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1. Spanish catheter ablation registry. 23rd official report of the Heart Rhythm Association of the Spanish Society of Cardiology (2023).

Author: Bazan, Victor, Arana, Eduardo, Rubio-Campal, José Manuel, Calvo, David, Álvarez Acosta, Luis, Hernández Afonso, Julio, Ramos Ardanaz, Pablo, Peñafiel Verdú, Pablo, Cano Calabria, Lucas R., Barrera Cordero, Alberto, Díaz Infante, Ernesto, Cózar León, Rocío, Lozano Granero, Vanesa Cristina, Martínez Sande, José Luis, Moya Mitjans, Àngel, Rodríguez Entem, Felipe, Salgado Aranda, Ricardo, Gil Ortega, Ignacio, Cabanas Grandío, Pilar, and Alcalde Rodriguez, Óscar
Abstract: Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2024
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2. Physicians’ beliefs and perceived importance of traumatic brain injury-associated agitation in critically ill patients: a survey of Canadian intensivists

Author: Saavedra-Mitjans, Mar, Frenette, Anne Julie, McCredie, Victoria A., Burry, Lisa, Arbour, Caroline, Mehta, Sangeeta, Charbonney, Emmanuel, Wang, Han Ting, Albert, Martin, Bernard, Francis, and Williamson, David
Abstract: Purpose: Agitation is a common behavioural problem following traumatic brain injury (TBI). Intensive care unit (ICU) physicians’ perspectives regarding TBI-associated agitation are unknown. Our objective was to describe physicians’ beliefs and perceived importance of TBI-associated agitation in critically ill patients. Methods: Following current standard guidance, we built an electronic, self-administrated, 42-item survey, pretested it for reliability and validity, and distributed it to 219 physicians working in 18 ICU level-1 trauma centres in Canada. We report the results using descriptive statistics. Results: The overall response rate was 93/219 (42%), and 76/93 (82%) respondents completed the full survey. Most respondents were men with ten or more years of experience. Respondents believed that pre-existing dementia (90%) and regular recreational drug use (86%) are risk factors for agitation. Concerning management, 91% believed that the use of physical restraints could worsen agitation, 90% believed that having family at the bedside reduces agitation, and 72% believed that alpha-2 adrenergic agonists are efficacious for managing TBI agitation. Variability was observed in beliefs on epidemiology, sex, gender, age, socioeconomic status, and other pharmacologic options. Respondents considered TBI agitation frequent enough to justify the implementation of management protocols (87%), perceived the current level of clinical evidence on TBI agitation management to be insufficient (84%), and expressed concerns about acute and long-term detrimental outcomes and burden to patients, health care professionals, and relatives (85%). Conclusion: Traumatic brain injury-associated agitation in critically ill patients was perceived as an important issue for most ICU physicians. Physicians agreed on multiple approaches to manage TBI-associated agitation although agreement on epidemiology and risk factors was variable.
Published: 2024
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3. The left atrial appendage closure by surgery-2 (LAACS-2) trial protocol rationale and design of a randomized multicenter trial investigating if left atrial appendage closure prevents stroke in patients undergoing open-heart surgery irrespective of...

Author: Madsen, Christoffer Læssøe, Park-Hansen, Jesper, Irmukhamedov, Akhmadjon, Carranza, Christian Lildal, Rafiq, Sulman, Rodriguez-Lecoq, Rafael, Palmer-Camino, Neiser, Modrau, Ivy Susanne, Hansson, Emma C., Jeppsson, Anders, Hadad, Rakin, Moya-Mitjans, Angel, Greve, Anders Møller, Christensen, Robin, Carstensen, Helle Gervig, Høst, Nis Baun, Dixen, Ulrik, Torp-Pedersen, Christian, Køber, Lars, and Gögenur, Ismail
Abstract: Current recommendations regarding the use of surgical left atrial appendage (LAA) closure to prevent thromboembolisms lack high-level evidence. Patients undergoing open-heart surgery often have several cardiovascular risk factors and a high occurrence of postoperative atrial fibrillation (AF)—with a high recurrence rate—and are thus at a high risk of stroke. Therefore, we hypothesized that concomitant LAA closure during open-heart surgery will reduce mid-term risk of stroke independently of preoperative AF status and CHA 2 DS 2 -VASc score. This protocol describes a randomized multicenter trial. Consecutive participants ≥18 years scheduled for first-time planned open-heart surgery from cardiac surgery centers in Denmark, Spain, and Sweden are included. Both patients with a previous diagnosis of paroxysmal or chronic AF, as well as those without AF, are eligible to participate, irrespective of their CHA 2 DS 2 -VASc score. Patients already planned for ablation or LAA closure during surgery, with current endocarditis, or where follow-up is not possible are considered noneligible. Patients are stratified by site, surgery type, and preoperative or planned oral anticoagulation treatment. Subsequently, patients are randomized 1:1 to either concomitant LAA closure or standard care (ie, open LAA). The primary outcome is stroke, including transient ischemic attack, as assigned by 2 independent neurologists blinded to the treatment allocation. To recognize a 60% relative risk reduction of the primary outcome with LAA closure, 1,500 patients are randomized and followed for 2 years (significance level of 0.05 and power of 90%). The LAACS-2 trial is likely to impact the LAA closure approach in most patients undergoing open-heart surgery. Trial registration: NCT03724318. [Display omitted] [ABSTRACT FROM AUTHOR]
Published: 2023
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4. Arrhythmic risk in single or recurrent episodes of unexplained syncope with complete bundle branch block.

Author: Francisco-Pascual, Jaume, Rivas-Gándara, Nuria, Maymi-Ballesteros, Manel, Badia-Molins, Clara, Bach-Oller, Montserrat, Benito, Begoña, Pérez-Rodón, Jordi, Santos-Ortega, Alba, Roca-Luque, Ivo, Rodríguez-Silva, Jesús, Jordán-Marchite, Pablo, Moya-Mitjans, Àngel, and Ferreira-González, Ignacio
Abstract: Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2023
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5. Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder

Author: Amare, Azmeraw T., Thalamuthu, Anbupalam, Schubert, Klaus Oliver, Fullerton, Janice M., Ahmed, Muktar, Hartmann, Simon, Papiol, Sergi, Heilbronner, Urs, Degenhardt, Franziska, Tekola-Ayele, Fasil, Hou, Liping, Hsu, Yi-Hsiang, Shekhtman, Tatyana, Adli, Mazda, Akula, Nirmala, Akiyama, Kazufumi, Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Hasler, Roland, Richard-Lepouriel, Hélène, Perroud, Nader, Backlund, Lena, Bhattacharjee, Abesh Kumar, Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Biernacka, Joanna M., Birner, Armin, Marie-Claire, Cynthia, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Cruceanu, Cristiana, Czerski, Piotr M., Dalkner, Nina, Del Zompo, Maria, DePaulo, J. Raymond, Étain, Bruno, Jamain, Stephane, Falkai, Peter, Forstner, Andreas J., Frisen, Louise, Frye, Mark A., Gard, Sébastien, Garnham, Julie S., Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Fallgatter, Andreas J., Stegmaier, Sophia, Ethofer, Thomas, Biere, Silvia, Petrova, Kristiyana, Schuster, Ceylan, Adorjan, Kristina, Budde, Monika, Heilbronner, Maria, Kalman, Janos L., Kohshour, Mojtaba Oraki, Reich-Erkelenz, Daniela, Schaupp, Sabrina K., Schulte, Eva C., Senner, Fanny, Vogl, Thomas, Anghelescu, Ion-George, Arolt, Volker, Dannlowski, Udo, Dietrich, Detlef, Figge, Christian, Jäger, Markus, Lang, Fabian U., Juckel, Georg, Konrad, Carsten, Reimer, Jens, Schmauß, Max, Schmitt, Andrea, Spitzer, Carsten, von Hagen, Martin, Wiltfang, Jens, Zimmermann, Jörg, Andlauer, Till F. M., Fischer, Andre, Bermpohl, Felix, Ritter, Philipp, Matura, Silke, Gryaznova, Anna, Falkenberg, Irina, Yildiz, Cüneyt, Kircher, Tilo, Schmidt, Julia, Koch, Marius, Gade, Kathrin, Trost, Sarah, Haussleiter, Ida S., Lambert, Martin, Rohenkohl, Anja C., Kraft, Vivien, Grof, Paul, Hashimoto, Ryota, Hauser, Joanna, Herms, Stefan, Hoffmann, Per, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kuo, Po-Hsiu, Kato, Tadafumi, Kelsoe, John, Kittel-Schneider, Sarah, Ferensztajn-Rochowiak, Ewa, König, Barbara, Kusumi, Ichiro, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G., Tortorella, Alfonso, Manchia, Mirko, Martinsson, Lina, McCarthy, Michael J., McElroy, Susan, Colom, Francesc, Millischer, Vincent, Mitjans, Marina, Mondimore, Francis M., Monteleone, Palmiero, Nievergelt, Caroline M., Nöthen, Markus M., Novák, Tomas, O’Donovan, Claire, Ozaki, Norio, Pfennig, Andrea, Pisanu, Claudia, Potash, James B., Reif, Andreas, Reininghaus, Eva, Rouleau, Guy A., Rybakowski, Janusz K., Schalling, Martin, Schofield, Peter R., Schweizer, Barbara W., Severino, Giovanni, Shilling, Paul D., Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire M., Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Maj, Mario, Turecki, Gustavo, Vieta, Eduard, Veeh, Julia, Witt, Stephanie H., Wright, Adam, Zandi, Peter P., Mitchell, Philip B., Bauer, Michael, Alda, Martin, Rietschel, Marcella, McMahon, Francis J., Schulze, Thomas G., Clark, Scott R., and Baune, Bernhard T.
Abstract: Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium’s possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGSwas developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N= 2367) and replicated in the combined PsyCourse (N= 89) and BipoLife (N= 102) studies. The associations of Li+PGSand lithium treatment response —defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P< 0.05. Li+PGSwas positively associated with lithium treatment response in the ConLi+Gen cohort, in both the categorical (P= 9.8 × 10−12, R2= 1.9%) and continuous (P= 6.4 × 10−9, R2= 2.6%) outcomes. Compared to bipolar patients in the 1stdecile of the risk distribution, individuals in the 10thdecile had 3.47-fold (95%CI: 2.22–5.47) higher odds of responding favorably to lithium. The results were replicated in the independent cohorts for the categorical treatment outcome (P= 3.9 × 10−4, R2= 0.9%), but not for the continuous outcome (P= 0.13). Gene-based analyses revealed 36 candidate genes that are enriched in biological pathways controlled by glutamate and acetylcholine. Li+PGSmay be useful in the development of pharmacogenomic testing strategies by enabling a classification of bipolar patients according to their response to treatment.
Published: 2023
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6. Registro español de ablación con catéter. XXII informe oficial de la Asociación del Ritmo Cardiaco de la Sociedad Española de Cardiología (2022)

Author: Cano, Óscar, Bazán, Víctor, Arana, Eduardo, Alcalde-Rodríguez, Óscar, Almendral-Garrote, Jesús, Alonso-Fernández, Pau, Álvarez-López, Miguel, Álvarez-Acosta, Luis, Anguera-Camos, Ignasi, Arce-León, Álvaro, Arenal, Ángel, Palomares, Miguel Ángel Arias, Arocha-Torres, María Fe, Asso-Abadía, Antonio, Barrera-Cordero, Alberto, Bastos-Amador, Pablo, Benezet-Mazuecos, Juan, Benito-Martínez, Eva María, Bochard-Villanueva, Bruno, Cabanas-Grandío, Pilar, Cabrera-Ramos, Mercedes, Cano-Calabria, Lucas R., del Castillo-Arrojo, Silvia, Cerveró, Alba, Datino-Romaniega, Tomás, Díaz-Infante, Ernesto, Domínguez-Mafé, Eloy, Durán-Guerrero, Juan Manuel, Teja, Juliana Elices, Emilce-Trucco, María, Espinosa-Viamonte, Hildemari, Fabregat-Andrés, Óscar, Fernández-Palacios, Gonzalo, Fernández-Lozano, Ignacio, Fernández-Gómez, Juan Manuel, Ferrer-Hita, Julio Jesús, Fidalgo-Andrés, María Luisa, García-Cuenca, Enrique, García-Rodríguez, Daniel, García-Fernández, Francisco Javier, Gil-Ortega, Ignacio, Gómez-Pulido, Federico, González-Ferrer, Juan José, Grande-Morales, Carlos Eugenio, Guasch-Casany, Eduard, Guerra-Ramos, José María, Herreros-Guilarte, Benito, Hidalgo-Olivares, Víctor Manuel, Ibáñez-Criado, Alicia, Ibáñez-Criado, José Luis, Jiménez-Díaz, Francisco Javier, Jiménez-López, Jesús, Jiménez-Candil, Javier, Lozano-Granero, Vanesa Cristina, Luque-Lezcano, Antonio Óscar, Martí-Almor, Julio, Martín-Sánchez, Gabriel, Martínez-Sande, José Luis, Martínez-Brotons, Ángel Miguel, Mazuelos-Bellido, Francisco, Mendoza-Lemes, Haridian, Menéndez-Ramírez, Diego, Merino-Llorens, José Luis, Moreno-Arribas, José, Moriña-Vázquez, Pablo, Mosquera-Pérez, Ignacio, Moya-Mitjans, Ángel, Osca-Asensi, Joaquín, Pastor-Fuentes, Agustín, Pavón-Jiménez, Ricardo, Pedrote-Martínez, Alonso, Peinado-Peinado, Rafael, Peláez-González, Antonio, Peñafiel-Verdú, Pablo, Pérez-Roselló, Víctor, Porta-Sánchez, Andreu, Portales-Fernández, Javier, Quesada-Dorador, Aurelio, Ramos-Ardanaz, Pablo, Rivas-Gándara, Nuria, Rodríguez-Entem, Felipe José, Rodríguez-Font, Enrique, Rodríguez-Muñoz, Daniel, Romero-Garrido, Rafael, Rubín-López, José Manuel, Rubio-Caballero, José Amador, Rubio-Campal, José Manuel, Ruíz-Duthil, Ana Delia, Ruíz-Hernández, Pablo M., Sainz-Godoy, Íñigo, Salgado-Aranda, Ricardo, Salvador-Montañés, Óscar, Sánchez-Borque, Pepa, Sandín-Fuentes, María de Gracia, Sarquella-Brugada, Georgia, Sarrias-Mercè, Axel, Saurí-Ortiz, Assumpció, Segura-Villalobos, Federico, Valverde-André, Irene, and Vázquez-Esmorís, Iván
Abstract: Se presentan los resultados del Registro español de ablación con catéter correspondientes a 2022.
Published: 2023
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7. Kahoot y Quizizz: cuando jugar en equipos marca la diferencia a la hora de motivar a leer noticias de ciencias.

