety. As a result, nursing students may lose motivation and desire to learn. Telerehabilitation is used for many conditions, including mental health conditions. Seventy-four nursing students, aged 18-24 years, who volunteered to participate in the study and who were having their first clinical experience, participated in the study. The participants were randomly divided into two groups, the exercise group (n=37) and the control group (n=37). The experimental group received a total of 16 sessions of progressive muscle relaxation exercises with telerehabilitation four times a week for four weeks. The control group received no treatment. There was no statistically significant difference in the mean Perceived Stress Scale for Nursing Students scores of the students in the experimental group after the tele-rehabilitation application, but there was a decrease in the mean score levels compared to the experimental group (p>0.05). At the end of the study, the Biopsychosocial Response Scale of Nursing Students mean scores of the exercise group decreased statistically significantly compared to the control group (p<0.05). It was observed that telerehabilitation practice may have a positive effect on clinical stress levels and stress responses of nursing students during their first clinical experience. [ABSTRACT FROM AUTHOR]

• There is no special program to improve the rational drug use level of nursing students in the nursing curriculum. • This study indicates, rational drug use program (RDUP) remarkably increased the level of RDU among nursing students. • This study demonstrates that web-based RDUP can be integrated into the nursing curriculum for increasing the RDU levels of nursing students. Rational drug use (RDU) is an issue that has global concerns for all health professionals. The aim of this study was to determine the effects of web-based rational drug use program (RDUP) for nursing students. A total of 224 nursing students were randomly assigned to the intervention (IG = 112) and control (CG = 112) groups. The IG received a 4-week web-based RDUP. Data were collected at baseline (T0), postintervention (in 1-week = T1), and postintervention (in 16-week = T2). The level of RDU was significantly higher in the IG than in the CG at T1 (F = 88.890; p<0.001; η2 = 0.287) and at T2 (F = 251.875; p<0.001; η2 = 0.533). Web-based RDUP was effective in level of rational drug use among nursing students. Therefore web-based RDUP should be included in the nursing curriculum. [ABSTRACT FROM AUTHOR]

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Current breast cancer treatment trends advocate nipple-sparing mastectomy (NSM) as the preferred technique for selected patients. A considerable and ptotic breast is often considered a relative contraindication for NSM due to the increased risk of skin and nipple necrosis. A retrospective review was performed for patients who underwent immediate prepectoral breast reconstruction (PPBR) after NSM with Wise-pattern incision between February 2020 and February 2023 at our institution. This procedure was offered to patients with grade II or III ptosis or large breasts eligible for NSM for therapeutic or prophylactic purpose. Exclusion criteria comprised a preoperative nipple-sternal notch distance greater than 30 cm, previous radiotherapy, pinch test <1 cm, body mass index (BMI) greater than 34 and active smoke. We present our short-term results with this technique. During the study period, 62 patients (76 breasts) had NSM with Wise-pattern incision. Patients had immediate PPBR with implant or tissue expander, both entirely wrapped with ADM. The median age of the patients was 57.0 years [The Interquartile Range (IQR 50.0–68.6)] with a median BMI of 25.5 (IQR 23.3–28.4). The median mastectomy specimen weight was 472 g (341−578). Median implant volume was 465 g (IQR 370–515). Major complications occurred in 8 patients (10.5%). Three patients experienced total nipple-areolar complex (NAC) necrosis (3.9%), and partial NAC necrosis occurred in 2 patients (2.6%). Two patients developed implant infection (2.6%). Univariate analysis showed a statistically significant correlation between major complications and the mastectomy specimen weight (p = 0.003). If oncologically indicated, NSM with Wise-pattern incision and immediate PPBR can safely be performed in selected patients with large and ptotic breasts. [Display omitted] [ABSTRACT FROM AUTHOR]