76 results on '"Norris, Paul"'
Search Results
2. The Senses of Sight in Lancelot Andrewes's Sermons.
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NORRIS, PAUL
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SERMON (Literary form) ,GOD ,MIND & body - Abstract
Copyright of Renaissance & Reformation / Renaissance et Réforme is the property of Iter Canada and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2021
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3. Head and neck oncological ablation and reconstruction in the COVID-19 era – our experience to date.
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Butler, Daniel, Davies-Husband, Cameron, Dhanda, Jagtar, Francis, Ian, Gulati, Aakshay, Kapoor, Karan, Newman, Laurence, Norris, Paul, Sadiq, Zaid, Surwald, Christian, Upile, Navdeep, Vorster, Tim, and Bisase, Brian
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COVID-19 ,COVID-19 pandemic ,HEAD & neck cancer - Abstract
The COVID-19 pandemic has caused unprecedented disruption to the routine operations of healthcare services across the world. As the potential duration of the pandemic remains uncertain, the need to develop strategies to continue urgent elective services has received increasing attention. A solution adopted in the Kent, Sussex and Surrey area of England has been to create COVID-19-protected cancer hubs. The Queen Victoria Hospital is the designated hub for head and neck cancer services in the area. We report on the evolution of the head and neck cancer care pathway and standard operating protocols put in place and how these have combined both national guidelines and local problem solving. It is hoped that our experience can help guide other centres as they re-establish head and neck cancer services during the ongoing pandemic. [ABSTRACT FROM AUTHOR]
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- 2020
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4. Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes.
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Levy, Bruce D., Abdulnour, Raja-Elie E., Tavares, Alexander, Brüggemann, Thayse R., Norris, Paul C., Bai, Yan, Ai, Xingbin, and Serhan, Charles N.
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Cysteinyl leukotrienes (CysLTs) are potent prophlogistic mediators in asthmatic patients; however, inhibition of CysLT receptor 1 is not a consistently effective treatment, suggesting additional regulatory mechanisms. Other cysteinyl-containing lipid mediators (LMs) derived from docosahexaenoic acid, namely maresin conjugates in tissue regeneration (MCTRs), were recently discovered. Therefore their production and actions in the lung are of considerable interest. We sought to determine MCTR production, bioactions, and mechanisms in the human lung and in patients with experimental allergic airway inflammation. LM metabololipidomic profiling of the lung was performed by using liquid chromatography with tandem mass spectrometry. Donor-derived human precision-cut lung slices were exposed to leukotriene (LT) D 4 , MCTRs, or both before determination of airway contraction. The actions of exogenous MCTRs on murine allergic host responses were determined in the setting of ovalbumin- and house dust mite–induced lung inflammation. Lipidomic profiling showed that the most abundant cysteinyl LMs in healthy human lungs were MCTRs, whereas CysLTs were most prevalent in patients with disease. MCTRs blocked LTD 4 -initiated airway contraction in human precision-cut lung slices. In mouse allergic lung inflammation MCTRs were present with temporally regulated production. With ovalbumin-induced inflammation, MCTR1 was most potent for promoting resolution of eosinophils, and MCTR3 potently decreased airway hyperreactivity to methacholine, bronchoalveolar lavage fluid albumin, and serum IgE levels. MCTR1 and MCTR3 inhibited lung eosinophilia after house dust mite–induced inflammation. These results identified lung MCTRs that blocked human LTD 4 -induced airway contraction and promoted resolution of murine allergic airway responses when added exogenously. Together, these findings uncover proresolving mechanisms for lung responses that can be disrupted in patients with disease. [ABSTRACT FROM AUTHOR]
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- 2020
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5. Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure.
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Tourki, Bochra, Kain, Vasundhara, Pullen, Amanda B., Norris, Paul C., Patel, Nirav, Arora, Pankaj, Leroy, Xavier, Serhan, Charles N., and Halade, Ganesh V.
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Recently, we observed that the specialized proresolving mediator (SPM) entity resolvin D1 activates lipoxin A 4 /formyl peptide receptor 2 (ALX/FPR2), which facilitates cardiac healing and persistent inflammation is a hallmark of impaired cardiac repair in aging. Splenic leukocyte-directed SPMs are essential for the safe clearance of inflammation and cardiac repair after injury; however, the target of SPMs remains undefined in cardiac healing and repair. To define the mechanistic basis of ALX/FPR2 as a resolvin D1 target, ALX/FPR2-null mice were examined extensively. The systolic-diastolic heart function was assessed using echocardiography, leukocytes were phenotyped using flow cytometry, and SPMs were quantitated using mass spectrometry. The presence of cardiorenal syndrome was validated using histology and renal markers. Lack of ALX/FPR2 led to the development of spontaneous obesity and diastolic dysfunction with reduced survival with aging. After cardiac injury, ALX/FPR2
−/− mice showed lower expression of lipoxygenases (−5, −12, −15) and a reduction in SPMs in the infarcted left ventricle and spleen, indicating nonresolving inflammation. Reduced SPM levels in the infarcted heart and spleen are suggestive of impaired cross-talk between the injured heart and splenic leukocytes, which are required for the resolution of inflammation. In contrast, cyclooxygenases (−1 and −2) were over amplified in the infarcted heart. Together, these results suggest interorgan signaling in which the spleen acts as both an SPM biosynthesizer and supplier in acute heart failure. ALX/FPR2 dysfunction magnified obesogenic cardiomyopathy and renal inflammation (↑NGAL, ↑TNF-α, ↑CCL2, ↑IL-1β) with elevated plasma creatinine levels in aging mice. At the cellular level, ALX/FPR2−/− mice showed impairment of macrophage phagocytic function ex-vivo with expansion of neutrophils after myocardial infarction. Lack of ALX/FPR2 induced obesity, reduced the life span, amplified leukocyte dysfunction, and facilitated profound interorgan nonresolving inflammation. Our study shows the integrative and indispensable role of ALX/FPR2 in lipid metabolism, cardiac inflammation–resolution processes, obesogenic aging, and renal homeostasis. • Lack of resolution sensor (ALX/FPR2) led to spontaneous, age-related obesity. • Absence of ALX/FPR2 triggered obesogenic cardiomyopathy and renal inflammation. • Deficiency of ALX/FPR2 reduced SPMs in the infarcted heart after cardiac injury. • ALX/FPR2 dysfunction impaired macrophage function and amplified inflammation. [ABSTRACT FROM AUTHOR]- Published
- 2020
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6. Identification of proresolving and inflammatory lipid mediators in human psoriasis.
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Sorokin, Alexander V., Norris, Paul C., English, Justin T., Dey, Amit K., Chaturvedi, Abhishek, Baumer, Yvonne, Silverman, Joanna, Playford, Martin P., Serhan, Charles N., and Mehta, Nehal N.