Author: Fabre Mitjans, Noëlle
Subjects: SCIENCE education, SCIENTIFIC literacy, EDUCATION students, EFFECTIVE teaching, SCIENCE students, TEST scoring, NEWS websites, STUDENTS
Abstract: Copyright of Revista Electrónica Interuniversitaria De Formación del Profesorado is the property of Asociacion Universitaria de Formacion del Profesorado (AUFOP) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2023
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8. RAGE/SNAIL1 signaling drives epithelial-mesenchymal plasticity in metastatic triple-negative breast cancer

Author: Pujals, Mireia, Mayans, Carla, Bellio, Chiara, Méndez, Olga, Greco, Emanuela, Fasani, Roberta, Alemany-Chavarria, Mercè, Zamora, Esther, Padilla, Laura, Mitjans, Francesc, Nuciforo, Paolo, Canals, Francesc, Nonell, Lara, Abad, María, Saura, Cristina, Tabernero, Josep, and Villanueva, Josep
Abstract: Epithelial/Mesenchymal (E/M) plasticity plays a fundamental role both in embryogenesis and during tumorigenesis. The receptor for advanced glycation end products (RAGE) is a driver of cell plasticity in fibrotic diseases; however, its role and molecular mechanism in triple-negative breast cancer (TNBC) remains unclear. Here, we demonstrate that RAGE signaling maintains the mesenchymal phenotype of aggressive TNBC cells by enforcing the expression of SNAIL1. Besides, we uncover a crosstalk mechanism between the TGF-β and RAGE pathways that is required for the acquisition of mesenchymal traits in TNBC cells. Consistently, RAGE inhibition elicits epithelial features that block migration and invasion capacities. Next, since RAGE is a sensor of the tumor microenvironment, we modeled acute acidosis in TNBC cells and showed it promotes enhanced production of RAGE ligands and the activation of RAGE-dependent invasive properties. Furthermore, acute acidosis increases SNAIL1 levels and tumor cell invasion in a RAGE-dependent manner. Finally, we demonstrate that in vivo inhibition of RAGE reduces metastasis incidence and expands survival, consistent with molecular effects that support the relevance of RAGE signaling in E/M plasticity. These results uncover new molecular insights on the regulation of E/M phenotypes in cancer metastasis and provide rationale for pharmacological intervention of this signaling axis.
Published: 2023
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9. Riesgo arrítmico en episodios únicos o recurrentes de síncope inexplicado con bloqueo completo de rama

Author: Francisco-Pascual, Jaume, Rivas-Gándara, Nuria, Maymi-Ballesteros, Manel, Badia-Molins, Clara, Bach-Oller, Montserrat, Benito, Begoña, Pérez-Rodón, Jordi, Santos-Ortega, Alba, Roca-Luque, Ivo, Rodríguez-Silva, Jesús, Jordán-Marchite, Pablo, Moya-Mitjans, Àngel, and Ferreira-González, Ignacio
Abstract: Los pacientes con un episodio sincopal inexplicable único (ESU) y bloqueo completo de rama del haz de His (BcR) con frecuencia se tratan de manera más conservadora que aquellos con episodios recurrentes (ESR). El objetivo fue analizar si existen diferencias entre pacientes con ESU o ESR y BcR en cuanto al riesgo arrítmico, el rendimiento diagnóstico de las pruebas y los resultados clínicos.
Published: 2023
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10. Concepción Cabrillana, Tomás Moro: Diálogos de Luciano. Introducción, traducción del original latino y notas

Author: Mitjans, Frank
Published: 2023
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11. Fearing the Black Body. The Racial History of Fatphobia.

Author: Alayón, A. Tito Mitjans
Subjects: DISCRIMINATION against overweight persons, DEHUMANIZATION, WHITE supremacy, PUBLIC opinion, RENAISSANCE art, SLAVE trade
Abstract: Copyright of Estudios Sociológicos is the property of El Colegio de Mexico AC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2022
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12. Fearing the Black Body. The Racial History of Fatphobia.

Author: Alayón, A. Tito Mitjans
Subjects: DISCRIMINATION against overweight persons, DEHUMANIZATION, WHITE supremacy, PUBLIC opinion, RENAISSANCE art, SLAVE trade
Abstract: Copyright of Estudios Sociológicos is the property of El Colegio de Mexico AC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2022
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13. Clinical and serological characteristics of Cuban patients with Systemic Lupus Erythematosus

Author: Noris-García, Elena, Montero Díaz, Minerva, Lanigan Gutiérrez, María Eugenia, Álvarez Contreras, Yanaisy, Mitjans Fuentes, Carlos Omar, and Robinson-Agramonte, María de los Ángeles
Abstract: Systemic lupus erythematosus (SLE) is the prototype of systemic autoimmune disease with clinical characteristics that show geographic variations. However, these differences between regions have not been fully described; therefore, the objective of this study is to describe the clinical and sociodemographic characteristics of Cuban patients with SLE.
Published: 2022
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14. Risk stratification of ventricular arrhythmias in repaired tetralogy of Fallot.

Author: Rivas-Gándara, Nuria, Francisco-Pascual, Jaume, Pijuan-Domenech, Antonia, Ribera-Solé, Aida, Dos-Subirá, Laura, Benito, Begoña, Terricabras, Maria, Pérez-Rodon, Jordi, Subirana, María Teresa, Santos-Ortega, Alba, Roses-Noguer, Ferran, Miranda, Berta, Moya-Mitjans, Àngel, and Ferreira-González, Ignacio
Abstract: Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2021
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15. The experience of giving birth in a hospital in Spain: Humanization versus technification

Author: Esteban-Sepúlveda, Silvia, Fabregas-Mitjans, Montserrat, Ordobas-Pages, Laura, Tutusaus-Arderiu, Ana, Andreica, Ligia Emanuela, and Leyva-Moral, Juan Manuel
Abstract: To explore and describe the experiences of women giving birth in a tertiary public hospital, with special focus on experiences related to humanized care and women's participation in decision making.
Published: 2022
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16. Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Author: Trubetskoy, Vassily, Pardiñas, Antonio F., Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B., Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A., Hall, Lynsey S., Lam, Max, Watanabe, Kyoko, Frei, Oleksandr, Ge, Tian, Harwood, Janet C., Koopmans, Frank, Magnusson, Sigurdur, Richards, Alexander L., Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen, Adams, Mark, Agartz, Ingrid, Atkinson, Elizabeth G., Agerbo, Esben, Al Eissa, Mariam, Albus, Margot, Alexander, Madeline, Alizadeh, Behrooz Z., Alptekin, Köksal, Als, Thomas D., Amin, Farooq, Arolt, Volker, Arrojo, Manuel, Athanasiu, Lavinia, Azevedo, Maria Helena, Bacanu, Silviu A., Bass, Nicholas J., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Benyamin, Beben, Bergen, Sarah E., Blasi, Giuseppe, Bobes, Julio, Bonassi, Stefano, Braun, Alice, Bressan, Rodrigo Affonseca, Bromet, Evelyn J., Bruggeman, Richard, Buckley, Peter F., Buckner, Randy L., Bybjerg-Grauholm, Jonas, Cahn, Wiepke, Cairns, Murray J., Calkins, Monica E., Carr, Vaughan J., Castle, David, Catts, Stanley V., Chambert, Kimberley D., Chan, Raymond C. K., Chaumette, Boris, Cheng, Wei, Cheung, Eric F. C., Chong, Siow Ann, Cohen, David, Consoli, Angèle, Cordeiro, Quirino, Costas, Javier, Curtis, Charles, Davidson, Michael, Davis, Kenneth L., de Haan, Lieuwe, Degenhardt, Franziska, DeLisi, Lynn E., Demontis, Ditte, Dickerson, Faith, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Duan, Jubao, Ducci, Giuseppe, Dudbridge, Frank, Eriksson, Johan G., Fañanás, Lourdes, Faraone, Stephen V., Fiorentino, Alessia, Forstner, Andreas, Frank, Josef, Freimer, Nelson B., Fromer, Menachem, Frustaci, Alessandra, Gadelha, Ary, Genovese, Giulio, Gershon, Elliot S., Giannitelli, Marianna, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., González Peñas, Javier, González-Pinto, Ana, Gopal, Srihari, Gratten, Jacob, Green, Michael F., Greenwood, Tiffany A., Guillin, Olivier, Gülöksüz, Sinan, Gur, Raquel E., Gur, Ruben C., Gutiérrez, Blanca, Hahn, Eric, Hakonarson, Hakon, Haroutunian, Vahram, Hartmann, Annette M., Harvey, Carol, Hayward, Caroline, Henskens, Frans A., Herms, Stefan, Hoffmann, Per, Howrigan, Daniel P., Ikeda, Masashi, Iyegbe, Conrad, Joa, Inge, Julià, Antonio, Kähler, Anna K., Kam-Thong, Tony, Kamatani, Yoichiro, Karachanak-Yankova, Sena, Kebir, Oussama, Keller, Matthew C., Kelly, Brian J., Khrunin, Andrey, Kim, Sung-Wan, Klovins, Janis, Kondratiev, Nikolay, Konte, Bettina, Kraft, Julia, Kubo, Michiaki, Kučinskas, Vaidutis, Kučinskiene, Zita Ausrele, Kusumawardhani, Agung, Kuzelova-Ptackova, Hana, Landi, Stefano, Lazzeroni, Laura C., Lee, Phil H., Legge, Sophie E., Lehrer, Douglas S., Lencer, Rebecca, Lerer, Bernard, Li, Miaoxin, Lieberman, Jeffrey, Light, Gregory A., Limborska, Svetlana, Liu, Chih-Min, Lönnqvist, Jouko, Loughland, Carmel M., Lubinski, Jan, Luykx, Jurjen J., Lynham, Amy, Macek, Milan, Mackinnon, Andrew, Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Malaspina, Dolores, Mallet, Jacques, Marder, Stephen R., Marsal, Sara, Martin, Alicia R., Martorell, Lourdes, Mattheisen, Manuel, McCarley, Robert W., McDonald, Colm, McGrath, John J., Medeiros, Helena, Meier, Sandra, Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mitjans, Marina, Molden, Espen, Molina, Esther, Molto, María Dolores, Mondelli, Valeria, Moreno, Carmen, Morley, Christopher P., Muntané, Gerard, Murphy, Kieran C., Myin-Germeys, Inez, Nenadić, Igor, Nestadt, Gerald, Nikitina-Zake, Liene, Noto, Cristiano, Nuechterlein, Keith H., O’Brien, Niamh Louise, O’Neill, F. Anthony, Oh, Sang-Yun, Olincy, Ann, Ota, Vanessa Kiyomi, Pantelis, Christos, Papadimitriou, George N., Parellada, Mara, Paunio, Tiina, Pellegrino, Renata, Periyasamy, Sathish, Perkins, Diana O., Pfuhlmann, Bruno, Pietiläinen, Olli, Pimm, Jonathan, Porteous, David, Powell, John, Quattrone, Diego, Quested, Digby, Radant, Allen D., Rampino, Antonio, Rapaport, Mark H., Rautanen, Anna, Reichenberg, Abraham, Roe, Cheryl, Roffman, Joshua L., Roth, Julian, Rothermundt, Matthias, Rutten, Bart P. F., Saker-Delye, Safaa, Salomaa, Veikko, Sanjuan, Julio, Santoro, Marcos Leite, Savitz, Adam, Schall, Ulrich, Scott, Rodney J., Seidman, Larry J., Sharp, Sally Isabel, Shi, Jianxin, Siever, Larry J., Sigurdsson, Engilbert, Sim, Kang, Skarabis, Nora, Slominsky, Petr, So, Hon-Cheong, Sobell, Janet L., Söderman, Erik, Stain, Helen J., Steen, Nils Eiel, Steixner-Kumar, Agnes A., Stögmann, Elisabeth, Stone, William S., Straub, Richard E., Streit, Fabian, Strengman, Eric, Stroup, T. Scott, Subramaniam, Mythily, Sugar, Catherine A., Suvisaari, Jaana, Svrakic, Dragan M., Swerdlow, Neal R., Szatkiewicz, Jin P., Ta, Thi Minh Tam, Takahashi, Atsushi, Terao, Chikashi, Thibaut, Florence, Toncheva, Draga, Tooney, Paul A., Torretta, Silvia, Tosato, Sarah, Tura, Gian Battista, Turetsky, Bruce I., Üçok, Alp, Vaaler, Arne, van Amelsvoort, Therese, van Winkel, Ruud, Veijola, Juha, Waddington, John, Walter, Henrik, Waterreus, Anna, Webb, Bradley T., Weiser, Mark, Williams, Nigel M., Witt, Stephanie H., Wormley, Brandon K., Wu, Jing Qin, Xu, Zhida, Yolken, Robert, Zai, Clement C., Zhou, Wei, Zhu, Feng, Zimprich, Fritz, Atbaşoğlu, Eşref Cem, Ayub, Muhammad, Benner, Christian, Bertolino, Alessandro, Black, Donald W., Bray, Nicholas J., Breen, Gerome, Buccola, Nancy G., Byerley, William F., Chen, Wei J., Cloninger, C. Robert, Crespo-Facorro, Benedicto, Donohoe, Gary, Freedman, Robert, Galletly, Cherrie, Gandal, Michael J., Gennarelli, Massimo, Hougaard, David M., Hwu, Hai-Gwo, Jablensky, Assen V., McCarroll, Steven A., Moran, Jennifer L., Mors, Ole, Mortensen, Preben B., Müller-Myhsok, Bertram, Neil, Amanda L., Nordentoft, Merete, Pato, Michele T., Petryshen, Tracey L., Pirinen, Matti, Pulver, Ann E., Schulze, Thomas G., Silverman, Jeremy M., Smoller, Jordan W., Stahl, Eli A., Tsuang, Debby W., Vilella, Elisabet, Wang, Shi-Heng, Xu, Shuhua, Adolfsson, Rolf, Arango, Celso, Baune, Bernhard T., Belangero, Sintia Iole, Børglum, Anders D., Braff, David, Bramon, Elvira, Buxbaum, Joseph D., Campion, Dominique, Cervilla, Jorge A., Cichon, Sven, Collier, David A., Corvin, Aiden, Curtis, David, Forti, Marta Di, Domenici, Enrico, Ehrenreich, Hannelore, Escott-Price, Valentina, Esko, Tõnu, Fanous, Ayman H., Gareeva, Anna, Gawlik, Micha, Gejman, Pablo V., Gill, Michael, Glatt, Stephen J., Golimbet, Vera, Hong, Kyung Sue, Hultman, Christina M., Hyman, Steven E., Iwata, Nakao, Jönsson, Erik G., Kahn, René S., Kennedy, James L., Khusnutdinova, Elza, Kirov, George, Knowles, James A., Krebs, Marie-Odile, Laurent-Levinson, Claudine, Lee, Jimmy, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., Malhotra, Dheeraj, McIntosh, Andrew, McQuillin, Andrew, Menezes, Paulo R., Morgan, Vera A., Morris, Derek W., Mowry, Bryan J., Murray, Robin M., Nimgaonkar, Vishwajit, Nöthen, Markus M., Ophoff, Roel A., Paciga, Sara A., Palotie, Aarno, Pato, Carlos N., Qin, Shengying, Rietschel, Marcella, Riley, Brien P., Rivera, Margarita, Rujescu, Dan, Saka, Meram C., Sanders, Alan R., Schwab, Sibylle G., Serretti, Alessandro, Sham, Pak C., Shi, Yongyong, St Clair, David, Stefánsson, Hreinn, Stefansson, Kari, Tsuang, Ming T., van Os, Jim, Vawter, Marquis P., Weinberger, Daniel R., Werge, Thomas, Wildenauer, Dieter B., Yu, Xin, Yue, Weihua, Holmans, Peter A., Pocklington, Andrew J., Roussos, Panos, Vassos, Evangelos, Verhage, Matthijs, Visscher, Peter M., Yang, Jian, Posthuma, Danielle, Andreassen, Ole A., Kendler, Kenneth S., Owen, Michael J., Wray, Naomi R., Daly, Mark J., Huang, Hailiang, Neale, Benjamin M., Sullivan, Patrick F., Ripke, Stephan, Walters, James T. R., and O’Donovan, Michael C.
Abstract: Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2Aand transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.
Published: 2022
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17. Development of Animal Fibres Composites for Construction Applications

