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SAFE-UP is a research project funded by the European Commission, that aims to proactively address the novel safety challenges of future road mobility environment, by developing tools and innovative safety methods leading to improvements in road traffic safety, which are addressed by four demonstrators. This paper focuses on Demonstrator 4, which develops a safety system based on Cooperative Intelligent Transport Systems (C-ITS) technology that provides enhanced communication between vehicles, road infrastructure and vulnerable road users (VRU). This demonstrator aims at: (i) the provision of timely warnings which could support in avoiding safety-critical situations between passenger cars and VRUs, (ii) the engagement of an active safety system in cases where the reaction time is limited. This paper presents the method followed to characterize the selected scenarios for Demonstrator 4.

Earlier detection of colorectal cancer (CRC) results in improved survival. Existing non-invasive biomarkers have suboptimal accuracy. Neurotensin (NTS) is involved in CRC carcinogenesis. This study evaluated the diagnostic potential of plasma NTS for colorectal polyps and cancers. Participants were selected based on national CRC referral guidelines. All subjects underwent colonoscopy. Average plasma concentrations were compared across different diagnostic groups. Predictors for detecting colorectal neoplasia were identified. Receiver operator characteristic (ROC) curve analysis assessed the diagnostic accuracy of NTS. An independent biobank was used as validation group. Of 165 participants, 46 had polyps or CRC. Significantly higher plasma NTS was found in the colonic neoplasia group (603.6 pg/ml vs. 407.2 pg/ml, p< 0.01). Risk factors for colonic polyps or cancers included Loge(plasma NTS concentration) (OR, 2.73; 95% CI, 1.33–5.59, p< 0.01), loge(Age) (OR, 15.49; 95% CI, 2.67–89.66, p< 0.01) and cigarette smoking (OR, 3.49; 95% CI, 1.31–9.26, p= 0.01). Plasma NTS had an optimal sensitivity of 60.4% and specificity of 71.6% for the diagnosis of colorectal polyps and cancers. Similar diagnostic accuracy was obtained in the validation group. Plasma NTS has the potential to be a non-invasive biomarker for colorectal neoplasia. It appears to be more accurate than existing blood markers and is unique in being able to detect precancerous polyps.

There is an ever-growing need, with the ongoing developments in research and the progress towards patient centered care, to delineate standardized protocols of management of anal cancer. However, guidelines from different societies show some degree of disagreement. This is a systematic review of the literature to identify similarities and discrepancies between the guidelines for the management of anal cancer drafted by the European Society for Medical Oncology (ESMO) and by the National Comprehensive Cancer Network (NCCN). We found essentially similar management for investigation, diagnosis, chemotherapy regimens, and radiotherapy doses in both ESMO and NCCN recommendations in the management of anal cancer. There were few differences, which included the levels of evidence and grades of recommendations, the delineation of radiotherapy fields, and the treatment of the elderly and personalized medicine based on genetics. The follow-up regime is also marginally different in the first 2 years. Even if the observed differences may be justified by a different implementation of evidence-based medicine among different countries for particular management modalities of anal cancer, we identified the grey areas which need further study. In addition, these facets should be assessed more carefully when planning future guidelines.

The study aimed to investigate the potential of In-Vehicle Information Systems (IVIS) integration on motorcycles for the most crucial functionalities and develop efficient and rider-friendly interfaces and interaction elements for riders comfort and safety. The main objectives were to estimate the safety impact and user acceptance of the prototypes in a series of pilot applications within the SAFERIDER project.

This document describes the results of the research study from accident data analysis to a wide user survey with over 512 users from 10 European countries from which the actual needs and use cases for driver hypovigilance diagnosis were drawn. Relevant issues range from experience with relevant incidents to willingness to have, willingness to pay and warning modalities preferences. Data are presented per total sample, as well as per key subgroup of users. They are compared with the actual functionality of existing systems and prototypes, concluding b a system definition that optimally combines user acceptance with user needs. This work formed the basis for the functionality of AWAKE system.