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LIPID metabolism ,PSORIASIS treatment ,LIPID analysis ,ASPIRIN ,CYTOKINES ,GENE expression ,INFLAMMATORY mediators ,INTERLEUKINS ,KERATINOCYTES ,LIPIDS ,LIQUID chromatography ,MASS spectrometry ,PSORIASIS ,SKIN ,PHENOTYPES ,METABOLOMICS - Abstract
Background Psoriasis (PSO) is an immune-mediated inflammatory disease associated with metabolic and cardiovascular comorbidities. It is now known that resolution of inflammation is an active process locally controlled by specialized proresolving mediators (SPMs), named resolvins (Rvs), protectins, and maresins. Objective It is unknown whether these potent lipid mediators (LMs) are involved in PSO pathophysiology and if the skin and blood have disease-specific SPMs phenotype profiles. Methods We used liquid chromatography-tandem mass spectrometry–based LM metabololipidomics to obtain skin and peripheral blood LM profiles from PSO compared to healthy subjects. Some LMs were tested in cell culture experiments with corresponding gene expression and protein concentration analyses. Results The levels of several LM were significantly elevated in lesional PSO skin compared to nonlesional and skin from healthy subjects. Particularly, RvD5, protectins Dx, and aspirin-triggered forms of lipoxin were present only in lesional PSO skin, whereas protectin D1 was present in nonlesional PSO skin. To determine specific roles of SPMs on skin-related inflammatory cytokines, RvD1 and RvD5 were incubated with human keratinocytes. RvD1 and RvD5 reduced the expression levels of interleukin 24 and S100A12 , whereas only RvD1 significantly abrogated interleukin-24 production by keratinocytes. Conclusions These findings suggest that an imbalance between locally produced proresolution and proinflammatory LMs identified in PSO skin and blood compartments might play a role in PSO pathophysiology. Moreover, some of the PSO-related cytokines can be modified by specific SPMs and involved mechanisms support investigation of targeting novel proresolving lipid mediators as a therapy for PSO. [ABSTRACT FROM AUTHOR]
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- 2018
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7. Same day cancellations of elective operations in a tertiary hospital in south-east England: a review of 11 000 patients in 1 year
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Boyapati, Raghuram P, Mehta, Jahnavi, and Norris, Paul
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Cancellations of elective operations have negative consequences, both for patients and the NHS. For the latter, reducing waiting times for surgical procedures remains a pressing concern, as does maintenance of adequate staffing. This study aimed to identify factors contributing to the cancellation of elective operations on the day of the procedure in order to suggest measures that could be taken to reduce these incidents. The retrospective details of just over 11 000 patients awaiting theatre admission for elective operations over a period of 1 year were obtained. The reasons behind last-minute operation cancellations were categorised as either patient factors or hospital factors. Data analysis suggested that the number of cancellations could be reduced by scheduling appointments with a senior doctor closer to the operation date.
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- 2020
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8. Resolvin D4 attenuates the severity of pathological thrombosis in mice
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Cherpokova, Deya, Jouvene, Charlotte C., Libreros, Stephania, DeRoo, Elise P., Chu, Long, de la Rosa, Xavier, Norris, Paul C., Wagner, Denisa D., and Serhan, Charles N.
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Deep vein thrombosis (DVT) is a common cardiovascular disease with a major effect on quality of life, and safe and effective therapeutic measures to efficiently reduce existent thrombus burden are scarce. Using a comprehensive targeted liquid chromatography-tandem mass spectrometry-based metabololipidomics approach, we established temporal clusters of endogenously biosynthesized specialized proresolving mediators (SPMs) and proinflammatory and prothrombotic lipid mediators during DVT progression in mice. Administration of resolvin D4 (RvD4), an SPM that was enriched at the natural onset of thrombus resolution, significantly reduced thrombus burden, with significantly less neutrophil infiltration and more proresolving monocytes in the thrombus, as well as an increased number of cells in an early apoptosis state. Moreover, RvD4 promoted the biosynthesis of other D-series resolvins involved in facilitating resolution of inflammation. Neutrophils from RvD4-treated mice were less susceptible to an ionomycin-induced release of neutrophil extracellular traps (NETs), a meshwork of decondensed chromatin lined with histones and neutrophil proteins critical for DVT development. These results suggest that delivery of SPMs, specifically RvD4, modulates the severity of thrombo-inflammatory disease in vivo and improves thrombus resolution.
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- 2019
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9. Resolvin D4 attenuates the severity of pathological thrombosis in mice
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Cherpokova, Deya, Jouvene, Charlotte C., Libreros, Stephania, DeRoo, Elise P., Chu, Long, de la Rosa, Xavier, Norris, Paul C., Wagner, Denisa D., and Serhan, Charles N.
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Deep vein thrombosis (DVT) is a common cardiovascular disease with a major effect on quality of life, and safe and effective therapeutic measures to efficiently reduce existent thrombus burden are scarce. Using a comprehensive targeted liquid chromatography-tandem mass spectrometry-based metabololipidomics approach, we established temporal clusters of endogenously biosynthesized specialized proresolving mediators (SPMs) and proinflammatory and prothrombotic lipid mediators during DVT progression in mice. Administration of resolvin D4 (RvD4), an SPM that was enriched at the natural onset of thrombus resolution, significantly reduced thrombus burden, with significantly less neutrophil infiltration and more proresolving monocytes in the thrombus, as well as an increased number of cells in an early apoptosis state. Moreover, RvD4 promoted the biosynthesis of other D-series resolvins involved in facilitating resolution of inflammation. Neutrophils from RvD4-treated mice were less susceptible to an ionomycin-induced release of neutrophil extracellular traps (NETs), a meshwork of decondensed chromatin lined with histones and neutrophil proteins critical for DVT development. These results suggest that delivery of SPMs, specifically RvD4, modulates the severity of thrombo-inflammatory disease in vivo and improves thrombus resolution.
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- 2019
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10. Endogenous Specialized Proresolving Mediator Profiles in a Novel Experimental Model of Lymphatic Obstruction and Intestinal Inflammation in African Green Monkeys
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Becker, Felix, Romero, Emily, Goetzmann, Jason, Hasselschwert, Dana L., Dray, Beth, Vanchiere, John, Fontenot, Jane, Yun, J. Winny, Norris, Paul C., White, Luke, Musso, Melany, Serhan, Charles N., Alexander, J. Steven, and Gavins, Felicity N.E.