Author: Alfocea-Roig, Anna, Huete-Hernandez, Sergio, Maldonado-Alameda, Alex, Giro-Paloma, Jessica, Chimenos-Ribera, Josep Maria, and Formosa-Mitjans, Joan
Abstract: Climate change has become one of the world’s leading threats. Currently, the construction industry has a high environmental footprint. For this reason, the scientific and technological sector is looking for new materials to reduce the environmental consequences of this division. It is well known that the valorisation of different by-products can contribute to the reduction of the energy global consumption and CO2 emissions. Magnesium Phosphate Cement (MPC) can be obtained by using Low Grade Magnesium Oxide (LG-MgO) as a by-product from the industrial process of magnesite calcination. In this research, a Sustainable MPC (Sust-MPC) for different construction purposes is developed by using LG-MgO along with monopotassium phosphate KH2PO4 (MKP) as raw materials. The increasing use of synthetic fibres in clothing, as well as China’s competitive prices on Animal Fibres (AF) market, have led to a commercial interest fibre decrease for wool-like AF in Spain. This study aims to formulate a Sust-MPC cement with Animal Fibre (AF) to reduce the cost of the new material (Sust-MPC-AF) and to increase the thermal insulation, allowing the use of Sust-MPC-AF in several potential applications. Besides, it should be emphasized that the final pH of Sust-MPC is neutral, which allows containing natural fibres. To develop Sust-MPC-AF, some properties such as thermal conductivity, density, Modulus of Elasticity (MoE), flexural strength, and economic cost were evaluated using the Design of Experiments (DoE). The DoE studies allowed obtaining a model for further optimization considering minimum thermal conductivity and cost dosages. The formulation 30L-25EW presents the minimum conductivity (?=0.140 W·m-1·K-1). Therefore, two optimal dosages (36L-25EW and 24L-22EW) are obtained by considering mixing variables such as AF/Cement ratio (AF/C) and AF/Extra Water ratio (AF/EW).
Published: 2022
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18. Etiology and prognosis of patients with unexplained syncope and mid-range left ventricular dysfunction.

Author: Francisco-Pascual, Jaume, Rodenas-Alesina, Eduard, Rivas-Gándara, Nuria, Belahnech, Yassin, Olivella San Emeterio, Aleix, Pérez-Rodón, Jordi, Benito, Begoña, Santos-Ortega, Alba, Moya-Mitjans, Àngel, Casas, Guillem, Cantalapiedra-Romero, Javier, Maldonado, Jenson, and Ferreira-González, Ignacio
Abstract: Background: Syncope in patients with mid-range left ventricular ejection fraction (LVEF) can be due to potentially serious arrhythmic causes. However, there is no clear consensus on the best way to manage these patients.Objectives: The objectives of this study were to determine the causes of syncope and assess the diagnostic yield and safety of a stepwise workup protocol in this population.Methods: This was a prospective observational study. A stepwise workup protocol was applied to patients with LVEF 35%-50% and unexplained syncope after the initial assessment (step 1).Results: One hundred four patients were included {median age 75.6 years; (interquartile range [IQR] 67.6-81.2 years); median LVEF 45% (IQR 40%-48%); median follow-up 2.0 years (IQR 0.7-3.3 years). In 71 patients (68.3%), a diagnosis was reached: 55 (77.5%) in step 2 (hospital admission and electrophysiology study) and 16 (36.5%) in step 3 (implantable cardiac monitor). Arrhythmic causes were the most common etiology (45.2% auriculoventricular block and 9.6% ventricular tachycardia). Sixty patients (57.7%) required the implantation of a cardiac device and 11 had a defibrillation function. Patients diagnosed in step 3 had a higher global risk of recurrence of syncope (hazard ratio 6.5; 95% confidence interval 2.3-18.0). The mortality rate was 8.1 per 100 person-years, and the sudden or unknown death rate was 0.9 per 100 person-years.Conclusion: In patients with mid-range left ventricular dysfunction and syncope of unknown cause, a systematic diagnostic strategy based on electrophysiology study and/or implantable cardiac monitor implantation allows a diagnosis to be reached in a high proportion of cases and guides the treatment. Arrhythmia is the most common cause of syncope in this population, particularly auriculoventricular block. [ABSTRACT FROM AUTHOR]
Published: 2021
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19. Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study

Author: Coombes, Brandon J., Millischer, Vincent, Batzler, Anthony, Larrabee, Beth, Hou, Liping, Papiol, Sergi, Heilbronner, Urs, Adli, Mazda, Akiyama, Kazufumi, Akula, Nirmala, Amare, Azmeraw T., Ardau, Raffaella, Arias, Barbara, Aubry, Jean-Michel, Backlund, Lena, Bauer, Michael, Baune, Bernhard T., Bellivier, Frank, Benabarre, Antoni, Bengesser, Susanne, Bhattacharjee, Abesh Kumar, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Clark, Scott R., Colom, Francesc, Cruceanu, Cristiana, Czerski, Piotr M., Dalkner, Nina, Degenhardt, Franziska, Del Zompo, Maria, DePaulo, J. Raymond, Étain, Bruno, Falkai, Peter, Ferensztajn-Rochowiak, Ewa, Forstner, Andreas J., Frisen, Louise, Gard, Sébastien, Garnham, Julie S., Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Grof, Paul, Hashimoto, Ryota, Hauser, Joanna, Herms, Stefan, Hoffmann, Per, Jamain, Stephane, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kato, Tadafumi, Kelsoe, John R., Kittel-Schneider, Sarah, König, Barbara, Kuo, Po-Hsiu, Kusumi, Ichiro, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G., Maj, Mario, Manchia, Mirko, Martinsson, Lina, McCarthy, Michael J., McElroy, Susan L., Mitchell, Philip B., Mitjans, Marina, Mondimore, Francis M., Monteleone, Palmiero, Nievergelt, Caroline M., Nöthen, Markus M., Novák, Tomas, O’Donovan, Claire, Osby, Urban, Ozaki, Norio, Pfennig, Andrea, Pisanu, Claudia, Potash, James B., Reif, Andreas, Reininghaus, Eva, Rietschel, Marcella, Rouleau, Guy A., Rybakowski, Janusz K., Schalling, Martin, Schofield, Peter R., Schubert, Klaus Oliver, Schweizer, Barbara W., Severino, Giovanni, Shekhtman, Tatyana, Shilling, Paul D., Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire M., Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Tortorella, Alfonso, Turecki, Gustavo, Vieta, Eduard, Witt, Stephanie H., Zandi, Peter P., Fullerton, Janice M., Alda, Martin, Frye, Mark A., Schulze, Thomas G., McMahon, Francis J., and Biernacka, Joanna M.
Abstract: Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (N= 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using lassosumand in a model including all three PRSs and other covariates, and the PRS of ADHD (β = −0.14; 95% confidence interval [CI]: −0.24 to −0.03; pvalue = 0.010) and MDD (β = −0.16; 95% CI: −0.27 to −0.04; pvalue = 0.005) predicted worse quantitative lithium response. A higher SCZ PRS was associated with higher rates of medication nonadherence (OR = 1.61; 95% CI: 1.34–1.93; pvalue = 2e−7). This study indicates that genetic risk for ADHD and depression may influence lithium treatment response. Interestingly, a higher SCZ PRS was associated with poor adherence, which can negatively impact treatment response. Incorporating genetic risk of ADHD, depression, and SCZ in combination with clinical risk may lead to better clinical care for patients with BD.
Published: 2021
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20. The “Discovery” of the Autograph of Thomas More's De Tristitia Christithrough Andrés Vázquez de Prada

