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1. Non-Invasive Imaging Techniques for Diagnosis of Pelvic Deep Endometriosis and Endometriosis Classification Systems: An International Consensus Statement.

Author

Condous, George, Gerges, Bassem, Thomassin-Naggara, Isabelle, Becker, Christian M., Tomassetti, Carla, Krentel, Harald, van Herendael, Bruno J., Malzoni, Mario, Abrao, Mauricio S., Saridogan, Ertan, Keckstein, Joerg, and Hudelist, Gernot

Abstract

The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) and International Deep Endometriosis Analysis (IDEA) group, the European Endometriosis League (EEL), the European Society for Gynaecological Endoscopy (ESGE), the European Society of Human Reproduction and Embryology (ESHRE), the International Society for Gynecologic Endoscopy (ISGE), the American Association of Gynecologic Laparoscopists (AAGL) and the European Society of Urogenital Radiology (ESUR) elected an international, multidisciplinary panel of gynecological surgeons, sonographers and radiologists, including a steering committee, which searched the literature for relevant articles in order to review the literature and provide evidence-based and clinically relevant statements on the use of imaging techniques for non-invasive diagnosis and classification of pelvic deep endometriosis. Preliminary statements were drafted based on review of the relevant literature. Following two rounds of revisions and voting orchestrated by chairs of the participating societies, consensus statements were finalized. A final version of the document was then resubmitted to the society chairs for approval. Twenty statements were drafted, of which 14 reached strong and three moderate agreement after the first voting round. The remaining three statements were discussed by all members of the steering committee and society chairs and rephrased, followed by an additional round of voting. At the conclusion of the process, 14 statements had strong and five statements moderate agreement, with one statement left in equipoise. This consensus work aims to guide clinicians involved in treating women with suspected endometriosis during patient assessment, counseling and planning of surgical treatment strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Impact of Day 1 carotid patency on outcome in dissection-related tandem occlusions treated with mechanical thrombectomy

Author

Perrin, Guillaume, Molinier, Elisabeth, Gory, Benjamin, Kyheng, Maeva, Labreuche, Julien, Pasi, Marco, Janot, Kevin, Bourcier, Romain, Sibon, Igor, Consoli, Arturo, Desilles, Jean-Philippe, Olivot, Jean-Marc, Papagiannaki, Chrysanthi, Soize, Sebastien, Gentric, Jean-Christophe, Dargazanli, Cyril, Caroff, Jildaz, Pop, Raoul, Naggara, Olivier, Moulin, Solene, Eker, Omer, Alias, Quentin, Clarençon, Frederic, Lapergue, Bertrand, and Marnat, Gaultier

Abstract

The clinical benefit of mechanical thrombectomy(MT) for stroke patients with tandem occlusion is similar to that of isolated intracranial occlusions. However, the management of cervical internal carotid artery(ICA) occlusion during the MT, particularly in the setting of carotid dissection, remains controversial. We aimed to investigate the clinical impact of cervical ICA patency at day 1 on 3-month functional outcome.

Published
2024
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5. Effects of weather conditions on endovascular treatment case volume for patients with ischemic stroke

Author

Malka, David, Janot, Kevin, Pasi, Marco, Desilles, Jean-Philippe, Marnat, Gaultier, Sibon, Igor, Consoli, Arturo, Dargazanli, Cyril, Arquizan, Caroline, Gory, Benjamin, Richard, Sébastien, Naggara, Olivier, Clarençon, Frédéric, Rosso, Charlotte, Bourcier, Romain, Eker, Omer, Caroff, Jildaz, Lapergue, Bertrand, and Boulouis, Grégoire

Abstract

Weather conditions have been shown to influence the occurrence of cardiovascular events. We tested the hypothesis that weather parameters may be associated with variations of case volume of endovascular treatment (EVT) for acute ischemic stroke.

Published
2023
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7. Resolution of Pain after Percutaneous Image-Guided Cryoablation of Extraperitoneal Endometriosis.

Author

Najdawi, Milan, Razakamanantsoa, Leo, Mousseaux, Cyril, Bendifallah, Sofiane, Touboul, Cyril, Thomassin-Naggara, Isabelle, Bazot, Marc, Barral, Matthias, and Cornelis, Francois H.

Abstract

To retrospectively evaluate the relief of pain after percutaneous image-guided cryoablation of symptomatic extraperitoneal endometriosis (EE). From 2017 to 2022, cryoablation of EE was performed at a single institution on a total of 47 lesions in 42 consecutive patients (median age, 37 years; interquartile range [IQR], 33–39.5 years). Patient and procedural characteristics were reviewed retrospectively. Tolerance and outcomes in terms of pain and patient satisfaction were evaluated. The median follow-up duration was 13.5 months (IQR, 1.1–37.7 months) after cryoablation. The median pain-free survival rate was 93.8% (95% confidence interval [CI], 77.3–98.4) at 6 months and 82.7% (95% CI, 58.8–93.5) after 12 months. Pain decreased from a median of 8/10 (IQR, 7–9) on the visual analog scale to 0/10 (IQR, 0–1) at the last follow-up (P <.0001). The median Patient Global Impression of Change score recorded at the last follow-up was 1/7 (IQR, 1–2). The efficacy rate of cryoablation to avoid secondary surgery was 92.8% (39/42) per patient and 93.6% (44/47) per nodule treated. Four patients (9.5%, 4/42) experienced an adverse event in the days following the procedure, and 1 patient (2%) experienced a severe adverse event. Percutaneous cryoablation is safe and effective in significantly reducing pain and obtaining local control of EE. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
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9. Malformaciones vasculares cerebrales en niños

Author

Vergnaud, E., Terzi, E., Blauwblomme, T., Naggara, O., Boulouis, F.G., and Meyer, P.G.

Abstract

Las malformaciones arteriovenosas (MAV) son anomalías congénitas que consisten en una conexión anormal entre arterias y venas cerebrales a través de neovasos. El 3-20% de las MAV se revelan en la infancia por una hemorragia cerebral, convulsiones o cefaleas, o en pruebas de imagen efectuadas por otro motivo en un paciente asintomático. Las malformaciones aneurismáticas de la vena de Galeno (MAVG) representan más del 80% de las MAV en niños menores de 2 años. Pueden tener consecuencias hemodinámicas sistémicas y cerebrales que varían en función de la importancia de la derivación arteriovenosa. El diagnóstico se efectúa en el recién nacido o el lactante de pocos meses, o en el período intrauterino. Las MAVG requieren un tratamiento multidisciplinario, que depende de la edad en el momento del diagnóstico y de la repercusión de la malformación. Las fístulas arteriovenosas piales se desarrollan sobre todo durante la infancia y la edad adulta, rara vez en el período intrauterino. También pueden tener consecuencias hemodinámicas sistémicas y cerebrales. A diferencia de las MAVG, el tratamiento endovascular debe efectuarse tan pronto como se establezca el diagnóstico. Las malformaciones de los senos durales rara vez tienen repercusiones sistémicas y dan lugar a manifestaciones clínicas relacionadas con un defecto del drenaje venoso cerebral. El diagnóstico es prenatal en alrededor del 25% de los casos. El tratamiento endovascular se lleva a cabo en torno a los 4-5 meses de edad o antes si existen factores de mal pronóstico. Las MAV parenquimatosas se diagnostican en menos del 20% de los casos en la infancia. Pueden revelarse por convulsiones o cefaleas, pero la hemorragia cerebral por ruptura es la primera manifestación. La ruptura de una MAV asociada a un coma es una urgencia medicoquirúrgica absoluta.

Published
2023
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10. Surgical and Percutaneous Image-Guided Therapies of Abdominal Wall Endometriosis: A Systematic Review of Current Evidence.

Author

Razakamanantsoa, Leo, Bodard, Sylvain, Najdawi, Milan, Dabi, Yohann, Bendifallah, Sofiane, Touboul, Cyril, Lehrer, Raphael, Agbonon, Remi, Di Giuseppe, Raphael, Barral, Matthias, Bazot, Marc, Brun, Jean-Luc, Roman, Horace, Marcelin, Clement, Thomassin-Naggara, Isabelle, and Cornelis, Francois H.