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Changes in the intestinal lymphatic vascular system, such as lymphatic obstruction, are characteristic features of inflammatory bowel diseases. The lymphatic vasculature forms a conduit to enable resolution of inflammation; this process is driven by specialized endogenous proresolving mediators (SPMs). To evaluate contributions of lymphatic obstruction to intestinal inflammation and to study profiles of SPMs, we generated a novel animal model of lymphatic obstruction using African green monkeys. Follow-up studies were performed at 7, 21, and 61 days. Inflammation was determined by histology. Luminex assays were performed to evaluate chemokine and cytokine levels. In addition, lipid mediator metabololipidomic profiling was performed to identify SPMs. After 7 days, lymphatic obstruction resulted in a localized inflammatory state, paralleled by an increase in inflammatory chemokines and cytokines, which were found to be up-regulated after 7 days but returned to baseline after 21 and 61 days. At the same time, a distinct pattern of SPMs was profiled, with an increase for D-series resolvins, protectins, maresins, and lipoxins at 61 days. These results indicate that intestinal lymphatic obstruction can lead to an acute inflammatory state, accompanied by an increase in proinflammatory mediators, followed by a phase of resolution, paralleled by an increase and decrease of respective SPMs.
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- 2019
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11. Resolution of sickle cell disease–associated inflammation and tissue damage with 17R-resolvin D1
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Matte, Alessandro, Recchiuti, Antonio, Federti, Enrica, Koehl, Bérengère, Mintz, Thomas, El Nemer, Wassim, Tharaux, Pierre-Louis, Brousse, Valentine, Andolfo, Immacolata, Lamolinara, Alessia, Weinberg, Olga, Siciliano, Angela, Norris, Paul C., Riley, Ian R., Iolascon, Achille, Serhan, Charles N., Brugnara, Carlo, and De Franceschi, Lucia
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Resolvins (Rvs), endogenous lipid mediators, play a key role in the resolution of inflammation. Sickle cell disease (SCD), a genetic disorder of hemoglobin, is characterized by inflammatory and vaso-occlusive pathologies. We document altered proresolving events following hypoxia/reperfusion in humanized SCD mice. We demonstrate novel protective actions of 17R-resolvin D1 (17R-RvD1; 7S, 8R, 17R-trihydroxy-4Z, 9E, 11E, 13Z, 15E, 19Z-docosahexaenoic acid) in reducing ex vivo human SCD blood leukocyte recruitment by microvascular endothelial cells and in vivo neutrophil adhesion and transmigration. In SCD mice exposed to hypoxia/reoxygenation, oral administration of 17R-RvD1 reduces systemic/local inflammation and vascular dysfunction in lung and kidney. The mechanism of action of 17R-RvD1 involves (1) enhancement of SCD erythrocytes and polymorphonuclear leukocyte efferocytosis, (2) blunting of NF-κB activation, and (3) a reduction in inflammatory cytokines, vascular activation markers, and E-selectin expression. Thus, 17R-RvD1 might represent a new therapeutic strategy for the inflammatory vasculopathy of SCD.
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- 2019
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12. Resolution of sickle cell disease–associated inflammation and tissue damage with 17R-resolvin D1
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Matte, Alessandro, Recchiuti, Antonio, Federti, Enrica, Koehl, Bérengère, Mintz, Thomas, El Nemer, Wassim, Tharaux, Pierre-Louis, Brousse, Valentine, Andolfo, Immacolata, Lamolinara, Alessia, Weinberg, Olga, Siciliano, Angela, Norris, Paul C., Riley, Ian R., Iolascon, Achille, Serhan, Charles N., Brugnara, Carlo, and De Franceschi, Lucia
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Resolvins (Rvs), endogenous lipid mediators, play a key role in the resolution of inflammation. Sickle cell disease (SCD), a genetic disorder of hemoglobin, is characterized by inflammatory and vaso-occlusive pathologies. We document altered proresolving events following hypoxia/reperfusion in humanized SCD mice. We demonstrate novel protective actions of 17R-resolvin D1 (17R-RvD1; 7S, 8R, 17R-trihydroxy-4Z, 9E, 11E, 13Z, 15E, 19Z-docosahexaenoic acid) in reducing ex vivo human SCD blood leukocyte recruitment by microvascular endothelial cells and in vivo neutrophil adhesion and transmigration. In SCD mice exposed to hypoxia/reoxygenation, oral administration of 17R-RvD1 reduces systemic/local inflammation and vascular dysfunction in lung and kidney. The mechanism of action of 17R-RvD1 involves (1) enhancement of SCD erythrocytes and polymorphonuclear leukocyte efferocytosis, (2) blunting of NF-κB activation, and (3) a reduction in inflammatory cytokines, vascular activation markers, and E-selectin expression. Thus, 17R-RvD1 might represent a new therapeutic strategy for the inflammatory vasculopathy of SCD.
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- 2019
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13. Frontline Science: Structural insights into Resolvin D4 actions and further metabolites via a new total organic synthesis and validation
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Winkler, Jeremy W., Libreros, Stephania, De La Rosa, Xavier, Sansbury, Brian E., Norris, Paul C., Chiang, Nan, Fichtner, David, Keyes, Gregory S., Wourms, Nicholas, Spite, Matthew, and Serhan, Charles N.
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Local production and downstream metabolism of specialized proresolving lipid mediators (SPMs) are pivotal in regulating their biological actions during resolution of inflammation. Resolvin D4 (RvD4: 4S,5R,17S‐trihydroxydocosa‐6E,8E,10Z,13Z,15E,19Zhexaenoic acid) is one of the more recently elucidated SPMs with complete stereochemistry biosynthesized from docosahexaenoic acid. Here, we report a new multimilligram commercial synthesis that afforded enough material for matching, validation, and further evaluation of RvD4 functions. Using LC‐MS‐MS profiling, RvD4 was identified at bioactive amounts in human (1 pg/mL) and mouse bone marrow (12 pg/femur and tibia). In mouse bone marrow, ischemia increased the formation of RvD4 > 37‐fold (455 pg/femur and tibia). Two separate mouse ischemic injury models were used, where RvD4 reduced second organ reperfusion lung injury > 50%, demonstrating organ protection. Structure–function relationships of RvD4 demonstrated > 40% increase in neutrophil and monocyte phagocytic function in human whole blood in comparison with 2 separate trans‐containing double bond isomers that were inactive. These 2 isomers were prepared by organic synthesis: 4S,5R,17S‐trihydroxydocosa‐6E,8E,10E,13Z,15E,19Z‐hexaenoic acid (10‐trans‐RvD4), a natural isomer, and 4S,5R,17S‐trihydroxydocosa‐6E,8E,10E,13E,15E,19Z‐hexaenoic acid (10,13‐trans‐RvD4), a rogue isomer. Compared to leukotriene B4, D‐series resolvins (RvD1, RvD2, RvD3, RvD4, or RvD5) did not stimulate human neutrophil chemotaxis monitored via real‐time microfluidics chambers. A novel 17‐oxo‐containing‐RvD4 product of eicosanoid oxidoreductase was identified with human bone marrow cells. Comparison of 17‐oxo‐RvD4 to RvD4 demonstrated that with human leukocytes 17‐oxo‐RvD4 was inactive. Together, these provide commercial‐scale synthesis that permitted a second independent validation of RvD4 complete stereochemical structure as well as evidence for RvD4 regulation in tissues and its stereoselective phagocyte responses. Resolvin D4 commercial‐scale total organic synthesis elucidates new functions.
