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The explanation and control of phase transitions remain cornerstones of contemporary physics. Landau provided an invaluable insight into the thermodynamics of complex systems by formulating their phase transitions in terms of an order parameter. Within this formulation, continuous evolution of the order parameter away from zero classifies the phase transition as second-order, whereas a discontinuous change signals a first-order transition. Here we show that the temperature-tuned insulator–metal transition in the prototypical correlated electron system NdNiO3defies this established binary classification. By harnessing a nanoscale optical probe of the local electronic conductivity, we reveal two physically distinct yet concurrent phase transitions in epitaxial NdNiO3films. Whereas the sample bulk exhibits a first-order transition between metal and insulator phases, we resolve anomalous nanoscale domain walls in the insulating state that undergo a distinctly continuous insulator–metal transition, with hallmarks of second-order behaviour. We ascribe these domain walls to boundaries between antiferromagnetically ordered domains within the charge ordered bulk. The close correspondence of these observations to predictions from a Landau theory of coupled charge and magnetic orders highlights the importance of coupled order parameters in driving the complex phase transition in NdNiO3. A phase transition between metallic and insulating states is observed to simultaneously happen in two ways at once. The bulk of the sample shows an instantaneous jump in the conductivity, while 1D domain walls show a slow switching into a metallic state.

Plasmon polaritons are hybrid excitations of light and mobile electrons that can confine the energy of long-wavelength radiation at the nanoscale. Plasmon polaritons may enable many enigmatic quantum effects, including lasing1 , topological protection2,3and dipole-forbidden absorption4 . A necessary condition for realizing such phenomena is a long plasmonic lifetime, which is notoriously difficult to achieve for highly confined modes5 . Plasmon polaritons in graphene—hybrids of Dirac quasiparticles and infrared photons—provide a platform for exploring light–matter interaction at the nanoscale6,7. However, plasmonic dissipation in graphene is substantial8 and its fundamental limits remain undetermined. Here we use nanometre-scale infrared imaging to investigate propagating plasmon polaritons in high-mobility encapsulated graphene at cryogenic temperatures. In this regime, the propagation of plasmon polaritons is primarily restricted by the dielectric losses of the encapsulated layers, with a minor contribution from electron–phonon interactions. At liquid-nitrogen temperatures, the intrinsic plasmonic propagation length can exceed 10 micrometres, or 50 plasmonic wavelengths, thus setting a record for highly confined and tunable polariton modes. Our nanoscale imaging results reveal the physics of plasmonic dissipation and will be instrumental in mitigating such losses in heterostructure engineering applications. The fundamental limits to plasmon damping in graphene are determined using nanoscale infrared imaging at cryogenic temperatures, and plasmon polaritons are observed to propagate over 10 micrometres in high-mobility encapsulated graphene.

AbstractBackground:Circulating miRNAs are potential biomarkers of the pathogenesis of certain diseases and in monitoring therapeutic responses. We hypothesized that serum miR-29 can determine risk of acute cardiac allograft rejection.Methods:Peripheral vein blood was collected from 50 healthy volunteers and 506 patients during post-transplant surveillance. Serum cardiac troponin I (cTnI) and miR-29 was detected by ELISA and qRT-PCR assay respectively. Rejection risk was defined as International Society of Heart and Lung Transplant score from leukocyte infiltration of an endomyocardial biopsy. No evidence of rejection was defined as grade R0, mild as R1, moderate as 2R and severe as 3R. Specificity and sensitivity of miR-29 to discriminate rejection was determined by the area under the curve (AUC) of receiver operating characteristic curve analysis. Correlations between miR29 and rejection grade were compared.Results:Serum miR-29 was 100.8 ± 42.4 copies/μl in R0 groups (P = 0.164 versus controls), 537.5 ± 84.3 copies/μl in R1 groups (P = 0.024) and 1478.4 ± 198.7 copies/μl in the joint R2/R3 groups (P = 0.001). MiR-29 was 1963.5 ± 214.7 six months after transplantation, 1242.5 ± 103.8 after a year, 825.6 ± 58.2 after 2 years, 413.8 ± 61.9 after 3 years and 270.6 ± 34.6 ng/mL after 4 years (P < 0.001). The level of miR-29 correlated positively with cTnI, NT-proBNP, white blood cell counts, and negatively with lymphocyte counts (all P < 0.001). The AUC values (95% CI) for discriminating R0 and R1 was 0.81 (0.75–0.89), and was 0.79 (0.72–0.86) for R0 and R2/R3 (both P < 0.01).Conclusion:miR-29 is a promising predictor of the risk of heart transplant rejection.