Abstract

Despite various surgical and nonsurgical strategies for abdominal wall endometriosis, the lack of definitive guidance on optimal treatment choice leads to clinical uncertainty. This review scrutinizes the safety and efficacy of abdominal wall endometriosis treatments to aid in decision-making. We performed a systematic literature review of PubMed, Embase, and Cochrane Library databases from 1947 until December 2023. A comprehensive literature search identified studies that assessed both surgical and nonsurgical interventions, including high-intensity focused ultrasound (HIFU), cryoablation, radiofrequency ablation, and microwave ablation. This review is registered in NIHR-PROSPERO (CRD 42023494969). Local tumor control (LTC), local pain relief (LPR), and adverse events (AE) were recorded. This review included 51 articles among 831 identified. All study designs were considered eligible for inclusion. A total of 2674 patients are included: 2219 patients (83%) undergoing surgery, and 455 (17%) undergoing percutaneous interventions (342 HIFU, 103 cryoablation, 1 radiofrequency ablation, 9 microwave ablation). Follow-up length was 18 months in median, ranging from 1 to 235 months. Overall LTC rates ranged from 86% to 100%. Surgical interventions consistently demonstrated the highest rate of LTC with a median rate of 100%, and LPR with a median rate of 98.2% (95% confidence interval [CI]: 93.9–97.7). HIFU showed median LTC and LPR rates, respectively of 95.65% (95% CI, 87.7–99.9) and 76.1% (95% CI, 61.8–90.4); and cryoablation of 85.7% (95% CI, 66.0–99.9) and 79.2% (95% CI, 67.4–91.03). Minor AE was reported after surgery in 17.5% of patients (225/1284) including 15.9% (199/1284) of mesh implantation; 76.4% (239/313) after HIFU; and 8.7% (9/103) after cryoablation. Severe AE was reported in 25 patients in the surgery group and 1 in the percutaneous group. The safety profile and efficacy of nonsurgical interventions support their clinical utility for management of abdominal wall endometriosis. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

Author

Bakker, Mark K., Kanning, Jos P., Abraham, Gad, Martinsen, Amy E., Winsvold, Bendik S., Zwart, John-Anker, Bourcier, Romain, Sawada, Tomonobu, Koido, Masaru, Kamatani, Yoichiro, Morel, Sandrine, Amouyel, Philippe, Debette, Stéphanie, Bijlenga, Philippe, Berrandou, Takiy, Ganesh, Santhi K., Bouatia-Naji, Nabila, Jones, Gregory, Bown, Matthew, Rinkel, Gabriel J.E., Veldink, Jan H., Ruigrok, Ynte M., Hege Aamodt, Anne, Heidi Skogholt, Anne, Brumpton, Ben M, Willer, Cristen J, Sandset, Else C, Kristoffersen, Espen S, Ellekjær, Hanne, Heuch, Ingrid, Nielsen, Jonas B, Hagen, Knut, Hveem, Kristian, Fritsche, Lars G, Thomas, Laurent F, Pedersen, Linda M, Gabrielsen, Maiken E, Holmen, Oddgeir L, Børte, Sigrid, Zhou, Wei, Abboud, Shérine, Pandolfo, Massimo, Thijs, Vincent, Leys, Didier, Bodenant, Marie, Louillet, Fabien, Touzé, Emmanuel, Mas, Jean-Louis, Samson, Yves, Leder, Sara, Léger, Anne, Deltour, Sandrine, Crozier, Sophie, Méresse, Isabelle, Canaple, Sandrine, Godefroy, Olivier, Giroud, Maurice, Béjot, Yannick, Decavel, Pierre, Medeiros, Elizabeth, Montiel, Paola, Moulin, Thierry, Vuillier, Fabrice, Dallongeville, Jean, Metso, Antti J, Metso, Tiina, Tatlisumak, Turgut, Grond-Ginsbach, Caspar, Lichy, Christoph, Kloss, Manja, Werner, Inge, Arnold, Marie-Luise, Dos Santos, Michael, Grau, Armin, Dichgans, Martin, Thomas-Feles, Constanze, Weber, Ralf, Brandt, Tobias, Pezzini, Alessandro, De Giuli, Valeria, Caria, Filomena, Poli, Loris, Padovani, Alessandro, Bersano, Anna, Lanfranconi, Silvia, Beretta, Simone, Ferrarese, Carlo, Giacolone, Giacomo, Paolucci, Stefano, Lyrer, Philippe, Engelter, Stefan, Fluri, Felix, Hatz, Florian, Gisler, Dominique, Bonati, Leo, Gensicke, Henrik, Amort, Margareth, Markus, Hugh, Majersik, Jennifer, Worrall, Bradford, Southerland, Andrew, Cole, John, Kittner, Steven, Evangelou, Evangelos, Warren, Helen R, Gao, He, Ntritsos, Georgios, Dimou, Niki, Esko, Tonu, Mägi, Reedik, Milani, Lili, Almgren, Peter, Boutin, Thibaud, Ding, Jun, Giulianini, Franco, Holliday, Elizabeth G, Jackson, Anne U, Li-Gao, Ruifang, Lin, Wei-Yu, Luan, Jian’an, Mangino, Massimo, Oldmeadow, Christopher, Peter Prins, Bram, Qian, Yong, Sargurupremraj, Muralidharan, Shah, Nabi, Surendran, Praveen, Thériault, Sébastien, Verweij, Niek, Willems, Sara M, Zhao, Jing-Hua, Connell, John, de Mutsert, Renée, Doney, Alex SF, Farrall, Martin, Menni, Cristina, Morris, Andrew D, Noordam, Raymond, Paré, Guillaume, Poulter, Neil R, Shields, Denis C, Stanton, Alice, Thom, Simon, Abecasis, Gonçalo, Amin, Najaf, Arking, Dan E, Ayers, Kristin L, Barbieri, Caterina M, Batini, Chiara, Bis, Joshua C, Blake, Tineka, Bochud, Murielle, Boehnke, Michael, Boerwinkle, Eric, Boomsma, Dorret I, Bottinger, Erwin P, Braund, Peter S, Brumat, Marco, Campbell, Archie, Campbell, Harry, Chakravarti, Aravinda, Chambers, John C, Chauhan, Ganesh, Ciullo, Marina, Cocca, Massimiliano, Collins, Francis, Cordell, Heather J, Davies, Gail, de Borst, Martin H, de Geus, Eco J, Deary, Ian J, Deelen, Joris, Del Greco M, Fabiola, Yusuf Demirkale, Cumhur, Dörr, Marcus, Ehret, Georg B, Elosua, Roberto, Enroth, Stefan, Mesut Erzurumluoglu, A, Ferreira, Teresa, Frånberg, Mattias, Franco, Oscar H, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Goel, Anuj, Gow, Alan J, Gudnason, Vilmundur, Guo, Xiuqing, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B, Harris, Sarah E, Hartman, Catharina A, Havulinna, Aki S, Hicks, Andrew A, Hofer, Edith, Hofman, Albert, Hottenga, Jouke-Jan, Huffman, Jennifer E, Hwang, Shih-Jen, Ingelsson, Erik, James, Alan, Jansen, Rick, Jarvelin, Marjo-Riitta, Joehanes, Roby, Johansson, Åsa, Johnson, Andrew D, Joshi, Peter K, Jousilahti, Pekka, Wouter Jukema, J, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Keavney, Bernard D, Khaw, Kay-Tee, Knekt, Paul, Knight, Joanne, Kolcic, Ivana, Kooner, Jaspal S, Koskinen, Seppo, Kristiansson, Kati, Kutalik, Zoltan, Laan, Maris, Larson, Marty, Launer, Lenore J, Lehne, Benjamin, Lehtimäki, Terho, Liewald, David CM, Lin, Li, Lind, Lars, Lindgren, Cecilia M, Liu, YongMei, Loos, Ruth JF, Lopez, Lorna M, Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamasoula, Chrysovalanto, Marrugat, Jaume, Marten, Jonathan, Milaneschi, Yuri, Morgan, Anna, Morris, Andrew P, Morrison, Alanna C, Munson, Peter J, Nalls, Mike A, Nandakumar, Priyanka, Nelson, Christopher P, Niiranen, Teemu, Nolte, Ilja M, Nutile, Teresa, Oldehinkel, Albertine J, Oostra, Ben A, O’Reilly, Paul F, Org, Elin, Padmanabhan, Sandosh, Palmas, Walter, Palotie, Aarno, Pattie, Alison, WJH Penninx, Brenda, Perola, Markus, Peters, Annette, Polasek, Ozren, Pramstaller, Peter P, Tri Nguyen, Quang, Raitakari, Olli T, Rettig, Rainer, Rice, Kenneth, Ridker, Paul M, Ried, Janina S, Riese, Harriëtte, Ripatti, Samuli, Robino, Antonietta, Rose, Lynda M, Rotter, Jerome I, Rudan, Igor, Ruggiero, Daniela, Saba, Yasaman, Sala, Cinzia F, Salomaa, Veikko, Samani, Nilesh J, Sarin, Antti-Pekka, Schmidt, Reinhold, Schmidt, Helena, Shrine, Nick, Siscovick, David, Smith, Albert V, Snieder, Harold, Sõber, Siim, Sorice, Rossella, Starr, John M, Stott, David J, Strachan, David P, Strawbridge, Rona J, Sundström, Johan, Swertz, Morris A, Taylor, Kent D, Teumer, Alexander, Tobin, Martin D, Tomaszewski, Maciej, Toniolo, Daniela, Traglia, Michela, Trompet, Stella, Tuomilehto, Jaakko, Tzourio, Christophe, Uitterlinden, André G, Vaez, Ahmad, van der Most, Peter J, van Duijn, Cornelia M, Verwoert, Germaine C, Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Vuckovic, Dragana, Watkins, Hugh, Wild, Sarah H, Willemsen, Gonneke, Wilson, James F, Wright, Alan F, Yao, Jie, Zemunik, Tatijana, Zhang, Weihua, Attia, John R, Butterworth, Adam S, Chasman, Daniel I, Conen, David, Cucca, Francesco, Danesh, John, Hayward, Caroline, Howson, Joanna MM, Laakso, Markku, Lakatta, Edward G, Langenberg, Claudia, Melander, Olle, Mook-Kanamori, Dennis O, Palmer, Colin NA, Risch, Lorenz, Scott, Robert A, Scott, Rodney J, Sever, Peter, Spector, Tim D, van der Harst, Pim, Wareham, Nicholas J, Zeggini, Eleftheria, Levy, Daniel, Munroe, Patricia B, Newton-Cheh, Christopher, Brown, Morris J, Metspalu, Andres, Psaty, Bruce M., Wain, Louise V, Elliott, Paul, Caulfield, Mark J, Gormley, Padhraig, Anttila, Verneri, Palta, Priit, Esko, Tonu, Pers, Tune H, Farh, Kai-How, Cuenca-Leon, Ester, Muona, Mikko, Furlotte, Nicholas A, Kurth, Tobias, Ingason, Andres, McMahon, George, Ligthart, Lannie, Terwindt, Gisela M, Kallela, Mikko, Freilinger, Tobias M, Ran, Caroline, Gordon, Scott G, Stam, Anine H, Steinberg, Stacy, Borck, Guntram, Koiranen, Markku, Quaye, Lydia, Adams, Hieab H H, Lehtimäki, Terho, Sarin, Antti-Pekka, Wedenoja, Juho, Hinds, David A, Buring, Julie E, Schürks, Markus, Ridker, Paul M, Gudlaug Hrafnsdottir, Maria, Stefansson, Hreinn, Ring, Susan M, Hottenga, Jouke-Jan, Penninx, Brenda W J H, Färkkilä, Markus, Artto, Ville, Kaunisto, Mari, Vepsäläinen, Salli, Malik, Rainer, Heath, Andrew C, Madden, Pamela A F, Martin, Nicholas G, Montgomery, Grant W, Kurki, Mitja I, Kals, Mart, Mägi, Reedik, Pärn, Kalle, Hämäläinen, Eija, Huang, Hailiang, Byrnes, Andrea E, Franke, Lude, Huang, Jie, Stergiakouli, Evie, Lee, Phil H, Sandor, Cynthia, Webber, Caleb, Cader, Zameel, Muller-Myhsok, Bertram, Schreiber, Stefan, Meitinger, Thomas, Eriksson, Johan G, Salomaa, Veikko, Heikkilä, Kauko, Loehrer, Elizabeth, Uitterlinden, Andre G, Hofman, Albert, van Duijn, Cornelia M, Cherkas, Lynn, Pedersen, Linda M, Stubhaug, Audun, Nielsen, Christopher S, Männikkö, Minna, Mihailov, Evelin, Milani, Lili, Göbel, Hartmut, Esserlind, Ann-Louise, Francke Christensen, Anne, Folkmann Hansen, Thomas, Werge, Thomas, Kaprio, Jaakko, Aromaa, Arpo J, Raitakari, Olli, Arfan Ikram, M, Spector, Tim, Järvelin, Marjo-Riitta, Metspalu, Andres, Kubisch, Christian, Strachan, David P, Ferrari, Michel D, Belin, Andrea C, Dichgans, Martin, Wessman, Maija, van den Maagdenberg, Arn M J M, Boomsma, Dorret I, Davey Smith, George, Stefansson, Kari, Eriksson, Nicholas, Daly, Mark J, Neale, Benjamin M, Olesen, Jes, Chasman, Daniel I, Nyholt, Dale R, Palotie, Aarno, Akiyama, Masato, Alg, Varinder S., Børte, Sigrid, Broderick, Joseph P., Brumpton, Ben M., Dauvillier, Jérôme, Desal, Hubert, Dina, Christian, Friedrich, Christoph M., Gaál-Paavola, Emília I., Gentric, Jean-Christophe, Hirsch, Sven, Hostettler, Isabel C., Houlden, Henry, Hveem, Kristian, Jääskeläinen, Juha E., Johnsen, Marianne Bakke, Li, Liming, Lin, Kuang, Lindgren, Antti, Martin, Olivier, Matsuda, Koichi, Millwood, Iona Y., Naggara, Olivier, Niemelä, Mika, Pera, Joanna, Redon, Richard, Rouleau, Guy A., Sandvei, Marie Søfteland, Schilling, Sabine, Shotar, Eimad, Slowik, Agnieszka, Terao, Chikashi, Verschuren, W. M. Monique, Walters, Robin G., Werring, David J., Willer, Cristen J., Woo, Daniel, Worrall, Bradford B., and Zhou, Sirui