Author: Mitjans, Frank
Published: 2021
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21. Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Author: Amare, Azmeraw T., Schubert, Klaus Oliver, Hou, Liping, Clark, Scott R., Papiol, Sergi, Cearns, Micah, Heilbronner, Urs, Degenhardt, Franziska, Tekola-Ayele, Fasil, Hsu, Yi-Hsiang, Shekhtman, Tatyana, Adli, Mazda, Akula, Nirmala, Akiyama, Kazufumi, Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Backlund, Lena, Bhattacharjee, Abesh Kumar, Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Biernacka, Joanna M., Birner, Armin, Brichant-Petitjean, Clara, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Cruceanu, Cristiana, Czerski, Piotr M., Dalkner, Nina, Dayer, Alexandre, Del Zompo, Maria, DePaulo, J. Raymond, Étain, Bruno, Jamain, Stephane, Falkai, Peter, Forstner, Andreas J., Frisen, Louise, Frye, Mark A., Fullerton, Janice M., Gard, Sébastien, Garnham, Julie S., Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Grof, Paul, Hashimoto, Ryota, Hauser, Joanna, Herms, Stefan, Hoffmann, Per, Hofmann, Andrea, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kuo, Po-Hsiu, Kato, Tadafumi, Kelsoe, John R., Kittel-Schneider, Sarah, Kliwicki, Sebastian, König, Barbara, Kusumi, Ichiro, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G., Tortorella, Alfonso, Manchia, Mirko, Martinsson, Lina, McCarthy, Michael J., McElroy, Susan L., Colom, Francesc, Mitjans, Marina, Mondimore, Francis M., Monteleone, Palmiero, Nievergelt, Caroline M., Nöthen, Markus M., Novák, Tomas, O’Donovan, Claire, Ozaki, Norio, Ösby, Urban, Pfennig, Andrea, Potash, James B., Reif, Andreas, Reininghaus, Eva, Rouleau, Guy A., Rybakowski, Janusz K., Schalling, Martin, Schofield, Peter R., Schweizer, Barbara W., Severino, Giovanni, Shilling, Paul D., Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire M., Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Maj, Mario, Turecki, Gustavo, Vieta, Eduard, Veeh, Julia, Witt, Stephanie H., Wright, Adam, Zandi, Peter P., Mitchell, Philip B., Bauer, Michael, Alda, Martin, Rietschel, Marcella, McMahon, Francis J., Schulze, Thomas G., and Baune, Bernhard T.
Abstract: Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for major depression (MD) at different GWAS pvalue thresholds using genetic data obtained from 2586 bipolar patients who received lithium treatment and took part in the Consortium on Lithium Genetics (ConLi+Gen) study. Summary statistics from genome-wide association studies in MD (135,458 cases and 344,901 controls) from the Psychiatric Genomics Consortium (PGC) were used for PGS weighting. Response to lithium treatment was defined by continuous scores and categorical outcome (responders versus non-responders) using measurements on the Aldascale. Associations between PGSs of MD and lithium treatment response were assessed using a linear and binary logistic regression modeling for the continuous and categorical outcomes, respectively. The analysis was performed for the entire cohort, and for European and Asian sub-samples. The PGSs for MD were significantly associated with lithium treatment response in multi-ethnic, European or Asian populations, at various pvalue thresholds. Bipolar patients with a low polygenic load for MD were more likely to respond well to lithium, compared to those patients with high polygenic load [lowest vs highest PGS quartiles, multi-ethnic sample: OR = 1.54 (95% CI: 1.18–2.01) and European sample: OR = 1.75 (95% CI: 1.30–2.36)]. While our analysis in the Asian sample found equivalent effect size in the same direction: OR = 1.71 (95% CI: 0.61–4.90), this was not statistically significant. Using PGS decile comparison, we found a similar trend of association between a high genetic loading for MD and lower response to lithium. Our findings underscore the genetic contribution to lithium response in BD and support the emerging concept of a lithium-responsive biotype in BD.
Published: 2021
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22. Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury

Author: Pan, Hong, Steixner-Kumar, Agnes A., Seelbach, Anna, Deutsch, Nadine, Ronnenberg, Anja, Tapken, Daniel, von Ahsen, Nico, Mitjans, Marina, Worthmann, Hans, Trippe, Ralf, Klein-Schmidt, Christina, Schopf, Nadine, Rentzsch, Kristin, Begemann, Martin, Wienands, Jürgen, Stöcker, Winfried, Weissenborn, Karin, Hollmann, Michael, Nave, Klaus-Armin, Lühder, Fred, and Ehrenreich, Hannelore
Abstract: Circulating autoantibodies (AB) of different immunoglobulin classes (IgM, IgA, and IgG), directed against the obligatory N-methyl-d-aspartate-receptor subunit NR1 (NMDAR1-AB), belong to the mammalian autoimmune repertoire, and appear with age-dependently high seroprevalence across health and disease. Upon access to the brain, they can exert NMDAR-antagonistic/ketamine-like actions. Still unanswered key questions, addressed here, are conditions of NMDAR1-AB formation/boosting, intraindividual persistence/course in serum over time, and (patho)physiological significance of NMDAR1-AB in modulating neuropsychiatric phenotypes. We demonstrate in a translational fashion from mouse to human that (1) serum NMDAR1-AB fluctuate upon long-term observation, independent of blood–brain barrier (BBB) perturbation; (2) a standardized small brain lesion in juvenile mice leads to increased NMDAR1-AB seroprevalence (IgM + IgG), together with enhanced Ig-class diversity; (3) CTLA4(immune-checkpoint) genotypes, previously found associated with autoimmune disease, predispose to serum NMDAR1-AB in humans; (4) finally, pursuing our prior findings of an early increase in NMDAR1-AB seroprevalence in human migrants, which implicated chronic life stress as inducer, we independently replicate these results with prospectively recruited refugee minors. Most importantly, we here provide the first experimental evidence in mice of chronic life stress promoting serum NMDAR1-AB (IgA). Strikingly, stress-induced depressive-like behavior in mice and depression/anxiety in humans are reduced in NMDAR1-AB carriers with compromised BBB where NMDAR1-AB can readily reach the brain. To conclude, NMDAR1-AB may have a role as endogenous NMDAR antagonists, formed or boosted under various circumstances, ranging from genetic predisposition to, e.g., tumors, infection, brain injury, and stress, altogether increasing over lifetime, and exerting a spectrum of possible effects, also including beneficial functions.
Published: 2021
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23. Syncope in Patients With Severe Aortic Stenosis: More Than Just an Obstruction Issue

Author: Francisco-Pascual, Jaume, Rodenas, Eduard, Belahnech, Yassin, Rivas-Gándara, Nuria, Pérez-Rodon, Jordi, Santos-Ortega, Alba, Benito, Begoña, Roca-Luque, Ivo, Cossio-Gil, Yolima, Serra Garcia, Vicens, Llerena-Butron, Sandra, Rodríguez-García, Julian, Moya-Mitjans, Angel, García-Dorado, David, and Ferreira-González, Ignacio
Abstract: Severe aortic stenosis (AoS) is considered a primary cause of syncope. However, other mechanisms may be present in these patients and accurate diagnosis can have important clinical implications. The aim of this study is to assess the different etiologies of syncope in patients with severe AoS and the impact on prognosis of attaining a certain or highly probable diagnosis for the syncope.
Published: 2021
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24. Pooling of urine samples for molecular detection of Chlamydia trachomatis, Neisseria gonorrhoeaeand Mycoplasma genitaliumas a screening strategy among young adults in Catalonia

Author: López-Corbeto, Evelin, González, Victoria, Lugo, Rossie, Rivaya, Belen, Casabona, Jordi, Matas, Lurdes, Crespo, Nayade, Garrofe, M. Jose, Alzuria, Rosa, Bureu, Elena, Fernandez, Isabel, Piquet, Montserrat, Florensa, Yolanda, Sarroca, Carme, Mari, Judit, Mitjans, Elisabet, Jorda, Ivana, Garcia, Sonia, Mausbach, Hildegard, Gomez, Teresa, Borras, Ainhoa, Llobera, Alba, Estruch, Ana, Cayuela, Mabel, Grau, Josep, Tarres, Judit, Guix, Dolors, Serrano, Lorena, Amezcua, Paula, Angelet, Meritxell, Barrionuevo, Carmen, Calviño, Rocio, Colldeforns, Margarida, Duran, Mercè, Garcia, M. Jose, Gonzalez, Maria, Hernandez, Gemma, Modenes, Jon Ander, Vila, Anna, Basset, Carme, Avecilla, Angels, Blasco, M. Pilar, Burgos, Lucia, Espelt, Ramon, Lopez-Grado, Edith, Molina, M. Ines, Prats, Elisenda, Patricio, Demetria, March, Gemma, Aguilar, Irene, Argiles, Sonia, Bayarri, M. Jose, Bertran, Judith, Burgos, Carmen, Carreres, Montserrat, Corredor, Ana, Fernandez, Victoria, Martinez, Gemma, Moreno, Gracia, Pallie, Alba, Pinto, Teresa, Ramirez, Maria, Rebollo, Cristina, Romano, Eusebia, Muxi, M. Consuelo, Escriche, Rosa, Pelegri, Judit, Caccioppoli, Luciano Carmelo, Grau, Elisabet, Xandri, Jordi, Cid, M. Julia, Aguilar, Laia, Almenar, Helena, Navales, Carlos, Baroja, Jordi, Oliver, M. Paz, Fornells, Carme, Hernandez, Marta, and Arranz, Estrella
Abstract: Bacterial sexually transmitted infections (STIs) have an important impact on reproductive health, highlighting the increase in Chlamydia trachomatisinfection rates among young people. To reduce the costs of STI detection, the pooling strategy is beneficial for high-throughput tests in low-prevalence populations using non-invasive samples.
Published: 2020
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25. Juego de roles: enfermeras o antropólogos.

Author: FÁBREGAS MITJANS, MONTSERRAT, CASADO MARÍN, LINA, COMPANY MORALES, MIGUEL, ZAFRA APARICI, EVA, LARREA KILLINGER, CRISTINA, and NÚRIA FABRELLAS PADRÉS, CRISTINA
Published: 2019

26. Syncope, conduction disturbance, and negative electrophysiological test: Predictive factors and risk score to predict pacemaker implantation during follow-up.

Author: Roca-Luque, Ivo, Francisco-Pascual, Jaume, Oristrell, Gerard, Rodríguez-García, Julián, Santos-Ortega, Alba, Martin-Sanchez, Gabriel, Rivas-Gandara, Nuria, Perez-Rodon, Jordi, Ferreira-Gonzalez, Ignacio, García-Dorado, David, and Moya-Mitjans, Angel
Abstract: Background: Patients with syncope and bundle branch block (BBB) are at risk for atrioventricular block (AVB). Electrophysiological study (EPS) can help in identifying patients at higher risk for AVB, but the false-negative rate is remarkable. Few data on the predictors of the need for pacemaker implantation during follow-up have been reported.Objective: The purpose of this study was to analyze the rate of patients who need pacemaker implantation after negative EPS and predictive factors.Methods: A single-center prospective study of 159 consecutive patients (73.9 ± 12.1 years; male 64.9%) with syncope and BBB (January 2012-December 2016) and negative EPS was conducted. An implantable loop recorder was implanted.Results: After 27.9 ± 10.8 months of follow-up, 39 patients (24.8%) underwent pacemaker implantation because of bradyarrhythmia. In the univariate analysis, bifascicular (right BBB + left fascicular block) block, bifascicular block + long PR interval, conduction disturbance different from isolated right BBB, HV ≥60 ms, and HV ≥70 ms after class I drug challenge were predictors of pacemaker implantation. In the multivariate analysis, only bifascicular block (hazard ratio 2.5; 95% confidence interval 1.4-4.8; P = .04) and HV interval ≥60 ms (hazard ratio 3.5; 95% confidence interval 1.8-6.2; P <.001) were statistically significant. A risk score according to the multivariate model identified 3 levels of pacemaker implantation rate (13.5%, 32.7%, and 66.7%; P <.001). No death or severe trauma related to bradyarrhythmia occurred.Conclusion: The strategy of an implantable loop recorder in patients with syncope and BBB is safe after negative EPS, but some patients might need pacemaker implantation during follow-up. A risk score based on HV ≥60 ms and bifascicular block can be useful in identifying patients at risk for advanced AVB after negative EPS. [ABSTRACT FROM AUTHOR]
Published: 2019
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27. Diagnostic Yield and Economic Assessment of a Diagnostic Protocol With Systematic Use of an External Loop Recorder for Patients With Palpitations.

Author: Francisco-Pascual, Jaume, Santos-Ortega, Alba, Roca-Luque, Ivo, Rivas-Gándara, Nuria, Pérez-Rodón, Jordi, Milà-Pascual, Laia, García-Dorado, David, and Moya-Mitjans, Àngel
Abstract: Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2019
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28. Diagnostic yield of the implantable loop recorder in octogenarians.