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- 2018
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14. Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics.
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English, Justin T., Norris, Paul C., Hodges, Robin R., Dartt, Darlene A., and Serhan, Charles N.
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Specialized pro-resolving mediators (SPM), e.g. Resolvin D1, Protectin D1, Lipoxin A₄, and Resolvin E1 have each shown to be active in ocular models reducing inflammation. In general, SPMs have specific agonist functions that stimulate resolution of infection and inflammation in animal disease models. The presence and quantity of SPM in human emotional tears is of interest. Here, utilizing a targeted LC-MS-MS metabololipidomics based approach we document the identification of pro-inflammatory (Prostaglandins and Leukotriene B₄) and pro-resolving lipid mediators (D-series Resolvins, Protectin D1, and Lipoxin A₄) in human emotional tears from 12 healthy individuals. SPMs from the Maresin family (Maresin 1 and Maresin 2) were not present in these samples. Principal Component Analysis (PCA) revealed gender differences in the production of specific mediators within these tear samples as the SPMs were essentially absent in these female donors. These results indicate that specific SPM signatures are present in human emotional tears at concentrations known to be bioactive. Moreover, they will help to further appreciate the mechanisms of production and action of SPMs in the eye, as well as their physiologic roles in human ocular disease resolution. [ABSTRACT FROM AUTHOR]
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- 2017
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15. Computational Modeling of Competitive Metabolism between ω3- and ω6-Polyunsaturated Fatty Acids in Inflammatory Macrophages.
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Gupta, Shakti, Yasuyuki Kihara, Maurya, Mano R., Norris, Paul C., Dennis, Edward A., and Subramaniam, Shankar
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- 2016
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16. The Elizabethan Mind: Searching for the Self in an Age of Uncertainty.
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NORRIS, PAUL
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POETICS ,DEMONOLOGY ,NONFICTION - Published
- 2023
17. Acidophile Diversity in Mineral Sulfide Oxidation.
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Rawlings, Douglas E., Johnson, D. Barrie, and Norris, Paul R.
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- 2007
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18. A Distinct Genotype of XP Complementation Group A: Surprisingly Mild Phenotype Highly Prevalent in Northern India/Pakistan/Afghanistan
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Sethi, Mieran, Haque, Shaheen, Fawcett, Heather, Wing, Jonathan F., Chandler, Natalie, Mohammed, Shehla, Frayling, Ian M., Norris, Paul G., McGibbon, David, Young, Antony R., Sarkany, Robert P.E., Lehmann, Alan R., and Fassihi, Hiva
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- 2016
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19. Primary and secondary intralymphatic histiocytosis.
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Bakr, Farrah, Webber, Naomi, Fassihi, Hiva, Swale, Victoria, Lewis, Fiona, Rytina, Ed, Ben-Zvi, Galia Tamar, Norris, Paul, Espinosa, Olivia, Dhar, Sunanda, Craig, Paul, and Robson, Alistair
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Background: Intralymphatic histiocytosis (IH) is a rare condition often associated with systemic disease. A benign condition, clinical presentations can vary greatly and its cause is largely unknown. Histologically, there are macrophages within distended lymphatic vessels, although this can be an incidental finding or the primary abnormality. Objective: We present a series of 7 cases of IH with and without disease associations, and a review of the literature. We propose IH as either primary (without associated conditions) or secondary (associated with systemic disease). Methods: This was a retrospective collection of patients whose skin biopsy specimens revealed intralymphatic collections of histiocytes. We reviewed their clinical presentation, disease associations, and staining of slides with CD68 in all cases, D2-40 in 5 cases, and HLA-DR in 4 cases. Results: Clinical features were highly variable, and not all cases were associated with systemic disease. One case had admixed reactive angioendotheliomatosis. All 4 cases stained for HLA-DR showed strong expression by the intralymphatic macrophages. Limitations: Retrospective analysis and limited numbers are limitations. Conclusion: IH is not always associated with systemic disease although macrophage activation nevertheless implies immune activation. [Copyright &y& Elsevier]
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- 2014
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20. FAMILIES OF NATIONS, VICTIMISATION AND ATTITUDES TOWARDS CRIMINAL JUSTICE.
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Norris, Paul A.
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CRIMINAL justice system ,CRIME victims ,CRIMINAL law ,SOCIAL policy ,PUBLIC welfare ,WELFARE state ,CRIMINOLOGY ,DEVELOPED countries - Abstract
Comparing and classifying OECD member states has provided a fruitful avenue for public policy research over many years (see for instance Espying-Andersen, 1990; Castles, 1998). The enhanced coverage of ICVS-5 means that for the first time comparable data relating to victimisation are available for those countries which have formed the mainstay of comparative research in other areas of public policy. There is strong reason to believe that the historical, political and cultural issues which it is argued have influenced the development of welfare states may also help explain variations in criminal justice outcomes across industrialised democracies (Cavadino and Dignan, 2006; Norris, 2007). Following the methodology of recent work in the comparative analysis of welfare systems (Obinger and Wagschal, 2001; Powell and Barrientos, 2004) this paper will consider country level victimisation rates from ICVS-5, using clustering techniques to identity groups of nations which exhibit similar levels and patterns of victimisation. It is argued that the clusters of nations present in the ICVS data reflect those found in other areas of social policy. Brief consideration is also given to how the application of typologies from social policy may suggest new questions, and provide new insights, to the study of comparative criminology. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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21. PUBLIC BROADCASTING IN THE DIGITAL AGE: ISSUES FOR TELEVISION IN NEW ZEALAND.
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Norris, Paul
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PUBLIC broadcasting ,CHILDREN'S television programs ,MASS media ,TELEVISION broadcasting ,GOVERNMENT agencies ,TELEVISION programs ,BROADCASTING industry - Abstract
New Zealand has a unique model of public broadcasting for television. The state broadcaster is almost totally commercial, although since 2003 it has been given a charter and some limited public funding. A state agency, NZ On Air, administers funding contestable between national broadcasters for public broadcasting, meaning in essence local (national) content in the threatened genres of drama, documentary, children's and minority programs. But this system is under challenge from the rise of multi-channel and the transition to digital. Audiences are fragmenting and the combined impact of broadband, the PVR and VOD threaten the notion of the broadcast schedule and the viability of commercial free-to-air television itself The concluding section of this paper examines issues for the New Zealand model in adapting to the digital challenge, and looks at the criteria on which the model's success or failure may be judged. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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22. A better way to prevent surgical complications after laryngectomy.