Published
2023
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12. Successful thrombectomy is beneficial in patients with pre-stroke disability: Results from an international multicenter cohort study

Author

Ducroux, Célina, Derex, Laurent, Nourredine, Mikaïl, Haesebaert, Julie, Buisson, Marielle, Alesefir, Walid, Boisseau, William, Daneault, Nicole, Deschaintre, Yan, Diestro, Jose Danilo B., Eker, Omer, Eneling, Johanna, Gioia, Laura C., Iancu, Daniella, Jacquin, Grégory, Odier, Céline, Stapf, Christian, Raymond, Jean, Roy, Daniel, Weill, Alain, Lapergue, Bertrand, Poppe, Alexandre Y., Piotin, Michel, Blanc, Raphael, Escalard, Hocine Redjem Simon, Desilles, Jean-Philippe, Delvoye, François, Smajda, Stanislas, Maier, Benjamin, Hebert, Solène, Mazighi, Mikael, Obadia, Mikael, Sabben, Candice, Seners, Pierre, Raynouard, Igor, Corabianu, Ovide, de Broucker, Thomas, Manchon, Eric, Taylor, Guillaume, Ben Maacha, Malek, Thion, Laurie-Anne, Lecler, Augustin, Savatovsky, Julien, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Ajili, Nadia, Lapergue, Bertrand, Weisenburger-Lile, David, Gorza, Lucas, Buard, Géraldine, Coskun, Oguzhan, Consoli, Arturo, Di Maria, Federico, Rodesh, Georges, Zimatore, Sergio, Leguen, Morgan, Gratieux, Julie, Pico, Fernando, Rakotoharinandrasana, Haja, Tassan, Philippe, Poll, Roxanna, Marinier, Sylvie, Nighoghossian, Norbert, Riva, Roberto, Eker, Omer, Turjman, Francis, Derex, Laurent, Cho, Tae-Hee, Mechtouff, Laura, Lukaszewicz, Anne Claire, Philippeau, Frédéric, Cakmak, Serkan, Blanc-Lasserre, Karine, Vallet, Anne-Evelyne, Marnat, Gaultier, Gariel, Florent, Barreau, Xavier, Berge, Jérôme, Menegon, Patrice, Sibon, Igor, Lucas, Ludovic, Olindo, Stéphane, Renou, Pauline, Sagnier, Sharmila, Poli, Mathilde, Debruxelles, Sabrina, Rouanet, François, Tourdias, Thomas, Liegey, Jean-Sebastien, Briau, Pierre, Pangon, Nicolas, Bourcier, Romain, Detraz, Lili, Daumas-Duport, Benjamin, Alexandre, Pierre-Louis, Roy, Monica, Lenoble, Cédric, Desal, Hubert, Guillon, Benoît, de Gaalon, Solène, Preterre, Cécile, Gory, Benjamin, Bracard, Serge, Anxionnat, René, Braun, Marc, Derelle, Anne-Laure, Tonnelet, Romain, Liao, Liang, Zhu, François, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Humbertjean, Lisa, Mione, Gioia, Lacour, Jean-Christophe, Riou-Comte, Nolwenn, Audibert, Gérard, Voicu, Marcela, Alb, Ionel, Reitter, Marie, Brezeanu, Madalina, Masson, Agnès, Tabarna, Adriana, Podar, Iona, Macian-montoro, Francisco, Saleme, Suzanna, Mounayer, Charbel, Rouchaud, Aymeric, Costalat, Vincent, Arquizan, Caroline, Dargazanli, Cyril, Gascou, Grégory, Lefèvre, Pierre-Henri, Derraz, Imad, Riquelme, Carlos, Gaillard, Nicolas, Mourand, Isabelle, Corti, Lucas, Cagnazzo, Federico, ter Schiphorst, Adrien, Francois, Eugene, Vannier, Stéphane, Ferre, Jean-christophe, Raoult, Helene, Ronziere, Thomas, Lassale, Maria, Paya, Christophe, Gauvrit, Jean-Yves, Tracol, Clément, Langnier-Lemercier, Sophie, Samson, Yves, Rosso, Charlotte, Leger, Anne, Deltour, Sandrine, Clarencon, Frederic, Shotar, Eimad, Spelle, Laurent, Denier, Christian, Chassin, Olivier, Chalumeau, Vanessa, Caroff, Jildaz, Chassin, Olivier, Venditti, Laura, Naggara, Olivier, Hassen, Wagih Ben, Boulouis, Grégoire, Rodriguez-Régent, Christine, Trystram, Denis, Kerleroux, Basile, Turc, Guillaume, Domigo, Valérie, Lamy, Catherine, Birchenall, Julia, Isabel, Clothilde, Lun, François, Viguier, Alain, Cognard, Christophe, Januel, Anne Christine, Olivot, Jean-Marc, Raposo, Nicolas, Bonneville, Fabrice, Albucher, Jean François, Calviere, Lionel, Darcourt, Jean, Tall, Philippe, Bellanger, Guillaume, Fontaine, Louis, Touze, Emmanuel, Barbier, Charlotte, Schneckenburger, Romain, Boulanger, Marion, Cogez, Julien, Guettier, Sophie, Timsit, Serge, Gentric, Jean-christophe, Ognard, Julien, Merrien, Francois Mathias, Wermester, Ozlem Ozkul, Massardier, Evelyne, Papagiannaki, Chrysanthi, Bourdain, Frédéric, Bernady, Patricia, Lagoarde-Segot, Laurent, Cailliez, Hélène, Veunac, Louis, Higue, David, Wolff, Valérie, Pop, Raoul, Beaujeux, Rémi, Dan-Sorin, Mihoc, Manisor, Monica, Le Bras, Anthony, Evain, Sarah, Le Guen, Arnaud, Richter, Sebastian, Hubrecht, Regis, Demasles, Stéphanie, Barroso, Bruno, Sablot, Denis, Farouil, Geoffroy, Tardieu, Maxime, Smadja, Philippe, Aptel, Sabine, and Seiler, Ian