Author: Lacunza-Ruiz, Francisco J., Moya-Mitjans, Angel, Martínez-Alday, Jesús, Barón-Esquivias, Gonzalo, Ruiz-Granell, Ricardo, García-Alberola, Arcadi, and the investigators of the Spanish Reveal Registry
Abstract: Background/objectives: Syncope in octogenarians represents an important problem in terms of comorbidity, quality of life and substantial medical costs, resulting from studies and treatments. An implantable loop ecorder (ILR) may improve diagnostic performance. The objective of the study was to evaluate the results of the ILR in a population of octogenarians.Design: Prospective registry of patients receiving an implantable loop recorder in 40 Spanish centers.Participants: 128 octogenarians implanted with a device for clinical evaluation of syncope.Methods: Prospective registry recording the incidence of new symptoms or device activations within the first year after the implant, the incidence of new diagnosis and treatments, and an evaluation of the safety of this strategy in this population. Dedicated database for the registry.Results: Forty-two patients (33% of the population) obtained a final etiological diagnosis of the syncope, which led to a specific treatment in 39 (31%) patients. No differences regarding the presence of conduction disturbances or structural heart disease were found in this population. A mortality of 4% was recorded during follow-up.Conclusion: The implantable loop recorder seems to be an effective and safe tool in the management of syncope in the octogenarian population. [ABSTRACT FROM AUTHOR]
Published: 2019
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29. Automation of Functional Mobility Assessments at Home Using a Multimodal Sensor System Integrating Inertial Measurement Units and Computer Vision (IMU-Vision)

Author: Spangler, Johanna, Mitjans, Marc, Collimore, Ashley, Gomes-Pires, Aysha, Levine, David M, Tron, Roberto, and Awad, Louis N
Published: 2024
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30. Site-Specific Antibody Drug Conjugates Using Streamlined Expressed Protein Ligation.

Author: Frutos, Silvia, Hernández, Jose Luis, Otero, Anabel, Calvis, Carme, Adan, Jaume, Mitjans, Francesc, and Vila-Perelló, Miquel
Published: 2018
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31. Current Situation of the Treatment of Arrhythmias in Children in Spain. Finding a Place of its Own.

Author: Rosés-Noguer, Ferran and Moya-Mitjans, Ángel
Published: 2018
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32. A risk score to predict the absence of left ventricular reverse remodeling: Implications for the timing of ICD implantation in primary prevention.

Author: Pérez-Rodon, Jordi, Galve, Enrique, Pérez-Bocanegra, Carmen, Soriano-Sánchez, Teresa, Recio-Iglesias, Jesús, Domingo-Baldrich, Eva, Alzola-Guevara, Mila, Ferreira-González, Ignacio, Marsal, Josep Ramon, Ribera-Solé, Aida, Gutierrez García-Moreno, Laura, Cruz-Carlos, Luz María, Rivas-Gandara, Nuria, Roca-Luque, Ivo, Francisco-Pascual, Jaume, Evangelista-Masip, Artur, Moya-Mitjans, Àngel, and García-Dorado, David
Abstract: Background A prophylactic implantable cardioverter defibrillator (ICD) in patients with heart failure and reduced left ventricular ejection fraction (HFrEF) is only indicated when left ventricular ejection fraction (LVEF) reassessment remains ≤35% after 3–6 months on optimal pharmacological therapy. However, LVEF may not improve during this period and the patient may be exposed to an unnecessary risk of sudden cardiac death. This study aimed to determine the incidence and predictors of the absence of left ventricular reverse remodeling (LVRR) after pharmacological treatment optimization in patients with HFrEF to design a risk score of absence of LVRR. Methods Consecutive outpatients with LVEF ≤35% were included in this observational prospective study. Up-titration of angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARBs), beta-blockers, mineralocorticoid receptor antagonists (MRAs), and ivabradine was performed in our Heart Failure (HF) Unit. The absence of LVRR was defined as the persistence of an LVEF ≤35% at the 6-month follow-up. Results One hundred and twenty patients were included. At the 6-month follow-up, 64%, 76%, 72%, and 7% of patients were at 100% of the target dose of ACE inhibitors/ARBs, beta-blockers, MRAs, and ivabradine, respectively. LVRR was observed in 48% of the patients. Ischemic cardiomyopathy, prolonged HF duration, and larger left ventricular end-diastolic diameter index (LVEDDI) were independent predictors of the absence of LVRR. The risk score based on these predictors showed a c -statistic value of 0.81. Conclusions Pharmacological treatment optimization is associated with LVRR in approximately half of cases, reducing potential ICD indications in parallel. However, ischemic cardiomyopathy, prolonged HF duration, and larger LVEDDI predict the absence of LVRR and favor ICD implantation without delay. The risk score based on the former predictors may help the clinician with the timing of ICD implantation. [ABSTRACT FROM AUTHOR]
Published: 2018
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33. Al_2O_3:Yb^3+ integrated microdisk laser label-free biosensor

Author: de Goede, Michiel, Chang, Lantian, Mu, Jinfeng, Dijkstra, Meindert, Obregón, Raquel, Martínez, Elena, Padilla, Laura, Mitjans, Francesc, and Garcia-Blanco, Sonia M.
Abstract: Whispering gallery mode resonator lasers hold the promise of an ultralow intrinsic limit of detection. However, the widespread use of these devices for biosensing applications has been hindered by the complexity and lack of robustness of the proposed configurations. In this work, we demonstrate biosensing with an integrated microdisk laser. Al_2O_3doped with Yb^3+ was utilized because of its low optical losses as well as its emission in the range 1020–1050 nm, outside the absorption band of water. Single-mode laser emission was obtained at a wavelength of 1024 nm with a linewidth of 250 kHz while the microdisk cavity was submerged in water. A limit of detection of 300 pM (3.6 ng/ml) of the protein rhS100A4 in urine was experimentally demonstrated, showing the potential of the proposed devices for biosensing.
Published: 2019

34. Registro Español de Ablación con Catéter. XVIII Informe Oficial de la Sección de Electrofisiología y Arritmias de la Sociedad Española de Cardiología (2018)

Author: Ibáñez Criado, José Luis, Quesada, Aurelio, Cózar, Rocío, Almendral-Garrote, Jesús, Alonso-Fernández, Pau, Alonso-Martín, Concepción, Alvarenga-Recalde, Nelson María, Álvarez-Acosta, Luis, Álvarez-López, Miguel, Anguera-Camos, Ignasi, Arana-Rueda, Eduardo, Arcocha-Torres, María Fe, Arias-Palomares, Miguel Ángel, Asso-Abadía, Antonio, Ballesteros-Derbenti, Gabriel Alejandro, Barrera-Cordero, Alberto, Benezet-Mazuecos, Juan, Bodegas-Cañas, Andrés I., Brugada-Terradellas, Josep, Cabadés-Rumbeu, Claudia, Cabanas-Grandío, María del Pilar, Cabrera-Gómez, Sandra, Cano-Calabria, Lucas R., del Castillo-Arrojo, Silvia, Castro-Urda, Víctor, Cózar-León, Rocío, Díaz-Infante, Ernesto, Durán-Guerrero, Juan Manuel, Elices-Teja, Juliana, Expósito-Pineda, María del Carmen, Fernández-Gómez, Juan Manuel, Ferrer-Hita, Julio Jesús, Fidalgo-Andrés, María Luisa, Fontenla-Cerezuela, Adolfo, García-Alberola, Arcadio, García-Bolao, J. Ignacio, García-Cuenca, Enrique, García-Fernández, Francisco Javier, Gil-Ortega, Ignacio, Gómez-Pulido, Federico, Grande-Ingelmo, Juan Manuel, Guasch-i-Casany, Eduard, Guerra-Ramos, José M., Heras-Herreros, Santiago, Hernández-Afonso, Julio, Herreros-Guilarte, Benito, Hidalgo-Olivares, Víctor Manuel, Ibáñez-Criado, Alicia, Ibáñez-Criado, José Luis, Ibars-Campaña, Sonia, Jáuregui-Abularach, Miguel Eduardo, Jiménez-Candil, F. Javier, Jiménez-Díaz, Javier, Jiménez-López, Jesús I., Lázaro-Rivera, Carla, Lozano-Herrera, José Miguel, Macías-Gallego, Alfonso, Magnani-Ragamato, Santiago, Martínez-Basterra, Javier, Martínez-Brotons, Ángel, Martínez-Sande, José Luis, Martín-Sánchez, Gabriel, Matías-Francés, Roberto, Merino-Llorens, José Luis, Mont-Girbau, Josep Lluis, Moreno-Arribas, José, Moreno-Planas, Javier, Moya-i-Mitjans, Ángel, Ortega-Molina, Marta, Osca-Asensi, Joaquín, Pastor-Fuentes, Agustín, Pavón-Jiménez, Ricardo, Peinado-Peinado, Rafael, Pérez-Álvarez, Luisa, Pérez-Castellano, Nicasio, Porro-Fernández, Rosa, Porta-Sánchez, Andreu, Punti-Sala, Jordi, Quesada-Dorador, Aurelio, Rivas-Gándara, Nuria, Rodrigo-Trallero, Gonzalo, Rodríguez-Entem, Felipe José, Rodríguez-Pérez, Juan Carlos, Romero-Garrido, Rafael, Rubín-López, José Manuel, Rubio-Caballero, José Amador, Rubio-Campal, José Manuel, Rubio-Sanz, Jerónimo, Ruiz-Hernández, Pablo M., Salgado-Aranda, Ricardo, Sánchez-Gómez, Juan Miguel, Sarquella-Brugada, Georgia, Sarrias-Mercé, Axel, Segura-Saint-Gerons, Jose María, Segura-Villalobos, Federico, and Valverde-André, Irene
Abstract: Se describen los resultados del Registro Nacional de Ablación con Catéter correspondientes al año 2018.
Published: 2019
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35. Oedipus's Riddle: Elizabethan transformation of the family portrait of Thomas More, an Appendix to “Non sum Oedipus sed Morus”

Author: Mitjans, Frank
Abstract: Holbein produced a drawing of Sir Thomas More and his Familywhich was a preparatory sketch for a larger painting. The painting was acquired by Karl von Liechtenstein-Kastelkron (1623–95), Archbishop of Olomouc, Moravia, and was last recorded in 1691 as being kept in the episcopal residence in Olomouc; it is generally assumed that the painting was lost in the 1752 fire at the Archbishop's château in Kroměřiž. There are, however, five extant versions of the Family Group. The three main versions are the full-sized oil on canvas, The Family of Sir Thomas More(1592), now at Nostell Priory, and two paintings of Sir Thomas More, his Household, and Descendants: one kept at the National Portrait Gallery, the other at the Victoria and Albert Museum, London. There has been much discussion about the transformation from a family at prayer—as portrayed in the original drawing—to a conversation on Seneca. Based on editions of Oedipusprior to the Nostell painting, the history of More's descendants, and a cameo that belonged to More's family, this paper argues that the Elizabethan transformation is a story of conformity and non-conformity.
Published: 2019
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36. Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model

Author: Pan, Hong, Oliveira, Bárbara, Saher, Gesine, Dere, Ekrem, Tapken, Daniel, Mitjans, Marina, Seidel, Jan, Wesolowski, Janina, Wakhloo, Debia, Klein-Schmidt, Christina, Ronnenberg, Anja, Schwabe, Kerstin, Trippe, Ralf, Mätz-Rensing, Kerstin, Berghoff, Stefan, Al-Krinawe, Yazeed, Martens, Henrik, Begemann, Martin, Stöcker, Winfried, Kaup, Franz-Josef, Mischke, Reinhard, Boretius, Susann, Nave, Klaus-Armin, Krauss, Joachim K., Hollmann, Michael, Lühder, Fred, and Ehrenreich, Hannelore
Abstract: Autoantibodies of the IgG class against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB) were considered pathognomonic for anti-NMDAR encephalitis. This view has been challenged by the age-dependent seroprevalence (up to >20%) of functional NMDAR1-AB of all immunoglobulin classes found in >5000 individuals, healthy or affected by different diseases. These findings question a merely encephalitogenic role of NMDAR1-AB. Here, we show that NMDAR1-AB belong to the normal autoimmune repertoire of dogs, cats, rats, mice, baboons, and rhesus macaques, and are functional in the NMDAR1 internalization assay based on human IPSC-derived cortical neurons. The age dependence of seroprevalence is lost in nonhuman primates in captivity and in human migrants, raising the intriguing possibility that chronic life stress may be related to NMDAR1-AB formation, predominantly of the IgA class. Active immunization of ApoE−/−and ApoE+/+mice against four peptides of the extracellular NMDAR1 domain or ovalbumin (control) leads to high circulating levels of specific AB. After 4 weeks, the endogenously formed NMDAR1-AB (IgG) induce psychosis-like symptoms upon MK-801 challenge in ApoE−/−mice, characterized by an open blood–brain barrier, but not in their ApoE+/+littermates, which are indistinguishable from ovalbumin controls. Importantly, NMDAR1-AB do not induce any sign of inflammation in the brain. Immunohistochemical staining for microglial activation markers and T lymphocytes in the hippocampus yields comparable results in ApoE−/−and ApoE+/+mice, irrespective of immunization against NMDAR1 or ovalbumin. These data suggest that NMDAR1-AB of the IgG class shape behavioral phenotypes upon access to the brain but do not cause brain inflammation on their own.
Published: 2019
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37. Violent aggression predicted by multiple pre-adult environmental hits

