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Purpose: The study examines alcohol and drug related accidental dwelling fire injuries during 2006–2016 in Merseyside in England. Design/methodology/approach: The study carries out an examination of alcohol and drug related fire injuries from 2006 to 2016 in Merseyside, including analysis of injuries by age group, gender, level of deprivation and housing type. Findings: Deprivation was a significant factor in alcohol and drug related fire injuries over the period studied, with 70% of such injuries occurring in areas with the highest level of deprivation. Males appeared roughly twice as likely to be injured in an alcohol and drug related fire incident than females. The majority of those injured were in the age range 35–59. Research limitations/implications: There were limitations on the generalizability of the research findings to other fire and rescue services, as Merseyside has some of the highest levels of alcohol consumption and deprivation in UK. Practical implications: An understanding of those vulnerable to alcohol and drug related fire risks can support more targeted fire prevention strategies and aid referrals to partner health agencies to help to reduce underlying alcohol and drug misuse issues. Originality/value: The study provides a detailed analysis of the circumstances associated with alcohol and drug related fire injuries over a ten-year period covered by a UK fire and rescue service, in particular, in terms alcohol and drug related fire injury risk differences between different groups.