Abstract

Patients with pre-stroke disability, defined as a modified Rankin Scale (mRS) ≥3, were excluded from most trials of endovascular thrombectomy (EVT) for acute stroke. We sought to evaluate the prognostic factors associated with favorable outcome in stroke patients with known disability undergoing EVT, and the impact of successful reperfusion.

Published
2023
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13. MR imaging of the Adnexa

Author

Rockall, Andrea G., Jalaguier-Coudray, Aurélie, and Thomassin-Naggara, Isabelle

Abstract

MR imaging has a high diagnostic accuracy and reproducibility to classify adnexal masses as benign or malignant, using a risk stratification scoring system, the Ovarian-Adnexal Reporting and Data System (O-RADS) MR imaging score. The first step in achieving high accuracy is to ensure high technical quality of the MR scan. The sequences needed are clearly described in this article, with tips for handling difficult cases. This information will assist in obtaining the best possible images, to allow for accurate use of the O-RADS MR imaging risk score.

Published
2023
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15. Risk factors of unexplained early neurological deterioration after treatment for ischemic stroke due to large vessel occlusion: a post hoc analysis of the HERMES study

Author

Bourcier, Romain, Goyal, Mayank, Muir, Keith W, Desal, Hubert, Dippel, Diederik W J, Majoie, Charles B L M, van Zwam, Wim H, Jovin, Tudor G, Mitchell, Peter J, Demchuk, Andrew M, van Oostenbrugge, Robert J, Brown, Scott B, Campbell, Bruce, White, Philip, Hill, Michael D, Saver, Jeffrey L, Weimar, Christian, Jahan, Reza, Guillemin, Francis, Bracard, Serge, and Naggara, Olivier

Abstract

BackgroundEarly neurological deterioration (END) after endovascular treatment (EVT) in patients with anterior circulation acute ischemic stroke (AIS) is associated with poor outcome. END may remain unexplained by parenchymal hemorrhage (UnEND). We aim to analyze the risk factors of UnEND in the medical management (MM) and EVT arms of the HERMES study.MethodsWe conducted a post-hoc analysis of anterior AIS patients who underwent EVT for proximal anterior occlusions. Risk factors of UnEND, defined as a worsening of ≥4 points between baseline National Institutes of Health Stroke Scale (NIHSS) and NIHSS at 24 hours without hemorrhage, were compared between both arms using mixed logistic regression models adjusted for baseline characteristics. An interaction analysis between the EVT and MM arms for risk factors of UnEND was conducted.ResultsAmong 1723 patients assessable for UnEND, 160 patients experienced an UnEND (9.3%), including 9.1% (78/854) in the EVT arm and 9.4% (82/869) in the MM arm. There was no significant difference in the incidence of UnEND between the two study arms. In the EVT population, independent risk factors of UnEND were lower baseline NIHSS, higher baseline glucose, and lower collateral grade. In the MM population, the only independent predictor of UnEND was higher baseline glucose. However, we did not demonstrate an interaction between EVT and MM for baseline factors as risk factors of UnEND. UnEND was, similarly in both treatment groups, a significant predictor of unfavorable outcome in both the EVT (p<0.001) and MM (p<0.001) arms.ConclusionsUnEND is not an uncommon event, with a similar rate which ever treatment arm is considered. In the clinical scenario of AIS due to large vessel occlusion, no patient-related factor seems to increase the risk for UnEND when treated by EVT compared with MM.

Published
2023
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16. Influence of prior intravenous thrombolysis in patients treated with mechanical thrombectomy for M2 occlusions: insight from the Endovascular Treatment in Ischemic Stroke (ETIS) registry

Author

Le Floch, Agathe, Clarencon, Frédéric, Rouchaud, Aymeric, Kyheng, Maeva, Labreuche, Julien, Sibon, Igor, Boulouis, Gregoire, Gory, Benjamin, Richard, Sébastien, Caroff, Jildaz, Blanc, Raphae¨l, Seners, Pierre, Eker, Omer F, Cho, Tae-Hee, Consoli, Arturo, Bourcier, Romain, guillon, benoit, Dargazanli, Cyril, Arquizan, Caroline, Denier, Christian, Eugene, Francois, Vannier, Stephane, Gentric, Jean-Christophe, Gauberti, Maxime, Naggara, Olivier, Rosso, Charlotte, Turc, Guillaume, Ozkul-Wermester, Ozlem, Cognard, Christophe, Albucher, Jean Francois, Timsit, Serge, Bourdain, Frederic, Le Bras, Anthony, Richter, Sebastian, Moulin, Solène, Pop, Raoul, Heck, Olivier, Moreno, Ricardo, L'Allinec, Vincent, Lapergue, Bertrand, and Marnat, Gaultier

Abstract

BackgroundIntravenous thrombolysis (IVT) for patients treated with mechanical thrombectomy (MT) for proximal occlusions has recently been questioned through randomized trials. However, few patients with M2 occlusions were included. We investigated the influence of prior IVT for patients presenting M2 occlusions treated with MT in comparison with MT alone.MethodsWe conducted a retrospective analysis of the Endovascular Treatment in Ischemic Stroke (ETIS) registry, a multicenter observational study. Data from consecutive patients treated with MT for M2 occlusions between January 2015 and January 2022 at 26 comprehensive stroke centers were analyzed. The primary endpoint was 90-day modified Rankin Scale score of 0–2. Outcomes were compared using propensity score approaches. We also performed sensitivity analysis in relevant subgroups of patients.ResultsAmong 1132 patients with M2 occlusions treated with MT, 570 received prior IVT. The two groups were comparable after propensity analysis. The rate of favorable functional outcome was significantly higher in the IVT+MT group compared with the MT alone group (59.8% vs 44.7%; adjusted OR 1.38, 95% CI 1.10 to 1.75, P=0.008). Hemorrhagic and procedural complications were similar in both groups. In sensitivity analysis excluding patients with anticoagulation treatment, favorable recanalization was more frequent in the IVT+MT group (OR 1.37, 95% CI 1.11 to 1.70, P=0.004).ConclusionsIn cases of M2 occlusions, prior IVT combined with MT resulted in better functional outcome than MT alone, without increasing the rate of hemorrhagic or procedural complications. These results suggest the benefit of IVT in patients undergoing MT for M2 occlusions.

Published
2023
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17. Aspirin versus aggressive antiplatelet therapy for acute carotid stenting plus thrombectomy in tandem occlusions: ETIS Registry results

Author

Marnat, Gaultier, Finistis, Stefanos, Moreno, Ricardo, Sibon, Igor, Pop, Raoul, Mazighi, Mikae¨l, Clarencon, Frédéric, Rosso, Charlotte, Dargazanli, Cyril, Darcourt, Jean, Olivot, Jean-Marc, Boulouis, Gregoire, Janot, Kevin, Moulin, Solène, Bourcier, Romain, Consoli, Arturo, Richard, Sébastien, Arquizan, Caroline, Vannier, Stephane, Richter, Sebastian, Gentric, Jean-Christophe, Papagiannaki, Chrisanthi, Naggara, Olivier, Eker, Omer F, Lapergue, Bertrand, Caroff, Jildaz, and Gory, Benjamin

Abstract

BackgroundPatients treated with acute carotid stenting (CAS) may have higher odds of a favorable outcome than those treated without CAS during thrombectomy in tandem occlusions. Antiplatelet therapy is associated with CAS to avoid stent thrombosis, which occurs in around 20% of patients and negatively impacts outcomes. In this study we compared two antiplatelet strategies in tandem occlusion strokes treated with CAS and intracranial thrombectomy in clinical practice.MethodsThe Endovascular Treatment in Ischemic Stroke Registry is an ongoing prospective observational study involving 21 comprehensive stroke centers performing thrombectomy in France. We analyzed patients with atherosclerotic tandem occlusions treated with acute CAS and intracranial thrombectomy who received at least one antiplatelet agent. Aggressive antiplatelet therapy included oral or intravenous glycoprotein (GP) IIb/IIIa or P2Y12 inhibitors. The primary outcome was cervical carotid artery patency at day 1 imaging follow-up.ResultsAmong the 187 included patients, 124 (66.3%) received aspirin alone and 63 (33.7%) received aggressive antiplatelet therapy. There was no significant difference regarding safety outcomes, especially in symptomatic intracerebral hemorrhage, parenchymal hematoma, and procedural complications. There was a significantly higher rate of carotid stent patency at day 1 in the aggressive antiplatelet therapy group (81.7% vs 97.1%, aOR 17.49, 95% CI 1.10 to 277.2, p=0.042). Odds of favorable functional outcome (90-day modified Rankin Scale score 0–2) were similar between the groups (OR 3.04, 95% CI 0.64 to 14.25, p=0.158).ConclusionsIn tandem occlusions treated with CAS plus thrombectomy, an aggressive antiplatelet regimen was associated with an increased rate of carotid stent patency at day 1 without safety concerns. Randomized trials are warranted to confirm these findings.