Author: Mitjans, Marina, Seidel, Jan, Begemann, Martin, Bockhop, Fabian, Moya-Higueras, Jorge, Bansal, Vikas, Wesolowski, Janina, Seelbach, Anna, Ibáñez, Manuel Ignacio, Kovacevic, Fatka, Duvar, Oguzhan, Fañanás, Lourdes, Wolf, Hannah-Ulrike, Ortet, Generós, Zwanzger, Peter, Klein, Verena, Lange, Ina, Tänzer, Andreas, Dudeck, Manuela, Penke, Lars, van Elst, Ludger Tebartz, Bittner, Robert A., Schmidmeier, Richard, Freese, Roland, Müller-Isberner, Rüdiger, Wiltfang, Jens, Bliesener, Thomas, Bonn, Stefan, Poustka, Luise, Müller, Jürgen L., Arias, Bárbara, and Ehrenreich, Hannelore
Abstract: Early exposure to negative environmental impact shapes individual behavior and potentially contributes to any mental disease. We reported previously that accumulated environmental risk markedly decreases age at schizophrenia onset. Follow-up of matched extreme group individuals (≤1 vs. ≥3 risks) unexpectedly revealed that high-risk subjects had >5 times greater probability of forensic hospitalization. In line with longstanding sociological theories, we hypothesized that risk accumulation before adulthood induces violent aggression and criminal conduct, independent of mental illness. We determined in 6 independent cohorts (4 schizophrenia and 2 general population samples) pre-adult risk exposure, comprising urbanicity, migration, physical and sexual abuse as primary, and cannabis or alcohol as secondary hits. All single hits by themselves were marginally associated with higher violent aggression. Most strikingly, however, their accumulation strongly predicted violent aggression (odds ratio 10.5). An epigenome-wide association scan to detect differential methylation of blood-derived DNA of selected extreme group individuals yielded overall negative results. Conversely, determination in peripheral blood mononuclear cells of histone-deacetylase1 mRNA as ‘umbrella mediator’ of epigenetic processes revealed an increase in the high-risk group, suggesting lasting epigenetic alterations. Together, we provide sound evidence of a disease-independent unfortunate relationship between well-defined pre-adult environmental hits and violent aggression, calling for more efficient prevention.
Published: 2019
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38. Rendimiento diagnóstico y evaluación económica de un protocolo diagnóstico basado en el uso sistemático de un registrador externo de eventos en asa cerrada en pacientes con palpitaciones

Author: Francisco-Pascual, Jaume, Santos-Ortega, Alba, Roca-Luque, Ivo, Rivas-Gándara, Nuria, Pérez-Rodón, Jordi, Milà-Pascual, Laia, García-Dorado, David, and Moya-Mitjans, Àngel
Abstract: Evaluar el rendimiento diagnóstico y los beneficios en términos de coste-efectividad de un nuevo protocolo diagnóstico basado en el uso sistemático de un registrador externo de eventos en asa cerrada (REE) de última generación comparado con una estrategia diagnóstica convencional en pacientes con palpitaciones recurrentes de causa desconocida.
Published: 2019
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39. Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study