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Boyapati, Raghuram, Gill, Tanisha, Ainkaran, Gayatree, Mahendran, Krishantini, Bisase, Brian, Norris, Paul, Davies-Husband, Cameron, Upile, Navdeep, Gulati, Aakshay, and Butler, Daniel
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LARYNGECTOMY ,SURGICAL complications ,FREE flaps - Abstract
Introduction: 1. Understanding the implications of post-operative vomiting on the rate of salivary leak amongst patients undergoing laryngectomy. 2. Developing a better way to prevent post-operative vomiting through creation of a departmental policy to minimise risk of vomiting. Methods: We carried out a retrospective study of 24 patients who underwent primary or salvage laryngectomies. A Microsoft Excel sheet data containing the age, sex, smoking status, medical comorbidities, laryngectomy type, reconstructive method and the complications were all recorded. vomiting and the antiemetics particularly in the initial 48 hour period was documented. Results: 19 were male and 5 were female. Age varied from 51-86 and 14 of these patients were smokers. 8 patients had radiotherapy and this was within the 3 year period prior to laryngectomy in all patients. 16 patients had primary and 8 underwent salvage. Reconstructive methods included pectoralis major regional flap in 10 and ALT free flap in 6 patients. 8 patients had direct closure. 4 patients who developed a salivary leak had the post-op vomiting in the first 48 hours contrasting with 7 of the 18 who didn't have the salivary leak but had post-operative vomiting.The average length of stay amongst those receiving regular anti-emetics was 16 days compared to thenon anti emeticgroup of 23 days. Conclusions: Standardisation of the post-operative anti-emetic protocol would likely reduce the risk of post-operative vomiting with the aim to reduce the rate of salivary leak. We are developing a policy of the prescription of anti-emetics on regular side of drug chart for all laryngectomy patients. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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23. Specificity of eicosanoid production depends on the TLR‐4‐stimulated macrophage phenotype
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Norris, Paul C., Reichart, Donna, Dumlao, Darren S., Glass, Christopher K., and Dennis, Edward A.
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Comparing different TLR‐4‐activated macrophages reveals metabolite quantity dependence on COX‐2 level and higher PGIS activity relative to other prostanoid syntheses that outcompetes with mPGES‐1. Eicosanoid metabolism differs in profile and quantity between macrophages of different tissue origin and method of elicitation, as well as between primary and immortalized macrophages after activation with inflammatory stimuli. Using a lipidomic approach, we comprehensively analyzed the eicosanoids made by murine RPMs, TGEMs, BMDM, and the macrophage‐like cell line RAW after stimulation with the TLR‐4‐specific agonist KLA. Direct correlation among total COX metabolites, COX side‐products (11‐HETE, 15‐HETE), COX‐2 mRNA, and protein at 8 h was found when comparing each cell type. Comprehensive qPCR analysis was used to compare relative transcript levels between the terminal prostanoid synthases themselves as well as between each cell type. Levels of PGE2, PGD2, and TxB2generally correlated with enzyme transcript expression of PGES, PGDS, and TBXS, providing evidence of comparable enzyme activities. PGIS transcript was expressed only in RPM and TGEM macrophages and at an exceptionally low level, despite high metabolite production compared with other synthases. Presence of PGIS in RPM and TGEM also lowered the production of PGE2versus PGD2by approximately tenfold relative to BMDM and RAW cells, which lacked this enzyme. Our results demonstrate that delayed PG production depends on the maximal level of COX‐2 expression in different macrophages after TLR‐4 stimulation. Also, the same enzymes in each cell largely dictate the profile of eicosanoids produced depending on the ratios of expression between them, with the exception of PGIS, which appears to have much greater synthetic capacity and competes selectively with mPGES‐1.
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- 2011
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24. Eczema: A rational approach.
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Woodrow, Sarah and Norris, Paul
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ECZEMA - Abstract
Focuses on the skin condition known as eczema. Types of clothing eczema sufferers should wear; Part played by diet in the treatment of eczema; Effectiveness of gamolenic acid (primrose oil) in the treatment of eczema; Types of soaps and bubble baths that should be used.
- Published
- 1996
25. A race to the bottom.
- Author
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Norris, Paul
- Abstract
The article focuses on the state of public broadcasting in New Zealand. It considers the television and publicly owned broadcaster TVNZ, which blew the opportunities provided by the Charter to create a shop window of high quality programs that would choose to apply Charter funding to commercial programs. Broadcasting Minister Jonathan Coleman encourages TVNZ to raise money to improve its rate of return on assets and increase the dividends it pays the government.
- Published
- 2010
26. Families of Nations, Victimisation and Attitudes Towards Criminal Justice
- Author
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Norris, Paul A.
- Abstract
Comparing and classifying OECD member states has provided a fruitful avenue for public policy research over many years (see for instance Espying-Andersen, 1990; Castles, 1998). The enhanced coverage of ICVS-5 means that for the first time comparable data relating to victimisation are available for those countries which have formed the mainstay of comparative research in other areas of public policy. There is strong reason to believe that the historical, political and cultural issues which it is argued have influenced the development of welfare states may also help explain variations in criminal justice outcomes across industrialised democracies (Cavadino and Dignan, 2006; Norris, 2007). Following the methodology of recent work in the comparative analysis of welfare systems (Obinger and Wagschal, 2001; Powell and Barrientos, 2004) this paper will consider country level victimisation rates from ICVS-5, using clustering techniques to identify groups of nations which exhibit similar levels and patterns of victimisation. It is argued that the clusters of nations present in the ICVS data reflect those found in other areas of social policy. Brief consideration is also given to how the application of typologies from social policy may suggest new questions, and provide new insights, to the study of comparative criminology.
- Published
- 2009
- Full Text
- View/download PDF
27. Ferrous Iron and Pyrite Oxidation by “Acidithiomicrobium” Species
- Author
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Davis-Belmar, Carol S. and Norris, Paul R.
- Abstract
Novel iron- and sulfur-oxidizing, moderate thermophiles were isolated from an acidic geothermal site and from a previously studied, pyrite-enrichment mixed culture (which also contained the related actinobacterium Acidimicrobium ferrooxidans). The novel species (proposed genus “Acidithiomicrobium”) grew autotrophically with ferrous iron at an optimum temperature of about 50°C, efficiently degraded pyrite at 55°C and also grew well autotrophically on sulfur. The extensive dissolution of pyrite during autotrophic growth contrasted with a requirement for yeast extract for significant growth of the related Acidimicrobium ferrooxidans.
- Published
- 2009
- Full Text
- View/download PDF
28. Pyrite Oxidation by Halotolerant, Thermotolerant Bacteria
- Author
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Norris, Paul R., Nicolle, James Le C., Calvo-Bado, L., and Angelatou, V.
- Abstract
Thermotolerant “Thiobacillus prosperus”-like bacteria were enriched from warm, acidic sediments of the island of Milos in the Aegean Sea. Analysis of 16S rRNA gene sequences indicated at least two thermotolerant species, with at least one of them present in similar niches at Vulcano, Italy. Iron solubilization in a pyrite-enrichment culture at 47°C was most rapid in the presence of NaCl at 30 g.l 1. One of the novel species (strain M7) grew in pure culture on pyrite with NaCl at 50 g.l-1, but iron solubilization was most rapid with 20 g NaCl.l 1 at just below 50°C.