Published
2023
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18. Poor clinical outcome despite successful basilar occlusion recanalization in the early time window: incidence and predictors

Author

Pop, Raoul, Finitsis, Stephanos Nikolaos, Arquizan, Caroline, Elhorany, Mahmoud, Naggara, Olivier, Darcourt, Jean, Clarencon, Frédéric, Richard, Sébastien, Marnat, Gaultier, Bourcier, Romain, Sibon, Igor, Dargazanli, Cyril, Blanc, Raphae¨l, Lapergue, Bertrand, Consoli, Arturo, Eugene, Francois, Vannier, Stephane, Caroff, Jildaz, Denier, Christian, Boulanger, Marion, Gauberti, Maxime, Rouchaud, Aymeric, Macian, Francisco, Rosso, Charlotte, Turc, Guillaume, Ozkul-Wermester, Ozlem, Albucher, Jean Francois, Le Bras, Anthony, Evain, Sarah, Wolff, Valerie, Timsit, Serge, Gentric, Jean-Christophe, Bourdain, Frédéric, Veunac, Louis, Papagiannaki, Chrysanthi, and Gory, Benjamin

Abstract

BackgroundEndovascular treatment (EVT) for basilar artery occlusions (BAO) is associated with a higher rate of futile recanalization compared with anterior circulation procedures. We aimed to identify the incidence and predictors of poor clinical outcome despite successful reperfusion in current clinical practice.MethodsWe used data from the ETIS (Endovascular Treatment in Ischemic Stroke) registry, a prospective multicenter observational registry of stroke treated with EVT in France. Patients undergoing EVT for acute BAO from January 2014 to May 2019 successfully treated within 8 hours from onset were included. Predictors of 90-day poor outcome (modified Rankin Scale (mRS) 4–6) were researched within patients with successful (modified Thrombolysis In Cerebral Infarction (mTICI 2b-3)) and excellent (mTICI 2c-3) reperfusion.ResultsAmong 242 patients treated within 8 hours, successful reperfusion was achieved in 195 (80.5%) and excellent reperfusion in 120 (49.5%). Poor outcome was observed in 107 (54.8%) and 60 (50%) patients, respectively. In patients with successful early reperfusion, age, higher initial National Institutes of Health Stroke Scale (NIHSS) score, lower posterior circulation Alberta Stroke Programme Early CT Score (pc-ASPECTS), and absence of prior intravenous thrombolysis were independent predictors of poor outcome. The only treatment factor with an independent predictive value was first-pass mTICI 2b-3 reperfusion (adjusted OR 0.13, 95% CI 0.05 to 0.37, p<0.001). In patients with excellent early reperfusion, independent predictors were age, initial NIHSS score, first-pass mTICI 2c-3 reperfusion, and hemorrhagic transformation on post-interventional imaging.ConclusionsEarly successful reperfusion with EVT occurred in 80.5% of patients, and the only treatment-related factor predictive of clinical outcome was first pass mTICI 2b-3 reperfusion. Further research is warranted to identify the optimal techniques and devices associated with first pass reperfusion in the posterior circulation.

Published
2023
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19. Thrombectomy in basilar artery occlusions: impact of number of passes and futile reperfusion

Author

de Havenon, Adam, Elhorany, Mahmoud, Boulouis, Gregoire, Naggara, Olivier, Darcourt, Jean, Clarencon, Frédéric, Richard, Sébastien, Marnat, Gaultier, Bourcier, Romain, Sibon, Igor, Arquizan, Caroline, Dargazanli, Cyril, Mai¨er, Benjamin, Seners, Pierre, Lapergue, Bertrand, Consoli, Arturo, Eugene, Francois, Vannier, Stephane, Caroff, Jildaz, Denier, Christian, Boulanger, Marion, Gauberti, Maxime, Rouchaud, Aymeric, Macian, Francisco, Rosso, Charlotte, Turc, Guillaume, Ozkul-Wermester, Ozlem, Papagiannaki, Chrisanthi, Albucher, Jean Francois, Le Bras, Anthony, Evain, Sarah, Wolff, Valerie, Pop, Raoul, Timsit, Serge, Gentric, Jean-Christophe, Bourdain, Frédéric, Veunac, Louis, Fahed, Robert, Finitsis, Stephanos Nikolaos, and Gory, Benjamin

Abstract

BackgroundThe number of mechanical thrombectomy (MT) passes is strongly associated with angiographic reperfusion as well as clinical outcomes in patients with anterior circulation ischemic stroke. However, these associations have not been analyzed in patients with basilar artery occlusion (BAO). We investigated the influence of the number of MT passes on the degree of reperfusion and clinical outcomes, and compared outcome after ≤3 passes versus >3 passes.MethodsWe used data from the prospective multicentric Endovascular Treatment in Ischemic Stroke (ETIS) Registry at 18 sites in France. Patients with BAO treated with MT were included. The primary outcome was a favorable outcome, defined as a modified Rankin Scale score of 0–3 at 90 days. We fit mixed multiple regression models, with center as a random effect.ResultsWe included 275 patients. Successful recanalization (modified Thrombolysis In Cerebral Infarction (mTICI) 2b-3) was achieved in 88.4%, and 41.8% had a favorable outcome. The odds ratio for favorable outcome with each pass above 1 was 0.41 (95% CI 0.23 to 0.73) and for recanalization (mTICI 2b-3) it was 0.70 (95% CI 0.57 to 0.87). In patients with ≤3 passes, the rate of favorable outcome in recanalized versus non-recanalized patients was 50.5% versus 10.0% (p=0.001), while in those with >3 passes it was 16.7% versus 15.2% (p=0.901).ConclusionsWe found that BAO patients had a significant relationship between the number of MT passes and both recanalization and favorable functional outcome. We further found that the benefit of recanalization in BAO patients was significant only when recanalization was achieved within three passes, encouraging at least three passes before stopping the procedure.

Published
2023
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21. Prognosis of triple-negative breast cancer associated with pregnancy: A propensity score-matched analysis from the French CALG (Cancer Associé à la Grossesse) network.

Author

Puchar, Anne, Despierres, Marie, Boudy, Anne-Sophie, Selleret, Lise, Gligorov, Joseph, Richard, Sandrine, Zilberman, Sonia, Ferrier, Clément, Dabi, Yohann, Varlas, Valentin, Thomassin-Naggara, Isabelle, Bendifallah, Sofiane, Touboul, Cyril, and Darai, Emile

Subjects
TRIPLE-negative breast cancer, BREAST cancer prognosis, PREGNANCY, OVERALL survival, BREAST cancer
Abstract

Triple-negative (TN) breast cancer represents one third of pregnancy-associated breast cancers (PABC). The aims of the current study were to describe oncological and obstetrical outcomes of patients with TN-PABC and to compare their prognosis with TN-non-PABC patients using a propensity score. Between January 2005 and December 2020, data of patients with histologically proven TN-PABC were collected and compared with data of TN-non-PABC patients under the age of 46 years diagnosed during the same period using a propensity score (PS). After PS matching (tumor size and lymph node involvement),there were 59 patients in each group. The median follow-up was 14 months (IQR 4.8–40.1) for the TN-PABC group and 60 months (IQR 30.7–101.4) for the TN-non-PABC group. Eight recurrences occurred in the TN-PABC group and 10 in the TN-non-PABC group (adjusted OR (AOR) = 0.60 (0.21–1.60), HR (Cox adjusted model- AHR) = 1.25 (0.53–2.94)). Two patients died in the TN-PABC group, and six in the TN-non-PABC group with an AOR = 0.23 (0.03–1.01) and an AHR = 0.58 (0.12–2.69). All the patients diagnosed during the second (n = 17) and third trimesters (n = 28) continued their pregnancies, with a median term at delivery of 38 WG (IQR 36–39). All patients gave birth to healthy newborns. Although the TN subtype is associated with poor prognosis in pregnant patients due to advanced stage at diagnosis and high lymph node involvement, our PS-matched case-control study showed that pregnancy per se does not worsen the prognosis in terms of recurrence-free and overall survival. • Triple-negative breast cancer are associated with poor prognosis. • Breast cancers occurring during pregnancy differ from those occurring in the post-partum period. • Pregnancy per se does not worsen the prognosis in triple-negative breast cancer. [ABSTRACT FROM AUTHOR]

Published
2022
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23. O-RADS MRI Classification of Indeterminate Adnexal Lesions: Time-Intensity Curve Analysis Is Better Than Visual Assessment

Author

Wengert, Georg J., Dabi, Yohann, Kermarrec, Edith, Jalaguier-Coudray, Aurélie, Poncelet, Edouard, Porcher, Raphaël, Thomassin-Naggara, Isabelle, and Rockall, Andrea G.

