Search

Neuropathic pain is a major public health problem because it has a considerable impact on life quality of patients. Neuropathic pain caused by a lesion or disease of the somatosensory nervous system, which causes unpleasant and abnormal sensation (dysesthesia), an increased response to painful stimuli (hyperalgesia), and pain in response to a stimulus that does not normally provoke pain (allodynia). P2X receptors from dorsal root ganglion (DRG) play a crucial role in facilitating pain transmission at peripheral and spinal sites. Resveratrol (Res) has neuroprotective effects and improves the pathological and behavioral outcomes of various types of nerve injury. The present study examined the effects of Res on neuropathic pain. Neuropathic pain animal model was created by partial sciatic nerve ligation (pSNL) surgery. We found that consecutive intraperitoneal administration of Res for 21 days reduced the mechanical and thermal nociceptive responses induced by pSNL in a dose-dependent manner. Moreover, Res administration reversed P2X3 expression and phosphorylation of ERK in DRG neurons after peripheral nerve injury. Our results suggested that Res may ameliorate neuropathic pain by suppressing P2X3 up-regulation and ERK phosphorylation in DRG of neuropathic pain rats. Therefore, we concluded that Res has a significant analgesic effect on alleviating neuropathic pain, and thus may serve as a therapeutic approach for neuropathic pain.

Baotoudong syenite pluton is located to the east of Baotou City, Inner Mongolia, the westernmost part of the Triassic alkaline magmatic belt along the northern margin of the North China Craton (NCC). Zircon U-Pb age, petrological, mineralogical and geochemical data of the pluton were obtained in this paper, to constrain its origin and mantle source characteristics. The pluton is composed of nepheline-clinopyroxene syenite and alkali-feldspar syenite, with zircon U-Pb age of 214.7±1.1 Ma. Diopside (cores)-aegirine-augite (rims), biotite, orthoclase and nepheline are the major minerals. The Baotoudong syenites have high contents of rare earth elements (REE), and are characterized by enrichment in light rare earth elements (LREE) and large ion lithophile elements (LILE; e.g., Rb, Ba, Sr), depletion in heavy rare earth elements (HREE) and high field strength elements (HFSE). They show enriched Sr-Nd isotopic compositions with initial 87Sr/86Sr ranging from 0.7061 to 0.7067 and εNd(t) values from–9.0 to–11.2. Mineralogy, petrology and geochemical studies show that the parental magma of the syenites is SiO2-undersaturated potassic-ultrapotassic, and is characterized by high contents of CaO, Fe2O3, K2O, Na2O and fluid compositions (H2O), and by high temperature and high oxygen fugacity. The syenites were originated from a phlogopite-rich, enriched lithospheric mantle source in garnet-stable area (>80 km). The occurrence of the Baotoudong syenites, together with many other ultrapotassic, alkaline complexes of similar ages on the northern margin of the NCC in Late Triassic implies that the lithospheric mantle beneath the northern margin of the NCC was previously metasomatized by melts/fluids from the subducted, altered paleo-Mongolian oceanic crust, and the northern margin of the craton has entered into an extensively extensional regime as a destructive continental margin in Late Triassic.

The Yaojiazhuang ultramafic-syenitic complex is one of the representative Triassic alkaline plutons on the northern margin of the North China Craton (NCC). Based on detailed study of the zircon U-Pb age, petrological, mineralogical, and geochemical data of the complex, the characteristics of the magmas system, the petrogenesis of different rock types, and the nature of the mantle source were discussed to provide new constraints on the origin and tectonic setting of the Triassic alkaline belt. Cumulus ultramafic rocks, clinopyroxene-syenites and syenites are the main rock types of the complex. The zircons from the syenites yielded a U-Pb age of 209 Ma. Diopside-augite, biotite, and sanidine-orthoclase are the major minerals, with subordinate apatite and magnetite. Rocks from the complex are enriched in large ion lithophile elements (LILE) and light rare earth elements (LREE), depleted in high field strength elements (HFSE) and heavy rare earth elements (HREE), and the initial 87Sr/86Sr ranges from 0.7057 to 0.7061 and ɛNd(t) from −9.4 to −11.4. Mineralogy and geochemical data demonstrate that the parent magma of the complex is SiO2-undersaturated ultrapotassic alkaline-peralkaline, and is characterized by high CaO content and fluid compositions (P2O5, CO2, H2O), and by high oxygen fugacity and high temperature. The complex was originated from a phlogopite-clinopyroxenite-rich lithospheric mantle source in the garnet-stable area (> 80 km) that had previously been metasomatized by melts/fluids from altered oceanic crust. The parent magma has been contaminated by little ancient TTG gneisses during magma emplacement. The development of the Yaojiazhuang complex indicates that the northern margin of the NCC has entered into an extensively extensional regime in the Late Triassic.

