16 results on '"Mohammadi, Elham"'
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2. Brain mitochondrial damage attenuation by quercetin and N-acetyl cysteine: peripheral and central antiemetic effects
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Abolfazli, Sajad, Foroumand, Sarvenaz, Mohammadi, Elham, Ahangar, Nematollah, Kheirandish, Ali, Fathi, Hamed, and Mohammadi, Hamidreza
- Abstract
Nausea serves as a protective mechanism in organisms to prevent excessive consumption of toxic substances. Due to the adverse effects of chemical anti-nausea drugs, there is a growing interest in using herbal remedies and natural antioxidants. In this study, we evaluated the neuroprotective effects of quercetin (QU) and N-acetylcysteine (NAC) against oxidative damage induced by nausea. Emesis was induced in chickens using ipecac and copper sulfate (600 and 60 mg/kg, orally, respectively). QU and NAC (with doses of 50, 100, 200 mg/kg), and their combination were administered, along with a standard therapy (metoclopramide; MET 2 mg/kg) for one-time. Mitochondrial function, lipid peroxidation (LPO), protein carbonyl (PC), glutathione level (GSH), and reactive oxygen species (ROS) as oxidative damage biomarkers were evaluated in the chicken’s brain mitochondria. QU and NAC significantly reduced emesis induced by copper sulfate and ipecac compared to the control group (P< 0.001). Significant differences in oxidative damage were observed in the groups received of copper sulfate and ipecac compared with control group. Levels of LPO, ROS, and PC were significantly decreased after the administration of QU and NAC in emesis induced by copper sulfate and ipecac. While, mitochondrial function and GSH levels were increased after the administration of QU and NAC. Combination therapy with QU and NAC yielded the most effective results. This study suggests that QU and NAC possess antiemetic effects through both peripheral and central mechanisms and exhibit neuroprotective effects against oxidative brain damage induced by emesis by increasing plasma antioxidants or scavenging free radicals.
- Published
- 2024
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3. Green synthesis of stable and biocompatible silver nanoparticles with natural flavonoid apigenin
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Mohammadi, Elham and Amini, Seyed Mohammad
- Abstract
The synthesis of silver nanoparticles has been carried out, controlling the size and using only apigenin as a reducing and coating agent. Unlike citrate-stabilized silver nanoparticles, the apigenin-coated nanoparticles are very stable in physiological environments. This unique stability is a result of a thick polyphenolic coating on the surface of the particles, which has been observed by electron microscopy. Based on Raman scattering, the phenolic coating originates from apigenin. Hemolysis induced by nanoparticles is less than 1% up to a concentration of 64 μg/ml and less than 5% up to a concentration of 128 μg/ml. These particles do not cause significant toxicity in human dermal fibroblast cells up to a concentration of 256 μg/ml. In the evaluation of the antioxidant properties of particles, it was found that they have antioxidant behavior up to a concentration of 32 μg/ml and pro-oxidant behavior at higher concentrations. Considering the biocompatibility of these nanoparticles, many biomedical applications can be considered for them.
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- 2024
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4. The factors influencing technological entrepreneurship in nanotechnology businesses
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Nikraftar, Tayebeh, Hosseini, Elahe, and Mohammadi, Elham
- Abstract
Purpose: Technological entrepreneurship has been a very significant topic in recent decades. It has a crucial role in economic modernization and growth. The need for technological entrepreneurship is because technology-based industries are expanding rapidly and are replacing traditional industries. Therefore, this study aimed at identifying the factors affecting the success of technological entrepreneurship in Iranian nanotechnology businesses. Design/methodology/approach: The research was conducted through mixed method. The participants in the qualitative section included 17 university experts and executive managers in the field of nanotechnology in Iran, and 75 nanotechnology business managers participated in the quantitative section. The interview and questionnaire were used to collect information. In order to measure and fit the models, the confirmatory factor analysis method and PLS3 software were used. Findings: The results indicated that the key factors affecting the success of the technological entrepreneurship process in nanotechnology were classified into five general categories: organizational, environmental, institutional, individual and technology factors. Moreover, it was shown that all these dimensions had a positive and significant effect on technological entrepreneurship. In addition, the organizational dimension has an essential role. Originality/value: Companies' ability to engage technological entrepreneurship is a vital factor in human resource management and strategic management. However, technological entrepreneurship in Iranian nanotechnology businesses has not been involved integrally in the context of companies.