- Published
- 2009
- Full Text
- View/download PDF
29. Ferrous Iron Oxidation by Salt-Tolerant “Thiobacillus prosperus”
- Author
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Davis-Belmar, Carol S., Nicolle, James Le C., and Norris, Paul R.
- Abstract
Growth on ferrous iron of a new isolate of the halotolerant acidophile “Thiobacillus prosperus” occurred with a substrate oxidation rate similar to that of Acidithiobacillus ferrooxidans, but with a requirement for salt (NaCl). These observations contrast with the previous description of “T. prosperus” in which a salt requirement was not noted and growth on ferrous iron was described as poor. As well as similar capacities for iron oxidation, these species were shown to possess similar clusters of genes (the rus operon) that encode proteins likely to be involved in transfer of electrons from ferrous iron. There were some differences in the organization of the genes and one of them that encodes a cytochrome c in At. ferrooxidans was absent from the “T. prosperus” cluster.
- Published
- 2007
- Full Text
- View/download PDF
30. The Bioshale Project: Search for a Sustainable Way of Exploiting Black Shale Ores Using Biotechnology
- Author
-
D'Hugues, P., Grotowski, A., Luszczkiewicz, A., Sadowski, Zygmunt, Farbiszewska, T., Sklodowska, Aleksandra, Loukola-Ruskeeniemi, K., Langwaldt, Jörg, Palma, J., Norris, Paul R., Glombitza, F., Groudev, Stoyan N., Pasava, J., and Johnson, D. Barrie
- Abstract
The Bioshale project, involving 13 partners throughout Europe, is co-funded by the European Commission under the FP6 program. The main objective of this project (which started in October 2004) is to identify and develop innovative biotechnological processes for ‘’eco-efficient’’ exploitation of metal-rich, black shale ores. Three extensive deposits have been selected for R&D actions. These are: (i) a site (in Talvivaara, Finland) that, at the outset of the project, had not been exploited; (ii) a deposit (in Lubin, Poland) that is currently being actively mined, and (iii) a third site (in Mansfeld, Germany) where the ore had been actively mined in the past, but which is no longer exploited. The black shale ores contain base (e.g. copper and nickel), precious (principally silver) and PGM metals, but also high contents of organic matter that potentially handicap metal recovery by conventional techniques. The main technical aspects of the work plan can be summarized as: (i) evaluation of the geological resources and selection of metal-bearing components; (ii) selection of biological consortia to be tested; (iii) assessment of bioprocessing routes, including hydrometallurgical processing; (iv) techno-economic evaluation of new processes from mining to metal recovery including social, and (v) assessing the environmental impacts of biotechnological compared to conventional processing of the ores. An overview of the main results obtained to date are presented, with special emphasis on the development of bioleaching technologies for metal recovery that can be applied to multielement concentrates and black shale ores.
- Published
- 2007
- Full Text
- View/download PDF
31. Randomized, placebo-controlled trial of the effects of drospirenone-estradiol on blood pressure and potassium balance in hypertensive postmenopausal women receiving hydrochlorothiazide
- Author
-
Preston, Richard A., Norris, Paul M., Alonso, Alberto B., Ni, Pingping, Hanes, Vladimir, and Karara, Adel H.
- Abstract
Drospirenone (DRSP), a spironolactone analog with aldosterone antagonist activity, is a novel progestogen developed for use as hormone therapy in postmenopausal women in combination with 17-estradiol (E2). DRSP/E2lowers blood pressure when used alone in hypertensive postmenopausal women or when administered concomitantly with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. DRSP/E2has not been studied in combination with the widely prescribed hydrochlorothiazide (HCTZ). We investigated the effects of 3 mg DRSP/1 mg E2versus placebo on blood pressure and potassium balance when added to existing therapy with 25 mg HCTZ in postmenopausal women with established stage I hypertension.
- Published
- 2007
- Full Text
- View/download PDF
32. Public Broadcasting in the Digital Age: Issues for Television in New Zealand
- Author
-
Norris, Paul
- Abstract
New Zealand has a unique model of public broadcasting for television. The state broadcaster is almost totally commercial, although since 2003 it has been given a charter and some limited public funding. A state agency, NZ On Air, administers funding contestable between national broadcasters for public broadcasting, meaning in essence local (national) content in the threatened genres of drama, documentary, children's and minority programs. But this system is under challenge from the rise of multi-channel and the transition to digital. Audiences are fragmenting and the combined impact of broadband, the PVR and VOD threaten the notion of the broadcast schedule and the viability of commercial free-to-air television itself. The concluding section of this paper examines issues for the New Zealand model in adapting to the digital challenge, and looks at the criteria on which the model's success or failure may be judged.
- Published
- 2005
- Full Text
- View/download PDF
33. Alterations of the Female Reproductive System in Recipients of Islet Grafts
- Author
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Cure, Pablo, Pileggi, Antonello, Froud, Tatiana, Norris, Paul M., Baidal, David A., Cornejo, Agustin, Hafiz, Muhammad M., Ponte, Gaston, Poggioli, Raffaella, Yu, Jeannie, Saab, Amanda, Selvaggi, Gennaro, Ricordi, Camillo, and Alejandro, Rodolfo
- Abstract
Transplantation of allogeneic tissues is becoming a wider practice for the replacement of organ function lost to congenital or acquired pathologies. Chronic immunosuppression remains a necessity to prevent organ rejection, despite increased risks of infection, organ toxicity, and malignancies. Abnormalities of female gonadal function in patients of reproductive age are recognized, however, pathological alterations of the reproductive system in patients treated with new generation immunosuppressive drugs are still poorly documented.
- Published
- 2004
- Full Text
- View/download PDF
34. Oral manifestations of systemic diseases
- Author
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Swinson, Brian, Witherow, Helen, Norris, Paul, and Lloyd, Tim
- Abstract
In the clinical examination for systemic diseases, inspection of the oral cavity is often overlooked. This area provides a wide array of clinical signs that may help the clinician establish a diagnosis. This article provides a summary of the more common oral manifestations of systemic disease.
