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Objective: To evaluate the antidiabetic effect of galactomannans extracted from Adenanthera pavonina's L. seeds (GAP) in streptozotocin (STZ) induced diabetic mice. Methods: The preliminary galactomannan yield from Adenanthera pavonina L. plant and extraction products composition were evaluated. Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, ¹H and 13C nuclear magnetic resonance, and molecular weight by gel permeation chromatography have been employed to characterize the extracted galactomannan. The mice were divided in four groups: Normal control, diabetic control, GAP (1% and 2%) treated and standard drug treated groups. Diabetic mice received treatment daily for 30 d. Diabetes was induced by STZ at a single dose of 120 mg/kg. Body weight, water and food intake, fasting blood glucose, total cholesterol and triglycerides were measured. Histopathological analysis of pancreas and liver were performed to evaluate STZ-induced tissue injuries. Results: The isolated and extracted galactomannan from Adenanthera pavonina was confirmed by various chemical characterization methods. GAP exhibited a 1.46:1 mannose: galactose ratio, and high molar weight. Both GAP enriched food decreased glycaemia, total cholesterol and triacylglycerol. GAP didn't interfere on food intakes or body weight, although it increased water intake. Furthermore, the relative liver weight indicated toxic galactomannan effects on the histopathological changes of the pancreas in STZ induced diabetes. Conclusions: It is concluded that GAP is a natural product that contains potent galactomannan and is useful in preventing and treating diabetes. [ABSTRACT FROM AUTHOR]

p -Hydroxycinnamic diester is very common in fruits and beverages. Furthermore, it belongs to the family of cinnamic acids. It is a chemical compound present in carnauba leaf powder, and it has promising pharmacological properties against non-transmissible chronic diseases. Then, the objective of this work was characterizing the chemical composition of p -hydroxycinnamic diester obtained from carnauba leaf powder, as thoroughly evaluate its antioxidant profile and to analyze its effect in diabetic mice induced by high-fat diet. Male C57BL/6J mice were induced by 60 days by a high-fat diet and treated for 30 days with p-hydroxycinnamic diester (200 e 400 mg/Kg) and metformin (200 mg/Kg). p -Hydroxycinnamic diester presented chemical structure consistent with the cinnamic acid derivatives reported in scientific literature. Furthermore, p -hydroxycinnamic diester exhibited excellent in vivo and in vitro antioxidant activity, and it also decreased glycemia, MDA, reactive oxygen species in liver tissue, body mass, water consumption of animals. p -Hydroxycinnamic diester had satisfactory results, and this product could be useful for diabetes treatment. [Display omitted] • Carnauba wax has promissing pharmacological properties. • P -hydroxycinnamic diesters from carnaúba wax presented hypoglicemic and antioxidant effect. • CG-MS revealed the majoritary presence of p -hidroxycinnamic derivates. [ABSTRACT FROM AUTHOR]