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Due to high antimicrobial activity against numerous microorganisms, silver nanoparticles (AgNPs) are being utilized in various areas. Microwave-accelerated AgNPs synthesis using Corylus avellanaleaf extract was evaluated. Based on randomly central composite design, 13 mixture solutions containing different amounts of the prepared extract (0.10–0.90 mL) and 1 mM silver nitrate solution (15–25 mL) were prepared and exposed to microwave irradiation for 180 s. Response surface methodology was utilized to evaluate the effects of the two independent variables on particle size and concentration of the synthesized AgNPs, as manifested in the place of broad emission peak (λmax) and its absorbance unit, respectively. Fourier transform infrared spectroscopy analysis indicated that the two hydroxyl and carboxylic acid functional groups with reducing activity existed in the prepared extract. Dynamic light scattering and transmission electron microscopy analyses revealed that the formed spherical AgNPs using optimum amounts of C. avellanaleaf extract (0.9 mL) and 1 mM silver nitrate solution (25 mL) had minimum particle size (103.5 nm) and polydispersity index (PDI) (0.209), and maximum concentration (140 ppm) and zeta potential (−21.8 mV). Results indicated that the formed AgNPs had high fungicidal effects against the spoiled fungi of Colletotrichum coccodesand Penicillium digitatum.

Recently, implantable electrospun nanofiber-based drug delivery devices have acquired a great interest in treating a tissue defect after tumor resection. In current work, Curcumin (CUR) as a natural antitumor agent was incorporated into the mesoporous silica nanoparticles (MSNs), and the CUR-loaded MSNs (CUR@MSNs) were consequently embedded into poly (lactic-co-glycolic acid) (PLGA) via a blending electrospinning process, resulting in an electrospun nanofiber-mediated drug release system (CUR@MSNs/PLGA NFs). The morphology and physicochemical properties of the prepared CUR@MSNs and the composite NFs were characterized through FE-SEM, TEM, TGA, FTIR, BET, and XRD. Also, the in vitrodischarge pattern of CUR from the NFs as well as their anticancer efficiency against MCF-7 breast cancer cells was assessed through MTT, wound healing assay, DAPI staining, and qPCR. The obtained results revealed that CUR@MSNs were successfully embedded into the randomly oriented bead-free electrospun PLGA NFs and exhibited a sustained and prolonged drug release profile. Besides, higher cytotoxicity and lower migration with increased apoptosis induction were detected in the cells treated with CUR@MSNs/PLGA NFs. Thus, the fabricated CUR@MSNs/PLGA composite electrospun NFs might attain a safe and highly promising application for potential postsurgical breast cancer treatment.