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Among hypertensive individuals, prevalence of sleep apnoea-hypopnea syndrome ranges from 30 to 40, while 50 of patients with SA are hypertensive. Classically, SA has been associated with a “non-dipping blood pressure profile”, usually defined as a nocturnal fall in blood pressure of less than 10, regardless of the presence of hypertension in the daytime. Aim was to investigate the dipping patern in the observed group of patients with sleep apnoea-hypopnea syndrome.

In patients with sleep apnea increased sympathetic activity during waking life is accompanied by sustained reduction in vagal tone which leads to the reduction of total heart rate variability. Heart rate has been designated as independent cardiovascular risk factor. Several studies have shown that reduced HRV can predict increased risk for subsequent cardiac events. Aim was to investigate the level of heart rate and heart rate variability in patients with sleep apnea-hypopnea syndrome and without documented CV events.

Sleep apnoea-hypopnea syndrome is defined as the cessation of breathing during sleepwhich lasts for at least 10seconds, on 5 or more occasions per hour. Apnoeic episodes result in hypoxia and hypercapnia which lead to higher sympathetic activation. Blood pressure elevation results in increased myocardial oxygen demand, with simultaneous reduction in oxygen supply due to hypoxia. Double product, or rate pressure product is an indirect measure of myocardial oxygen consumption. Aim was to indirectly determine the effect of hypoxia on myocardial oxygen consumption estimated via double product.

Patients with sleep apnoea-hypopnea syndrome show very high levels of sympathetic activity, which may affect both short-term and long-term blood pressure regulation. Spectral analysis of heart rate variability allows simple, non-invasive testing of the autonomic function. Aim was to determine the level of sympathetic activity using spectral analysis of HRV in hypertensive patients withwithout SA.

Set of new markers obtained from ABPM has been used to improve sensitivity and specificity in the evaluation of the diagnosis of hypertension and effectiveness of the treatment. Among these parameters is the use of blood pressure load, the percentage of values above a given constant reference limit or computed by reference to daytime and nighttime limits. Aim was to investigate the percentage of blood pressure load and it's benefit as a marker of hypertension control in patients with sleep apnoae-hypopnea syndrome.

More than 50 of patients with sleep apnea have hypertension and about 30 of hypertensives have sleep apnea as demonstrated in numerous studies. Aim was to investigate the prevalence of hypertension in patients with sleep apnoea-hypopnea syndrome in UCC Kragujevac, Serbia.

Microvascular angina or cardiac syndrome X, describes patients with anginal chest pain, signs of ischaemia on ECG and a positive stress test, but with non-obstructive coronary angiography. Coronary heart disease is the main cause of mortality in many Western countries and is represented by stable angina pectoris, unstable angina pectoris, myocardial infarction without ST segment elevation (NSTEMI) and myocardial infarction with ST segment elevation (STEMI). The aim of this study was to examine differences in the values of diastolic blood pressure in patients with microvascular angina and patients with CAD including stable angina, unstable angina, STEMI and NSTEMI.

Microvascular angina includes a heterogeneous group of patients with typical chest pain, positive exercise stress test and angiographically smooth coronary arteries. Coronary heart disease is the most common type of heart disease and includes: stable angina pectoris, unstable angina pectoris, myocardial infarction without ST segment elevation (NSTEMI) and myocardial infarction with ST segment elevation (STEMI). The aim of this study was to examine differences in the values of mean arterial pressure in patients with microvascular angina and patients with CAD including: stable angina, unstable angina, STEMI and NSTEMI.