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- 2021
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5. Effect of Gradient Layer of TiO2- HA on Properties of the Ha Coated Ti-6Al-4V
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Azari, Rezvan, Rezaie, Hamid Reza, Khavandi, Alireza, and Mohammadi, Elham Malek
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The use of hydroxyapatite (HA) coating on metallic implants has always been a challenge due to a discrepancy between ceramic coating and metallic substrate properties. In this study, functionally graded TiO
2 -HA coating (FGC TiO2 -HA), with bottom-up composition: 100% TiO2 , 50% TiO2 -50% HA, 100% HA, produced by sol-gel method on the Ti-6Al-4V alloy substrate. The XRD, FTIR and DSC results signified desired phase achievement. The quality assessment and scratch resistance of FGC TiO2 -HA in comparison with control samples (single-layer HA and double-layer TiO2 -HA coatings) were assessed by SEM and FESEM images and nanoscratch test. According to the tests outcomes, The TiO2 intermediate layer increases the HA coating’s strength (22%) and surface hardness, while gradient layer of TiO2 -HA improves (14%) this consequence by progressing the coating integrity.- Published
- 2020
6. Study of holdup and slip velocity in an L-shaped pulsed sieve-plate extraction column
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Mohammadi, Elham, Towfighi, Jafar, Safdari, Jaber, and Mallah, Mohammad
- Abstract
High-end applications require a very tall vertical extraction column in some cases which deteriorates protection against radiation and cannot be employed for indoor applications. On the other hand, horizontal extraction columns offer higher efficiency and pretension, but lower maximum throughput. In order to address this issue, the L-shaped pulsed extraction column is a new type of extractors which were recently introduced for such applications with area constraints. The objective of this study is to evaluate the effects of operating parameters and physical properties on the variation of holdup and slip velocity in this type of extractors for three liquid systems including toluene–water, butyl acetate–water and nbutanol–water without and under mass transfer condition. A comprehensive investigation on the determination of predictive ability of available correlations for the holdup and slip velocity in pulsed plate columns has been conducted. Finally, new correlations are proposed for prediction of these parameters regarding operational conditions and physical properties.
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- 2019
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7. Cooperative influence of D2EHPA and TBP on the reactive extraction of cobalt from sulfuric acid leach solution in a horizontal semi-industrial column.
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Amani, Pouria, Asadi, Javad, Mohammadi, Elham, Akhgar, Sahar, and Esmaili, Mohammad
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COBALT ,SULFURIC acid ,PHOSPHORIC acid - Abstract
This article concerns the recovery of cobalt from a sulfuric acid leach solution in a horizontal pulsed perforated-plate column. Firstly, the influence of initial aqueous pH and the concentration of di(2-ethylhexly) phosphoric acid + tri-butyl phosphate has been investigated. It is observed that the mixture of these extractants is able to satisfactorily extract Co(II) from sulfate solution. Moreover, the influences of operational parameters including the phase flow rates along with pulsation intensity on the holdup, drop sizes and their distribution as well as extraction and stripping efficiencies and dispersion coefficients have been evaluated. Results show the highest efficiency of 95.3% and 93.2% for extraction and stripping of Co(II) at pulsation intensity of 1.30 cm/s. Finally, new correlations for predicting mean drop size and holdup in the column are presented, which provide the average absolute relative error of 8.27% and 5.46% respectively. [ABSTRACT FROM AUTHOR]
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- 2017
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8. Design aspect of a novel L-shaped pulsed column for liquid–liquid extraction applications: Energy consumption and the characteristics velocity concept
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Amani, Pouria, Mohammadi, Elham, and Akhgar, Sahar
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This article deals with the evaluation of the consumption of energy for a steady state solvent extraction in a novel L-shaped pulsed sieve-plate column, which is highly required for design and optimization of the periodic flow processes for industrial applications. In this regard, a comprehensive evaluation on the energy consumption in case of a pulsed flow for three different chemical systems is conducted and besides the influence of pulsation intensity, the effect of geometrical parameters including the plate spacing and the plate free area is investigated as well. Moreover, the concept of characteristic velocity models at flooding points is evaluated with respect to the variation of pressure drop along the column at different operational conditions.
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- 2018
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9. The priorities and coping strategies of severely food insecure households in Beira in response to Cyclone Idai.
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McCordic, Cameron, Mohammadi, Elham, and Singh, Simron
- Abstract
• Severely food insecure households faced significant challenges before Cyclone Idai. • Following Cyclone Idai, these households prioritized housing, food and water. • Common coping strategies included re-allocating and collecting entitlements. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Cooperative influence of D2EHPA and TBP on the reactive extraction of cobalt from sulfuric acid leach solution in a horizontal semi-industrial column
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Amani, Pouria, Asadi, Javad, Mohammadi, Elham, Akhgar, Sahar, and Esmaili, Mohammad
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- 2017
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11. Accuracy of SOFA score in prediction of 30-day outcome of critically ill patients
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Safari, Saeed, Shojaee, Majid, Rahmati, Farhad, Barartloo, Alireza, Hahshemi, Behrooz, Forouzanfar, Mohammad Mehdi, and Mohammadi, Elham
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Researchers have attempted to design various scoring systems to determine the severity and predict the outcome of critically ill patients. The present study aimed to evaluate the accuracy of SOFA score in predicting 1-month outcome of these patients in emergency department.