Author: Kirmeier, Eva, Eriksson, Lars I, Lewald, Heidrun, Jonsson Fagerlund, Malin, Hoeft, Andreas, Hollmann, Markus, Meistelman, Claude, Hunter, Jennifer M, Ulm, Kurt, Blobner, Manfred, Abad Gurumeta, Alfredo, Abernethy, Caroline, Abigail, Patrick, Achaibar, Kira, Adam, Emily, Afshari, Arash, Agudelo Montoya, M. Elizabeth, Akgün, Fatma Nur, Aletti, Gabriele, Alkış, Neslihan, Allan, Katie, Allan, Ashley, Allaouchiche, Bernard, Allcock, Clare, Almasy, Emoke, Amey, Isobel, Amigoni, Maria, Andersen, Elin, Andersson, Peder, Anipchenko, Natalya, Antunes, Pedro, Armstrong, Earlene, Aslam, Tayyba Naz, Aslin, Bjorn, Assunção, José Pedro, Ausserer, Julia, Avvai, Mary, Awad, Nahla, Ayas Montero, Begoña, Ayuso, Mercedes, Azevedo, Patricia, Badarau, Victoria, Badescu, Roxana, Baiardo Redaelli, Martina, Baird, Colin, Baird, Yolanda, Baker, Tim, Balaji, Packianathaswamy, Bălan, Cristina, Balandin, Alina, Balescu-Arion, Carmen, Baliuliene, Vilda, Baltasar Isabel, Jorge, Baluch, Saif Nasr, Bandrabur, Daniela, Bankewitz, Carla, Barber, Katrina, Barbera, Francesco, Barcraft-Barnes, Helena, Barletti, Valentina, Barnett, Gill, Baron, Kirsty, Barros, Ana, Barsan, Victoria, Bartlett, Pauline, Batistaki, Chrysanthi, Baumgarten, Georg, Baytas, Volkan, Beauchamp, Nigel, Becerra Cayetano, Isabel A., Bell, Stephanie, Bellandi, Mattia, Belletti, Alessandro, Belmonte Cuenca, Julio, Benitez-Cano, Adela, Beretta, Luigi, Berger, Marc, Bergmann, Nicole, Bergmark, Kristina, Bermudez Lopez, Maria, Bernotaite, Monika, Beurskens, Charlotte, Bidd, Heena, Bifulco, Francesca, Bignami, Elena, Bilic, Aleksandar, Bilskiene, Diana, Bischoff, Petra, Bishop, Luke, Bjonness, Therese, Blaylock, Hether, Blethyn, Kate, Blincoe, Thomas, Blokhin, Ivan, Blunt, Nadia, Boer, Christa, Bois, Grégory, Bonicolini, Eleonora, Booth, Joanna, Borecka-Kedzierska, Miroslawa, Borstnar, Katarina, Borys, Michał, Boselli, Emmanuel, Bouvet, Lionel, Bouwman, Arthur, Bowen, Leonora, Bowrey, Sarah, Boxall, Leigh, Božić, Teodora, Bradley, Tom, Branco, Teresa, Brazzi, Luca, Brazzoni, Marcella, Brear, Tracy, Brogly, Nicolas, Brohi, Farooq, Broms, Jacob, Bubliauskas, Andrius, Bucolo, Gea Erika, Buerkle, Hartmut, Buggy, Donal, Buhre, Wolfgang, Bukauskas, Tomas, Butturini, Francesco, Byttner, Anders, Cabrera Díaz, Itahísa, Calderon, Adriana, Calhau, Ricardo, Callejo, Angel, Cammu, Guy, Campesato, Manuela, Can, Özlem S, Candeias, Margarida, Cantor, Andreea, Carise, Elsa, Carmona, Cristina, Carreteiro, Joana, Carrieri, Cosima, Carter, Anna, Casal, Manuela, Casanova, Irene, Cascella, Marco, Casero, Luis M., Casiraghi, Guiseppina Maria, Castelo-Branco, Laila, Castro Arranz, Carlos, Cernea, Daniela Denisa, Cervantes, Jesoporiol, Chandler, Ben, Charnock, Robert, Chatzimicali, Aikaterini, Chinery, Elane, Chishti, Ahmed, Chondhury, Priyakam, Christie, Emily, Christodoudiles, George, Ciardo, Stefano, Cimpeanu, Luminata, Cindea, Iulia, Cinnella, Gilda, Clark, Sebastian, Clayton, Matthew, Cocu, Simona, Collyer, Thomas, Colvin, Carie, Cope, Sean, Copeta, Filomena, Copotoiu, Sanda-Maria, Correia de Barros, Filinto, Corso, Ruggero Massimo, Cortegiani, Andrea, Costa, Gabriela, Cowton, Amanda, Cox, Nicolas, Craig, James, Cricca, Valentina, Cronin, John, Cunha, Mariana, Cuomo, Arturo, Curley, Katherine, Czuczwar, Mirosław, Dabrowska, Domenika, Damster, Sabrine, Danguy des Déserts, Marc, Daniliuc, Aura, Danninger, Thomas, Darwish, Imad, Dascalu, Corina, Davies, Kirsty, Davies, Simon, De Boer, Hans, De Flaviis, Adelisa, De Selincourt, Gabrielle, Deana, Cristian, Debaene, Bertrand, Debreceni, Gabor, Dedhia, Jatin, Delgado Garcia, Isabel, Della Rocca, Giorgio, Delroy-Buelles, Llana, Desai, Tejal, Dhillon, Parveen, Di Giacinto, Ida, Di Mauro, Piero, Diaz Gomez, Tamara V., Dimitrovski, Aleksandar, Dinic, Vesna, Dîrzu, Dan-Sebastian, Divander, Mona Britt, Dolinar, Janez, Domingues, Susana, Doolan, James, Downes, Charlotte, Dragoescu, Nicoleta Alice, Droc, Gabriela, Dum, Elisabeth, Dumitrescu, Alexandra, Duncan, Louise, Dzurňáková, Paul, Eberl, Susanne, Edwards, Jayne, Edwards, Mark, Ekelund, Kim, Ekengren, Patrik, Elghouty, Eyad, Ellerkmann, Richard, Ellis, Helen, Elme, Andreas, Ernst, Thomas, Errando, Carlos Luis, Estenes, Simao, Ewaldsson, Callis, Farid, Nahla, Featherstone, James, Febres, Daniela, Fedorov, Sergey, Feggeler, Johanna, Feijten, Prisca, Fellmann, Tobias, Fernandez Candil, Juan, Fernandez Castineira, Ana, Fernández Castineira, Juan, Fernando, Aruna, Ferrando, Carlos, Ferreira, Leonia, Ferreira, Patrick, Feyling, Anders, Filipescu, Daniela, Fleischer, Andreas, Floris, Leda, Foerster, Urs, Fox, Benjamin, Franke, Uwe, Frasca, Denis, Frey, Christian, Frost, Victoria, Fullin, Giorgio, Fumagalli, Jacopo, Furneval, Julie, Fusari, Maurizio, Gallacher, Stuart, Galushka, Svetlana, Gambale, Giorgio, Gambino, Irene, Garcia-Perez, Maria Luisa, Garg, Sanjeev, Garlak, Justyna, Gavranovic, Zeljka, Gavrilov, Roman, Gaynor, Lames, Gecaj Gashi, Agreta, Georghiou, Maria, Gerjevic, Bozena, Gferer, Gudrun, Giarratano, Antonino, Gibson, Andy, Gievski, Vanja, Giles, Julian, Gillberg, Lars, Gilowska, Katarzyna, Gilsanz Rodriguez, Fernando, Gioia, Antonio, Giovannoni, Cecilia, Girotra, Vandana, Gkinas, Dimitrios, Gkiokas, George, Godoroja, Daniela, Goebel, Ulrich, Goel, Vandana, Gonzalez, Matilde, Goranovic, Tatjana, Gornik-Wlaszczuk, Ewa, Gosavi, Smita, Gottfridsson, peter, Gottschalk, André, Granell, Manuel, Granstrom, Anna, Grassetto, Alberto, Greenwood, Anna, Grigoras, Ioana, Grintescu, Ioana, Gritsan, Alexey, Gritsan, Galina, Grynyuk, Andriy, Guadagnin, Giovanni Maria, Guarnieri, Marcello, Güçlü, Çiğdem, Guerrero Diez, Maria, Gunenc, Ferim, Günther, Ulf, Gupta, Pawan, Guttenthaler, Vera, Hack, Yvonne, Hafisayena, Ade, Hagau, Natalia, Haldar, Jagannath, Hales, Dawn, Hancı, Volkan, Hanna-Jumma, Sameer, Harazim, Hana, Harlet, Pierre, Harper, Daniel, Harris, Benjamin, Harvey, Orla, Hashimi, Medita, Hawkins, Lesley, Hayes, Conrad, Heaton, James, Heier, Tom, Helliwell, Laurence, Hemmes, Sabrine, Henderson, Kate, Hermanides, Jeroen, Hermanns, Henning, Herrera Hueso, Berta, Hestenes, Siv, Hettiarachchi, Roshane, Highgate, Judith, Hodgson, Keith, Hoelbling, Daniel, Holland, Jonathan, Horhota, Lucian, Hormis, Anil, Hribar, Renata, Hua, Alina, Humphreys, Sally, Humphries, Ryan, Humpliková, Simona, Hunt, Janez, Husnain, Ali, Hussein, Ahmed, Hyams, Benjamin, Iannuccelli, Fabrizio, Ilette, Katie, Ilyas, Carl, Inan, Turgay, India, Immaculada, Ionițăv, Victor, Irwin, Foo, Jain, Vipul, Janez, Benedikt, Jankovic, Radmilo, Jenkins, Sarah, Jenko, Matej, Jimenez, Raquel, Jiménez Gomez, Bárbara, Joachim, Sugganthi, Joelsson-Alm, Eva, John, John, Jonikaite, Lina, Jovic, Miomir, Jungwirth, Bettina, Junke, Etienne, Kabakov, Borys, Kadaoui, Salah-Din, Kanski, Andrzej, Karadag, Süheyla, Karbonskiene, Aurika, Karjagin, Juri, Kasnik, Darja, Katanolli, Fatos, Katsika, Eleni, Kaufmann, Kai, Keane, Helen, Kelly, Martin, Kent, Melanie, Keraitiene, Grazina, Khudhur, Ahmed, Khuenl-Brady, Karin, Kidd, Laurie, King, Siobhan, Kirchgäßner, Katharina, Klancir, Tino, Klucniks, Andris, Knotzer, Johann, Knowlden, Peter, Koers, Lena, Kompan, Janez, Koneti, Kiran K, Kooij, Fabian, Koolen, Eric, Koopman - van Gemert, Anna Wilhelmina Margaretha Maria, Kopp, Kristen, Korfiotis, Dimitrios, Korolkov, Oleg, Kosinová, Martina, Köstenberger, Markus, Kotzinger, Oskar, Kovačević, Marko, Kranke, Peter, Kranke, Eva, Kraus, Christiane, Kraus, Stephanie, Kubitzek, Christiane, Kucharski, Rafal, Kucukguclu, Semih, Kudrashou, Allaksandr, Kumar, Vinayak, Kummen, Live, Kunit, Cornelia, Kushakovsky, Vlad, Kuvaki, Bahar, Kuzmanovska, Biljana, Kyttari, Aikaterina, Landoni, Giovanni, Lau, Gary, Lazarev, Konstantin, Legett, Samantha, Legrottaglie, Anna Maria, Leonardi, Silvia, Leong, Maria, Lercher, Helene, Leuvrey, Matthieu, Leva, Brigitte, Levstek, Meta, Limb, James, Lindholm, Espen, Linton, Fiona, Liperi, Corradero, Lipski, Fabian, Lirk, Philipp, Lisi, Alberto, Lišková, Katarina, Lluch Oltra, Aitana, Loganathan, Vinothan, Lombardi, Stefania, Lopez, Eloisa, Lopez Rodríguez, Maria, Lorenzini, Laura, Lowicka, Malgorzata, Lugovoy, Alexander, Luippold, Madeleine, Lumb, Andrew, Macas, Andrius, Macgregor, Mark, Machado, Humberto, Maciariello, Maria, Madeira, Isabel, Maitan, Stefan, Majewski, Jacek, Maldini, Branka, Malewski, Georgia, Manfredini, Livia, Männer, Olja, Marchand, Bahareh, Marcu, Alexandra, Margalef, Jordi, Margarson, Michael, Marinheiro, Lucia, Markic, Ana, Markovic Bozic, Jasmina, Marrazzo, Francesco, Martin, Jane, Martin Ayuso, Maria, Martinez, Esteher, Martino, Enrico Antonio, Martinson, Victoria, Marusic-Gaser, Katarina, Mascarenhas, Catia, Mathis, Cindy, Matsota, Paraskevi, Mavrommati, Eleni, Mazul Sunko, Branka, McCourt, Killian, McGill, Neil, McKee, Raymond, Meço, Başak Ceyda, Meier, Sonja, Melbourne, Susan, Melbybråthen, Grethe, Meli, Andrea, Melia, Aiden, Melotti, Rita Maria, Menga, Maria Rosaria, Mercer, Pauline, Merotra, Susan, Mescolini, Silvia, Metterlein, Thomas, Michalov, Martin, Michlig, Sam, Midgley, Susan, Milić, Morena, Milojevic, Milan, Miñana, Amanda, Minto, Gary, Mirabella, Lucia, Mirea, Liliana, Mittelstädt, Ludger, Moeglen, Aude, Moise, Alida, Mokini, Zhirajr, Molin, Anna, Moltó, Luis, Monea, Maria Concetta, Montalto, Francesca, Montgomery, Jane, Montgomery, Claire, Montillo, Gerardo, Moore, Sally, Moore, Faye, Moreira, Zelia, Moreno, Tania, Moreno, Ricardo, Moret, Enrique, Moreton, Sarah, Morgan, Marianne, Moro Velasco, Concepción, Morri, Davide, Moull, Alice, Moura, Fernando, Mráz, Peter, Mrozek, Katarzyna, Mukhtar, Karim, Muniyappa, Sudeshkumar, Murray, Heather, Murthy, Burra VS, Mushambi, Mary, Nadolski, Maria, Nardelli, Pasquale, Nardin, Giordano, Navarro Pérez, Rosalía, Naveiro, Andrea, Negri, Manuela, Nesek Adam, Visnja, Neskovic, Vojislava, Neuwersch, Stefan, Neves, Miriam, Nguyen, Bavinh, Ní Eochagáin, Aisling, Nicholas, Caroline, Nightingale, Jeremy, Norrie, Kylie, Novak-Jankovic, Vesna, Novakova, Andrea, Novillo, Marta, Numan, Sandra, Oduro-Dominah, Louise, Oldner, Anders, Oliveira, Isabel, Ologoiu, Daniela, Oloktsidou, Irini, O'Reilly, Rosalind, Orlando, Alessandro, Ovezov, Alexey, Ozbilgin, Sule, Paal, Peter, Padin Barreiro, Lidia, Palugniok, Ryszard, Papaioannou, Alexandra, Papapostolou, Konstantinos, Paranthaman, Prabhakar, Pardey Bracho, Gilda, Parente, Suzana, Parfeni, Alexandru, Pasin, Laura, Passey, Samuel, Pastor, Ernesto, Patch, Sarah, Patil, Andan, Paunescu, Marilena-Alina, Pehboeck, Daniel, Pereira, Manuela, Pereira, Carla, Perez Caballero, Paula, Pérez García, Aníbal, Pérez Soto, Antonia, Perez Tejero, Gisela, Perez-Cerda, Francisco, Pesenti, Antonio, Petta, Rocco, Philippe, Simon, Pickering, David, Pico Veloso, Jandro, Pina, Pedro, Pinho-Oliveira, Vítor, Pinol, Santiago, Pinto, Rita, Pistidda, Laura, Pitterle, Manuela, Piwowarczyk, Paweł, Plotnikova, Olga, Pohl, Holger, Poldermann, Jorinde, Polkovicová, Lucia, Pompei, Livia, Popescu, Mihai, Popović, Radmila, Pota, Vincenzo, Potocnik, Miriam, Potręć, Beata, Potter, Alison, Pramod, Nalwaya, Prchalova, Martina, Preckel, Benedikt, Pugh, Richard, Pulletz, Mark, Radoeshki, Aleksandar, Rafi, Amir, Ragazzi, Riccardo, Raineri Santi, Maurizio, Rajamanickam, Tamiselvan, Rajput, Zahra, Ramachandran, Rajeskar, Ramasamy, Radhika, Ramessur, Suneil, Rao, Roshan, Rasmussen, Anders, Rato, André, Razaque, Usman, Real Navacerrada, M. Isabel, Reavley, Caroline, Reid, James, Reschreiter, Henrik, Rial, Erick, Ribas Carrasco, Patricia, Ribeiro, Sandy, Rich, Nathalie, Richardson, Lydia, Rimaitis, Kestutis, Rimaitis, Marius, Ringvold, Else-Marie, Ripke, Fabian, Ristescu, Irina, Ritchie, Keith, Ródenas, Frederic, Rodrigues, Patrícia, Rogers, Emma, Rogerson, David, Romagnoli, Stefano, Romero, Esther, Rondovic, Goran, Rose, Bernd Oliver, Roth, Winfried, Rotter, Marie-Therese, Rousseau, Guy, Rudjord, Anders, Rueffert, Henrik, Rundgren, Malin, Rupprecht, Korbinian, Rushton, Andrew, Russotto, Vincenzo, Rypulak, Elżbieta, Ryszka, Maciej, Sà, Jacinta, Sà Couto, Paula, Saby, Sandrine, Sagic, Jelena, Saleh, Omar, Sales, Gabriele, Sánchez Sánchez, Yván, Sanghera, Sumayer, Şanli Karip, Ceren, Santiveri Papiol, Francisco Javier, Santos, Sofia, Sarno, Stephen, Saul, Daniel, Saunders, David, Savic, Nenad, Scalco, Loïc, Scanlon, Deborah, Schaller, Stefan, Schax, Christoph, Scheffer, Gert Jan, Schening, Anna, Schiavone, Vincenzo, Schmidt-Ehrenberg, Florian, Schmidt-Mutter, Catherine, Schönberg, Christina, Schopflin, Christian, Schreiber, Jan-Uwe, Schultz, Marcus, Schurig, Marlen, Scott, Carmen, Sebestian, Siby, Sehgal, Selena, Sem, Victoria, Semenas, Egidijus, Serafini, Elena, Serchan, Pashalitsa, Shields, Martin, Shobha, Ramakrishnan, Shosholcheva, Mirjana, Siamansour, Tanja, Siddaiah, Narendra, Siddiqi, Khalid, Sinclair, Rhona, Singh, Permendra, Singh, Rajendra, Sinha, Aneeta, Sinha, Ashok, Skinner, Amanda, Smee, Elizabeth, Smekalova, Olga, Smith, Neil, Smith, Thomas, Smitz, Carine, Smole, Daniel, Sojčić, Nataša, Soler Pedrola, Maria, Somanath, Sameer, Sonksen, Julian, Sorella, Maria Christina, Sörmus, Alar, Soro, Marina, Soto, Carmen, Spada, Anna, Spadaro, Savino, Spaeth, Johannes, Sparr, Harald, Spielmann, Annika, Spindler-Vesel, Alenka, Stamelos, Matthaios, Stancombe L, Liucia, Stanculescu, Andreea, Standl, Thomas, Standley, Tom, Stanek, Ondrej, Stanisavljević, Snežana, Starczewska, Malgorzata, Stäuble, Christiane, Steen, Julie, Stefan, Oana Maria, Stell, Elizabeth, Stera, Caterina, Stevens, Markus, Stoerckel, Marlène, Stošić, Biljana, Stourac, Petr, Stroumpoulis, Konstantinos, Struck, Rafael, Suarez de la Rica, Alejandro, Sultanpori, Altaf, Sundara Rajan, Rajinikanth, Suying, Ong, Svensen, Christer, Swan, Louise, Syrogianni, Paulina, Sysiak, Justyna, Szederjesi, Janos, Taddei, Stefania, Tan Hao, Ern, Tanou, Virginia, Tarabová, Katarina, Tardaguila Sancho, Paula, Tarroso, Maria, Tartaglione, Marco, Taylor, Emma, Tbaily, Lee, Telford, Richard, Terenzoni, Massimo, Theodoraki, Kassiani, Thornley, Helen, Tiganiuc, Liviu, Toim, Hardo, Tomescu, Dana, Tommasino, Concezione, Toni, Jessica, Toninelli, Arturo, Toretti, Ilaria, Townley, Stephen, Trepenaitis, Darius, Trethowan, Brian, Tsaousi, Georgia, Tsiftsi, Aikaterini, Tudor, Adrada, Turan, Güldem, Turhan, Sanem Çakar, Unic-Stojanovic, Dragana, Unterbuchner, Christoph, Unzueta, Carmen, Uranjek, Jasna, Ursic, Tomaz, Vaida, Simona, Valldeperas Ferrer, Silvia, Valldeperas Hernandez, Maria Inmaculada, Valsamidis, Dimitri, Van Beek, Rienk, Van dasselaer, Nick, Van Der Beek, Tim, Van Duivenvoorde, Yoni, van Klei, Wilton A., Van Poorter, Frans, Van Zaane, Bas, Van Zundert, Tom, Van Zyl, Rebekka, Vargas Munoz, Ana Milena, Varsani, Nimu, Vasconcelos, Pedro, Vassilakis, Georgios, Vecchiatini, Tommaso, Vecera, Lubomir, Vercauteren, Marcel, Verdouw, Bas, Verheyen, Veerle, Verri, Marco, Vicari Sottosanti, Luigi Giancarlo, Vico, Manuel, Vidal Mitjans, Patricia, Vilardi, Anna, Vissicchio, Daniela, Vitale, Giovanni, Vitković, Bibiana, Vizcaychipi, Marcela Paola, Voicu, Alexandra, Voje, Minca, Volfová, Ivana, Volta, Carlo Alberto, Von Lutterotti, Theresa, von Tiesenhausen, Anna, Vrecic-Slabe, Simona, Vukcevic, Dejan, Vukovic, Rade, Vullo, P. Agostina, Wade, Andrew, Wallberg, Hanna, Wallden, Jakob, Wallner, Johann, Walther Sturesson, Louise, Watson, Davina, Weber, Stefan, Wegiel Leskiewiq, Anna, Weller, Debbie, Wensing, Carine, Werkmann, Markus, Westberg, Henrik, Wikström, Erik, Williams, Benedict, Williams, Benedict, Wilson, Robin, Wirth, Steffen, Wittmann, Maria, Wood, Laura, Wright, Stella, Zachoval, Christian, Zambon, Massimo, Zampieri, Silvia, Zampone, Salvatore, Zangrillo, Alberto, Zani, Gianluca, Zavackiene, Asta, Zieglerder, Raphael, Zonneveldt, Harry, Zsisku, Lajos, Zucker, Tom-Philipp, Żukowski, Maciej, Zuleika, Mehrun, and Zupanĕiĕ, Darja
Abstract: Results from retrospective studies suggest that use of neuromuscular blocking agents during general anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use of neuromuscular blocking agents is associated with postoperative pulmonary complications.
Published: 2019
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40. Flecainide Versus Procainamide in Electrophysiological Study in Patients With Syncope and Wide QRS Duration