Abstract

Time-intensity curve analysis is more accurate than visual assessment to achieve optimal diagnostic accuracy with the Ovarian-Adnexal Reporting and Data System MRI score.

Published
2022
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24. O-RADS MRI Risk Stratification System: Guide for Assessing Adnexal Lesions from the ACR O-RADS Committee

Author

Sadowski, Elizabeth A., Thomassin-Naggara, Isabelle, Rockall, Andrea, Maturen, Katherine E., Forstner, Rosemarie, Jha, Priyanka, Nougaret, Stephanie, Siegelman, Evan S., and Reinhold, Caroline

Abstract

The Ovarian-Adnexal Reporting and Data System MRI risk score is a stratification system for assigning malignancy probability to adnexal lesions and can improve communication between radiologists and referring physicians to optimize treatment of women with adnexal lesions.

Published
2022
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25. Synthetic FLAIR as a Substitute for FLAIR Sequence in Acute Ischemic Stroke

Author

Benzakoun, Joseph, Deslys, Marc-Antoine, Legrand, Laurence, Hmeydia, Ghazi, Turc, Guillaume, Hassen, Wagih Ben, Charron, Sylvain, Debacker, Clément, Naggara, Olivier, Baron, Jean-Claude, Thirion, Bertrand, and Oppenheim, Catherine

Abstract

Synthetic fluid-attenuated inversion recovery (FLAIR) generated with deep learning is as accurate as a real FLAIR sequence for the identification of early stroke.

Published
2022
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26. Ovarian-Adnexal Reporting Lexicon for MRI: A White Paper of the ACR Ovarian-Adnexal Reporting and Data Systems MRI Committee.

Author

Reinhold, Caroline, Rockall, Andrea, Sadowski, Elizabeth A., Siegelman, Evan S., Maturen, Katherine E., Vargas, Hebert Alberto, Forstner, Rosemarie, Glanc, Phyllis, Andreotti, Rochelle F., and Thomassin-Naggara, Isabelle

Abstract

MRI is used in the evaluation of ovarian and adnexal lesions. MRI can further characterize lesions seen on ultrasound to help decrease the number of false-positive lesions and avoid unnecessary surgery in benign lesions. Currently, the reporting of ovarian and adnexal findings on MRI is inconsistent because of the lack of standardized descriptor terminology. The development of uniform reporting descriptors can lead to improved interpretation agreement and communication between radiologists and referring physicians. The Ovarian-Adnexal Reporting and Data Systems MRI Committee was formed under the direction of the ACR to create a standardized lexicon for adnexal lesions with the goal of improving the quality and consistency of imaging reports. This white paper describes the consensus process in the creation of a standardized lexicon for ovarian and adnexal lesions for MRI and the resultant lexicon. [ABSTRACT FROM AUTHOR]

Published
2021
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27. Influence of prior intravenous thrombolysis on outcome after failed mechanical thrombectomy: ETIS registry analysis

Author

Rozes, Claire, Maier, Benjamin, Gory, Benjamin, Bourcier, Romain, Kyheng, Maeva, Labreuche, Julien, Consoli, Arturo, Mazighi, Mikael, Blanc, Raphae¨l, Caroff, Jildaz, Eugene, Francois, Naggara, Olivier, Gariel, Florent, Sibon, Igor, Lapergue, Bertrand, and Marnat, Gaultier

Abstract

BackgroundDespite constant improvements in recent years, sufficient reperfusion after mechanical thrombectomy (MT) is not reached in up to 15% of patients with large vessel occlusion stroke (LVOS). The outcome of patients with unsuccessful reperfusion after MT especially after intravenous thrombolysis (IVT) use is not known. We investigated the influence of initial IVT in this particular group of patients with failed intracranial recanalization.MethodsWe conducted a retrospective analysis of the Endovascular Treatment in Ischemic Stroke (ETIS) registry from January 2015 to December 2019. Patients presenting with LVOS of the anterior circulation and final modified Thrombolysis in Cerebral Infarction score (mTICI) of 0, 1 or 2a were included. Posterior circulation, isolated cervical carotid occlusions and successful reperfusions (mTICI 2b, 2c or 3) were excluded. The primary endpoint was favorable outcome (modified Rankin Scale score of 0–2) after 3 months. Secondary endpoints were safety outcomes including mortality, any intracranial hemorrhage (ICH), parenchymal hematoma (PH) and symptomatic intracranial hemorrhage (sICH) rates.ResultsAmong 5076 patients with LVOS treated with MT, 524 patients with insufficient recanalization met inclusion criteria, of which 242 received IVT and 282 did not. Functional outcome was improved in the MT+IVT group compared with the MT alone group, although the difference did not reach statistical significance (23.0% vs 12.9%; adjusted OR=1.82; 95% CI 0.98 to 3.38; p=0.058). However, 3 month mRS shift analysis showed a significant benefit of IVT (adjusted OR=1.68; 95% CI 1.56 to 6.54). ICH and sICH rates were similar in both groups, although PH rate was higher in the MT+IVT group (adjusted OR=3.20; 95% CI 1.56 to 6.54).ConclusionsAmong patients with LVOS in the anterior circulation and unsuccessful MT, IVT was associated with improved functional outcome even after unsuccessful MT. Despite recent trials questioning the place of IVT in the LVOS reperfusion strategy, these findings emphasize a subgroup of patients still benefiting from IVT.

Published
2022
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28. Pediatric brain arteriovenous malformation recurrence: a cohort study, systematic review and meta-analysis

Author

Hak, Jean-Francois, Boulouis, Gregoire, Kerleroux, Basile, Benichi, Sandro, Stricker, Sarah, Gariel, Florent, Garzelli, Lorenzo, Meyer, Philippe, Kossorotoff, Manoelle, Boddaert, Nathalie, Vidal, Vincent, Girard, Nadine, Dangouloff-Ros, Volodia, Brunelle, Francis, Fullerton, Heather, Hetts, Steven W, Blauwblomme, Thomas, and Naggara, Olivier

Abstract

BackgroundRecurrence following obliteration of brain arteriovenous malformations (AVMs) is common in children surgically treated, but recurrences following endovascular (EVT) and radiosurgical approaches are scantily reported.ObjectiveTo analyze the rates and risk factors for AVM recurrence after obliteration in a single-center cohort of children with ruptured AVMs treated with multimodal approaches, and to carry out a comprehensive review and meta-analysis of current data.MethodsChildren with ruptured AVMs between 2000 and 2019 enrolled in a prospective registry were retrospectively screened and included after angiographically determined obliteration to differentiate children with/without recurrence. A complementary systematic review and meta-analysis of studies investigating AVM recurrence in children between 2000 and 2020 was aggregated to explore the overall recurrence rates across treatment modalities by analyzing surgery versus other treatments.ResultsSeventy children with obliterated AVMs were included. AVM recurrences (n=10) were more commonly treated with EVT as final treatment (60% in the recurrence vs 13.3% in the no-recurrence group, p=0.018). Infratentorial locations were associated with earlier and more frequent recurrences (adjusted relative risk=4.62, 95% CI 1.08 to 19.04; p=0.04).In the aggregate analysis, the pooled rate of AVM recurrence was 10.9% (95% CI 8.7% to 13.5%). Younger age at presentation was associated with more frequent recurrences (RR per year increase, 0.97, 95% CI 0.93 to 0.99; p=0.046).ConclusionLocation of infratentorial AVMs and younger age at presentation may be associated with earlier and more frequent recurrences. The higher rates of recurrence in patients with AVMs obliterated with EVT questions its role in an intent-to-cure approach and reinforces its position as an adjunct to surgery and/or radiosurgery.

