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The present study analyses human immunoglobulin G (IgG) antibodies directed against the Paracoccidioides brasiliensisexoantigen, gp43, as well as the presence of gp43-IgG immune complexes (ICs) in 31 samples of saliva and serum from 19 patients with paracoccidioidomycosis (PCM) and 12 normal donors. Additional analysis of secretory IgA (sIgA) was performed on the same saliva samples. Consistent with previous findings, a significant increased specific IgG level was observed in PCM patients' saliva and serum (P< 0·05). The analysis of serum gp43 and gp43-IgG IC demonstrated a higher level in patients with PCM (P< 0·05); however, this difference was not statistically significant with regard to gp43 and gp43-IgG in saliva when compared to the healthy donors. A high level of sIgA in saliva of PCM patients compared to that of normal donors was also observed (P< 0·05). Patients exhibiting low levels of serum IgG but with high titres of IC were observed, thus strengthening the idea of the necessity to use more than one marker for diagnosis and treatment monitoring of PCM. This is the first report of sIgA in PCM patients' saliva and may be indicative of a protective role in neutralizing antigens on mucosal surfaces.

The issue of mental competence in relation to consent to treatment has been high-lighted in the recently amended Mental Health Act in Ontario. The definition of mental competence in this context, how it is to be determined, and some practical implications of the Section of the Act pertaining to this matter, are discussed. The case history of a young woman is used to illustrate some of the points made.

The present study analyses human immunoglobulin G (IgG) antibodies directed against the Paracoccidioides brasiliensis exoantigen, gp43, as well as the presence of gp43-IgG immune complexes (ICs) in 31 samples of saliva and serum from 19 patients with paracoccidioidomycosis (PCM) and 12 normal donors. Additional analysis of secretory IgA (sIgA) was performed on the same saliva samples. Consistent with previous findings, a significant increased specific IgG level was observed in PCM patients saliva and serum (P<0·05). The analysis of serum gp43 and gp43-IgG IC demonstrated a higher level in patients with PCM (P<0·05); however, this difference was not statistically significant with regard to gp43 and gp43-IgG in saliva when compared to the healthy donors. A high level of sIgA in saliva of PCM patients compared to that of normal donors was also observed (P<0·05). Patients exhibiting low levels of serum IgG but with high titres of IC were observed, thus strengthening the idea of the necessity to use more than one marker for diagnosis and treatment monitoring of PCM. This is the first report of sIgA in PCM patients saliva and may be indicative of a protective role in neutralizing antigens on mucosal surfaces.

Dehalogenation and phenylation take place competitively in the photoreaction of polyhalobenzenes such as (I), (VII), and (XII).

A failure-time model, which leads to inverse Gaussian random samples, with common ratios of mean to variance, is considered. Hypothesis testing problems, analogous to those arising in two-way analysis of variance, are discussed in detail. The work of Tweedie (1957) plays an important role in the development, despite the fact that his analysis of reciprocals procedure has a different homogeneity assumption and does not deal with crossed classifications, and hence does not directly apply to the model under investigation.