Author: Roca-Luque, Ivo, Francisco-Pasqual, Jaume, Oristrell, Gerard, Rodríguez-García, Julián, Santos-Ortega, Alba, Martin-Sanchez, Gabriel, Rivas-Gandara, Nuria, Perez-Rodon, Jordi, Ferreira-Gonzalez, Ignacio, García-Dorado, David, and Moya-Mitjans, Angel
Abstract: This study sought to compare the differences between procainamide and flecainide to stress the His-Purkinje system during electrophysiological study (EPS) in patients with syncope and bundle branch block (BBB).
Published: 2019
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41. Workshop Summary: Exoplanet Orbits and Dynamics

Author: Maire, Anne-Lise, Delrez, Laetitia, Pozuelos, Francisco J., Becker, Juliette, Espinoza, Nestor, Lillo-Box, Jorge, Revol, Alexandre, Absil, Olivier, Agol, Eric, Almenara, José M., Anglada-Escudé, Guillem, Beust, Hervé, Blunt, Sarah, Bolmont, Emeline, Bonavita, Mariangela, Brandner, Wolfgang, Mirek Brandt, G., Brandt, Timothy D., Brown, Garett, Cantero Mitjans, Carles, Charalambous, Carolina, Chauvin, Gaël, Correia, Alexandre C. M., Cranmer, Miles, Defrère, Denis, Deleuil, Magali, Demory, Brice-Olivier, De Rosa, Robert J., Desidera, Silvano, Dévora-Pajares, Martín, Díaz, Rodrigo F., Do Ó, Clarissa, Ducrot, Elsa, Dupuy, Trent J., Ferrer-Chávez, Rodrigo, Fontanive, Clémence, Gillon, Michaël, Giuppone, Cristian, Gkouvelis, Leonardos, de Oliveira Gomes, Gabriel, Gomes, Sérgio R. A., Günther, Maximilian N., Hadden, Sam, Han, Yinuo, Hernandez, David M., Jehin, Emmanuel, Kane, Stephen R., Kervella, Pierre, Kiefer, Flavien, Konopacky, Quinn M., Langlois, Maud, Lanssens, Benjamin, Lazzoni, Cecilia, Lendl, Monika, Li, Yiting, Libert, Anne-Sophie, Lovos, Flavia, Miculán, Romina G., Murray, Zachary, Pallé, Enric, Rein, Hanno, Rodet, Laetitia, Roisin, Arnaud, Sahlmann, Johannes, Siverd, Robert, Stalport, Manu, Carlos Suárez, Juan, Tamayo, Daniel, Teyssandier, Jean, Thuillier, Antoine, Timmermans, Mathilde, Triaud, Amaury H. M. J., Trifonov, Trifon, Valente, Ema F. S., Van Grootel, Valérie, Vasist, Malavika, Wang, Jason J., Wyatt, Mark C., Xuan, Jerry, Young, Steven, and Zimmerman, Neil T.
Abstract: Exoplanetary systems show a wide variety of architectures, which can be explained by different formation and dynamical evolution processes. Precise orbital monitoring is mandatory to accurately constrain their orbital and dynamical parameters. Although major observational and theoretical advances have been made in understanding the architecture and dynamical properties of exoplanetary systems, many outstanding questions remain. This paper aims to give a brief review of a few current challenges in orbital and dynamical studies of exoplanetary systems and a few future prospects for improving our knowledge. Joint data analyses from several techniques are providing precise measurements of orbits and masses for a growing sample of exoplanetary systems, both with close-in orbits and with wide orbits, as well as different evolutionary stages. The sample of young planets detected around stars with circumstellar disks is also growing, allowing for simultaneous studies of planets and their birthplace environments. These analyses will expand with ongoing and future facilities from both ground and space, allowing for detailed tests of formation, evolution, and atmospheric models of exoplanets. Moreover, these detailed analyses may offer the possibility of finding missing components of exoplanetary systems, such as exomoons, or even finding new exotic configurations such as co-orbital planets. In addition to unveiling the architecture of planetary systems, precise measurements of orbital parameters and stellar properties—in combination with more realistic models for tidal interactions and the integration of such models in N-body codes—will improve the inference of the past history of mature exoplanetary systems in close-in orbits. These improvements will allow a better understanding of planetary formation and evolution, placing the solar system in context.
Published: 2023
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42. Estudio longitudinal de la inserción laboral de los estudiantes de máster en Enfermería.

Author: MARTÍNEZ-MOMBLAN, MARÍA ANTONIA, SANTOS, ALICIA, CAMPILLO ZARAGOZA, BEATRIZ, SERRET SERRET, MARIA, SIRVENT ANGULO, M., MITJANS GALITO, J., SANTESMASES MASANA, ROSALIA, and ABADES PORCEL, MERCEDES
Published: 2017

43. Site-Specific Antibody Drug Conjugates Using Streamlined Expressed Protein Ligation

Author: Frutos, Silvia, Hernández, Jose Luis, Otero, Anabel, Calvis, Carme, Adan, Jaume, Mitjans, Francesc, and Vila-Perelló, Miquel
Abstract: Antibody-Drug Conjugates (ADCs) have been shown to produce clinical benefit in cancer patient thanks to their ability to target highly cytotoxic small molecules to tumor cells. However, the development of these complex molecules faces significant challenges due to the need to combine a large biologic drug with a small molecule drug to generate the desired bioconjugate. We describe here the use of a protein ligation methodology, based on the native chemical ligation reaction to generate site-specific Antibody-Drug Conjugates, which does not require the incorporation of unnatural modifications into the antibody. Fully native antibodies, with only the desired cytotoxic molecules attached, can be generated, thus minimizing the risk that additional modifications required for the site-specific conjugation pose a risk to the antibody activity. We demonstrate that our approach can be used to generate site-specifically modified ADCs, with potent in vitroand in vivoantitumor activity in a breast cancer tumor model.
Published: 2018
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44. Estado actual del tratamiento de las arritmias en la edad pediátrica en España. Buscando su espacio

Author: Rosés-Noguer, Ferran and Moya-Mitjans, Ángel
Published: 2018
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45. Protocolo diagnóstico del síncope y pérdidas transitorias del conocimiento en el anciano

Author: Carrera, J. Pérez-Jara, Mitjans, A. Moya, Martínez, A. Martín, Alonso, R. Rodríguez, and González, C. Benítez
Abstract: Los síncopes y otras pérdidas transitorias de conocimiento son una patología frecuente en los ancianos que también aparecen como caídas inexplicadas. La historia clínica, exploración física, determinaciones de tensión arterial en ambos brazos y ortostática, electrocardiograma y analítica, si procede, son las pruebas iniciales fundamentales en su valoración. Las causas de los síncopes son variadas, desde la patología estructural cardíaca, arritmias, síncopes reflejos como el vasovagal, situacionales, síndrome del seno carotídeo e hipotensión ortostática, hasta los no sincopales como la epilepsia, las hipoglucemias, los trastornos metabólicos o los pseudosíncopes psicógenos. El manejo posterior se basa en la valoración geriátrica y la evaluación de la fragilidad, determinación de si fue síncope, búsqueda de la causa y estratificación del riesgo. Es frecuente encontrar más de una causa o factor predisponente. En ancianos frágiles, las dificultades para la sospecha clínica favorecen el empleo de pruebas complementarias que suelen ser bien toleradas.
Published: 2018
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46. Convergence of placenta biology and genetic risk for schizophrenia

Author: Ursini, Gianluca, Punzi, Giovanna, Chen, Qiang, Marenco, Stefano, Robinson, Joshua, Porcelli, Annamaria, Hamilton, Emily, Mitjans, Marina, Maddalena, Giancarlo, Begemann, Martin, Seidel, Jan, Yanamori, Hidenaga, Jaffe, Andrew, Berman, Karen, Egan, Michael, Straub, Richard, Colantuoni, Carlo, Blasi, Giuseppe, Hashimoto, Ryota, Rujescu, Dan, Ehrenreich, Hannelore, Bertolino, Alessandro, and Weinberger, Daniel
Abstract: Defining the environmental context in which genes enhance disease susceptibility can provide insight into the pathogenesis of complex disorders. We report that the intra-uterine environment modulates the association of schizophrenia with genomic risk (in this study, genome-wide association study–derived polygenic risk scores (PRSs)). In independent samples from the United States, Italy, and Germany, the liability of schizophrenia explained by PRS is more than five times greater in the presence of early-life complications (ELCs) compared with their absence. Patients with ELC histories have significantly higher PRS than patients without ELC histories, which is confirmed in additional samples from Germany and Japan. The gene set composed of schizophrenia loci that interact with ELCs is highly expressed in placenta, is differentially expressed in placentae from complicated in comparison with normal pregnancies, and is differentially upregulated in placentae from male compared with female offspring. Pathway analyses reveal that genes driving the PRS-ELC interaction are involved in cellular stress response; genes that do not drive such interaction implicate orthogonal biological processes (for example, synaptic function). We conclude that a subset of the most significant genetic variants associated with schizophrenia converge on a developmental trajectory sensitive to events that affect the placental response to stress, which may offer insights into sex biases and primary prevention. Early-life complications modulate the association of genomic risk and schizophrenia.
Published: 2018
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47. Pedro de Ribadeneyra's “Ecclesiastical History of the Schism of the Kingdom of England”: A Spanish Jesuit's History of the English Reformation, ed. and trans. Spencer J. Weinreich

Author: Mitjans, Frank
Published: 2018
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48. Long-Term Follow-Up After Ablation of Intra-Atrial Re-Entrant Tachycardia in Patients With Congenital Heart Disease

Author: Roca-Luque, Ivo, Rivas-Gándara, Nuria, Dos Subirà, Laura, Francisco Pascual, Jaume, Pijuan-Domenech, Antònia, Pérez-Rodon, Jordi, Subirana-Domenech, M.Teresa, Santos-Ortega, Alba, Rosés-Noguer, Ferran, Miranda-Barrio, Berta, Ferreira-Gonzalez, Ignacio, Casaldàliga Ferrer, Jaume, García-Dorado García, David, and Moya Mitjans, Angel
Abstract: The aim of this study was to analyze the long-term outcomes after intra-atrial re-entrant tachycardia (IART) ablation in congenital heart disease (CHD).
Published: 2018
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49. OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals

Author: Ehrenreich, H, Mitjans, M, Van der Auwera, S, Centeno, T P, Begemann, M, Grabe, H J, Bonn, S, and Nave, K-A
Abstract: Despite high heritability of schizophrenia, genome-wide association studies (GWAS) have not yet revealed distinct combinations of single-nucleotide polymorphisms (SNPs), relevant for mental disease-related, quantifiable behavioral phenotypes. Here we propose an individual-based model to use genome-wide significant markers for extracting first genetic signatures of such behavioral continua. ‘OTTO’ (old Germanic=heritage) marks an individual characterized by a prominent phenotype and a particular load of phenotype-associated risk SNPs derived from GWAS that likely contributed to the development of his personal mental illness. This load of risk SNPs is shared by a small squad of ‘similars’ scattered under the genetically and phenotypically extremely heterogeneous umbrella of a schizophrenia end point diagnosis and to a variable degree also by healthy subjects. In a discovery sample of >1000 deeply phenotyped schizophrenia patients and several independent replication samples, including the general population, a gradual increase in the severity of ‘OTTO’s phenotype’ expression is observed with an increasing share of ‘OTTO’s risk SNPs’, as exemplified here by autistic and affective phenotypes. These data suggest a model in which the genetic contribution to dimensional behavioral traits can be extracted from combinations of GWAS SNPs derived from individuals with prominent phenotypes. Even though still in the ‘model phase’ owing to a world-wide lack of sufficiently powered, deeply phenotyped replication samples, the OTTO approach constitutes a conceptually novel strategy to delineate biological subcategories of mental diseases starting from GWAS findings and individual subjects.
Published: 2018
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50. In response to: The neuroprotective effect of quetiapine in critically ill traumatic brain injury patients.

Author: Saavedra Mitjans, Mar, Burry, Lisa, Williamson, David, and Mitjans, Mar Saavedra
Published: 2020
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