Published
2022
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29. Collateral status reperfusion and outcomes after endovascular therapy: insight from the Endovascular Treatment in Ischemic Stroke (ETIS) Registry

Author

Anadani, Mohammad, Finitsis, Stephanos, Clarencon, Frédéric, Richard, Sébastien, Marnat, Gaultier, Bourcier, Romain, Sibon, Igor, Dargazanli, Cyril, Arquizan, Caroline, Blanc, Raphael, Lapergue, Bertrand, Consoli, Arturo, Eugene, Francois, Vannier, Stephane, Spelle, Laurent, Denier, Christian, Boulanger, Marion, Gauberti, Maxime, Liebeskind, David S, de Havenon, Adam, Saleme, Suzana, Macian, Francisco, Rosso, Charlotte, Naggara, Olivier, Turc, Guillaume, Ozkul-Wermester, Ozlem, Papagiannaki, Chrisanthi, Viguier, Alain, Cognard, Christophe, Le Bras, Anthony, Evain, Sarah, Wolff, Valerie, Pop, Raoul, Timsit, Serge, Gentric, Jean-Christophe, Bourdain, Frédéric, Veunac, Louis, Maier, Benjamin, and Gory, Benjamin

Abstract

BackgroundStudies have suggested that collateral status modifies the effect of successful reperfusion on functional outcome after endovascular therapy (EVT). We aimed to assess the association between collateral status and EVT outcomes and to investigate whether collateral status modified the effect of successful reperfusion on EVT outcomes.MethodsWe used data from the ongoing, prospective, multicenter Endovascular Treatment in Ischemic Stroke (ETIS) Registry. Collaterals were graded according to the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR) guidelines. Patients were divided into two groups based on angiographic collateral status: poor (grade 0–2) versus good (grade 3–4) collaterals.ResultsAmong 2020 patients included in the study, 959 (47%) had good collaterals. Good collaterals were associated with favorable outcome (90-day modified Rankin Scale (mRS) 0–2) (OR 1.5, 95% CI 1.19 to 1.88). Probability of good outcome decreased with increased time from onset to reperfusion in both good and poor collateral groups. Successful reperfusion was associated with higher odds of favorable outcome in good collaterals (OR 6.01, 95% CI 3.27 to 11.04) and poor collaterals (OR 5.65, 95% CI 3.32 to 9.63) with no significant interaction. Similarly, successful reperfusion was associated with higher odds of excellent outcome (90-day mRS 0–1) and lower odds of mortality in both groups with no significant interaction. The benefit of successful reperfusion decreased with time from onset in both groups, but the curve was steeper in the poor collateral group.ConclusionsCollateral status predicted functional outcome after EVT. However, collateral status on the pretreatment angiogram did not decrease the clinical benefit of successful reperfusion.

Published
2022
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30. Arterial Spin Labeling for the Etiological Workup of Intracerebral Hemorrhage in Children

Author

Hak, Jean François, Boulouis, Grégoire, Kerleroux, Basile, Benichi, Sandro, Stricker, Sarah, Gariel, Florent, Garzelli, Lorenzo, Meyer, Philippe, Kossorotoff, Manoelle, Boddaert, Nathalie, Vidal, Vincent, Girard, Nadine, Dangouloff Ros, Volodia, Brunelle, Francis, Blauwblomme, Thomas, and Naggara, Olivier

Abstract

Supplemental Digital Content is available in the text.

Published
2022
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31. Thrombectomy Complications in Large Vessel Occlusions: Incidence, Predictors, and Clinical Impact in the ETIS Registry

Author

Happi Ngankou, Emmanuel, Gory, Benjamin, Marnat, Gaultier, Richard, Sébastien, Bourcier, Romain, Sibon, Igor, Dargazanli, Cyril, Arquizan, Caroline, Maïer, Benjamin, Blanc, Raphaël, Lapergue, Bertrand, Consoli, Arturo, Vannier, Stéphane, Spelle, Laurent, Denier, Christian, Boulanger, Marion, Gauberti, Maxime, Saleme, Suzana, Macian, Francisco, Clarençon, Frédéric, Rosso, Charlotte, Naggara, Olivier, Turc, Guillaume, Ozkul-Wermester, Ozlem, Papagiannaki, Chrysanthi, Viguier, Alain, Cognard, Christophe, Lebras, Anthony, Evain, Sarah, Wolff, Valérie, Pop, Raoul, Timsit, Serge, Gentric, Jean-Christophe, Bourdain, Frédéric, Veunac, Louis, Eugène, François, and Finitsis, Stephanos

Abstract

Supplemental Digital Content is available in the text.

Published
2021
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32. Impact of Prior Antiplatelet Therapy on Outcomes After Endovascular Therapy for Acute Stroke

Author

Couture, Marie, Finitsis, Stephanos, Marnat, Gaultier, Richard, Sébastien, Bourcier, Romain, Constant-dits-Beaufils, Pacôme, Dargazanli, Cyril, Arquizan, Caroline, Mazighi, Mikaël, Blanc, Raphaël, Eugène, François, Vannier, Stéphane, Spelle, Laurent, Denier, Christian, Touzé, Emmanuel, Barbier, Charlotte, Saleme, Suzana, Macian, Francisco, Rosso, Charlotte, Clarençon, Frédéric, Naggara, Olivier, Turc, Guillaume, Ozkul-Wermester, Ozlem, Papagiannaki, Chrysanthi, Viguier, Alain, Cognard, Christophe, Lebras, Anthony, Evain, Sarah, Wolff, Valérie, Pop, Raoul, Timsit, Serge, Gentric, Jean-Christophe, Bourdain, Frédéric, Veunac, Louis, Lapergue, Bertrand, Consoli, Arturo, Gory, Benjamin, and Sibon, Igor

Abstract

Supplemental Digital Content is available in the text.

Published
2021
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33. Functional Outcome, Recanalization, and Hemorrhage Rates After Large Vessel Occlusion Stroke Treated With Tenecteplase Before Thrombectomy

Author

Gerschenfeld, Gaspard, Smadja, Didier, Turc, Guillaume, Olindo, Stephane, Laborne, François-Xavier, Yger, Marion, Caroff, Jildaz, Gonçalves, Bruno, Seners, Pierre, Cantier, Marie, l'Hermitte, Yann, Aghasaryan, Manvel, Alecu, Cosmin, Marnat, Gaultier, Ben Hassen, Wagih, Kalsoum, Erwah, Clarençon, Frédéric, Piotin, Michel, Spelle, Laurent, Denier, Christian, Sibon, Igor, Alamowitch, Sonia, Chausson, Nicolas, Degos, Vincent, Sarov, Mariana, Legris, Nicolas, Chassin, Olivier, Soumah, Djibril, Altarcha, Tony, Imbernon, Carole, Renou, Pauline, Poli, Mathilde, Debruxelles, Sabrina, Sagnier, Sharmila, Rouanet, François, Liegey, Jean-Sebastien, Calvet, David, Baron, Jean-Claude, Bottin, Laure, Delorme, Stephen, Capron, Jean, Doukhi, Diana, Ghazanfari, Sam, Weisenburger, David, Lescieux, Edwige, Gariel, Florent, Barreau, Xavier, Menegon, Patrice, Tourdias, Thomas, Oppenheim, Catherine, Naggara, Olivier, Tuilier, Titien, Sourour, Nader, Sourour, Nader, Shotar, Eimad, Lenck, Stéphanie, Premat, Kévin, Blanc, Raphaël, Escalard, Simon, Fahed, Robert, Smajda, Stanislas, and Mazighi, Mikael

Published
2021
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34. Relevance of Brain Regions' Eloquence Assessment in Patients With a Large Ischemic Core Treated With Mechanical Thrombectomy

Author

Kerleroux, Basile, Benzakoun, Joseph, Janot, Kévin, Dargazanli, Cyril, Eraya, Dimitri Daly, Ben Hassen, Wagih, Zhu, François, Gory, Benjamin, Hak, Jean-Francois, Perot, Charline, Detraz, Lili, Bourcier, Romain, Aymeric, Rouchaud, Forestier, Géraud, Marnat, Gaultier, Gariel, Florent, Mordasini, Pasquale, Seners, Pierre, Turc, Guillaume, Kaesmacher, Johannes, Oppenheim, Catherine, Naggara, Olivier, Boulouis, Gregoire, Fischer, Urs, Gralla, Jan, Mosimann, Pascal J, Arnold, Marcel, Meinel, Thomas R, Costalat, Vincent, Benali, Amel, Derraz, Imad, Lefevre, Pierre-Henri, Gascou, Grégory, Riquelme, Carlos, Bonafe, Alain, Le Bars, Emmanuelle, Moynier, Marinette, Barreau, Xavier, Berge, Jérôme, Menegon, Patrice, Tourdias, Thomas, Lucas, Ludovic, Sibon, Igor, Saleme, Suzanna, Mounayer, Charbel, Girard, Nadine, Bartoli, Jean-Michel, Brunel, Hervé, Testud, Benoit, Puech, Basile, Laksiri, Nadia, Robinet, Emmanuelle, Pelletier, Jean, Herbreteau, Denis, Bibi, Richard, Narata, Ana-Paula, Boustia, Fakhreddine, Maldonado, Igor, Cottier, Jean- Philippe, Gaudron, Marie, Annan, Mariam, Meder, Jean-François, Trystram, Denis, Rodriguez, Christine, Edjlali, Myriam, Desal, Hubert, Daumasduport, Benjamin, Lallinec, Vincent, Lenoble, Cédric, Alexandre, Pierre-Louis, Bracard, Serge, Anxionnat, René, Degrelle, Anne-Laure, Tonnelet, Romain, Lao, Liang, Richard, Sébastien, Humbertjean, Lisa, Mione, Gioia, and Labour, Jean Christophe

Published
2021
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35. Dissecazione delle arterie carotidee e vertebrali extracraniche

Author

Bodiguel, E., Naggara, O., and Mas, J.-L.