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- 2016
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12. Flow cytometric immunophenotyping of feline bone marrow cells and haematopoietic progenitor cells using anti-human antibodies.
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Araghi, Atefeh, Nassiri, Seyed Mahdi, Atyabi, Nahid, Rahbarghazi, Reza, and Mohammadi, Elham
- Abstract
There is a paucity of species-specific antibodies available for feline haematopoietic conditions. The purpose of this study was to broaden the panel of antibodies available for use in the immunophenotypic characterisation of feline haematopoietic cells by testing clones of anti-human monoclonal antibodies (mAbs) on normal, neoplastic and cultured feline haematopoietic progenitors to determine cross-reactivity to feline counterparts. In this study, 24 clones of anti-human mAbs were tested on normal or neoplastic feline bone marrow and peripheral blood cells. Six of these mAbs, including anti-cluster of differentiation (CD)61, anti-CD18, anti-CD14, anti-CD235a, anti-CD41 and anti-CD29, cross-reacted with normal feline bone marrow cells, whereas anti-CD33 and anti-CD117 cross-reacted with the blast cells in the bone marrow of two cats with myelodysplastic syndrome, and anti-CD71, anti-235a, anti-41 and anti-42 cross-reacted with immature erythroid cells in a cat with erythroleukaemia. In a feline immunodeficiency virus-positive cat, bone marrow cells were labelled with anti-CD33, anti-14 and anti-45. Anti-CD18, anti-CD14, anti-CD41 and anti-CD61 also reacted with the peripheral blood cells of the healthy cats. The feline haematopoietic progenitors formed colonies in the methylcellulose-based semisolid medium with significant enrichment of colony-forming unit-granulocyte, monocyte and burst-forming unit-erythroid. A panel of six anti-feline mAbs (anti-CD21-like, anti-T lymphocytes, anti-CD172a, anti-granulocyte, anti-CD45-like and anti-CD18) and eight anti-human antibodies (anti-CD71, anti-CD33, anti-CD235a, anti-CD41, anti-CD61, anti-CD117, anti-CD38 and anti-CD34) were used for the immunophenotypic characterisation of the feline bone marrow progenitors. CD45, CD33, CD235a and CD18 were expressed by the feline haematopoietic progenitor cells, with the highest expression level for CD45. [ABSTRACT FROM PUBLISHER]
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- 2014
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13. Effect of pomegranate juice on vascular adhesion factors: A systematic review and meta-analysis.
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Asgary, Sedigheh, Karimi, Raheleh, Joshi, Tanuj, Kilpatrick, Kaitlyn L., Moradi, Sajjad, Samimi, Zeinab, Mohammadi, Elham, Farzaei, Mohammad Hosein, and Bishayee, Anupam
- Abstract
Background: Cardiovascular diseases, obesity, and insulin resistance demonstrate elements of functional impairment of the endothelium. Treatment of endothelial dysfunction with natural products, such as pomegranate, can open new ways in the treatment of cardiovascular diseases.Purpose: The present meta-analysis provides information in highlighting the role of pomegranate in endothelial dysfunction.Methods: Various databases, such as PubMed, Scopus, Web of Science, Cochrane, and Google Scholar, were searched up to July 2020 using relevant keywords. We have selected the studies that investigated the effects of pomegranate on vascular adhesion factors, including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin, and interleukin-6 (IL-6). MD with 95% CrI with 100,000 iterations by using Markov chain Monte Carlo code were used.Results: Pooled effect size of articles in human studies indicated that pomegranate juice was not significantly effective on ICAM-1 [MD: -0.42; CrI: (-1.01, 0.17)], VCAM-1 [MD: -0.20; CrI: (-1.95, 1.40)], and E-selectin [MD: -0.21; CrI: (-1.62, 1.21)] compared to the control group. But it can significantly reduce IL-6 [MD: -1.07; CrI: (-1.90, -0.19)].Conclusion: Generally, present study showed that pomegranate juice has no significant effect on vascular adhesion factors, ICAM-1, VCAM-1, and E-selectin, but can reduce IL-6 significantly. Future prospective randomized clinical trials with longer intervention duration are warranted to obtain a precise conclusion. [ABSTRACT FROM AUTHOR]- Published
- 2021
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14. Electronic waste in the Caribbean: An impending environmental disaster or an opportunity for a circular economy?