The main rock types of the Boluonuo and Daguangding plutons are diorite, quartz diorite, tonalite, granodiorite, and subordinate plagioclase-bearing hornblendite and hornblende gabbro. Zircon SHRIMP U-Pb dating for a quartz diorite of the Boluonuo pluton suggests that the pluton was emplaced at about 296 ± 4 Ma. Plagioclase-bearing hornblendites show typical cumulative textures, which, in combination with their convex-upward REE patterns and the large variation of compatible elements such as Co, V and Sc, suggests that these hornblendites formed through accumulation of hornblende during magma evolution. Microgranular mafic enclaves (MMEs) are common in the Boluonuo and Daguangding intermediate to felsic plutons. Many plagioclase grains show compositional and textural disequilibrium, with calcium-rich cores (An46–50) mantled abruptly by sodium-rich plagioclase (An26–33). Whole-rock samples of the plutons are characterized by quite negative ?Nd(t) values (-16.5 to -11.8) and ?Hf(t) values (-22.5 to -16.8), and the ?Nd(t) values are negatively correlated with silica contents. All these features suggest that the intermediate to felsic plutons formed through magma mixing of enriched mantle-derived, evolved basaltic magma with granitic, crustal melts, followed by fractional crystallization of mainly hornblende and small amounts of pyroxene, apatite and zircon. The hornblende-dominated fractionation contributed significantly to the adakite-like features of the intermediate to felsic plutons, like the high Sr and Sr/Y ratios and low Yb abundance. In addition, the Boluonuo and Daguangding plutons are highly enriched in LILEs (e.g., Ba and Sr), but depleted in HFSEs (e.g., Nb, Zr and Ti), which is typical of arc magmas. Therefore, the formation of Boluonuo and Daguangding plutons was probably related to the subduction of the Paleo-Asian oceanic slab beneath the North China Craton in the Paleozoic.The main rock types of the Boluonuo and Daguangding plutons are diorite, quartz diorite, tonalite, granodiorite, and subordinate plagioclase-bearing hornblendite and hornblende gabbro. Zircon SHRIMP U-Pb dating for a quartz diorite of the Boluonuo pluton suggests that the pluton was emplaced at about 296 ± 4 Ma. Plagioclase-bearing hornblendites show typical cumulative textures, which, in combination with their convex-upward REE patterns and the large variation of compatible elements such as Co, V and Sc, suggests that these hornblendites formed through accumulation of hornblende during magma evolution. Microgranular mafic enclaves (MMEs) are common in the Boluonuo and Daguangding intermediate to felsic plutons. Many plagioclase grains show compositional and textural disequilibrium, with calcium-rich cores (An46–50) mantled abruptly by sodium-rich plagioclase (An26–33). Whole-rock samples of the plutons are characterized by quite negative ?Nd(t) values (-16.5 to -11.8) and ?Hf(t) values (-22.5 to -16.8), and the ?Nd(t) values are negatively correlated with silica contents. All these features suggest that the intermediate to felsic plutons formed through magma mixing of enriched mantle-derived, evolved basaltic magma with granitic, crustal melts, followed by fractional crystallization of mainly hornblende and small amounts of pyroxene, apatite and zircon. The hornblende-dominated fractionation contributed significantly to the adakite-like features of the intermediate to felsic plutons, like the high Sr and Sr/Y ratios and low Yb abundance. In addition, the Boluonuo and Daguangding plutons are highly enriched in LILEs (e.g., Ba and Sr), but depleted in HFSEs (e.g., Nb, Zr and Ti), which is typical of arc magmas. Therefore, the formation of Boluonuo and Daguangding plutons was probably related to the subduction of the Paleo-Asian oceanic slab beneath the North China Craton in the Paleozoic.