Abstract

Una dissecazione arteriosa cervicale deriva dal clivaggio della parete arteriosa da parte di un ematoma che può o meno comunicare con il lume arterioso attraverso una breccia intimale. La maggior parte delle dissecazioni è spontanea o si verifica dopo un trauma cervicale minore. Esse si traducono in sintomi e segni locali (cefalee, cervicalgie, segno di Claude Bernard-Horner, acufeni, paralisi di nervi cranici) e in manifestazioni ischemiche cerebrali, oculari o, anche, midollari. I segni locali spesso precedono le manifestazioni ischemiche e il ritardo varia da poche ore a qualche settimana. Il metodo diagnostico di riferimento è la risonanza magnetica (RM). Le indicazioni per il trattamento antitrombotico (antiaggregante o anticoagulante) non sono chiare. L’evoluzione avviene, il più delle volte, verso la normalizzazione o la stabilizzazione del lume arterioso entro 3 mesi in media. A 1 anno, circa l’80% delle dissecazioni è normalizzato o stabilizzato. Oltre le poche settimane della fase acuta, il rischio annuo di recidiva della dissecazione è basso (circa dell’1%).

Published
2021
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36. Hemorrhage Expansion After Pediatric Intracerebral Hemorrhage.

Author

Boulouis, Gregoire, Hak, Jean-François, Kerleroux, Basile, Benichi, Sandro, Stricker, Sarah, Gariel, Florent, Alias, Quentin, Bourgeois, Marie, Meyer, Philippe, Kossorotoff, Manoelle, Garzelli, Lorenzo, Garcelon, Nicolas, Boddaert, Nathalie, Morotti, Andrea, Blauwblomme, Thomas, and Naggara, Olivier

Published
2021
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37. Une BETTER check-listIRM pour mieux différencier le léiomyosarcome du léiomyome atypique utérin

Author

Kermarrec, Édith, Nougaret, Stéphanie, Bazot, Marc, Wahab, Cendos Abdel, Bekhouche, Asma, and Thomassin-Naggara, Isabelle

Abstract

Le but de cet article est d’illustrer un acronyme diagnostique permettant aux radiologues de mieux différencier le léiomyosarcome utérin du léiomyome atypique en IRM pelvienne. Il a été présenté au congrès annuel 2018 de la Radiological Society of North America(RSNA) sous forme d’un poster réalisé par plusieurs experts internationaux qui ont proposé d’utiliser le mot BET1T2ER pour analyser plusieurs critères de suspicion de léiomyosarcome.

Published
2021
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38. Effect of Operator’s Experience on Proficiency in Mechanical Thrombectomy

Author

Zhu, François, Ben Hassen, Wagih, Bricout, Nicolas, Kerleroux, Basile, Janot, Kevin, Gory, Benjamin, Anxionnat, René, Richard, Sébastien, Marchal, Adrien, Blanc, Raphael, Piotin, Michel, Consoli, Arturo, Trystram, Denis, Rodriguez Regent, Christine, Desilles, Jean-Philippe, Weisenburger-Lile, David, Escalard, Simon, Herbreteau, Denis, Ifergan, Heloise, Lima Maldonado, Igor, Labreuche, Julien, Henon, Hilde, Naggara, Olivier, Lapergue, Bertrand, and Boulouis, Grégoire

Abstract

Supplemental Digital Content is available in the text.

Published
2021
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41. Hemorrhage Expansion After Pediatric Intracerebral Hemorrhage.

Author

Boulouis, Gregoire, Hak, Jean-François, Kerleroux, Basile, Benichi, Sandro, Stricker, Sarah, Gariel, Florent, Alias, Quentin, Bourgeois, Marie, Meyer, Philippe, Kossorotoff, Manoelle, Garzelli, Lorenzo, Garcelon, Nicolas, Boddaert, Nathalie, Morotti, Andrea, Blauwblomme, Thomas, and Naggara, Olivier

Published
2021
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43. Acute enlargement, morphological changes, and rupture of intracranial infectious aneurysm in infective endocarditis. Serial imaging.

Author

Boukobza, Monique, Naggara, Olivier, Duval, Xavier, and Laissy, Jean-Pierre

Abstract

• Intracranial infectious aneurysms (IIAs) can show rapid increase in size, morphological changes. • Rapid transformation over time, with the risk of rupture of IIAs, is unpredictable. • Necessity of repeated imaging follow-up (Angio-CT, MRA) in IE patients under antibiotic therapy. • If IIA shows rapid growth with serial imaging, it should be treated without further delay. A 72-year-old man received a transcatheter aortic valve implantation (TAVI) 2 years ago for leakage of the degenerative bioprosthesis with Corevalve n°31 implantation, presented infective endocarditis (IE) (streptococcus sanguinis) of the bioprosthetic aortic valve. One month after antibiotic treatment was initiated, he presented a left-sided hemiplegia, a right frontal hematoma. MRI/contrast-enhanced magnetic resonance angiography (CE-MRA) revealed 2 infectious intracranial aneurysms (IIAs) of the right (10 mm) and left middle cerebral artery (MCA) (M2 segment, 5 mm). The right MCA IIA was treated within 1 day by glue-embolization. Seven days later, the patient acutely developed motor aphasia. CE-MRA showed significant enlargement (15 mm) and morphologic change of the ruptured left MCA IIA. This IIA was treated with Onyx-embolization. This case adds additional evidence that IIAs, during IE, can show rapid growth and morphological change over a 7 day course and emphasizes the imperative need of close imaging follow-up when IIAs are managed by antibiotic therapy. [ABSTRACT FROM AUTHOR]

Published
2020
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45. Acute Stroke Management During the COVID-19 Pandemic: Does Confinement Impact Eligibility for Endovascular Therapy?

Author

Hajdu, Steven D., Pittet, Valerie, Puccinelli, Francesco, Ben Hassen, Wagih, Ben Maacha, Malek, Blanc, Raphaël, Bracco, Sandra, Broocks, Gabriel, Bartolini, Bruno, Casseri, Tommaso, Clarençon, Frederic, Naggara, Olivier, Eugène, François, Ferré, Jean-Christophe, Guédon, Alexis, Houdart, Emmanuel, Krings, Timo, Lehmann, Pierre, Limbucci, Nicola, and Machi, Paolo

Published
2020
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48. Nontraumatic Pediatric Intracerebral Hemorrhage.

Author

Boulouis, Gregoire, Blauwblomme, Thomas, Hak, Jean François, Benichi, Sandro, Kirton, Adam, Meyer, Philippe, Chevignard, Mathilde, Tournier-Lasserve, Elisabeth, Mackay, Mark T., Chabrier, Stéphane, Cordonnier, Charlotte, Kossorotoff, Manoëlle, and Naggara, Olivier

Published
2019
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49. Teaching NeuroImage: Traumatic Dissection of Lenticulostriate Arteries Within an Enlarged Perivascular Space

Author

Janvier, Paul, Kerleroux, Basile, Varlan, David, Rodriguez-Régent, Christine, Trystram, Denis, Allard, Julien, Drai, Maxime, Oppenheim, Catherine, Ben Hassen, Wagih, and Naggara, Olivier

Abstract

A 33-year-old woman was admitted with right side hemiplegia after head trauma. Brain MRI revealed an acute ischemic stroke in the left lenticulostriate territory and a parenchymal hematoma (Figure 1). The hematoma occurred within an enlarged perivascular space (PVS), which had been incidentally discovered 10 years earlier.1,2It was suspected that a traumatic dissection of lenticulostriate arteries within the PVS was responsible for both ischemic and hemorrhagic events (Figure 1). Healing of the hematoma and disappearance of the PVS and the lenticulostriate arteries were observed 2 months later (Figure 2). Excessive mobility of lenticulostriate arteries within an enlarged PVS may explain the mechanism of traumatic dissection in this case.

Published
2022
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50. Hyperacute Recanalization Strategies and Childhood Stroke in the Evidence Age

Author

Chabrier, Stéphane, Ozanne, Augustin, Naggara, Olivier, Boulouis, Grégoire, Husson, Béatrice, and Kossorotoff, Manoëlle

Abstract

No controlled pharmacological studies are available in the field of pediatric stroke, except for sickle cell disease. Therefore, while pharmacological and mechanical recanalization treatments have repeatedly shown clinical benefit in adults with arterial ischemic stroke, pediatric strokologists still cannot base their therapeutic management (including hyperacute strategies) on high-level evidence. Once again, pediatricians face the same dichotomic choice: adapting adult procedures now versus waiting—for a long time—for the corresponding pediatric trials. One way out is building a compromise based on observational studies with large, longitudinal, comprehensive, real-life, and multisource dataset. Two recent high-quality observational studies have delivered promising conclusions on recanalization treatments in pediatric arterial ischemic stroke. TIPSTER (Thrombolysis in Pediatric Stroke Extended Results) showed that the risk of severe intracranial hemorrhage after intravenous thrombolysis is low; the Save Childs Study reported encouraging data about pediatric thrombectomy. Beyond the conclusion of a satisfactory global safety profile, a thorough analysis of the methods, populations, results, and therapeutic complications of these studies helps us to refine indications/contraindications and highlights the safeguards we need to rely on when discussing thrombolysis and thrombectomy in children. In conclusion, pediatric strokologists should not refrain from using clot lysis/retrieval tools in selected children with arterial ischemic stroke. But the implementation of hyperacute care is only feasible if the right candidate is identified through the sharing of common adult/pediatric protocols and ward collaboration, formalized well before the child’s arrival. These anticipated protocols should never undervalue contraindications from adult guidelines and must involve the necessary pediatric expertise when facing specific causes of stroke, such as focal cerebral arteriopathy of childhood.

Published
2021
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