- Author
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Mohammadi, Elham, Singh, Simron Jit, and Habib, Komal
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ELECTRONIC waste ,ELECTRONIC waste management ,ENVIRONMENTAL disasters ,WASTE management ,SMALL states ,ELECTRONIC equipment - Abstract
Islands are bounded systems, often plagued with several sustainability challenges of limited land and resource availability, as well as pressing waste management issues. Despite these known problems, research aiming to help develop proper e-waste management systems for small island nations is scarce. Focusing on five Caribbean island states, this study provides the first comprehensive view of e-waste generation trends in an island context and explores the factors driving those trends. The study estimates Electrical and Electronic Equipment (EEE) flows for the five island cases over a period of 60 years (1965–2025), including e-waste that these flows have and will generate. A dynamic material flow analysis (MFA) approach has been used to estimate these flows and stocks for 206 product types. The results show that the five Caribbean islands produced double the e-waste per capita per year, i.e., 13 kg/cap/year compared to global average of 6.1 kg/cap/year in 2016. The aggregated amount of e-waste generated per year on these five islands seems to significantly rise in future: from 27,500 tonnes in 2010 to an estimated amount of 59,000 tonnes in 2025. This considerable estimated e-waste generation rate, when not properly managed, is not only harmful for the local environment, but also translates into considerable health impacts and loss of valuable resources. From a sustainability perspective, small islands should consider moving away from a linear to a circular economy that will limit waste generation as well as reliance on the supply of virgin materials from outside. Image, graphical abstract [ABSTRACT FROM AUTHOR]
- Published
- 2021
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15. Distribution of intraocular pressure in healthy Iranian children: the Shiraz Pediatric Eye Study.
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Masoumpour, Masoumeh Beygom, Nowroozzadeh, M. Hossein, Talebnejad, Mohammad Reza, Mahdaviazad, Hamideh, Khalili, Mohammad Reza, Keshtkar, Maryam, Mohammadi, Elham, and Tajbakhsh, Zahra
- Subjects
INTRAOCULAR pressure ,SCHOOL children ,MULTIPLE regression analysis ,EYE - Abstract
To describe the mean and normal range of intraocular pressure (IOP) and its associations in healthy Iranian school children using the noncontact tonometer. In this cross-sectional study as part of the Shiraz Pediatric Eye Study, a stratified random sampling was performed among elementary school children of Shiraz, Iran. Basic demographics and socioeconomic status of households, past medical history, drug history, and eye health history were collected for each eligible student. Children underwent complete ophthalmic examination. Axial length, corneal curvature, and anterior chamber depth were measured using the IOL-Master 500. Of 2,001 eligible children, 1,901 (95.0%; 3,802 eyes) with a mean age of 9.1 ± 1.6 years (standard deviation; range, 6-12 years) had reliable IOP. The mean spherical equivalent refraction was 0.5 ± 1.3 D for the right eye and 0.6 ± 1.2 D for the left eye. Mean IOP in the right eye was 15.1 ± 2.5 mm Hg (median, 15.0; range, 8.0–27.0 mm Hg); in the left eye, 15.2 ± 2.5 mm Hg (median, 15.0; range, 9.0–28.0 mm Hg). In multiple regression analyses, the mean IOP was significantly lower among asthmatic children compared to normal participants (P = 0.007). The measured IOP was significantly higher in myopic participants than hyperopic patients (P = 0.003). This study provides a useful normative IOP database using the noncontact tonometer for healthy Iranian school children. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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16. Folic acid decorated mesoporous silica nanospheres loaded with gadolinium for breast cancer cell imaging
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Hosseinabadi, Safdar Zare, Safari, Sepideh, Mirzaei, Mehdi, Mohammadi, Elham, Amini, Seyed Mohammad, and Mehravi, Bita
- Abstract
In cancer cells, some of the transporters are overexpressed. Therefore targeted contrast agent delivery by functionalized nanoparticles is probable to advanced molecular imaging and cancer cell identification in the early stages of cancer. In this research, folic acid-modified mesoporous silica nanospheres, loaded with gadolinium, were prepared and characterized by various techniques. FSG nanoprobe cellular uptake was analyzed quantitatively and qualitatively by ICP-AES, flow cytometry, and fluorescent microscopy in cell lines which expressed different levels of folic acid receptors. The cellular uptake of FSG nanoprobe by cancer cells was about 62% which is 2.6 times higher than cellular uptake of nanoprobe without folic acid targeting group. The average of FSG nanoprobe cellular uptake was 0.6 ± 0.1 pg Gd3+per cancer cell without any toxicity. The r1relaxivity of this nanoprobe in cancer cells was measured at 10.1 ± 6.0 mM?1s?1per Gd3+base. The results demonstrated that the present synthesized nanoprobe is promising one for cancer cell detection and delivering a sufficient amount of Gd3+as contrast agents into cancer cells.
- Published
- 2020
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