- Published
- 2004
- Full Text
- View/download PDF
35. Selenium speciation analysis of selenium-enriched supplements by HPLC with ultrasonic nebulisation ICP-MS and electrospray MSMS detection
- Author
-
Goenaga Infante, Heidi, O’Connor, Gavin, Rayman, Margaret, Wahlen, Raimund, Entwisle, John, Norris, Paul, Hearn, Ruth, and Catterick, Tim
- Abstract
Size-exclusion, anion-exchange and reversed-phase ion-pair RP-IP HPLC were used in combination with ICP-QMS for selenium Se-specific detection and quantitation of Se-compounds in extracts of Se-yeast and Se-methylselenocysteine SeMC based supplements. On-line electrospray ionisation ESI-MSMS combined with RP-IP HPLC allowed characterisation of such materials in terms of species identification. Accelerated solvent extraction ASE was evaluated for extraction of the Se-compounds from the complex matrices in water. Alternatively, digestion with proteolytic enzymes was used for yeast protein hydrolysis. The use of ultrasonic nebulisation in combination with HPLC-ICP-QMS for Se speciation led to detection limits up to six-fold lower as low as ng l−1levels than those obtained with pneumatic nebulisation. Such enhancement of the ICP-MS capabilities for Se detection, combined with an improved separation using the newly developed RP-IP-HPLC method, allowed quantification of minor Se species such as SeMC in yeast extracts. Identification of the main compounds in yeast and SeleniumMC™ tablet hydrolysates as SeMet and SeMC, respectively, was accomplished by on-line RP-IP HPLC with ESI-MSMS. Identification of SeMC in yeast digests, on the basis of retention time, molecular mass determination for the M H 80Se ions mz184 and detection of its product ions, is reported here for the first time. The mass spectral confirmation for SeMC in yeast is of interest, as this species is believed to be metabolised in animals and humans to methylselenol CH3SeH, an anti-carcinogenic Se-metabolite.
- Published
- 2004
- Full Text
- View/download PDF
36. Beyond the Long Good Friday—Reforming the RUC
- Author
-
Norris, Paul
- Abstract
While the Patten Report provides a recent review, policing in Northern Ireland has rarely slipped out of the headlines. This paper offers a brief historical critique of the RUC, and then shows that a significant number of Catholics and Nationalists are unhappy with current policing arrangements. With the Good Friday Agreement there is the possibility of a political settlement in Northern Ireland, which is a necessary condition for the reform of the RUC. The Patten Commission was set up by the Good Friday Agreement and reported on 9 September 1999. There is now an unprecedented opportunity to build a police service acceptable to all the main factions.
- Published
- 2000
- Full Text
- View/download PDF
37. The deep circumflex iliac artery perforator flap (DCIAP)—A reconstructive option for the large composite oro-mandibular cutaneous defect.
- Author
-
Bisase, Brian, Sloane, James, Coombes, Darryl M., and Norris, Paul M.
- Subjects
ILIAC artery ,PERFORATOR flaps (Surgery) ,MANDIBULAR nerve ,FREE flaps ,FACIAL abnormality patients ,PERIOPERATIVE care - Abstract
Abstract: The deep circumflex iliac artery (DCIA) flap is often used for mandibular reconstruction but it is bulky and causes additional donor-site morbidity because of the inclusion of an “obligatory internal oblique muscle”. Large composite segmental mandibular resections that consist of floor of mouth, subtotal tongue, and adjacent facial skin are a challenge in terms of reconstruction. They often require 2 free flaps or a free scapular flap and both have disadvantages. The deep circumflex iliac artery perforator (DCIAP) flap with a cutaneous component overcomes the disadvantages. We describe reconstructions with DCIAP flaps in 3 patients with large mandibular composite segmental defects. We report our experience of the flap and discuss some of the difficulties we encountered and the points we learned perioperatively. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
38. Malakoplakia of the face: A rare but important diagnosis.
- Author
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Coombes, Darryl M., Norris, Paul M., Barrett, A.W., and Brown, Andrew E.
- Subjects
DIAGNOSIS of facial diseases ,INFLAMMATION ,FUNGATING wounds ,HISTOPATHOLOGY ,MEDICAL microbiology ,HEAD diseases ,RARE diseases - Abstract
Abstract: Malakoplakia that presents in the head and neck is rare. We describe a case in a man who presented with a fungating mass in the periauricular skin that was thought to be a malignant tumour. Histopathological and microbiological investigations established a diagnosis of malakoplakia. [Copyright &y& Elsevier]
- Published
- 2010
- Full Text
- View/download PDF
39. Characteristics of a moderately thermophilic and acidophilic iron-oxidizing Thiobacillus
- Author
-
Brierley, James A., Norris, Paul R., Kelly, Donovan P., and Roux, Norman W.
- Abstract
Thiobacillus TH1 is an acidophilic chemolithotrophic heterotroph growing at temperatures up to about 50°C on media containing ferrous iron or pyrite when supplemented with yeast extract or glutathione. Virtually no carbon dioxide fixation occurred during growth on iron with yeast extract. Its DNA contains 48 mol % guanine + cytosine. The organism effects the thermophilic leaching of metals from pyrite, chalcopyrite, CuS, and copper concentrates. Oxidation of soluble ferrous iron at pH 1.6 was competitively inhibited by ferric iron and had a K
m of 7.3 mM FeSO4 .- Published
- 1978
- Full Text
- View/download PDF
40. Mineral sulphide oxidation by moderately thermophilic acidophilic bacteria
- Author
-
Marsh, Rowena and Norris, Paul
- Abstract
Mineral sulphide dissolution during autotrophic growth of moderate thermophiles and the limitation of pyrite and chalcopyrite oxidation by acidity and temperature respectively are described.
- Published
- 1983
- Full Text
- View/download PDF
41. A Histological Study of the Evolution of Solar Urticaria
- Author
-
Norris, Paul G., Murphy, Gillian M., Hawk, John L. M., and Winkelmann, Richard K.
- Abstract
† The histological evolution of solar simulator-induced lesions of solar urticaria was investigated in four severely affected white patients. A series of two to 32 minimal whealing doses of radiation, each much lower than the 24-hour minimal erythema dose, was administered to separate buttock sites. Biopsy specimens were obtained from the exposed areas at five minutes and two and 24 hours later, as well as from adjacent nonexposed skin. Lesions showed a statistically significant dose-dependent increase, predominantly perivascular, in upper dermal neutrophil and eosinophil numbers at five minutes and two hours, but not at 24 hours, and at higher radiation doses in mononuclear cell numbers by 24 hours. Nonirradiated patient skin and irradiated control subject skin was not similarly affected. These changes may be associated with the pathogenesis of solar urticaria.(Arch Dermatol 1988;124:80-83)
- Published
- 1988
- Full Text
- View/download PDF
42. Steric, electronic and solvation effects in the co-ordination of amines by the [Fe(CN)5(OH2)]3- ion
- Author
-
R. Norris, Paul, L. S. Harper, Pascal, and M. Pratt, John
- Abstract
Equilibrium constants K for the substitution of co-ordinated H2O in [FeII(CN)5(OH2)]3- by sterically hindered amines (both α and β branching, viz. NH2Me–NMe3 and NH2Me–NH2But) and by aniline have been determined in aqueous solution with I = 0.1 mol dm-3 (NaClO4) at 25 °C by UV/VIS spectrophotometry. Comparison with published data on the rates of Fe–N bond fission and their further correlation with the energetics of protonation of the free amines shows that the observed variation in log K for aliphatic amines reflects ‘solvation’ as well as more typically steric effects. Aniline differs from the aliphatic amines both in its smaller crystal-field splitting (shared by other aromatic amines) and a low value of log K comparable to that of NMe3.