The success of metal-based plasmonics for manipulating light at the nanoscale has been empowered by imaginative designs and advanced nano-fabrication. However, the fundamental optical and electronic properties of elemental metals, the prevailing plasmonic media, are difficult to alter using external stimuli. This limitation is particularly restrictive in applications that require modification of the plasmonic response at sub-picosecond timescales. This handicap has prompted the search for alternative plasmonic media, with graphene emerging as one of the most capable candidates for infrared wavelengths. Here we visualize and elucidate the properties of non-equilibrium photo-induced plasmons in a high-mobility graphene monolayer. We activate plasmons with femtosecond optical pulses in a specimen of graphene that otherwise lacks infrared plasmonic response at equilibrium. In combination with static nano-imaging results on plasmon propagation, our infrared pump–probe nano-spectroscopy investigation reveals new aspects of carrier relaxation in heterostructures based on high-purity graphene.

CP-690?550 inhibits Janus kinase 3 with nanomolar potency. In this dose-escalation study, we assessed the safety, tolerability, effects on lymphocyte subsets, and pharmacokinetics of CP-690?550 when coadministered with mycophenolate mofetil in stable renal allograft recipients for 28 days. Twenty-eight patients were enrolled. Six patients received CP-690?550 5 mg twice daily (BID), 6 patients received 15 mg BID, 10 patients received 30 mg BID, and 6 patients received placebo. The most frequent adverse events were infections and gastrointestinal (abdominal pain, diarrhea, dyspepsia, and vomiting). CP-690?550 15 mg BID and 30 mg BID were associated with a mean decrease in hemoglobin from baseline of 11 and a mean decrease in absolute natural killer cell counts of 50. CP-690?550 30 mg BID was also associated with a mean increase in absolute CD19B-lymphocytes of 130. There were no changes in the number of neutrophils, total lymphocytes, platelets, or CD4or CD8T cells; clinical chemistry; vital signs; or electrocardiograms from the pretreatment baseline. Administration of CP-690?550 without a concomitant calcineurin inhibitor resulted in CP-690?550 exposures consistent with previous studies in nontransplant subjects. Additional dose-ranging studies are warranted to evaluate the safety and efficacy of CP-690?550 in renal transplant recipients over longer treatment duration.

CP-690 550 inhibits Janus kinase 3 with nanomolar potency. In this dose-escalation study, we assessed the safety, tolerability, effects on lymphocyte subsets, and pharmacokinetics of CP-690 550 when coadministered with mycophenolate mofetil in stable renal allograft recipients for 28 days. Twenty-eight patients were enrolled. Six patients received CP-690 550 5 mg twice daily (BID), 6 patients received 15 mg BID, 10 patients received 30 mg BID, and 6 patients received placebo. The most frequent adverse events were infections and gastrointestinal (abdominal pain, diarrhea, dyspepsia, and vomiting). CP-690 550 15 mg BID and 30 mg BID were associated with a mean decrease in hemoglobin from baseline of 11% and a mean decrease in absolute natural killer cell counts of 50%. CP-690 550 30 mg BID was also associated with a mean increase in absolute CD19+B-lymphocytes of 130%. There were no changes in the number of neutrophils, total lymphocytes, platelets, or CD4+or CD8+T cells; clinical chemistry; vital signs; or electrocardiograms from the pretreatment baseline. Administration of CP-690 550 without a concomitant calcineurin inhibitor resulted in CP-690 550 exposures consistent with previous studies in nontransplant subjects. Additional dose-ranging studies are warranted to evaluate the safety and efficacy of CP-690 550 in renal transplant recipients over longer treatment duration.

The inverted parabola remains an exactly solvable tunneling barrier when imaginary parts are added to the potential. They represent the effect of particle absorption. In the limit of strong absorption (“opaque barrier”) convenient limiting forms for the tunneling probability are derived using asymptotic expansions of the exact scattering solution. An application to Zener tunneling is made and the result is compared to the case of tunneling under viscous dissipation. Significant differences are found between these two approaches to tunneling under dissipation.

The singular behaviour of the electrostatic dipole field is compared with that of the magnetostatic one, with pedagogical access to the difference between the two established without necessarily resorting to certain advanced differentiation identities involving delta functions. Such an approach may be more suitable for a regular curriculum in electrodynamics.