- Published
- 1997
- Full Text
- View/download PDF
43. Interactions of thiophenes and acidophilic, thermophilic bacteria
- Author
-
Constanti, Magda, Giralt, Jaume, Bordons, Albert, and Norris, Paul R.
- Abstract
The growth and oxygen consumption of a variety of thermophilic, acidophilic bacteria in the presence of thiophene-2-carboxylate (T2C) and dibenzothiophene (DBT) have been determined. T2C was extremely toxic to the acidophiles in comparison with neutrophiles, but appeared to be degraded by a heterotrophicSulfolobus- likethermophile. DBT proved to be unstable at high temperatures, even in the absence of bacteria, and was not a substrate for the thermophiles.
- Published
- 1992
- Full Text
- View/download PDF
44. Reviews
- Author
-
Nichol, Chris, Roscoe, Jane, Winter, Pahmi, and Norris, Paul
- Abstract
Can there be peace of mind in the dominion of signs?Review of Nick Perry, The Dominion of Signs, Auckland: Auckland University Press, 1994, 162pp, ISBN 1 86940 100 X.National preoccupationsReview of Claudia Bell Inventing New Zealand: Everyday Myths ofPakeha Identity, Auckland: Penguin Books, 1996, 208pp, 15 B&W plates ISBN 0 140 24496 4An ailing public sphereReview of Judy McGregor (ed) Dangerous Democracy? News Media Politics In New Zealand, Palmerston North: Dunmore Press, 1996, 250pp, ISBN 0 064 69259 5.Telling tales of a television revolutionReview of Paul Smith Revolution in the Air, Auckland, Addison Wesley Longman, 1996, 166pp, ISBN 0 582 87810 1.
- Published
- 1996
- Full Text
- View/download PDF
45. Toxicity and accumulation of thallium in bacteria and yeast
- Author
-
Norris, Paul, Man, Wing Kee, Hughes, Martin N., and Kelly, Donovan P.
- Abstract
Thallium sulphate inhibited microbial growth, withBacillus megaterium KM, more sensitive to the metal thanSaccharomyces cerevisiae andEscherichia coli. Inhibition ofB. megaterium KM andS. cerevisiae, but not ofE. coli, was alleviated by increasing the potassium concentration of the medium; inhibition of respiration ofS. cerevisiae, but not ofE. coli, was similarly alleviated. Thallium was rapidly bound, presumably to cell surfaces, byS. cerevisiae andE. coli, and was progressively accumulated by energy-dependent transport systems (probably concerned primarily with potassium uptake) with both organisms. Thallium uptake kinetics suggested more than one transport system operated in yeast, possibly reflecting a multiplicity of potassium transport systems. ApparentK
m andKi values for competitive inhibition of thallium uptake by potassium indicatedS. cerevisiae to have a higher affinity for thallium uptake than for potassium, whileE. coli had a transport system with a higher affinity for potassium than for thallium. The likely systems for thallium transport are discussed. A mutant ofE. coli with tenfold decreased sensitivity to thallium was isolated and apparently effected surface binding of thallium in amounts equivalent to the wild type organism, but showed no subsequent uptake and accumulation of the metal from buffer, even though it was able to accumulate potassium to normal intracellular concentrations during growth.- Published
- 1976
- Full Text
- View/download PDF
46. Giving a Practitioner's Viewpoint, to a Recent Cadmus Education Foundation Session of “Edp Audit and Control III”
- Author
-
Norris, Paul
- Published
- 1973
- Full Text
- View/download PDF
47. Pro-resolving lipid mediator lipoxin A4attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome
- Author
-
Derada Troletti, Claudio, Enzmann, Gaby, Chiurchiù, Valerio, Kamermans, Alwin, Tietz, Silvia Martina, Norris, Paul C., Jahromi, Neda Haghayegh, Leuti, Alessandro, van der Pol, Susanne M.A., Schouten, Marijn, Serhan, Charles N., de Vries, Helga E., Engelhardt, Britta, and Kooij, Gijs
- Abstract
The chronic neuro-inflammatory character of multiple sclerosis (MS) suggests that the natural process to resolve inflammation is impaired. This protective process is orchestrated by specialized pro-resolving lipid mediators (SPMs), but to date, the role of SPMs in MS remains largely unknown. Here, we provide in vivoevidence that treatment with the SPM lipoxin A4(LXA4) ameliorates clinical symptoms of experimental autoimmune encephalomyelitis (EAE) and inhibits CD4+and CD8+T cell infiltration into the central nervous system (CNS). Moreover, we show that LXA4potently reduces encephalitogenic Th1 and Th17 effector functions, both in vivoand in isolated human T cells from healthy donors and patients with relapsing-remitting MS. Finally, we demonstrate that LXA4affects the spinal cord lipidome by significantly reducing the levels of pro-inflammatory lipid mediators during EAE. Collectively, our findings provide mechanistic insight into LXA4-mediated amelioration of neuro-inflammation and highlight the potential clinical application of LXA4for MS.
- Published
- 2021
- Full Text
- View/download PDF
48. It's only a game.
- Author
-
Boswell, Don, O'Dwyer, Luke, Harrison, Helen, Gerard, Pip, Clark, Fraser, Rakovic, Zoran, Fisher, Graeme, Marsh, Brian, Norris, Paul, Hood, Ronald, Macaulay, Genna, Morris, Diane, Moiseiwitsch, Boris, and Money, Keith
- Abstract
Several letters to the editor are presented in response to articles in previous issue including "Black beauty," by Don Boswell in the January 27, 2007 issue, "My big fat Australian dollar," in the January 20, 2007 issue by Luke O'Dwyer, and "It's your deal," by Brian Marsh in the January 27, 2007 issue.
- Published
- 2007
49. LETTERS.
- Author
-
Macdonald, J., Lane, Bredon, Millanta, Clive, Duncan, John, Burgess, Barry, Moss, Maggle, Corby, Phillipa, Norris, Paul, Fenaughty, John, Wilson, Derek J., McCarthy, David, Conway, Lucy, Glendenning, Yvonne, Griffin, John, and Hill, David
- Abstract
Several letters to the editor are presented in response to articles in previous issues including "Class Action," which appeared in the October 28, 2006 issue, "Well in Proportion," published in the October 14, 2006 issue and "A Clown Like Ellis," by Marc Ellis which appeared in the October 21, 2006 issue.
- Published
- 2006
50. Acute vs late extracranial facial nerve branch(s) repair: A comparative study.
- Author
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Hills, Alexander, Bisase, Brian, Norris, Paul, Kapoor, Karan, Shelley, Mike, Nduka, Charles, and Kannan, Ruben
- Subjects
FACIAL nerve ,COMPARATIVE studies ,NERVE grafting ,TWO-way analysis of variance - Published
- 2019
- Full Text
- View/download PDF
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